Abstract: The invention provides a method for obtaining information useful to determine the effect of sun exposure on the skin of an individual, the method comprising the steps of: (a) obtaining genomic DNA from skin cells derived from the individual, wherein the skin cells include epidermal skin cells; and (b) observing cytosine methylation of at least two CpG loci in the genomic DNA selected from the group consisting of: cg02066936 cg16929393 cg05715751 cg21177821 cg05504117 cg00772091 cg06066180 cg00675160 cg00067720 cg02491003 cg24490133 cg05355684 cg19283806 cg23976431 cg00025972 cg07050101 cg10557907 cg25588389 cg24114899 cg22695351 cg24105685 cg13181164 cg04258138 cg13181974 cg24357619 cg17196051 cg27546066 cg01203651 cg09496748 cg00297912 cg19757573 cg03243551 cg10634273 cg23225508 cg10397765 cg02037307 cg15084618 cg25677261 cg10294853 cg19145082 cg12577010 cg24489344 cg08243465 cg04935109 cg19720260 cg16293892 cg16210355 cg03597159 cg26837962 cg18582260 cg10624914 cg12474705 cg04425614 cg15701237 cg09055205 cg

Abstract: The invention provides a compound of formula (I): or a pharmaceutically-acceptable salt thereof, that is an inhibitor of JAK kinases. The invention also provides pharmaceutical compositions comprising such compound, a crystalline form, methods of using such compound to treat inflammatory skin diseases and other diseases, and processes and intermediates useful for preparing such compound.

Abstract: The present invention to a method, a kit, etc., for predicting the response BNCT using a BSH-related medicine-containing boron preparation and a BPA-containing boron preparation, the method and kit being characterized by examining the expression of CD44, a translation-related factor and/or LAT1 in cancer cells of a sample. When the expression of the CD44 or translation-related factor in the cancer cells of the sample is high, it can be predicted that the BNCT using the BSSH-related medicine-containing boron preparation is likely to be responsive. When the expression of the LAT1 in the cancer cells of the sample is high, it can be predicted that the BNCT using the BPA-containing boron preparation is likely to be responsive.

Abstract: A magnetic shielding system that includes a shield that is non-uniform in the axial direction and a shield cap that is non-uniform in the radial direction. Each shield in the system may have a magnetic permeability, thickness, and/or radius that varies in the axial direction to create low-reluctance paths that redirect flux away from a sample towards the ends of the shield. Each shield cap in the system may have a magnetic permeability and/or thickness that varies in the radial direction to create low-reluctance paths that redirect flux away from the sample towards shield walls. An inner shielding layer formed from a material of low permeability and moderate-to-high coercivity may be implemented as the innermost layer of a magnetic shielding system.

Abstract: A network node includes a pushbutton to provide a button-press event and a pairer to receive the button-press event while not being in a secure domain. In response to the button-press, the pairer alternates between acting as an endpoint node and acting as a temporary domain master, until pairing is completed. In an alternative embodiment, the node includes a multi-pairer to receive the button press event and, in response, to open a pairing window, to become a domain master of a secure network and to join more than one other network node receiving a button press event to the secure network until the pairing window closes.

Abstract: A preferred embodiment suspension trauma relief strap assembly for use with a full body harness includes a pair of straps connectable in two configurations. The first configuration is formed by engaging a hook of one strap with one of a plurality of closed loop arrangements of the other strap to form a sling upon which a person donning the full body harness may stand. The second configuration is formed by engaging the hook of the one strap with one of the plurality of closed loop arrangements of the one strap and engaging the hook of the other strap with one of the plurality of closed loop arrangements of the other strap to form two slings upon which a person donning the full body harness may stand.

Abstract: A wiper system including a brushless DC electric motor having a rotor, a stator having coils for electromagnetically exciting the rotor, a device for determining the angular position of the rotor with respect to the stator, a control unit configured to generate control signals for supplying power to the electromagnetic excitation coils according to the angular position of the rotor determined by the device for determining the angular position of the rotor, a reduction gear mechanism linked, on one side, to the rotor of the electric motor and, on the other side, to an output shaft that is intended to be linked to an external mechanism. The rotor includes at least one Hall effect sensor associated with a control magnet that rotates with the rotor and the gear motor also having a processing unit connected to the device for determining the angular position of the rotor.

Abstract: A method for exposing a pattern in an area on a surface using a charged particle beam system is disclosed and includes determining a local pattern density for the area of the pattern based on an original set of exposure information. A pre-PEC maximum dose is determined for the area. The original set of exposure information is modified with the pre-PLC maximum dose.

Abstract: A rigid package for tobacco articles with a hinged lid having: a group of tobacco articles; an inner container which houses the group of tobacco articles; an outer container which houses the inner container in a movable manner, so as to allow the inner container to move relative to the outer container; a hinged lid; and a moving mechanism, which moves the inner container relative to the outer container using the rotation movement of the lid and has a rigid connection tab, which connects a wall of the inner container to a wall of the lid.

Abstract: A filtrate reducer for temperature-resistant calcium-resistant water-based drilling fluid used in oil and gas reservoir protection, a drilling fluid, and uses of the filtrate reducer and the drilling fluid are described. The filtrate reducer contains structural units represented by formulas (1), (2), and (3) herein. The water-based drilling fluid contains the filtrate reducer, and exhibits good inhibitive, rheological, filtrate reducing, and reservoir protection performance when it is applied in the drilling process in a high-temperature high-calcium deep salt-gypsum formation.

Abstract: A system and a method for an automated guided vehicle (AGV) includes a chassis; a load supporting apparatus disposed on the chassis, the load supporting apparatus including a platform to support a load, a lifting mechanism comprising one or more jacks, the platform coupled to the one or more jacks, the one or more jacks configured to raise or lower the platform, and a rotation mechanism coupled to the platform, the rotation mechanism configured to rotate the platform, wherein the rotation mechanism is configured to rotate the platform in response to the AGV turning.

Abstract: A sintered concrete having the following mean chemical composition, as mass percentages on the basis of the oxides and for a total of 100%; ZrO2: 55 to 70%, SiO2: 25 to 40%, P2O5: 0.2 to 9.0%, Al2O3: 0.5 to 7.0%, CaO: >0.2%, CaO+MgO+B2O3+Fe2O3: 0.2 to 10.0%, MgO+B2O3+Fe2O3; ?7.5%, B2O3+MgO: ?4.5%, ZrO2+SiO2+P2O5+Al2O3+CaO+MgO+B2O3+Fe2O3: ?95.0%, and containing more than 70% of zircon, as a mass percentage on the basis of the mass of the crystalline phases.

Abstract: The invention relates to a device for cleaning an optical sensor (2) of an optical detection system for a motor vehicle, said device comprising an assembly for guiding and distributing a cleaning fluid and a drying fluid. Electric motor-driven means (9) are used to move said fluid-guiding and fluid-distributing assembly in a linear movement between a working position in which the fluids can be distributed over an outer surface of the optical sensor (2) and an idle position. Said invention is applicable to motor vehicles.

Abstract: A hybrid computer generates samples for machine learning. The hybrid computer includes a processor that implements a Boltzmann machine, e.g., a quantum Boltzmann machine, which returns equilibrium samples from eigenstates of a quantum Hamiltonian. Subsets of samples are provided to training and validations modules. Operation can include: receiving a training set; preparing a model described by an Ising Hamiltonian; initializing model parameters; segmenting the training set into subsets; creating a sample set by repeatedly drawing samples until the determined number of samples has been drawn; and updating the model. Operation can include partitioning the training set into input and output data sets, and determining a conditional probability distribution that describes a probability of observing an output vector given a selected input vector, e.g.

Abstract: In a system and method for voice activity detection (VAD) including: obtaining audio frames from a multi-microphone array; calculating steered response power (SRP) values of the audio frames; calculating entropy levels based on the SRP values; detecting a sequence of audio frames in which the entropy levels are substantially constant across the sequence of frames and denoting an entropy level of the sequence as a background entropy; identifying an incoming audio frame as containing voice activity if the difference between a level of entropy of the current audio frame and the background entropy is larger than a first threshold, and as not containing voice activity otherwise.

Abstract: Compounds of formula (I): wherein A1, A2, Ra, Rb, Rc, Rd, R3, R4, R5 and T are as defined in the description. Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.

Abstract: A system for application monitoring includes an interface to receive an indication regarding an application. The system includes a processor to determine whether the application is compliant based at least in part on a set of policy rules, and in the event that the application is compliant, provide an indication that the application is compliant.

Abstract: A system for providing mobile content to a mobile communication device includes a first computing system including one or more servers to cause a graphical user interface to be displayed at a second computing system, the graphical user interface (i) enabling a user of the second computing system to at least one of create, edit, or select the mobile content and (ii) enabling the user of the second computing system to provide a phone number associated with the mobile communication device, the mobile communication device being separate and remote from the first computing system and the second computing system.

Abstract: Provided herein are methods for the treatment of bladder cancer.

Abstract: The invention provides a method for obtaining information useful to determine the intrinsic age of skin of an individual, the method comprising the steps of: (a) obtaining genomic DNA from skin cells derived from the individual; and (b) observing cytosine methylation of >30 CpG loci in the genomic DNA selected from the group consisting of: cg19381811 cg19670290 cg15393490 cg01465824 cg04999352 cg09046979 cg10426318 cg09077126 cg24374161 cg14896948 cg14412967 cg16937583 cg17508941 cg24757926 cg03936449 cg17953764 cg00442430 cg06621744 cg08076830 cg06882058 cg25351606 cg02662828 cg20897936 cg07878486 cg21992250 cg06335867 cg15171839 cg09017434 cg04044664 cg20442599 cg15488596 cg10384245 cg23368787 cg07960624 cg08622677 cg13848598 cg02273797 cg22593953 cg23213887 cg20234007 cg26492368 cg06470727 cg13612317 cg09432376 cg12530994 cg05457221 cg04766371 cg03614721 cg22624391 cg27369542 cg18322569 cg27284120 cg21303763 cg05238606 cg16300030 cg00085493 cg11239720 cg23942526 cg10568624 cg07217499 cg03405983 cg255908