Abstract: The present invention relates to the field of disorders of the central nervous system, in particular neurological and psychiatric disorders, and the prevention and/or treatment thereof. In particular, the present invention relates to the finding that soluble amyloid precursor protein a (sAPP?) presents a particular binding site, which allows for binding to the GABABR1a receptor, thereby causing an agonistic effect through specific binding to Sushi domain 1 of GABABR1a. As a result, the frequencies of excitatory and inhibitory postsynaptic currents are reduced. Accordingly, the invention provides compounds able to interfere with the association of sAPP? with Sushi domain 1 of GABABR1a and as such with selective impairment of GABABR1sa beneficial in neurological and psychiatric disorders. The invention as well provides methods and (high content) screening assays for the production of said compounds.

Abstract: The invention relates to oil-in-water emulsion in which specific oils (e.g., lauric oils) are used in the oil phase while surprisingly maintaining excellent transparency. In one aspect, said emulsions comprise fatty acid in oil phase. The invention comprises an energy efficient process for making said fatty acid containing transparent nanoemulsions.

Abstract: The invention relates to a method for automatic and continuous measurement of a sedation state of a patient in an intensive care unit. The method according to the invention comprises the following steps: providing signals representative of the condition of the patient, said signals comprising cardio-circulatory signals, signals representative of the respiratory activity and signals representative of the motor activity of the patient; and determining a global index representative of the sedation state of the patient.

Abstract: Disclosed is a cosmetic composition comprising (i) 1 to 30 wt % of a non-hydrocarbon emollient; and (ii) 2 to 60 wt % of a blend of silicone elastomer gel of the Formula (I) and solvent; wherein the solvent for the silicone elastomer gel is selected from cyclic or linear polydimethylsiloxanes; wherein the w/w ratio of the amount of the non-hydrocarbon emollient to the combined amounts of the silicone elastomer gel and said solvent is from 1:50 to 1:1 and where the amount of the non-hydrocarbon emollient is less than the amount of the silicone elastomer gel; and wherein the composition comprises less than 2 wt % capric caprylic triglycerides and less than 5 wt % crosslinked elastomeric silicone polyether, wherein said non-hydrocarbon emollient is an alkenyl or alkyl ester of a C10-20 fatty acid, an ether-ester, a polyhydric alcohol ester, a wax ester, a mono-, di- or triglyceride, a sterol ester, a fatty alcohol, a fatty acid, lanolin or its derivative, wax ester, a phospholipid, beeswax or a sterol.

Abstract: A shopping management control system based on an acquaintance discount code includes an input controller configured to recognize information in an acquaintance discount code to be provided by a user according to an input of the user; a management controller configured to determined that the the input controller recognized the information to generate an acquaintance discount code of the user and store and manage the acquaintance discount code of the user; a display controller configured to display the acquaintance discount code of the user generated through the management controller on a screen of a terminal of a user; and a feedback controller configured to feed back, when the acquaintance discount code of the user is received and an item is purchased by using the acquaintance discount code, one or more pieces of application information of the acquaintance discount code to the user.

Abstract: Embodiments of the disclosure relate to tetrahydropyrazolopyrimidine compounds that act as antagonists or inhibitors for Toll-like receptors 7 and/or 8, and their use in pharmaceutical compositions effective for treatment of systemic lupus erythematosus (SLE) and lupus nephritis.

Abstract: A support leveling device includes leveling feet mounted on a bottom plate of an appliance. Each leveling foot comprises a sheath, having a hollow cavity with an opening, and mounted on the plate; a regulating foot, the plate having a through hole corresponding to the opening of the hollow cavity, one end of the regulating foot passing through the through hole and extending into the hollow cavity of the sheath for axial movement relative thereto, and another end of the regulating foot located at an outer side of the bottom plate and supported on a support surface; and a hydraulic medium sealed in a cavity defined by the regulating foot and the sheath. When the leveling foot is placed on an uneven support surface, the regulating feet are stressed to axially move along the sheath, and the hydraulic medium is stressed to act on the regulating foot for support leveling.

Abstract: A process and composition for improvement of the moisturization state of the stratum corneum of human skin epidermis comprising applying to the skin an effective amount of a composition (C) for topical use comprising at least one cosmetically acceptable excipient and a composition C1 consisting of 20-50% by weight of composition C2, which in turn includes from 3-25% by weight of a polyol, from 25-45% by weight anhydrides of the polyol, and from 30-72% by weight of polyol glycosides of the polyol, with the remainder of composition C2 to 100% by weight being made up of water; and from 50-80% by weight of glycerol and/or glycerol oligomers, with the ratio of polyol glycosides to glycerol and/or glycerol oligomers greater than or equal to 1/10 and less than or equal to 1/2.

Abstract: Described herein are antibodies, and antigen-binding fragments thereof, that are specific for folate receptor alpha, related polynucleotides, expression vectors, and cells that express the described antibodies. Also provided are methods of using the described antibodies, and antigen-binding fragments thereof, and related kits to detect folate receptor alpha. Provided herein are also methods for diagnosing folate receptor alpha-expressing cancers using the described antibodies, and antigen-binding fragments thereof. The methods involve determining the amount of folate receptor alpha in a sample derived from a subject and comparing this level with the level of folate receptor alpha in a control sample or reference sample.

Abstract: Provided is a compound represented by formula (IV) or a salt thereof, wherein the content of the compound represented by formula (I) is 350 ppm by mass or less.

Abstract: A pneumatic tyre comprises a tread portion, a pair of opposing sidewall portions and a pair of opposing bead portions, the tread portion extending radially outwards from the sidewall portions and the sidewall portions extending radially outwards from the bead portions, wherein each bead portion comprises an axially inward side and an axially outward side which are joined at a base of the bead portion and each axially outward side of the bead portion comprises a concave region extending axially inwards. Each concave region further comprises a convex region located within the concave region which extends axially outwards.

Abstract: Disclosed is a method for producing a stage for amplifying the power of a variable envelope signal including at least one amplifier. For each amplifier, a form of ideal variation in average power POUTL is selected. For each value of each setting parameter and for each average input power value, a value of an optimisation criterion is calculated on the basis of the mathematical expectation of at least one optimisation parameter. An optimum value of each setting parameter is determined and the amplification stage is produced with a number of amplifiers in parallel determined on the basis of an average output power value and with, for each amplifier, matching circuits providing the optimum values of the setting parameters. The invention also relates to an amplification stage produced in this manner.

Abstract: Wheel (100) for a vehicle window wiper drive system, said wheel comprising electrical contact means (400), a first and a second electrical contact means (410, 411) of said electrical contact means being in electrical continuity, and the first and the second electrical contact means being for a respective slider (200a, 200b), said wheel being characterized in that the angular extension (?) of said electrical contact means in the plane of the wheel is strictly less than 360° and said electrical contact means being situated on a face of the wheel intended to receive a linkage.

Abstract: A method for directing a self-assembly of a block copolymer comprising a first and a second block is provided. The method including: providing a substrate comprising at least one concavity therein, the concavity comprising at least a sidewall and a bottom, the bottom having a preferential wetting affinity for the second block with respect to the first block; grafting a first grafting material onto the sidewall, selectively with respect to the bottom, the first grafting material having a preferential wetting affinity for the first block with respect to the second block; grafting a second grafting material onto the bottom and optionally onto the sidewall, the second grafting material having a preferential wetting affinity towards the first block with respect to the second block; and providing the block copolymer on the substrate, at least within the at least one concavity.

Abstract: Provided herein is N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl (tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4?-(morpholinomethyl)-[1,1?-biphenyl]-3-carboxamide hydrobromide. Also provided herein is a particular polymorph form of this compound.

Abstract: An electric heating system is provided including first and at least second electric heating devices. The first and at least second electric heating devices each include or have associated therewith communication means, whereby data concerning all or one or more of the heating devices can be communicated directly to or between the first and at least second electric heating devices.

Abstract: In a method and magnetic resonance (MR) apparatus for MR image reconstruction, an image reconstruction algorithm is used that operates on one calibration matrix that is formed by reorganizing a number of individual, undersampled k-space data sets respectively acquired by multiple reception coils in a parallel MR data acquisition from a subject exhibiting motion. The motion causes the k-space data sets to exhibit errors. In order to use the calibration matrix in the reconstruction algorithm, it is subjected to an iterative rank reduction procedure in which, in each iteration, a residual is calculated for each data point that represents how poorly, due to motion-induced corruptions, that data point satisfies the low rank constraint, and non-satisfying data points are removed from the data point for the next iteration. The resulting low rank matrix at the end of the iterations is then used to produce images with fewer motion-induced errors.

Abstract: The invention provides compounds of formula (I): or pharmaceutically-acceptable salts thereof, that are inhibitors of Janus kinases. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using such compounds to treat inflammatory and autoimmune skin diseases.