Abstract: The invention relates to a tag to secure a string of a tea bag to a handle of a teapot, the tag being flexible and resilient and comprising at least two adjacent areas separated by a cut that are partially separable from the tag.

Abstract: Flexible implant for electrically recording or stimulating a nerve structure, said flexible implant comprising: a first layer of electrically insulating diamond; an electrode of electrically conductive doped diamond, in contact with the first layer of electrically insulating diamond; an electrically conductive layer in contact with the electrode and the first layer, so as to define a conductive track for the electrode; and a second layer of electrically insulating diamond, at least in contact with the electrically conductive layer and a remaining portion of the first layer, all of the above arranged such that: electrically insulating diamond/electrically conductive doped diamond sealing is provided at the electrode (3) by resumption of epitaxial growth; and the electrically conductive layer is encapsulated by the electrode (3), the first layer and the second layer, at the electrode and over the entirety of the remaining surface thereof except over an area defining an electrical contact.

Abstract: The invention provides compounds of formula (I): wherein the variables are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are inhibitors of JAK kinases. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat inflammatory bowel diseases, and processes and intermediates useful for preparing such compounds.

Abstract: The present disclosure relates to a method and a device for measuring at least one atmospheric parameter (gas, temperature). The method includes implementing steps of acquiring spectral images in the ultraviolet and/or the visible and/or the infrared range and scanning according to a tomographic principle. The spectral images are acquired using a network of optical systems such as infrared cameras, and are used to estimate the air quality and/or meteorological and/or climate parameters in a geographic area, for example an urban agglomeration.

Abstract: The present disclosure is directed to a compact wrist rotator and flexor mechanism for use with a prosthetic hand. The wrist rotator and flexor uses a set of motors to provide a driven mechanism having two degrees of freedom, a wrist rotation and a wrist flexion. The rotator uses a motor with an inverted shaft gearbox combined with a worm gear and a face gear transmission to generate continuous and non-backdrivable rotation. The rotator is integrated into a flexor that uses a lead screw acting as a linear actuator to provide strong non-backdrivable flexion and extension. Due to the arrangement of the drives, the resulting wrist rotator and flexor mechanism has a low and compact profile.

Abstract: Method of operating an energy system, said energy system comprising: a local common transmission bus; at least one local energy connected to said bus; at least one local load connected to said bus; an energy store connected to said bus; a controllable interface arranged to exchange energy between said bus and an external distribution network external to said energy system; a controller adapted to control said interface so as to carry out said exchange of energy. According to the invention, the controller defines three modes based on the state of charge of the energy store which determine if, and how, energy is exchanged with the external network so as to optimize self-consumption and to perform ramp-rate reduction and peak shaving as appropriate.

Abstract: The present disclosure provides pladienolide compounds, pharmaceutical compositions containing such compounds, and pladienolide compounds for use in methods of medical treatment. These compounds may be useful in the treatment of cancer, particularly cancers in which agents that target the spliceosome and mutations therein are known to be useful. Also provided herein are pladienolide compounds for use in methods of treating cancers by administering at least one pladienolide compound disclosed herein and at least one additional therapy.

Abstract: The invention provides compounds which are prodrugs of a JAK inhibitor agent for the targeted delivery of the JAK inhibitor to the gastrointestinal tract of a mammal. The invention also provides pharmaceutical compositions comprising the compounds, methods of using the compounds to treat gastrointestinal inflammatory diseases, and processes and intermediates useful for preparing the compounds.

Abstract: Disclosed herein is a method for treating tumor, comprising administering a liposomal composition comprising eribulin or a pharmaceutically acceptable salt thereof and a PD-1 antagonist to a patient in need thereof.

Abstract: A filter for the filtration of a fluid, such as a liquid, includes or composed of a support element made of a porous ceramic material, the element having a tubular or parallelepipedal shape delimited by an external surface and including, in its internal portion, a set of adjacent channels with axes parallel to one another and separated from one another by walls of the porous inorganic material, wherein at least a portion of the channels and/or at least a portion of the external surface are covered with a porous separating membrane layer, wherein the layer is made of a material essentially composed of sintered grains of silicon carbide (SiC), and the weight content of elemental oxygen of the layer is less than 0.5%.

Abstract: A heater includes: a conductive ceramic cylinder tube provided with a plurality of cells, each cell being defined by a pair of first cell-walls and a pair of second cell-walls, each first cell-wall extending in a radial direction of the ceramic cylinder tube, and each second cell-wall extending so as to cross the radial direction of the ceramic cylinder tube; an inner electrode electrically coupled to an inner wall of the ceramic cylinder tube; and an outer electrode electrically coupled to an outer wall of the ceramic cylinder tube. Linear portions are radially arranged in the ceramic cylinder tube, each linear portion linearly extending in the radial direction of the ceramic cylinder tube so as to include a plurality of first cell-walls that are arranged on the same axial line that in the radial direction and current flows radially at least via the linear portions between the inner and outer electrodes.

Abstract: The present invention relates to an oral complex preparation comprising: a capsule containing a fat-soluble first drug; and a solid preparation containing a second drug, the solid preparation being embedded into the capsule and including an oil-proof material coating layer on the surface thereof The oral complex preparation of the present invention prepared by embedding the solid preparation including the oil-proof material coating layer on the surface thereof and containing the second drug into the capsule containing the fat-soluble first drug enables two types of drug ingredients to be simultaneously administered.

Abstract: A light-emitting device and a manufacturing method thereof are provided. The light-emitting device includes a substrate, an epitaxial blocking layer, and a light-emitting epitaxial structure. The substrate has a surface, in which the surface includes a plurality of protruding parts and a plurality of recess parts relative to the protruding parts. The epitaxial blocking layer disposed on the substrate covers the recess parts and exposes the protruding parts. The light-emitting epitaxial structure disposed on the substrate is connected to the protruding parts and is disposed above the recess parts. The light-emitting epitaxial structure is formed by using the protruding parts as a growth surface thereof so as to have a better crystalline quality.

Abstract: In one aspect, the invention relates to a compound of the structure: or a pharmaceutically acceptable salt thereof, and a crystalline form of this compound, having neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising this compound; methods of using this compound; and processes for preparing this compound.

Abstract: The present invention provides an infrared detector pixel structure and manufacturing method thereof.

Abstract: Provided is an anti-EphA4 antibody that can bind to EphA4 and enhance the cleavage of EphA4, as well as a pharmaceutical composition comprising the antibody as the active ingredient. A mouse anti-EphA4 antibody that has binding affinity towards EphA4 and can enhance the cleavage of EphA4 was obtained, and the sequence of the complementarity-determining region (CDR) of the mouse anti-EphA4 antibody was identified. Subsequently, the anti-EphA4 antibody of interest was obtained by producing a humanized antibody of the mouse anti-EphA4 antibody.

Abstract: Disclosed is a pyrazole amide compound as represented by general formula I, wherein, R1 is selected from hydrogen, C1-C4 alkyl, C2-C6 alkenyl and C2-C6 alkyl; and R2 and R3 can be the same or different, and are respectively and independently selected from the C1-C6 alkyl. The general formula I compound has an excellent bactericidal activity, and can be used to prevent and control fungal diseases.

Abstract: Various techniques and apparatus permit fabrication of superconductive circuits. A superconducting integrated circuit comprising a superconducting stud via, a kinetic inductor, and a capacitor may be formed. Forming a superconducting stud via in a superconducting integrated circuit may include masking with a hard mask and masking with a soft mask. Forming a superconducting stud via in a superconducting integrated circuit may include depositing a dielectric etch stop layer. Interlayer misalignment in the fabrication of a superconducting integrated circuit may be measured by an electrical vernier. Interlayer misalignment in the fabrication of a superconducting integrated circuit may be measured by a chain of electrical verniers and a Wheatstone bridge. A superconducting integrated circuit with three or more metal layers may include an enclosed, matched, on-chip transmission line. A metal wiring layer in a superconducting integrated circuit may be encapsulated.