Abstract: The invention relates to a system for applying a superimposed time-varying frequency electromagnetic wave to a target object or a target region that is formed by the target object and a medium surrounding the target object, comprising a device for generating a superimposed time-varying frequency electromagnetic wave where the time-varying AC wave is riding on the predefined DC bias voltage. When applied to the object or region, the superimposed time-varying frequency electromagnetic wave is able to induce a flow of ionic current having a DC component traveling in a pulsating and time-varying manner in the target object and/or in the medium and effect induced vibration of electrons and molecules of the target object and the medium. The invention also relates to a method applying a superimposed time-varying frequency electromagnetic wave to a target object or a target region.

Abstract: A method for implementing an adapted patient care for an individual suffering from liver fibrosis after assessing liver fibrosis progression in the individual, and thus determining whether the individual is a slow, medium or fast fibroser. Also, a method for treating an individual suffering from liver fibrosis and identified as a fast fibroser, which includes the steps of identifying the individual as a fast fibroser by assessing fibrosis progression and treating the individual by administering without delay at least one therapeutic agent for treating liver fibrosis, or for treating the underlying cause responsible for liver fibrosis, or both.

Abstract: The invention relates to a method for transferring a space payload from a first orbit to a second orbit. Said method is characterized in that the space payload, moving about the first orbit, is attached to a removable orbital towing assistance device including at least one fuel pouch. Said method includes the steps of: —attaching (E1) an orbital transfer vehicle to the removable orbital towing assistance device; and —transferring (E2) the space payload and the removable orbital towing assistance device to the second orbit by means of the orbital transfer vehicle. The invention also relates to a removable orbital towing assistance device intended for a space payload and an orbital transfer vehicle and enabling direct supply of fuel to the vehicle and/or the space payload.

Abstract: A foot for household appliance and a household appliance are provided. The foot includes: a hydraulic plate; a sheath, fixedly connected with the hydraulic plate; an adjustable foot, arranged in the sheath and capable of axially moving relative to the sheath, an accommodating chamber is formed by the hydraulic plate, the sheath and the adjustable foot; a hydraulic medium, arranged in the accommodating chamber, and the hydraulic medium is compressed or expanded depending on pressure changes to drive the adjustable foot to move axially in the sheath for leveling. At least two feet are communicated with each other to allow the hydraulic medium to flow between the feet. A liquid flowing passage for allowing the hydraulic medium to flow is arranged in the hydraulic plate. A control device for controlling the liquid flowing passage to open or close is arranged on at least one of the feet.

Abstract: The present invention discloses an expandable liner hanger system comprising a central pipe and an expandable pipe, with an expansion cone provided therebetween the central pipe and expandable pipe in a way that the expansion cone is movable along the central pipe, so that the expandable pipe is expanded; wherein, the expansion cone comprises an expansion cone seat move along the central pipe, and an expansion cone sleeve fitted over the expansion cone seat, the connection between the expansion cone seat and the expansion cone sleeve is configured in a way that the expansion cone sleeve can move upward together with the expansion cone seat along the central pipe so that the expandable pipe is expanded, and the central pipe can drive the expansion cone seat to disengage from the expansion cone sleeve.

Abstract: A snare system for use with a drum has a snare assembly with snares extended longitudinally between opposite end plates. The end plates define a slot from a top surface to a bottom surface with obliquely extending walls. Two connectors, each with a strap carrying a latch member, are attached to opposite sides of the drum via its strap with latch member within the drum rim. Each latch member includes a flange with oblique configuration complimentary to the oblique slot in the end plates. The snare assembly is attached via sliding engagement of the respective flanges into the respective slots with the surfaces of each in surface-to-surface contact so that the connectors maintain the snare assembly attached to the drum. The snare assembly is removable quickly by reverse sliding of the flanges from the slots to interchange with a different snare assembly having end plates with a common configuration.

Abstract: The present invention is in the technical field of breast cancer management, and more particularly relates to the diagnosis and/or prognosing of triple-negative breast cancer (TNBC). The invention is more particularly based on the finding that specific biomarkers are abberantly expressed in patients suffering from a triple-negative breast cancer recurrence, and are highly related to the aggressiveness of this disease, and thus to survival of said patient.

Abstract: There is described a scratch-free snow removal tool comprising a flexible blade presenting a sweeping surface extending in a plane. The flexible blade defines a blade edge which is continuous and can be made of silicone or TPE. The blade support is more rigid than the flexible blade. A plurality of fingers is provided, which are more rigid than the flexible blade and extend in the plane of the sweeping surface, from the blade support toward the blade edge without reaching the blade edge.

Abstract: The present invention relates to specific interleukin-15 (IL-15) antagonist polypeptides and uses thereof for the treatment of inflammatory and auto-immune diseases. In particular, the present invention relates to a specific interleukin-15 (IL-15) antagonist polypeptide comprising i) a IL15-Ralpha sushi-containing polypeptide comprising an amino acid sequence having at least 80% of identity with the amino acid sequence of SEQ ID NO:1 ii) a linker and iii) an IL-polypeptide comprising the amino acid sequence having at least at least 80% of identity with the amino acid sequence of SEQ ID NO:4 provided that the glutamine (Q) residue at position 108 is mutated.

Abstract: An adjustment mechanism the includes a screw, a support having first and second transverse walls perpendicular to the screw, a casing having first and second end faces arranged facing the first and second transverse walls and having a nut housing which opens in opposite first and second openings, a first elastomer pad interposed between the first transverse wall of the support and the first end face of the casing, a second elastomer pad interposed between the second transverse wall of the support and the second end face of the casing, a nut screwed onto the screw, a bearing engaged in the second opening of the casing and traversed by the screw. The nut is in rigid abutment against the casing in the direction of the first opening and the bearing is in elastic abutment against the second elastomer pad.

Abstract: An armchair comprising a seat chassis supported on a support chassis by a pair of support columns, a chair back structure pivotally attached to a rear end of the seat chassis and to the support chassis, and a leg support structure pivotally attached to a front end of the seat chassis and connected to a beam, wherein the beam is attached the chair back structure. A first actuating device is mounted to the chair back, where a protracting end of the first actuating device is connected to the seat chassis. The armchair further comprises a second actuating device mounted to the support chassis, a footrest connected to a protracting end of the second actuating device, a third actuating device attached to the seat chassis, and a seating structure connected to a protracting end of the third actuating device and mounted above the seat chassis, wherein the seating structure includes an operative position projecting upwards and forwards by the third actuating device at a tilting angle from the seat chassis.

Abstract: The present invention concerns a method of synthesizing a iodo- or astatoarene comprising the reaction of a diaryliodonium compound with a iodide or astatide salt, respectively. The invention also relates to said iodo- or astatoarene and diaryliodonium compound as such. The invention also concerns a method of synthesizing a iodo- or astatolabelled biomolecule and/or vector using said iodo- or astatoarene.

Abstract: Frozen confection composition comprising from 0 wt % to 5 wt % fat, from 0 wt % to 10 wt % protein, a fat to protein ratio of less than 1:1 and an emulsifier; wherein the fat droplets of the homogenised pre-mix of the frozen confection have an average droplet size d (3,2) of below 0.6 micron, and significantly reduced shrinkage of the product is observed on heat shock testing of the frozen confection product.

Abstract: A method of characterizing the protein O-GlcNAcylation site-specificity of an antibody. A method of detecting or quantifying the expression of site-specific O-GlcNAcylated proteins expressed in cells and biological samples. A method of diagnosing cancer in a host based on the cellular expression of site-specific O-GlcNAcylated proteins. A method of screening anti-cancer compounds according to their ability to increase a level O-GlcNAcylation of oncogene or tumor suppressor proteins. Methods of treating cancer in an animal host by administering compounds that increase a level of O-GlcNAcylated c-myc or p53 in cancer cells. A method of distinguishing subclasses of pancreatic cancer according to the sensitivity of pancreatic cancer cells to an imidazole derivative, and a method of personalized pancreatic cancer treatment delivered according to the sensitivity subclasses.

Abstract: A method of supplying and replenishing a laundry dosing system with one or more reservoirs providing stocks of components for laundry includes monitoring consumption of each of the components in the one or more reservoirs; automatically determining when each one or more reservoirs need replenishment from the monitoring; and replenishing one or more components in response to a monitoring result.

Abstract: Described herein are anti-CD277 antibodies which: activates or inhibit the cytolytic function of V?9/V?2 T cells, and/or costimulates T cells together with CD3-TCR, and/or costimulates T cells in addition to CD28-B7 costimulation, and/or increases the activity and/or survival of monocytes and dendritic cells. The use of said antibodies in therapy is also described.

Abstract: The invention relates to a shaped detergent product comprising 10-100 wt. % of a solid amorphous phase and 0-90 wt. % of one or more other solid phases, said solid amorphous phase comprising: 25-88 wt. % free acid equivalent of aminopolycarboxylate; 10-60 wt. % free acid equivalent of an acid, said acid not being an am inopolycarboxylate; 2-30 wt. % water; wherein the shaped detergent product contains at least 0.5 wt. % surfactant.

Abstract: Disclosed is a therapeutic agent for hepatocellular carcinoma, comprising 5-((2-(4-(2-hydroxyethyl)piperidin-4-yl)benzamide)pyridin-4-yl)oxy)-6-(2-methoxyethoxy)-N-methyl-1H-indole-1-carboxamide or a pharmacologically acceptable salt thereof.

Abstract: Methods for treating a renal cell carcinoma with an improved combination of lenvatinib or a pharmaceutically acceptable salt thereof and everolimus are provided. These methods further comprises adjusting the dosages of lenvatinib during the onset of adverse effects to lead to improved treatment methods for human subjects with renal cell carcinoma. Particularly useful dosages and dose modifications upon the occurrence of adverse events are also provided.

Abstract: A plasma etching method includes a physisorption step for causing an adsorbate that is based on first processing gas to be physisorbed onto a film to be etched, while cooling an object to be processed on which the film to be etched is provided; and an etching step for etching the film to be etched by causing the adsorbate to react with the film to be etched, using the plasma of second processing gas.