Abstract: A device is provided that plugs a drainpipe via an opening formed therein. The device includes a lever arm having front and rear portions, and a plug seal assembly securely coupled to the front portion of the lever arm, the plug seal assembly having a plug designed to mechanically seal the drainpipe whenever the device is locked into a plugging position within the drainpipe, and a through-hole that passes from a front side of the plug seal assembly to a rear side thereof. The device also includes a positioning arm assembly rotatably coupled to the rear portion of the lever arm and is adapted to releasably engage with the rear portion of the lever arm and a bottom rim of the opening to lock the device into the plugging position. The device also includes a fluid fill hose one end of which is sealably coupled to the through-hole.

Abstract: The present invention relates to a topical composition and more particularly a topical composition for antimicrobial benefit. According to the present invention there is provided a topical composition comprising Niacinamide and picolinamide wherein the molar ratio of Niacinamide to picolinamide is from I:20 to 20:I.

Abstract: The invention provides compounds of formula (I): or a pharmaceutically-acceptable salt thereof, wherein the variables are defined in the specification, that are inhibitors of JAK kinases, particularly JAK3. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using such compounds to treat gastrointestinal and other inflammatory diseases.

Abstract: The invention provides CadA polypeptides with mutations that increase activity in alkaline pH compared to the wild-type lysine decarboxylase. The invention also provides methods of generating such mutant polypeptides, microorganisms genetically modified to overexpress the mutant polypeptides, and methods of generating such microorganism.

Abstract: A mask structure and a method for manufacturing a mask structure for a lithography process is provided. The method includes providing a substrate covered with an absorber layer on a side thereof; providing a patterned layer over the absorber layer, the patterned layer comprising at least one opening; and forming at least one assist mask feature in the at least one opening, wherein the at least one assist mask feature is formed by performing a directed self-assembly (DSA) patterning process comprising providing a BCP material in the at least one opening and inducing phase separation of a BCP material into a first component and a second component, the first component being the at least one assist mask feature and being periodically distributed with respect to the second component.

Abstract: Systems and methods for controlling shelf display units and for graphically presenting information on shelf display units are disclosed. A system includes one or more display units configured to be coupled to shelves of a modular shelving system, one or more processors communicatively coupled to the one or more display units, one or more memory components communicatively coupled to the one or more processors, and machine readable instructions stored in the one or more memory components. When executed by the one or more processors, the machine readable instructions cause the system to determine a product identifier corresponding to a product, identify one or more display units to update in response to determining the product identifier corresponding to the product, and update a graphical output of the one or more display units identified to be updated in response to identifying the one or more display units to update.

Abstract: A lens holder assembly (49) and method of using the lens holder assembly (49) to mark an ophthalmic lens (3) is provided. The lens holder assembly (49) comprises a stem (61) having a central axis and a first opening (5) extending along the central axis of the body (65), a second opening (7) integrated within the stem (61) such that the second opening (7) is substantially parallel to the first opening (5), and at least one illumination source positioned within the second opening (7). The illumination source is capable of emitting light through the second opening (7) for illuminating at least a portion of an ophthalmic lens (3). At least a portion of the lens (3) is placed over the first opening (5). Suction is applied to the lens (3), and a marking is applied to a surface of the lens (3).

Abstract: Described herein are anti-CD277 antibodies which: activates or inhibit the cytolytic function of V?9/V?2 T cells, and/or costimulates T cells together with CD3-TCR, and/or costimulates T cells in addition to CD28-B7 costimulation, and/or increases the activity and/or survival of monocytes and dendritic cells. The use of said antibodies in therapy is also described.

Abstract: An embodiment is a circuit for use with a display device, the circuit including: a first input node configured to be operatively coupled to a first port of a data source device that provides the display device with data, to receive a first direct voltage used for a real-time display of the data on the display device; and at least one output node, configured to operatively provide the display device with at least one output voltage generated based on the first direct voltage, wherein the first port is isolated from a data port used to transmit the data.

Abstract: A window assembly comprises a substrate with a transparent layer that defines an area having a periphery. An outer region devoid of the transparent layer is defined adjacent the transparent layer along the periphery. A conductive element disposed on the substrate and comprises a first portion overlapping an area of the transparent layer and abutting and being in direct electrical contact with the transparent layer. The conductive element further comprises a second portion integrally extending from the first portion and disposed in the outer region. The periphery of the transparent layer delineates the first and second portions of the conductive element. The second portion has an area defining an enclosed slot. A feeding element couples to the conductive element for energizing the enclosed slot as a slot antenna. An energizing element couples to the conductive element for energizing the conductive element to implement a bus bar.

Abstract: A blood flow reducer (20) for insertion in a blood vessel, the reducer (20) being adapted to be deformed from a first configuration to an expanded configuration, wherein, in the expanded configuration, the reducer (20) defines an axial lumen (40) for allowing blood flow therethrough, the axial lumen (40) having a smallest cross-section, the reducer (20) has a largest cross-section, and the smallest cross-section is comprised between 20% and 90% of the largest cross-section. In particular, the smallest cross-section is strictly comprised between 70% and 90% of the largest cross-section. A method for preconditioning a liver of a living being before partial hepatectomy, wherein a 10 to 30% stenosis is created in a branch of a portal vein conducting blood to a first liver lobe.

Abstract: A lavatory monument configured to be positioned in an aircraft interior that includes an enclosure that includes first, second, third and fourth walls, and defines a lavatory interior, a first lavatory compartment that includes a first urinal unit positioned therein, and a second lavatory compartment that includes a second urinal unit positioned therein. The first lavatory compartment includes a first door and the second lavatory compartment includes a second door. A divider wall separates at least a portion of the first lavatory compartment from at least a portion of the second lavatory compartment. The first door is positioned on one of the first or second walls and the second door is positioned on one of the first or third walls.

Abstract: Methods of synthesizing intermediates useful for the synthesis of halichondrin B analogs are described.

Abstract: A crossbow assembly may include a riser and a pair of bow limbs that attach to the riser. The limb attachment surfaces on the riser may be separated such that a minimum distance between them is not greater than 5 inches. The minimum distance may be at least as wide as a user's foot. The riser may have an opening that extends between the limb attachment surfaces. The limb attachment surfaces may be angled between 60 and 30 degrees. The riser may have a foot stirrup that begins behind the limb attachment surfaces and extends beyond them.

Abstract: Personal care topical compositions at skin-tolerant pH with cystine which is solubilized or has small crystal size below 20 microns. A process of making the composition is also described.