Abstract: A shaped detergent product comprising 10 to 100 wt. % of a first solid phase and 0 to 90 wt. % of one or more other phases, said first solid phase comprising: a) non-crystalline chiral aminopolycarboxylate; b) non-crystalline organic acid other than component a); c) at most 30 wt. % water; d) at most 50 wt. % of non-crystalline water-soluble component other than component a) or component b); e) at most 20 wt. % of homogeneously dispersed crystalline material; wherein the combination of the components a), b) and c) is present in the first solid phase in a concentration of at least 35 wt. % of the total weight of said solid phase; and wherein components a), b) and c) are present in the solid phase in a ratio of from 25 to 88 parts by weight of free acid equivalent of component a): from 10 to 60 parts by weight of free acid equivalent of component b) : from 2 to 30 parts by weight of component c); and wherein the shaped detergent product comprises at least 0.5 wt. % surfactant.

Abstract: A nutraceutical and/or pharmaceutical composition designed to stimulate the production of type 2 beta-defensins. The composition includes as a sole active ingredient a gluco-oligosaccharide presenting the following basic oligomeric structure: for the treatment of intestinal inflammations in the quantity of 0.5 to 10 g. Application to the treatment of functional colopathy.

Abstract: Disclosed is a composition including (per 100% weight): a) 90 wt.-% to 99.0 wt.-% water including, in dissolved form, 0.002 mol/L to 0.1 mol/L of at least one salt of ammonium cation or of a monovalent or multivalent metal cation with an organic or inorganic anion; b) 0.5 wt.-% to 5 wt.-% of a crosslinked anionic polyelectrolyte; and c) 0.5 wt.-% to 5 wt.-% of a compound having formula (II): R1—(O—CH2—CH2)p—OH (II), where the weight ratio of the crosslinked anionic polyelectrolyte to the compound of formula (II) is greater than or equal to 0.2 and less than or equal to 2.0, and the molar ratio of the compound of formula (II) to the salt greater than or equal to 0.05 and less than or equal to 1. Also disclosed is a composition in cosmetics and a method for lightening the thickened salt-rich composition.

Abstract: The invention provides compounds of formula (I): or a pharmaceutically-acceptable salt thereof, wherein the variables are defined in the specification, that are inhibitors of JAK kinases, particularly JAK3. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using such compounds to treat gastrointestinal and other inflammatory diseases.

Abstract: Disclosed herein are compounds, or pharmaceutically acceptable salts thereof, and methods of using the compounds for treating breast cancer by administration to a subject in need thereof a therapeutically effective amount of the compounds or pharmaceutically acceptable salts thereof. The breast cancer may be an ER-positive breast cancer and/or the subject in need of treatment may express a mutant ER-? protein.

Abstract: Disclosed are porous composite particles and compositions comprising the same. The porous composite particles comprising base of an amphiphilic or hydrophobic polymer and 0.1 to 20% of a pigment based on the total weight of porous composite particles, where said particles have 50 to 95 vol % internal porosity and an outer surface which is either continuous and devoid of pores or is discontinuous comprising plurality of pores whose total area is 0.01 to 30% of the total outer surface area. When typically applied, the compositions impart improving the characteristics of skin.

Abstract: The present invention relates to an improved process for the preparation of 3?,7?-dihydroxy6?-ethyl-?-cholan-24-oic acid compound of formula-1, represented by the following structural formula: Formula-1 The present invention also relates to process for the preparation of ethylene diamine and tertiary butyl amine salts of 3?,7?-dihydroxy6?-ethyl-5?-cholan-24-oic acid which are useful in the preparation of pure 3?,7?-dihydroxy6?-ethyl-5?-cholan-24-oic acid.

Abstract: Disclosed is cleansing composition comprising: (i) a surfactant; and, (ii) a complex of an oligodynamic metal with a chemoattractant, wherein zeta potential of the complex is from +30 mV to ?30 mV and wherein said complex is not in nanoparticulate form; and wherein the chemoattractant is a protein. Also disclosed is a method of sanitising an animate or inanimate substrate by reducing viable count of bacteria residing thereon by at least 2-log, comprising the steps of: (i) applying to the substrate a composition as disclosed or an aqueous suspension thereof; (ii) allowing said composition or the suspension to remain in contact with said substrate for a contact time of up to 60 seconds; and, (iii) rinsing the composition or the suspension with water, or wiping it with a wipe.

Abstract: The invention provides a compound of formula (I): or a pharmaceutically-acceptable salt thereof, that is an inhibitor of JAK kinases. The invention also provides pharmaceutical compositions comprising such compound, a crystalline form, methods of using such compound to treat inflammatory skin diseases and other diseases, and processes and intermediates useful for preparing such compound.

Abstract: A full width measurement system includes a frame having a first and second rails. The first and second rails are positioned transverse to a moving sheet of material such that the first and second rails are positioned on opposite sides of the moving sheet. Sources may be positioned along the first rail in a predetermined arrangement across a width of the moving sheet. Each of the sources are configured to emit energy toward the moving sheet in a predetermined pattern. Detectors may be positioned along the second rail in a predetermined alignment with respect to the sources such that each of the detectors detect an energy level from multiple respective sources after the energy from the respective sources has passed through the moving sheet. Controller circuitry is configured to receive signals from the detectors and provide real time measured parameters spanning the width of the moving sheet of material.

Abstract: Real-time results for events and topics as published in original sourced electronic documents are presented in response to search queries. The invention can be used in environments such as automated news aggregators, search engines, and other electronic systems which compile information having temporal qualities and which includes timely information on events presented on mobile devices with reduced screen sizes.

Abstract: The method concerns a method of communication between end-user terminals and user terminals that are static or have low relative mobility with respect to each other, wherein a control server: —selects the terminals that are static or have low relative mobility from among the assembly of terminals, the other terminals being referred to as end terminals; —determines a graph, the nodes of which are static or low relative mobility terminals, —determines, on this graph of nodes, a sub-graph of dominant nodes; —selects, in the sub-graph of dominant nodes, at least one gateway node capable of establishing a communication with the Cloud Computing type network over their second cellular communication link; —selects the nodes of the graph which do not belong to the nodes of the sub-graph, as nodes having only the access/relay function to the dynamic multi-hop proximity network for the end-user terminals; —transmits its hierarchy status over the second cellular communication link, only individually to each of the variou

Abstract: The invention relates to a detergent composition comprising:—(a) from 0.0001 to 1 wt. %, preferably from 0.0001 to 0.1 wt. %, more preferably from 0.0001 to 0.01 wt. %, most preferably from 0.0005 to 0.001 wt. % of a shading dye; and, (b) from 0.0001 to 10 wt. %, preferably from 0.0005 to 8 wt. %, more preferably from 0.001 to 5 wt. %, most preferably from 0.002 to 0.2 wt. % of a cellulase selected from any sequence with a sequence identity of at least 80%, preferably at least 85%, further preferred at least 90%, even more preferred at least 92%, also preferred at least 95%, particularly preferred at least 98% and most preferred at least 99% to SEQ ID NO: 11, SEQ ID NO: 13, SEQ ID NO: 15 or SEQ ID NO: 17.

Abstract: Temporal qualities of events described in electronic documents are verified using a variety of techniques, including human based feedback from contributors near a location of the event in question. The invention can be used in environments such as automated news aggregators, search engines, and other electronic systems which compile information having temporal qualities and which includes timely information on events presented on mobile devices with reduced screen sizes.

Abstract: The invention relates to a method of retrofitting a vacuum deposition chamber of an apparatus for coating optical substrates, the vacuum deposition chamber comprising a second resistance evaporator crucible. The method comprises installing a resistance evaporator comprising a crucible into the operational vacuum deposition chamber such that the crucible is disposed above the vacuum deposition chamber floor, and such that the second resistance evaporator crucible is closer to the vacuum deposition chamber floor than the installed crucible.

Abstract: The invention is directed to a process for preparing compounds which are useful as intermediates for the preparation of medicinal agents having inhibitory activity for JAK.

Abstract: Systems and methods for environmentally sealing electrical connections of window assemblies are disclosed. A mechanically protective enclosure assembly is adhered to a transparent pane including glass. The enclosure assembly includes a first member, a second member, and an opening. The first member includes a transparent-pane engaging surface, a first interface surface, and a plurality of first walls extending therebetween. The second member is attached to the first member. The second member includes a top member, a second interface surface, and a plurality of second walls extending therebetween. The first interface surface engages the second interface surface to provide a first fluid-tight seal. The opening is defined by at least one of the plurality of first walls and at least one of the plurality of second walls. The opening engages the wiring harness to provide a second fluid-tight seal therebetween.

Abstract: Provided is a weighing apparatus with a flowmeter function includes a load sensor unit configured to detect a load of a flow rate calculation target, an A/D conversion unit configured to sequentially convert load signals from the load sensor unit into digital load data at predetermined intervals, an arithmetic processing unit configured to sequentially convert the load data into weighed values to calculate flow rate values, and a storage unit for storing the weighed values. The arithmetic processing unit calculates change amounts in weighed values and calculates a flow rate value based on a flow rate calculation cycle set based on a minimum time by which the change amounts become equal to or more than a change amount in weighed value, the change amount being calculated based on a minimum indication of weighed value and the required resolution of weighed value and satisfying a required resolution.

Abstract: Some embodiments are directed to a method of determining a sintering thermal impedance of a sintering layer by: providing a substrate having a predetermined substrate thermal impedance and disposing the sintering layer on the substrate forming with the sintering layer a stack. Placing at least one semiconductor die, that includes a semiconductor element with at least two element electrodes on the sintering layer. Injecting an electrical current through the at least two element electrodes for measuring a temperature sensitive parameter of the semiconductor element. Heating the stack with a predetermined heat power and determining, while sintering, a semiconductor element temperature from the measured temperature sensitive parameter.