Abstract: A method for forming on a substrate a cross-linked layer for directing the self-assembly of a self-assembling material is provided. The method including: (a) providing a structure having the substrate; (b) providing on the substrate a layer of a photo- and thermally cross-linkable substance which, when crosslinked, is suitable for directing the self-assembly of a self-assembling material; (d) photocrosslinking the cross-linkable substance partially; and (d) cross-linking the substance further thermally, thereby forming the cross-linked layer.
Type:
Grant
Filed:
February 18, 2019
Date of Patent:
November 17, 2020
Assignees:
IMEC VZW, Katholieke Universiteit Leuven, KU LEUVEN R&D
Abstract: The present invention relates to a method of interpreting different antibiogram images in which it is possible to recognize a phenotype of bacterial resistance relative to antibiotics by comparing photographs using a photographic image bank of the reference antibiogram without any need to interpret them using the EUCAST or CA-SFM interpretation data; providing that for a given phenotype, there is available a collection of photographs of a plurality of bacteria of the same species and of the same phenotype.
Type:
Grant
Filed:
October 5, 2015
Date of Patent:
November 17, 2020
Assignees:
FONDATION MEDITERRANEE INFECTION, UNIVERSITE D'AIX MARSEILLE, ASSISTANCE PUBLIQUE—HOPITAUX DE MARSEILLE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE)
Inventors:
Jean-Marc Rolain, Didier Raoult, Stéphanie Le Page, Sylvain Buffet
Abstract: A method of operating an atomic force microscope, comprising a probe, the probe being moved forth and back during respective trace and retrace times of a scan line, the method comprising: a) during trace time, oscillating the probe, b) generating a z feedback signal to keep an amplitude of oscillation of the probe constant at a setpoint value, the z feedback signal being generated by a first feedback loop, c) during retrace time, placing the probe in a drift compensation state by changing the setpoint value to a different value so that the z feedback signal being generated by the first feedback loop causes the probe to move away from the sample and oscillate free, d) detecting an amplitude of free oscillation of the probe and adjusting with a second feedback loop its excitation signal to maintain the amplitude of free oscillation of the probe close to a set value.
Type:
Grant
Filed:
April 26, 2017
Date of Patent:
November 17, 2020
Assignees:
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), UNIVERSITE D'AIX-MARSEILLE
Abstract: The invention relates to an adapter (13) designed to connect a wiper blade (1) to a drive arm (2) of a windscreen wiping system (3) for vehicles, the adapter (13) being outfitted with at least one locking means (18) designed to lock the adapter (13) in a terminal portion (11) of the drive arm (2), the adapter (13) comprising a pivoting means (27) of the locking means (18), characterized in that the adapter (13) comprises a portion (40) at least partially bounding off a volume (26) of the adapter (13), the locking means (18) comprising at least one appendage (39) which extends into the inside of the volume (26).
Type:
Grant
Filed:
April 27, 2018
Date of Patent:
November 17, 2020
Assignee:
Valeo Systèmes d'Essuyage
Inventors:
Vincent Gaucher, Stéphane Houssat, Guillaume Mouleyre
Abstract: The invention provides compounds of formula (I): where the variables are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are useful as JAK kinase inhibitors. The invention also provides pharmaceutical compositions comprising such compounds and methods of using such compounds to treat respiratory diseases.
Type:
Grant
Filed:
September 3, 2019
Date of Patent:
November 17, 2020
Assignee:
Theravance Biopharma R&D IP, LLC
Inventors:
Daniel D. Long, Cameron Smith, Corbin Thompson
Abstract: A laundry system for dispensing one or more ingredient compositions from ingredient reservoirs for supplying to a washing machine drum, the laundry system comprising: (i) an apparatus which comprises a dispensing device and multiple ingredient reservoirs; (ii) said multiple ingredient reservoirs containing the various ingredient compositions in controllable fluid communication with the dispensing device and each ingredient reservoir comprising at least one ingredient reservoir identifier; (iii) said dispensing device being operable to selectively dispense portions of the ingredient compositions from respective ingredient reservoirs as a result of commands by the user to provide a dose of laundry product, and further comprising (iv) an ingredient reservoir control system for controlling said selective dispensing of respective ingredient compositions from specific ingredient reservoirs identified by respective ingredient reservoir identifiers such that the device can selectively dispense ingredient compositions
Type:
Application
Filed:
January 29, 2019
Publication date:
November 12, 2020
Applicant:
Conopco, Inc., d/b/a UNILEVER
Inventors:
Deborah Jane COOKE, Brian Patrick NEWBY, Ellen Suzanne PIERCY, Katharine Jane SHAW, Robert Linsay TRELOAR
Abstract: The present disclosure provides pharmaceutical combinations comprising at least one spliceosome modulator and at least one inhibitor chosen from BCL2, BCL2/BCLxL, and BCLxL inhibitors. Also provided are methods of treating cancer comprising administering a therapeutically effective amount of at least one spliceosome modulator and a therapeutically effective amount of at least one inhibitor chosen from BCL2, BCL2/BCLxL, and BCLxL inhibitors.
Type:
Application
Filed:
October 30, 2018
Publication date:
November 12, 2020
Applicant:
Eisai R&D Management Co., Ltd.
Inventors:
Daniel AIRD, Laura CORSON, Ping ZHU, Markus WARMUTH, Silvia BUONAMICI, Peter Gerard SMITH, Peter FEKKES
Abstract: This invention relates to syndet-based compositions having pH of 4.5 to 5.5 wherein use of caprylic acid has been unexpectedly found to enhance bacterial kill.
Abstract: The invention concerns an adapter (2) intended to be fitted to an end part of a drive arm, the adapter (2) comprising at least one front part (11), at least one section of which is U-shaped, and at least one rear part (12), at least one section of which is U-shaped, characterized in that the front part (11) and the rear part (12) are hinged together via a hinge means (13).
Type:
Grant
Filed:
September 28, 2017
Date of Patent:
November 10, 2020
Assignee:
Valeo Systèmes d'Essuyage
Inventors:
Stéphane Houssat, Vincent Gaucher, Olivier Jomard
Abstract: The present invention relates to a cross-linkable rubber composition, a cross-linked rubber composition obtained by cross-linking such a rubber composition, a method of preparing a tire and a tire. A cross-linkable rubber composition comprises, per hundred parts by weight of rubber (phr): 100 phr of a diene-based elastomer component with an average molecular weight Mn in a range of ?100000 to ?5000000 g/mol and a homopolymer of polybutadiene, wherein the homopolymer of polybutadiene has an average molecular weight Mn in a range of ?10000 to ?45000 g/mol and a glass transition temperature Tg in a range of ??110° C. to ??60° C.
Type:
Grant
Filed:
September 14, 2017
Date of Patent:
November 10, 2020
Assignee:
APOLLO TYRES GLOBAL R&D B.V.
Inventors:
Swarupini Ganesan, Sander Marinus, Hendrik Stevens
Abstract: Humidifiers can include a liquid tank removably attachable to a base portion. The liquid tank can include an upper connector configured to engage a lower connector of the base portion when the liquid tank and the base portion are attached. The liquid tank can include a touch interface configured to receive a touch input from outside of the liquid tank and a liquid level sensor configured to output a signal representative of a level of liquid in the liquid tank. The base portion can include a controller that is in electrical communication with the liquid level sensor and the touch interface when the upper connector engages the lower connector. The controller can be configured to adjust operation of the humidifier based on signals received from the touch interface and can receive signals from the liquid level sensor representative of the amount of liquid in the liquid tank.
Type:
Grant
Filed:
August 1, 2017
Date of Patent:
November 10, 2020
Assignee:
D-M-S Holdings, Inc.
Inventors:
Stephen Minakian, Oishee Sarkar, Samuel Bradley, Vidya Vasudevan
Abstract: Provided herein are antibodies that specifically bind Tau and methods of using the same.
Type:
Grant
Filed:
October 16, 2018
Date of Patent:
November 10, 2020
Assignees:
Eisai R&D Management Co., Ltd., UCL Business LTD
Inventors:
Malcolm Ian Roberts, James Martin Staddon, Hettihewage Alfred Rohan De Silva, Jared Spidel, Hirofumi Aoyagi, Shigeru Akasofu, Yutaka Hashizume, Kishan Agarwala
Abstract: The photoreactor comprises at least one housing (11) for at least one reaction vessel and at least one light source for lighting said at least one reaction vessel, and the photoreactor comprises: a first module (1) provided with said at least one housing (11) for at least one reaction vessel and comprising a cooling/heating circuit (15) for regulating the temperature of said at least one reaction vessel; a second module (2) provided with said at least one light source; and a thermal insulating layer (5) placed between the first module (1) and the second module (2). It improves reproducibility of the reactions by temperature and light intensity control.
Type:
Grant
Filed:
May 30, 2018
Date of Patent:
November 10, 2020
Assignees:
FUNDACIÓ INSTITUT CATALÀ D'INVESTIGACIÓ QUÍMICA (ICIQ), INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS (ICREA)
Inventors:
Julio Lloret-Fillol, Carla Casadevall Serrano, José Luis León, Arnau Call Quintana, Alicia Casitas Montero, Joan Jose Pla, Javier Pérez Hernández, Francesc Xavier Caldentey Frontera
Abstract: A method in a separation system including parallel fluid paths each having a separation module, includes providing a sensor of the same type in at least each of the parallel fluid paths except one: measuring a characteristic fluid property with at least one of the sensors in the parallel fluid paths; possibly measuring the same characteristic fluid property with a system sensor positioned in the outlet of the separation system; and comparing measured characteristic fluid properties to evaluate and/or qualify the performance of the separation system.
Abstract: To reliably exercise radio communication of calibration data. In order to achieve the above-described object, a balance (10) includes a weight sensor (12), a built-in weight (20) to be loaded on the weight sensor, an adding and removing unit (21) for the built-in weight, an arithmetic processing unit (14) configured to drive the adding and removing unit, and a radio communication device (41) connected to the arithmetic processing unit, wherein the arithmetic processing unit includes a radio wave environment check section (32) configured to check a radio wave environment, and a calibration execution section (33) configured to add or remove the built-in weight and issue a command to the radio communication device to transfer calibration data when the radio wave environment check section determines that the radio wave is good.
Abstract: Decorative composite body containing a plate-like carrier body made of plastics material, and at least one decorative element fixed in the carrier body, wherein the carrier body consists at least regionally of a fibre-reinforced plastics material, and wherein the decorative element is cohesively bonded to melted or at least partially liquefied and resolidified plastics material of the plate-like carrier body, and wherein that side of the carrier body on which the at least one decorative element is arranged, is additionally provided with a film, preferably made of PMMA, and/or with a cover plate, preferably made of PMMA.
Type:
Grant
Filed:
November 1, 2016
Date of Patent:
November 10, 2020
Assignee:
D. Swarovski KG
Inventors:
Walter Hermann, Robin Kunstl, Markus Santer
Abstract: In one aspect, the invention relates to compounds having the formula XII: where Ra, Rb, R2, R7, and X are as defined in the specification, or a pharmaceutically acceptable salt thereof. The compounds described herein are prodrugs of compounds having neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising these compounds; methods of using these compounds; and processes and intermediates for preparing these compounds.