Abstract: The invention relates to a skincare cosmetic composition comprising birch sap, birch bark extract, and optional ingredients commonly used in skincare cosmetics, without water typically added as a separate component.

Abstract: The invention provides a compound of formula (I): or a pharmaceutically-acceptable salt thereof, that is an inhibitor of JAK kinases. The invention also provides pharmaceutical compositions comprising such compound, a crystalline form, methods of using such compound to treat inflammatory skin diseases and other diseases, and processes and intermediates useful for preparing such compound.

Abstract: A lock cylinder, for a cylinder lock, having a cylinder housing with a core receiving cut-out and axially extending blocking grooves open to the core receiving cut-out. The lock cylinder having a cylinder core supported inside the core receiving cut-out and having a plurality of guide slots extending through the core. Plate tumblers supported in the guide slots such that they can be displaced back and forth in the plate sliding direction between a locking position, in which the cylinder core is connected to the cylinder housing in a non-rotating manner about a cylinder axis, and a non-locking position, in which they are driven into the cylinder core and the cylinder core can rotate about the cylinder axis. Wherein two plate tumblers are connected to a single spring so as to be driven in opposite directions into their respective locking positions.

Abstract: A window assembly includes a transparent substrate, an electrical conductor provided on a surface of the substrate, and a solderless electrical connector for energizing the electrical conductor. The solderless electrical connector includes a cover adhered to the substrate to define a hollow volume, and a biasing member disposed within the hollow volume and elastically compressed between the cover and the electrical conductor. The biasing member is formed from a polymeric material and is electrically conductive.

Abstract: A switch system that includes a switch assembly with a housing having a bottom surface that includes a latch pocket defined therein. The latch pocket includes a top surface and the housing defines an interior that includes either a magnetic switch or a magnet disposed therein. One of the magnetic switch or magnet is positioned adjacent the top surface of the latch pocket in the other is associated with the distal end of latch bolt. The system also includes a latch bolt. When the latch bolt is in the unlatched position it is not received in the latch pocket, the magnetic switch is in the first state and an electrical component is in a first state. When the latch bolt is in the latched position it is received in the latch pocket, the magnetic switch is in the second state and the electrical component is switched to a second state.

Abstract: A vehicle door lock having a rotary latch arrangement and a release mechanism. The rotary latch arrangement includes a lock case in which a pivoted rotary latch and a pivoted locking pawl are arranged. The release mechanism includes a first release device with a traverse tube, a cable pull mechanism with a traction element led through the traverse tube and means for actuating the cable pull mechanism, and a pivotable actuation lever that engages in the lock case and which comprises two opposite actuation lever lateral surfaces. The actuation lever is rotatably connected with the first release device to be driven about an actuation lever rotary axis, wherein the locking pawl can be actuated by rotating the actuation lever so that the locking mechanism of the rotary latch can be released.

Abstract: The present disclosure describes a system, method, and computer readable medium for providing information to a receiving party in a communications network. The method includes receiving a message from a sending party and performing a lookup of information relating to the sending party in a database via an Internet Protocol connection. The lookup is based on an identifier of at least one of the sending party and the receiving party. Subsequently, the information is provided to the receiving party based on the availability of the information in the database.

Abstract: A firearm includes a frame to which a barrel and slide are slideably mounted and in which a magazine is slideably received. A bumper telescoped on a push rod slideable with the slide pushes a shell in the magazine onto a pivotal carrier. Locking wings pivotally mounted to the barrel are cammed in troughs of a cam block as the barrel and the slide parallel to the longitudinal axis of the barrel relative to the cam block, so that lock tabs are removably received in locking recesses in the slide to removably lock the barrel and slide together. A trigger is slideably mounted to the frame for movement parallel to the longitudinal axis of the barrel for pivoting a sear lever engagable with a biased striker and moving a safety from an interfering position relative to the striker.

Abstract: The invention relates to a Myc dominant negative mutant, called Omomyc, for use in medicine and for use in the prevention and/or treatment of cancer. The invention also refers to a fusion protein comprising Omomyc and pharmaceutical composition thereof and their use in medicine and, in particular, for treatment of cancer.

Abstract: The invention relates to a commutator motor (10), particularly as part of a windscreen-wiper motor (100), having at least four magnet elements (11 to 14) which are arranged on a reference-circle diameter around an axis of rotation of an armature shaft (2) with polarity that alternates in the circumferential direction, and having an armature (15) with armature slots (N1 to N18) and armature teeth (Z1 to Z18), wherein winding wires (20) having a multiplicity of windings (27, 28) in each case for constructing coils (C1 to C9) are arranged in the armature slots (N1 to N18), wherein a start (21) and an end (22) of a winding wire (20) is electrically conductively connected to a commutator hook (H1 to H18) in each case, wherein a winding wire (20) has two winding-wire sections (25, 26), which are arranged in the region of different magnet elements (11 to 14) in such a manner that a first winding-wire section (25) with a first number of windings (27) in a first winding direction is assigned to a first magnet element

Abstract: A method is provided for forming a porous, electrochemically active lithium manganese oxide layer on a substrate, the method comprising: depositing a porous manganese oxide layer on the substrate; providing a Li containing layer on the porous manganese oxide layer; and afterwards performing an annealing step at a temperature in the range between 200° C. and 400° C., thereby inducing a solid-state reaction between the porous manganese oxide layer and the Li containing layer. The method may further comprise, before depositing the porous manganese oxide layer: depositing a seed layer on the substrate. A method of the present disclosure may be used for forming electrode layers of lithium-ion batteries.

Abstract: The invention provides a solid composition of the peripheral mu opioid antagonist axelopran and a combination dosage form of the mu opioid antagonist axelopran sulfate in an immediate release form and an opioid analgesic agent which may be in an extended release, sustained release, modified release, or controlled release form and methods of preparing such a combination dosage form.

Abstract: An automated system and method for assisting in decision making for the treatment of stroke patients is provided, and specifically for assisting a physician whether the patient should be administered a drug or transferred to another hospital to undergo an endovascular thrombectomy procedure. A variety of factors are input into the system with limited human intervention and a tool automatically determines the probability of whether the patient will have a better outcome if transferred or not. The factors include clinical factors, imaging factors and time to transfer factors. The tool includes processes for automatically determining several imaging factors, including the determination of clot length, collateral blood flow, the presence of forward blood flow within and around the clot, and the clot permeability. The tool has capability to continuously update the treatment protocol and other output results using current clinical, health system or other relevant information or feedback.

Abstract: Methods and devices for sterilizing viscous peptide compositions which have shear thinning rheological properties at high concentrations.

Abstract: The invention relates to an adapter 26 for connecting a wiper blade 12 to a driving arm, the adapter comprising two lateral longitudinal walls 42a, 42b spaced apart from one another so as to form therebetween at least one housing 45 configured in order to receive at least in part a connector 24 of the wiper blade, at least one of the lateral walls 42a, 42b comprising at least one hole 56, said lateral wall 42a, 42b further comprising a bearing means 54, 54a projecting from an external face 75 of the lateral wall 42a, 42b, characterized in that the bearing means 54, 54a is traversed by at least one hole 56, said bearing means 54, 54a being made as one with the external face 75 of the lateral wail 42a, 42b.

Abstract: A mirror for an ophthalmic laser treatment device that is movable on an axis from a position in a treatment laser beam path to a position out of the treatment laser beam path. The mirror reflects light from a light source into the eye of a patient. The mirror is biased towards a position in the path and is moved out of the path by an actuator just long enough for the laser treatment to be applied and without noticeable interruption to viewing by a user.

Abstract: A tilt-less liner apparatus and system for unloading bulk cargo from a container liner using a first layer on the container liner floor having a friction reducing top layer and a friction enhancing bottom layer to secure first layer against movement. A second layer of flexible high strength material folded in over lapping multiple pre-folded sections from at least two to eight folded stacked layers are used to cover the friction reducing top first layer. The second layer is connected to a coiling means and motor for coiling up and removing the second layer from the container over the friction reducing top layer of the first layer and the bulk cargo comes out with the second layer into a hopper provided with means for bulk product distribution. Vibrators, depth measuring devices and speed controls are provided to control bulk cargo unloading and prevent blockage build up.

Abstract: A method for fracturing or mask data preparation is disclosed in which a plurality of single-beam charged particle beam shots is used to create a plurality of multi-beam shots, where multi-beam exposure information is determined for each of the single-beam shots, and then the resulting multi-beam exposure information is used to generate a set of multi-beam shots. Additionally, a method for fracturing or mask data preparation is disclosed in which a plurality of single-beam shots is used to generate a set of multi-beam shots by calculating an image which the single-beam shots would form on a surface.

Abstract: Laundry composition dosing device (1) having two segregated chambers (5, 7) such that a first laundry composition, for example a fabric conditioner stored in the first chamber (5) is pourable via a first opening (4) by a user without dispensing a second laundry composition stored in the second chamber (7).

Abstract: The invention relates to a motor vehicle wiping unit (1) comprising: at least one motor (2) configured to drive at least one windscreen wiper (5, 6) in a to-and-fro movement over a motor vehicle glass surface (11), at least one reduction gear (3) arranged at the output of the motor (2), and a controller (4) configured to determine a command for the motor (C), characterized in that the controller (4) is configured to determine the command for the motor (C) by taking into account at least one variable parameter linked to the efficiency of the reduction gear (3) such as to counterbalance the variation in the efficiency of the reduction gear (3) by changing the electrical power to be provided to the motor (2). The present invention also relates to a method for commanding the rotational speed of a motor for driving at least one windscreen wiper in a to-and-fro movement over a motor vehicle glass surface.