Abstract: The present invention relates to an improved process for the preparation of (2S)-2-[(4R)-2-oxo-4-propyltetrahydro-1H-pyrrol-1-yl] butanamide compound of formula-1, its intermediates, novel salt compounds of intermediates of the compound of formula-1. Further the use of novel salts in the preparation of the compound of formula-1. The present invention also relates to the novel process for the preparation of the compound of formula-1.

Abstract: A vehicle leveler which includes a first portion with a leading edge and a trailing edge, the trailing edge is disposed further from the driveway than the leading edge. The leveler also includes a second portion with a leading edge and a trailing edge, the leading edge of the second portion is removably attached to the trailing edge of the first portion and the leading edge of the second portion is disposed further from the driveway than the trailing edge of the second portion. The second portion also includes an extension portion. The vehicle leveler has opposing side portions which have a top surface that forms a walkway. A safety barrier with two opposed gates is mounted adjacent to the vehicle leveler. The safety barrier when in an open position acts as a fall protection barrier for a user.

Abstract: The invention relates to method of enhancing yield of alkyl taurate amides using enhancing specifically phosphoric acid catalysts. It further relates to the use of phosphoric acid to enhance yield while avoiding and/or reducing undesirable browning.

Abstract: The present disclosure provides novel pladienolide compounds, pharmaceutical compositions containing such compounds, and methods for using the compounds as therapeutic agents. These compounds may be useful in the treatment of cancers, particularly cancers in which agents that target the spliceosome and mutations therein are known to be useful. Also provided herein are methods of treating cancers by administering at least one compound disclosed herein and at least one additional therapy.

Abstract: The invention provides a solid composition of the peripheral mu opioid antagonist axelopran and a combination dosage form of the mu opioid antagonist axelopran sulfate in an immediate release form and an opioid analgesic agent which may be in an extended release, sustained release, modified release, or controlled release form and methods of preparing such a combination dosage form.

Abstract: The present invention relates to an aqueous extract useful notably for the regeneration of human or animal cells, notably mammalian cells, comprising an aqueous extract free of any insoluble solid debris of ground planarian organisms having a regeneration capacity, containing at least the intracellular components of the cells of said organisms of a cell lysate of said cells of said organisms.

Abstract: A network separation device that can separate an internal network and an external network with little changes in the networks in a video surveillance system providing monitoring picture data through the internal network and the external network. The network separation device receives monitoring picture data from a monitoring camera that acquires a monitoring picture, transmits outbound picture data unidirectionally to an external network client through an external network in response to a request of the external network client, and transmits inbound picture data to an internal network client through an internal network in response to another request from of the internal network client.

Abstract: A system and method of operation embeds a three-dimensional structure in a topology of an analog processor, for example a quantum processor. The analog processor may include a plurality of qubits arranged in tiles or cells. A number of qubits and communicatively coupled as logical qubits, each logical qubit which span across a plurality of tiles or cells of the qubits. Communicatively coupling between qubits of any given logical qubit can be implemented via application or assignment of a first ferromagnetic coupling strength to each of a number of couplers that communicatively couple the respective qubits in the logical qubit. Other ferromagnetic coupling strengths can be applied or assigned to couplers that communicatively couple qubits that are not part of the logical qubit. The first ferromagnetic coupling strength may be substantially higher than the other ferromagnetic coupling strengths.

Abstract: A system and method and apparatus collect behavioral biometric and facial recognition data for biometric analysis by asking a user to type text to an electronic device. Fusion of knowledge based authentication, behavioral biometrics and facial recognition provides strong authentication and liveness detection, while keeping user experience to simply typing.

Abstract: The invention features soluble fibroblast growth factor receptor 3 (sFGFR3) polypeptides. The invention also features methods of using sFGFR3 polypeptides to treat skeletal growth retardation disorders, such as achondroplasia.

Abstract: The present invention provides exosomes isolated from an animal, wherein the animal (a) has overcome a disease caused by a pathogen, and (b) it is free from the pathogen that causes the diseases. The invention also provides process for obtaining these exosomes and the use thereof in therapy.

Abstract: An electric motor includes a stator; an annular end cap, fastened at a first end of the stator; a threaded seat that is mounted at an outward end face of the annular end cap for receiving a first gas foil thrust bearing; a shaft, inserted through the stator, through the annular end cap, and through the threaded seat; a thrust runner mounted at an end of said shaft adjacent the threaded seat; a first gas foil thrust bearing that is mounted into the threaded seat, adjacent a face of the thrust runner facing the stator; a bearing cap that has a threaded fitting by which it is attached onto the threaded seat; and a second gas foil thrust bearing that is mounted into the bearing cap adjacent to a face of the thrust runner opposite the first gas foil thrust bearing.

Abstract: An electronic device including a digital circuit to be compensated and a compensation device for compensating PVT variations of this digital circuit. This compensation device is arranged also for controlling the operating speed of the digital circuit and can also be arranged for equalising a rise time and a fall time of a logic gate including the transistors of the digital circuit. The electronic device implements a first loop, allowing to control the operating speed of the digital circuit by exploiting the same voltage at the compensation terminals of the compensation device and at the terminals at the digital circuit and at a critical path replica module allowing to control the threshold voltages of the respective transistors. The electronic device can implement also a second loop allowing to equalise the rise and fall times of a logic gate including the transistors of the digital circuit.

Abstract: Photovoltaic module comprising: a front sheet arranged on a light incident side of said photovoltaic module; a back sheet arranged on an opposite side of said photovoltaic module to said front sheet; a photovoltaic conversion device disposed between said front sheet and said back sheet; at least one front encapsulation layer disposed between said photovoltaic conversion device and said front sheet; wherein said front encapsulation layer comprises pigment particles distributed therein

Abstract: A carpenter's, mason's, or plumber's level with an elastic, flexible cord for attachment to a plank, pipe, or workpiece is disclosed. The level has a linear, bar-shaped body with a rectangular cross-section, where portions of the body may be hollow or have recessed openings therein. The level has an elastic cord connected to the body, wherein the cord is stretch-wrapped around a plank, pipe or like workpiece to attach the level thereto for angular tilt measurement. A groove, a contour, a notch, a boss, a ridge, a hole, a recess, a hook, or the like can be used to hold or snare the elastic cord when in use and to store the elastic cord on the level body when not in use. The level body has an opening to receive a bubble vial for angular tilt indication.

Abstract: Photovoltaic module comprising: a front sheet arranged on a light incident side of said photovoltaic module; a back sheet arranged on an opposite side of said photovoltaic module to said front sheet; a photovoltaic conversion device disposed between said front sheet and said; back sheet; at least one front encapsulation layer disposed between said photovoltaic conversion device and said front sheet and comprising pigment particles distributed therein; characterized in that said, front encapsulation layer comprise a first zone a second zone, said first zone being situated closer said front sheet than said second zone, said first zone comprising a higher density of pigment particles than said second zone.

Abstract: An inflatable transfer mattress includes a top panel, a bottom panel having a perimeter sealingly coupled to a perimeter of the top panel to define an internal volume therebetween, a first wedge pocket coupled to an outer surface of the top panel, and a first inflatable wedge. The internal volume is configured to receive an air flow therein. The first inflatable wedge is sized and configured to be inserted into the first wedge pocket and is configured to be transitioned from a deflated state to an inflated state. The first inflatable wedge is configured to rotate a patient to a predetermined angle with respect to the top panel in the inflated state.

Abstract: Provided herein are bifunctional compounds that bind tau protein and/or promote targeted ubiquitination for the degradation of tau protein. In particular, provided are compounds that can bind tau protein, a protein whose aggregation is implicated in a variety of neurodegenerative disease (e.g., tauopathies), and can promote its degradation by recruiting an E3 ubiquitin ligase (e.g., Cereblon), which can ubiquitinate tau protein, marking it for proteasomal degradation. Also provided are radiolabeled forms of the bifunctional compounds, pharmaceutical compositions comprising the bifunctional compounds, methods of detecting and/or diagnosing neurological disorders, methods of detecting and/or diagnosing pathological aggregation of tau protein (e.g., in the central nervous system), methods of treating and/or preventing neurological disorders, and methods of promoting the degradation of tau protein by E3 ubiquitin ligase activity in a subject by administering a compound or composition described herein.

Abstract: Water soluble iron carbohydrate complex obtainable from an aqueous solution of iron (III) salt and an aqueous solution of the oxidation product of one or more maltrodextrins using an aqueous oxone solution at a pH-value within the alkaline range, where, when one maltodextrin is present, its dextrose equivalent lies between 5 and 20, and when a mixture of several maltodextrins is present, the dextrose equivalent of the mixture lies between 5 and 20 and the dextrose equivalent of each individual maltodextrin contained in the mixture lies between 2 and 40, process for its production and medicament for the treatment and prophylaxis of iron deficiency anaemia conditions.