Abstract: The present invention provides novel Compound (1) having tumor vascular remodeling effect and/or anti-CAF (Cancer Associated Fibroblasts) activity, or a pharmaceutically acceptable salt thereof, optionally in a pharmaceutically acceptable carrier, and medical uses thereof.

Abstract: The present invention concerns a detergent composition, comprising: a) from 2 to 95 wt. %, preferably from 2 to 50 wt. %, more preferably from 2 to 40 wt. % of an organic acid derivative of mono- and di-glycerides of the form:— (I) wherein one or two, of R1, R2 and R3 are independently selected from an acyl group of the formula R4CO—; where R4 is a linear or branched, saturated or mon-unsaturated C9 to C21 alkyl chain; wherein one or two, of R1, R2 and R3 is selected from an organic acid of generic formulation (HOOC)nXCO—; wherein X is saturated or monounsaturated organic group containing 1 to 6 carbon atoms and n=1 to 3; wherein one or none of R1, R2 and R3 is selected from H; and, b) from 0.5 to 25 wt. %, preferably from 1 to 20 wt. %, more preferably from 1 to 10 wt. % of non-ionic surfactant; and to domestic method of treatment of a textile using said composition.

Abstract: A graft preparation system that includes a base, a guide extending laterally outward from the base and including a top interface and a bottom interface that removably receives a graft thereon, and a plurality of slots extending through the guide between the top interface and the bottom interface. Each slot of the plurality of slots are sized to receive a needle therethrough such that the plurality of slots form a plurality of channels from the top interface to the bottom interface. The guide is configured to facilitate placement of a suture attached to the needle from the top interface into at least one of the channels formed by the plurality of slots such that the suture is received through the graft at the bottom interface.

Abstract: Apparatus and methods are described for use with a digital microscope unit that includes a digital microscope. A biological cell sample disposed within a sample carrier, is received into the digital microscope unit. For at least one imaging field of the biological cell sample, it is determined that, within the imaging field, there is a variation in the focal depth of the biological sample with respect to the microscope. At least one image of the imaging field is captured. A characteristic of the biological sample is determined by analyzing the captured image of the imaging field, the analyzing including, in response to determining that there is a variation in the focal depth of the biological sample with respect to the microscope, accounting for the variation in the focal depth of the biological sample with respect to the microscope. Other applications are also described.

Abstract: Disclosed is a compound of formula (I) in which a, R1-R5 and X1 are as described herein. Also disclosed are a pharmaceutical composition containing the compound and a method of using the compound for treating cancer, such as renal cancer.

Abstract: Apparatus and methods are described for use with a blood sample (48, 50), including measuring hemoglobin concentration within at least a portion (48) of the blood sample, by performing a first measurement on the blood sample. Mean corpuscular hemoglobin in the blood sample (48, 50) is measured, by performing a second measurement on the blood sample (48, 50). A parameter of the blood sample is determined, based on a relationship between the concentration of hemoglobin and the mean corpuscular hemoglobin. Other applications are also described.

Abstract: Screws are provided which have a longitudinal axis and include a threaded shank and a head wherein a socket is formed to be engaged by a wrench and having a pluri-lobed outer profile comprising a series of lobes circumferentially offset and separated by a series of circumferentially offset protrusions of the head. Each protrusion is delimited by two flanks and a front length joining the radially inner ends of the flanks and is convex and symmetrical with respect to a center axis radially oriented with respect to the longitudinal axis. The front length is formed by a center face and two inclined side faces each of which joins the radially inner end of the respective flank with a respective end of the center face, which is oriented orthogonally with respect to the center axis of the protrusion. Pluri-lobed wrenches adapted for use with such screws are also provided.

Abstract: Water contaminated with antibiotics, pharmaceuticals, microorganisms and other organic material stripped of these contaminating products with a specialized gas sparged hydrocyclone apparatus using an ozone containing gas as the stripping gas. The stripping gas contains 50-98 volume percent ozone, and the contaminated water is exposed to UV light prior to introduction into the sparger.

Abstract: Disclosed is a method for calculating a control setpoint of a hybrid powertrain of a motor vehicle, the hybrid powertrain including an electric motor and an internal combustion engine (ICE) that is equipped with a gearbox and that is supplied with fuel. The method includes: acquiring a value relative to a power requested at the vehicle's drive wheels; and determining the contribution of the electric motor and the ICE in order to satisfy the request for power at the drive wheels. The determination step involves calculating a triplet of three values, one value relating to the electromechanical power that the electric motor must provide, one value relating to the thermomechanical power that the ICE must provide and one value relating to the ratio that needs to be engaged in the gearbox, this triplet minimising the fuel consumption of the ICE and the current consumption of the electric motor.

Abstract: The systems, devices, articles, and methods described herein generally relate to analog computers, for example quantum processors comprising qubits, couplers, and, or cavities. Analog computers, for example quantum processor based computers, are the subject of various sources of error which can hinder operation, potentially reducing computational accuracy and speed. Sources of error can be broadly characterized, for example as i) a background susceptibility do to inherently characteristics of the circuitry design, ii) as an h/J ratio imbalance, iii) bit flip errors, iv) fidelity, and v) Anderson localization, and various combinations of the aforesaid.

Abstract: A wireless mesh network may have a plurality of nodes, each of which is able to dynamically establish itself as a gateway when a connection with an end-user device is detected. To route data to an end-user device, each node that is not, itself, a gateway to that device may route traffic along a path to the appropriate gateway. If a node does not have such a path in memory, it may broadcast an inquiry to all nodes with which communicates directly, to determine whether any of those nodes are a gateway to the end-user device, or have a path to the end-user device in memory. Thus, paths to gateways may propagate among the nodes. If multiple paths are available, a node may select the path that provides the best data transmission. Each node may replace pathways that are no longer valid, allowing the network to repair itself if needed.

Abstract: A headband for a protective helmet comprises a front portion configured to be secured to the protective helmet; a left rear portion that is selectively connected to the front portion; a right rear portion that is selectively connected to the front portion and is configured to overlap the left rear portion; and a means for securing a position of the left rear portion relative to the right rear portion, such as a ratchet mechanism. A headband kit includes multiple left rear portions, each of which can be selectively connected to the front portion, and multiple right rear portions, each of which can be selectively connected to the front portion.

Abstract: Machine and method for producing substantially cylindrical articles of the tobacco processing industry; a material with cavities is fed, along a given path, through an insertion station, where powder material is inserted into the cavities, so as to obtain a strand, and through a wrapping station, in the area of which a strip is wrapped around the strand; the powder material is inserted into each cavity by a relative insertion unit, which moves in a synchronous manner along a coupling portion of the given path.

Abstract: An adapter (112) for connecting a wiper blade to a drive arm, the adapter comprising two substantially parallel walls (28) connected together by at least one connecting element (30), said walls comprising first inner side faces (28a) between which said at least one connecting element extends, and outer side faces (28b) comprising protruding sliding guide patterns (132), characterised in that said patterns are divided into lines and columns.

Abstract: The present invention provides a serum and its blood components isolated from blood, wherein the blood is drawn from body of a patient, and a normal saline solution mixed with the serum and its blood components, characterized in that a Reagent A having at least one type of adjuvant, and a Reagent B having at least one type of transfer factor peptide and a buffered saline, and Reagent C having an alpha lipoic acid are added to the mixture of the serum and its blood components and the normal saline solution, such that the composition enhances cell-mediated immunity and T suppressor cells in the patient to act against autoimmune disease. The present invention also provides a method for producing such composition for immunotherapy thereof.

Abstract: A device for cleaning a camera lens (6), by means of a cleaning head, comprises a fixed cleaning head and a camera that is made mobile by means of drive means (10), the head being accommodated in a structural element (2) of the vehicle. The drive means are suitable for generating a relative movement of the camera in relation to the cleaning head, between a passive image capture position in which the camera is disposed accommodated in said structural element of the vehicle facing the cleaning head, and an active position in which the camera is deployed at a distance from the structural element of the vehicle to allow image capture. The device is particularly effective when applied to the cleaning of a reversing camera implanted in motor vehicles.

Abstract: Apparatus and methods are described for use with a cell sample. For each of one or more imaging fields of the cell sample, a depth scan of the cell sample is performed using a microscope. One of the depth levels is identified as being an optimum focal plane for imaging one or more entities within the sample using the microscope, at least partially in response to detecting that the depth level corresponds to a drop in image contrast relative to image contrast at other depth levels. Based upon the depth level identified as being the optimum focal plane for each of the one or more imaging fields of the cell sample, a scanning depth interval over which to perform a depth scan of the cell sample at a further imaging field is defined. Other applications are also described.

Abstract: The present invention shows that the isolated NFL-TBS40-63 peptide is highly specific for neural stem cells. It is therefore presented here for use in a method for detecting these cells in vitro or in vivo, for addressing chemical compounds or biological materials to said cells, or for treating neurodegenerative disorders or brain tumours.

Abstract: Degeneracy in analog processor (e.g., quantum processor) operation is mitigated via use of floppy qubits or domains of floppy qubits (i.e., qubit(s) for which the state can be flipped with no change in energy), which can significantly boost hardware performance on certain problems, as well as improve hardware performance for more general problem sets. Samples are drawn from an analog processor, and devices comprising the analog processor evaluated for floppiness. A normalized floppiness metric is calculated, and an offset added to advance the device in annealing. Degeneracy in a hybrid computing system that comprises a quantum processor is mitigated by determining a magnetic susceptibility of a qubit, and tuning a tunneling rate for the qubit based on a tunneling rate offset determined based on the magnetic susceptibility. Quantum annealing evolution is controlled by causing the evolution to pause for a determined pause duration.

Abstract: The invention proposes an adapter (26) for a windscreen wiper, having a body (25) which is delimited by two external lateral faces (29a, 29b) and which is configured to be mounted in a complementary yoke (28) of a wiper arm having a pair of front locking pegs (44a) and an abutment surface (39) which cooperate with associated parts of the adapter, each of the lateral faces of the adapter (26) having a front locking notch (59) which receives a front locking peg (44b), and wherein the adapter (26) is provided with a resilient branch (62) bearing an unlocking button (64) which cooperates with the abutment surface (39), characterized in that the resilient branch (62) extends longitudinally beyond a transverse end face (27b) of the body (25) of the adapter (26).