Abstract: A facility use measuring device includes a processor and a memory storing instructions. The processor is configured to set a plurality of staying areas for determining the presence or absence of stay of users on images, to generate stay information relating to the presence or absence of stay of the users for each of the staying areas based on a change situation, to compare pieces of stay information for every at least two staying areas and determine a group configuration regarding the users who respectively stay in the staying areas based on similarity of the pieces of stay information, to generate use information relating a use situation of a facility according to the group configuration, based on the pieces of stay information for each of the staying areas and a determination result of the group configuration, and to generate display information displaying the use information and output the display information.

Abstract: An end piece (100) for a wiper (102) provided with a rigidifying element (110) comprises a channel (120) for receipt of the rigidifying element, as well as first positioning stops (130), and a first means (150) for locking this element. The end piece comprises at least one second positioning stop (140) in order to cooperate equally well with a first or second type of rigidifying element with different dimensions. The first positioning stops (130) are operational when the first type of rigidifying element (110) is inserted in the channel, and at least one second positioning stop (140) is operational when the second type of rigidifying element is inserted in the receipt channel (120).

Abstract: Compounds of formula (I) that are capable of acting as purine receptor antagonists, pharmaceutical compositions including the compounds, and methods of making the compounds, are disclosed. The compounds and compositions can be used in treating or preventing disorders related to purine receptor hyperfunctioning.

Abstract: Proteomic methods for identifying cancer related proteins and related products and kits are provided. The cancer specific proteins are extracellular matrix proteins that are associated with various aspects of cancer. Panels or signature sets of proteins useful in the detection, diagnosis and treatment of cancers as well as monitoring therapeutic progress in a cancer patient are provided herein along with methods for their detection and for their use in targeting imaging and/or therapeutic agents to the tumors via binding to the specified proteins. The proteins were identified using proteomics analyses of tissue samples taken from cancer patients. In certain aspects the proteins are particularly useful in colon cancer patients.

Abstract: A Resistive Random Access Memory (RRAM) device and a method of its manufacture are disclosed. The RRAM device comprises a lower oxygen affinity bottom electrode, a hygroscopic solid-state dielectric layer, comprising hydroxyl groups, and a higher oxygen affinity top electrode. In some embodiments, the hygroscopic solid-state dielectric layer is a rare-earth metal oxide layer.

Abstract: The present invention provides methods for selecting an individual with psoriasis (Ps) or psoriatic arthritis (PsA) who should receive or who is likely to respond to a treatment with an anti-tumor necrosis factor alpha (anti-TNF?) therapy. In addition, provided herein are methods for selecting an individual with Ps or PsA who should receive or who is likely to respond to a therapy that is not an anti-TNF? therapy, e.g., a non-anti-TNF? therapy for the treatment of Ps or PsA. Specifically, the methods of the present invention relate to detecting the presence of distinct alleles of the PDE3A-SLCO1C1 locus which are associated with a clinical response to an anti-TNF? therapy or a non-anti-TNF therapy in patients with Ps or PsA.

Abstract: An apparatus for supplying a respiratory gas to a patient within the scope of the diagnosis and/or the treatment of sleep-related breathing disorders includes an electronic signal processing device for generating a pressure control signal on the basis of indicative signals relating to the breathing activity and/or the physiological state of a person. The signal processing device comprises a signal inputting device and an extraction device for generating data field entries according to predefined signal analysis procedures. A pressure signal generator is provided for generating the pressure control signal, taking into account determined data field entries which are at least selected by the extraction device.

Abstract: Embodiments of the present disclosure are directed to optical packages having a package body that includes a light protection coating on at least one surface of a transparent material. The light protection coating includes one or more openings to allow light to be transmitted to the optical device within the package body. In one embodiment, the light protection coating and the openings allow substantially perpendicular radiation to be directed to the optical device within the package body. In one exemplary embodiment the light protection coating is located on an outer surface of the transparent material. In another embodiment, the light protection coating is located on an inner surface of the transparent material inside of the package body.

Abstract: Process for preparation of MK-7 type of vitamin K2 is characterized by attaching hexaprenyl chain of “all-trans” configuration to monoprenyl derivative of menadiol following “1+6” synthetic strategy. According to the invention, a-sulfonyl carbanion generated in situ from the protected monoprenyl menadiol of the formula (II), wherein R1 represents C1-3-alkyl group, is reacted with hexaprenyl halide of the formula (VII), wherein X represents halogen atom, preferably bromine, both Z? and Z? represent H or one of Z? and Z? represents H and the other represents phenylsulfonyl group —SO2Ph in the alkylation reaction. The hexaprenyl halide of formula (VII) is obtained by coupling two triprenyl units in alkylation reaction, with or without separation of the intermediates.

Abstract: A method implemented by computer means for determining a visual effect of an ophthalmic lens, the method comprising: —an optical data receiving step (S1), during which optical data relating to the optical function of an ophthalmic lens is received, —an acquisition step (S2), during which at least one image of the visual environment of a user is acquired, —a depth map determining step (S3), during which a depth map of the acquired image of the visual environment of the user is determined, —a visual effect determining step (S4), during which based on the depth map and the optical data, a visual effect that would be introduced by the ophthalmic lens if the visual environment was seen through the ophthalmic lens is determined.

Abstract: The present disclosure provides compounds and methods that are useful for the preparation of compounds useful as orexin-2 receptor antagonists.

Abstract: A hypermedia object associated with an application, displayed on a display screen, and responsive to information is disclosed. The information is provided by a user interface input device having two-dimensional pointing functions and at least one additional user-adjustable input for entering values from a range of more than two possible values. The hypermedia object includes a first visual representation of the hypermedia object for display in a first region of a display screen, an associated responsive area in a second region of the display for in activating the hypermedia object, and a procedure for allowing a user to activate the hypermedia object from a user-initiated action enacted on the user interface input device. Activating the hypermedia object enables the entry of at least one additional user-adjustable input value for use by the associated application.

Abstract: In one aspect, the invention relates to compounds having the formula: where R1, R2, R3, R4, and R5 are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.

Abstract: The present invention relates to a method for assessing the presence and/or the severity of a lesion in an organ or tissue of a subject through automated analysis of at least one image of said organ or tissue, wherein said organ or tissue is preferably a liver organ or liver tissue, comprising the calculation of a score combining descriptors of said image, wherein said method comprises the steps of: a. measuring on said at least one image at least two descriptors of said at least one image; b. mathematically combining said at least two descriptors in a score; and c. assessing the presence and/or the severity of a lesion in the organ or tissue based on the value of the score calculated at step (b).

Abstract: An exercise device has a frame supporting guide links to which foot support links are pivotally attached. Upper pulleys are pivotally connected to the frame. Lower pulleys are connected to the foot support links. A vertical drive assembly is coupled to the foot support links by flexible elements. The flexible elements extend from the vertical drive assembly, about an upper pulley, about a lower pulley and to a second end connected to the frame.

Abstract: Systems, apparatus, and methods for controlling power modes in electronic devices are provided. A system may include an electronic device and an input device that sends power mode selection information via a network to a power mode selection receiving component in the electronic device. The electronic device includes a first power component that powers a first component, and a switching component that controls the first power component. The electronic device may include a second power component that powers a second component. The switching component may control the second power component. The power mode selection receiving component and the switching component may be powered independently of the first and the second component. If the power mode selection information indicates an off mode, the electronic device may provide power to the power mode selection receiving component and the switching component and not to the first and the second component.

Abstract: A blow molded bottle (1): a) which is self-collapsible during its emptying; b) which comprises at least two transversal grooves and/or ribs (6.1), preferably located in the tubular body portion (6), equipped with collapse starters (6.2); c) wherein the mean wall thickness (Tmean) of the tubular body portion (6) is—in an increasing order of preference—less than or equal to 200; 180; 160; 150 ?m; preferably comprised between 65 and 150; and more preferably comprised between 90 and 130 ?m. The invention also discloses a method, a preform (100) and a mold for the manufacture of the aforementioned container by blow molding. The invention also discloses a method for bottling liquid into the bottles (1), a method for dispensing the liquid, a dispenser for implementing the method and a method for packing the thin-walled bottles, in view of storage and transportation.

Abstract: A splitboard boot binding system with single multi-angle climbing wire. The pivotable climbing wire is configured for use with any compatible ski tour interface, and folds away under the boot binding baseplate when the bindings are transferred to a ride mode interface. In ski tour mode, the baseplate pivots on a toe axis and is supported by the climbing wire when the heel is raised. Advantageously, the climbing wire is very lightweight and seats interchangeably in a plurality of detent positions on a compatible heelblock. There are no interferences with conjoint use of a slide-in crampon seated between the heelblock and the toe pivot or with use in systems having a heel locker. Surprisingly, in some combinations the climbing wire may also be used to retain the slider track in ride mode. The combinations and sub-combinations require no tools for adjustment or operation and operate cooperatively.

Abstract: The present invention relates to compositions which comprise salt of acyl glutamate as primary surfactant or primary anionic surfactant and which compositions are clear, low pH isotropic composition.