Abstract: The present disclosure relates to a seat member comprising a first shell, a second shell fixed to the first shell, and a padding covering the second shell such that the second shell is sandwiched between the first shell and the padding, the padding being configured to support a user, and a ventilation system comprising a fan and a duct, the duct being defined by the first shell and the second shell and forming an air passage placing the fan and padding in communication via holes in the second shell. The duct comprises a housing able to receive the fan, and the first shell comprises a door through which the fan can be placed in the housing, the fan having a first orifice for the passage of air between the exterior and the fan, the door having a hole located facing the first orifice.

Abstract: The present disclosure concerns a broadband hyperspectral imaging spectrophotometer configured to analyze an object and includes an illumination assembly having a source for emitting a light beam and configured so that the light beam scans line by line the object to be analyzed, a focusing mirror, a first mirror folding, and a planar scanning mirror movable in rotation. The illumination assembly, the focusing mirror, the first folding mirror and the planar mirror are arranged to bring the light beam to the object along a line which will be displaced on the object via the scanning mirror. The imaging spectrophotometer further includes two measuring sensors by a distance between the object and the scanning mirror. The focusing mirror is movable in translation to adapt the imager to the measured distance by the measuring sensors.

Abstract: A nose clip and a tail clip for a splitboard ski assembly may each comprise at least three hooks. The nose clip and the tail clip may be adaptable to various splitboard ski designs. A stretcher for a skin assembly may be configured to interface with the tail clip. The tail clip may comprise at least two elongated apertures defining a rail. The stretcher may be configured to interface with the rail via friction and/or secure a skin assembly to a splitboard ski assembly.

Abstract: Compositions and methods of this disclosure include liquid cosmetic compositions, for example, an eyeliner, that is applied to the surface of a user (e.g., a person), the surface including, for example, an eyelid, the liquid cosmetic product including a ferromagnetic component that is capable of being attracted by and attached to a magnet, the magnet part of a false eyelash.

Abstract: A combinational circuit block has input pins configured to receive input digital signals and output pins configured to provide output digital signals as a function of the input digital signals received. A test input pin receives a test input signal. A test output pin provides a test output signal as a function of the test input signal received. A set of scan registers are selectively coupled to either the combinational circuit block or to one another so as to form a scan chain of scan registers serially coupled between the test input pin and the test output pin. The scan registers in the set of scan registers are clocked by a clock signal. At least one input register is coupled between the test input pin and a first scan register of the scan chain. The at least one input register is clocked by an inverted replica of the clock signal.

Abstract: Methods, compositions, and systems for treating subject(s) in need of plasma Factor VIII, particularly a subject having preexisting anti-FVIII inhibitory antibodies, are provided. The methods involve administering to the subject a therapeutically effective amount of an inflammation suppressor, a therapeutically effective amount of a CD8+ T cell depleting agent, and a therapeutically effective amount of a composition comprising a lentiviral vector (LV) comprising an optimized FVIII expression cassette expressibly linked to a megakaryocyte-specific promoter. Such methods, compositions, and systems are useful to treat subjects with blood clotting disorder(s), such as hemophilia A.

Abstract: The invention relates to a system for laser photocoagulation of the retina, comprising: a photocoagulation laser (1); an optical path (5) connecting the upstream photocoagulation laser (1) to a downstream laser outlet opening (6) intended to be positioned in front of the retina; an adaptive optical element (9) positioned in the optical path and configured to modify the wavefront of the laser beam being propagated in the optical path, in order to compensate for aberrations of the eye that occur as far as the retina; a position control loop (10) controlling a first actuator (14) positioned in the optical path downstream of the adaptive optical element in order to control the position of the laser outlet opening relative to the retina to be treated; and at least one imaging device (8) configured to obtain an image of the retina diverted from the optical path.

Abstract: The present invention provides methods for the synthesis of ketones involving a Ni/Zr-mediated coupling reaction. The Ni/Zr-mediated ketolization reactions can be used in the synthesis of halichondrins (e.g., halichondrin A, B, C; homohalichondrin A, B, C; norhalichondrin A, B, C), and analogs thereof. Therefore, the present invention also provides synthetic methods useful for the synthesis of halichondrins, and analogs thereof. Also provided herein are compounds (i.e., intermediates) useful in the synthesis of halichondrins, and analogs thereof.

Abstract: A pharmaceutical composition comprising a compound represented by the formula (I) or pharmaceutically acceptable salt thereof or solvate thereof, and a basic substance is excellent in dissolution, is stable even after a long term storage, and is useful as a preventive or therapeutic agent against a tumor: wherein, R1 is a hydrogen atom, a C1-6 alkyl group or a C3-8 cycloalkyl group; and R2 is a hydrogen atom or a methoxy group.

Abstract: A front spoiler assembly for a motor vehicle. The front spoiler assembly includes a spoiler lip which is arranged to extend at least partially in a transverse direction of the motor vehicle in a front area of the motor vehicle. The spoiler lip includes a front side, a spoiler lip outer edge which faces away from a front part of the motor vehicle, and at least two spoiler areas. At least one actuator device moves the at least two spoiler areas either separately or together from a retracted rest position to an extended spoiler position. The at least two spoiler areas are separated from each other at the front side of the spoiler lip by at least one depression form which extends into the spoiler lip outer edge.

Abstract: Various irrigation fluid containment systems and components are disclosed. In some embodiments, the irrigation fluid containment system comprises a medical kit and/or an irrigation kit. In some embodiments, the irrigation fluid containment system comprises a medical basin and/or an irrigation basin. In some embodiments, the irrigation fluid containment system comprises an irrigation shield. In some embodiments, the irrigation fluid containment system comprises a suction hose.

Abstract: The present invention relates to a rotor (1) of a rotary electric machine, comprising: a body (3) comprising a cylindrical central core (5) and a circumferential plurality of arms (B1 . . . B18) extending radially out from the cylindrical central core (5), the body (3) being intended to be mounted with the ability to move about an axis of rotation X, a coilset produced by windings of turns and forming at least one series of coils (C1 . . . C9, C1? . . . C9?), a coil (C1 . . . C9, C1? . . . C9?) comprising a predetermined number of turns around at least two arms (B1 . . . B18) of the body (3), two adjacent coils (C1 . . . C9, C1? . . . C9?) of a series being angularly offset from one another with a partial overlap, in which the last coil (C9, C9?), situated radially furthest towards the outside, comprises a predetermined number of turns that is lower than the predetermined number of turns of the other coils of the series (C1 . . . C8, C1? . . . C8?).

Abstract: Methods for simulating the movement of fluid through a formation volume comprises defining a lab-scale model representing rock fabric and associated permeability along a single well location within a formation volume and converting the lab-scale model to a field-scale model representing rock fabric and associated permeability at the single well location. The field-scale model representing rock fabric and associated permeability is correlated with field-scale log data and interpolated between multiple well locations so as to create a field-scale model representing rock fabric and associated permeability across the formation volume so that the movement of fluid through the formation volume can be simulated.

Abstract: Provided is a battery pack, and more particularly, a battery pack capable of preventing degradation of performance at a low temperature by allowing a portion of air exhausted through an exhaust port to be introduced into an inhalation port to optimize a temperature of external air introduced into a cell module.

Abstract: An RF joint rotating about an axis of rotation (Z) includes a number N, greater than or equal to 1, of RF transmission channels, a first, internal surface of symmetry of revolution about the axis (Z) and of RF transmission having a first, internal radius r1, and a second, external surface of symmetry of revolution about the axis (Z) and of RF transmission having a second, external radius r2, strictly less than the first, internal radius r1.

Abstract: A computer system uses a pool of predefined functions and pre-trained networks to accelerate the process of building a large neural network or building a combination of (i) an ensemble of other machine learning systems with (ii) a deep neural network. Copies of a predefined function node or network may be placed in multiple locations in a network being built. In building a neural network using a pool of predefined networks, the computer system only needs to decide the relative location of each copy of a predefined network or function. The location may be determined by (i) the connections to a predefined network from source nodes and (ii) the connections from a predefined network to nodes in an upper network. The computer system may perform an iterative process of selecting trial locations for connecting arcs and evaluating the connections to choose the best ones.

Abstract: Computer systems and computer-implemented methods train a machine-learning regression system. The method comprises the step of generating, with a machine-learning generator, output patterns; distorting the output patterns of the generator by a scale factor to generate distorted output patterns; and training the machine-learning regression system to predict the scaling factor, where the regression system receives the distorted output patterns as input and learns and the scaling factor is a target value for the regression system. The method may further comprise, after training the machine-learning regression system, training a second machine-learning generator by back propagating partial derivatives of an error cost function from the regression system to the second machine-learning generator and training the second machine-learning generator using stochastic gradient descent.

Abstract: The present invention provides a novel liposome composition containing eribulin or its pharmacologically permissible salt, and its method of manufacture.