Abstract: A mechanical computer keyboard including a plurality of keys and an input/output (i/o) interface for output of registration of pressing one or more of the plurality of keys. Each key includes a keycap, a key switch including a stem, a key registration unit for registering a keystroke, and a spring for forcing the keycap in a neutral release position and providing a perceptible increase in pressing force. The keyboard further includes an analog-to-digital converter and the keys include a distance sensor unit for determining a travel distance of the pushing-down of the keycap by measuring a complex electrical impedance corresponding to the travel distance of the pushing-down the keycap, wherein the analog-to-digital converter is configured to convert the complex electrical impedance to a digital input signal including a digitalized keystroke travel distance for outputting of the digital input signal by the i/o interface towards the computer.

Abstract: The invention provides compounds of formula (I): which contain a 4-membered heterocyclic amide, where the variables are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are useful as JAK kinase inhibitors. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat respiratory diseases, and processes and intermediates useful for preparing such compounds.

Abstract: A metal-halo oxyanion electrode and battery including the metal-halo oxyanion electrode is described.

Abstract: The present invention provides a composition and method for treating diseases associated with demyelination of the nerves, such as ALS, RA, Tremors/Parkinson's Disease, and MS, Alzheimer's disease, ALS, Guillain-Barre syndrome, atherosclerosis, schizophrenia, Tremors/Parkinson's disease, senile dementia, Muscular Dystrophy, Attention Deficit Disorder, Attention Deficit Hyperactivity Disorder, Complex Regional Pain Syndrome, Diabetes, Neuropathic Pain, Spider Arthritis West Nile Virus, Fibromyalgia, Shingles, Gout, Migraine Headaches, Post Polio Syndrome, Central Virus Deafness, Asthma, Chronic Pain Of Unknown Origin and Hepatitis C and for treating non-viral based cancers. By administering measured doses of an immunity-provoking agent and a bacterial antigen activator, patients suffering from ALS, RA, MS, Tremors/Parkinson's Disease, and prostate cancer and others realized immediate beneficial results with no side effects.

Abstract: The invention relates to a wiper blade (10) to clean a vehicle window (1), with a wiper blade body (18), with the wiper blade adapter (14) to fasten the wiper blade (10) to a wiper arm (12), with at least one spray opening (20) arranged on the longitudinal side of the wiper blade body (18) for spraying a cleaning medium on the vehicle window (1), wherein the at least one spray opening (20) is hydraulically connected to a supply element (30) arranged in the area of the wiper blade adapter (14), and wherein the supply element (30) has at least one connection element (31, 32) to supply at least one cleaning liquid (2) to the supply element (30). It is provided according to the invention that the supply element (30) has a device (40) to supply air and a mixing device (35) to generate a cleaning foam as a cleaning medium, the cleaning medium being composed of the cleaning liquid (2) and the air.

Abstract: Provided herein is a crystalline hydrate of the compound of formula 1: Also provides herein are pharmaceutical compositions comprising such crystalline hydrate, methods of using such crystalline hydrate to treat respiratory diseases, and processes useful for preparing such crystalline hydrate.

Abstract: A device is dynamically isolated via a broadband switch that includes a plurality of cascade elements in series, wherein each cascade element comprises a first set of SQUIDs in series, a matching capacitor, and a second set of SQUIDs in series. The broadband switch is set to a passing state via flux bias lines during programming and readout of the device and set to a suppression state during device's calculation to reduce operation errors at the device. A device is electrically isolated from high-frequencies via an unbiased broadband switch. A device is coupled to a tunable thermal bath that includes a broadband switch.

Abstract: A cable car carriage for transporting goods or passengers has two opposing spaced-apart crawlers. Each of the crawlers has a crawler chain composed of juxtaposed chain links. A support cable can be inserted between the opposing crawlers on the opposing chain links of the crawler chains. A pressing mechanism connects the crawlers with one another, and is designed to adjust the distance between the crawlers as well as the pressing force of the two crawlers relative to each other and/or the pressing force of the two crawlers against the support cable. The crawler chains are driven in a circulating movement by a drive via a crawler running gear, thus moving the cable car carriage along the support cable. A cable crane, a passenger gondola, a cable saddle, and a transport assembly employing the cable car carriage are also disclosed.

Abstract: A display apparatus is disclosed for enabling a user to experience a 3D perception when visual information is presented by the display apparatus. The display apparatus has an image forming unit having a two-dimensional array of image subpixels arranged to emit light for presenting associated visual information, and an optical system having an array of diffractive optical elements associated with respective ones of the array of image subpixels. Each diffractive optical element is arranged to diffract light from the associated image subpixel into a diffraction pattern with a plurality of diffraction orders to provide the visual information from the associated image subpixel to a plurality of directional viewing regions associated with the plurality of diffraction orders.

Abstract: The present invention concerns methods and approaches for modifying guanosine tetraphosphate (ppGpp) homeostasis in photosynthetic eukaryotes, in particular plants or algae, in order to modulate senescence for the remobilisation of nitrogen and other nutrients from the chloroplast, and modified photosynthetic eukaryotes thus produced.

Abstract: The invention relates to urinary catheters having a catheter tube with a first connection on the distal end and at least one catheter eye to be positioned in the urinary bladder. The urinary catheters are distinguished in particular in that they may be used problem-free as indwelling catheters. To this end, disposed in the urinary bladder is a reservoir container that is connected via a channel running parallel to the catheter tube to a second connection as distal end of the channel. In addition, the channel is connected to the urethra via at least one opening of the channel wall.

Abstract: A three-phase load is powered by a PWM (e.g., SVPWM) driven DC-AC inverter having a single shunt-topology. A shunt voltage and a branch voltage of the inverter (across a transistor to be calibrated) are measured during a second period of each SVPWM sector, and the drain-to-source resistance of the calibrated transistor is calculated. During the fourth period of each SVPWM sector, the branch voltage is measured again, and another branch voltage across another transistor is measured. Using the drain-to-source resistance of the calibrated transistor and the voltage across the calibrated transistor measured during the fourth period, the phase current through the calibrated transistor is calculated. Using the other branch voltage measured during the fourth period and the drain-to-source resistance of its corresponding transistor (known from a prior SVPWM sector), the phase current through that transistor is calculated. From the two calculated phase currents, the other phase current can be calculated.

Abstract: A self-contained satellite-navigation-based (SatNav-based) method and micro system is disclosed, wherein SatNav-derived (e.g., GPS-derived) position and velocity measurements are obtained and processed to achieve a low cost, micro size, real-time solution for the position and velocity of the carrier relative to a vertical and/or horizontal plane of previously measured location and heading, and for the slant range from a fixed position located on said vertical or horizontal plane. The method includes two parts: 1) a method for defining both the spatial orientation of the vertical and/or horizontal plane of interest, along with a selected fixed position of interest on one of those planes, and 2) a method for obtaining the real-time relative position and velocity of the carrier relative to the plane(s) of interest, and its position relative to the fixed position of interest.

Abstract: Cap arrangements for per-well fluidics and gas exchange for microplate, microtiter, and microarray technologies are presented for use with cell cultures or other applications. In example implementations, each individual well within in a conventional or specialized microplate can be fully or partially isolated with capping or other arrangements which can include conduits for controlled introduction, removal, and/or exchange of fluids and/or gases. Conduit networks can include small controllable valves that operate under software control, and micro-scale pumps can also be included. Conduit interconnections can include one or more of controllable-valve distribution buses, next-neighbor interconnections, and other active or passive interconnection topologies.

Abstract: The present invention relates to a composition exhibiting a bile-salt hydrolase activity for its use for the treatment or the prevention of giardiasis, said composition comprising a bile-salt hydrolase (BSH)enzyme, a bacterium able to secrete a BSH, a recombinant host cell able to secrete a BSH, or a combination thereof. The present invention also relates to the use of a composition exhibiting a BSH activity for the treatment or the prevention of giardiasis, and to a pharmaceutical composition or a food composition comprising, as an active principle, a BSH, a lactic acid bacterium able to secrete a BSH, or a recombinant host cell able to secrete a BSH.

Abstract: The present invention relates to compositions and methods for the treatment of nucleotide repeat expansion disorders such as myotonic dystrophy.

Abstract: An unwinder for web material includes: a first and second reel holder, a dynamic storage device, a junction device arranged between the first or second reel holder and the dynamic storage device and configured to join an end portion of web material running out on the first reel to an initial portion of web material of the second reel, an actuator configured to pull the web material. The dynamic storage device includes: a plurality of first return rollers, a carriage mounted on a guide and free to move along the guide approaching or moving away from the first return rollers, a plurality of second return rollers mounted idly on the carriage. The return rollers define a zigzag path for the web material. The dynamic storage device includes a plurality of motorized shafts and each first return roller is mounted by means of two rolling bearings on a respective motorized shaft.

Abstract: The present invention relates to a savoury, liquid concentrate comprising gelatinized legume starch, more particularly a savoury concentrate that can be used as a base for the preparation of broth, bouillons, soups, sauces, gravies, etc. The present invention also relates to a method of preparing such a concentrate.

Abstract: A cooling device includes a metal member, a cooling member, and a sheet-shaped thermal conductive member. The metal member thermally couples with an element that generates heat. The cooling member includes a channel for refrigerant to flow. The thermal conductive member includes an adhesive surface adhered to the metal member and a non-adhesive surface pressed against and thermally coupled in contact with the cooling member. The thermal conductive member and the cooling member are separable.

Abstract: Disclosed is an in-vitro method to determine efficacy of a cosmetic composition or of one or more ingredients comprised therein to inhibit a particulate pollutant from contacting skin, said method comprising the steps of: (i) contacting a human skin equivalent with a cosmetic composition to form, upon drying, a layer thereof extending along mutually perpendicular X and Y and Z axis where along said Z axis said layer is 1 to 100 ?m, where said Z axis indicates thickness of said layer; (ii) depositing, on said layer, a known amount of a model fine particulate matter comprising a first substance responsive to depth profile analysis where said cosmetic composition comprises a second substance, not comprised in said model fine particulate matter but also responsive to said depth profile analysis where the response of said first and second substances are distinguishable; (iii) for a pre-determined period after depositing said model fine particulate matter, periodically measuring response of said first and said seco