Abstract: The present invention relates to endolysin variants comprising an endolysin to which a peptide stretch with membrane or LPS disrupting activity is fused. Moreover, the present invention relates to nucleic acid molecules encoding said modified endolysin variant, vectors comprising said nucleic acid molecules and host cells comprising either said nucleic acid molecules or said vectors. In addition, the present invention relates to a method for producing said endolysin variant. Further, the present invention relates to said modified endolysin variant for use as a medicament, in particular for the treatment or prevention of Gram-negative bacterial infections, as diagnostic means, disinfectant or as cosmetic substance. The present invention also relates to the removal or reduction or prevention of Gram-negative bacterial contamination of foodstuff, of food processing equipment, of food processing plants, of surfaces coming into contact with foodstuff, of medical devices, of surfaces in hospitals and surgeries.

Abstract: A process for creating a production specification for a customized eyeglass frame for a patient includes the following steps. A library is accessed having fully parameterized standardized models for characterizing a plurality of eyeglass frame styles. The models are configured to accept a plurality of customization inputs including patient biometric data. A customized model of an eyeglass frame is then constructed by populating the fully parameterized standardized model corresponding to the eyeglass frame style selected by the patient with the customization inputs for the patient. An output is generated from the customized model, the output corresponding to the production specification for the customized eyeglass frame.

Abstract: The present invention relates to novel humanized, chimeric and murine antibodies that have binding specificity for the human CC chemokine ligand 20 (CCL20). The present invention further relates to heavy chains and light chains of said antibodies. The invention also relates to isolated nucleic acids, recombinant vectors and host cells that comprise a sequence which encodes a heavy chain and/or a light chain of said antibodies, and to a method of preparing said antibodies. The anti-CCL20 antibodies of the invention can be used in therapeutic applications to treat, for example, inflammatory and autoimmune disorders and cancer.

Abstract: A food product having at least one moulded body. The moulded body has a food mass and an array of baked items or a substantially centrally located baked item. At least one member of the array of baked items or the centrally located baked item form a consumable unit together with at least a portion of the moulded body. Further, at least one portion of at least one baked item is not covered with the first food mass and is visible from at least one side of the moulded body.

Abstract: The present invention relates to a mutant NNK1 allele, especially a mutant carrying a mutation at position of amino acid 807 of the wild type sequence. The invention relates further to the use of said mutant allele to increase the fermentation rate in yeast, preferably in Saccharomyces. The mutant allele is especially useful to increase the xylose to ethanol fermentation rate.

Abstract: A reverser for a timepiece comprises a first input wheel which carries a first satellite pinion. An output mobile assembly comprises a first ratchet with which the first satellite pinion forms a click locking in rotation the output mobile assembly with respect to the first input wheel only in a first direction of rotation. A second input wheel has the same axis of rotation as the first input wheel and the output mobile assembly. A second satellite pinion and a second ratchet form together a click locking in rotation the output mobile assembly with respect to the second input wheel only in the first direction of rotation.

Abstract: According to one aspect, the invention relates to an angular optical filtering element (Ei) optimized for angular filtering about a given operating angle of incidence (?i, 1) in a given spectral band. The angular filtering element (Ei) comprises a first nanostructured, band-pass, spectral filter (11i, 301) and a second nanostructured, band-pass, spectral filter (12i, 302). Each of the first and second spectral filters comprises, respectively, in said spectral band, a first and a second central filtering wavelength that respectively has a first and second angular dispersion curve defined depending on the angle of incidence (?inc) on the optical filtering element (Ei), the curves of angular dispersion being secant about the operating angle of incidence (?i, 1) of the optical filtering element. The invention applies to the production of a selective angular filtering device and to a multidirectional optical detection system.

Abstract: An electronic circuit is for switching a power transistor having a drain coupled to a drain node, a source coupled to a lower voltage supply, and a gate coupled to a gate node. The electronic circuit includes first current generation circuitry to generate a first current to flow into the gate node in response to assertion off an ON signal, the first current being substantially constant. Second current generation circuitry generates a second current to flow into the gate node in response to deassertion of an OFF signal, the second current being inversely proportional to a gate to source voltage of the power transistor. First comparison circuitry compares a drain voltage at the drain node to a reference voltage, and activates third current generation circuitry to generate a third current to flow into the gate node when the drain voltage is less than the reference voltage.

Abstract: A method for using a device for coupling with a space satellite before the satellite is launched for the purpose of de-orbiting the satellite and/or returning it to Earth. The device includes: controller for controlling the device; propulsion system operatively connected with the controller; receiver for receiving control signals operatively connected with the controller; powering system for electrically powering the device; coupler for mechanically coupling the device with the satellite before the satellite is launched. The propulsion system is enabled by the controller on receipt of control signals for deorbiting the satellite and transferring it to a given orbit.

Abstract: A power converter includes an input and an output with an energy storage circuit and a power switching circuit coupled between the input and the output. A feedback circuit generates a feedback voltage which is differentially compared to a reference in an error amplifier circuit to generate an error amplification signal. A comparator circuit generates a control signal for controlling on/off of the power switching circuit based on a first comparison signal related to the error amplification signal and a second comparison signal related to a charging current of the energy storage circuit. A regulating circuit is coupled between an output of the error amplifier circuit and an input of the comparator circuit for receiving the first comparison signal, the regulating circuit is configured to couple a voltage compensation signal related to an input voltage received by the input to an output of the error amplifier, so as to reduce a variation amount of the error amplification signal when the input voltage varies.

Abstract: A motor vehicle windscreen wiper windscreen washer liquid distribution system including a windscreen washer liquid distribution network is disclosed. The windscreen washer liquid distribution network includes at least one hydraulic pipe including at least one windscreen washer liquid circulation passage, at least one hydraulic connector connected to the circulation passage, and at least one thermally conductive member in thermal contact with the at least one hydraulic connector and with a heating element of the distribution system.

Abstract: The present invention concerns compounds of formula I or a pharmaceutically acceptable salt thereof which inhibit HIF prolyl hydroxylase, their use for enhancing endogenous production of erythropoietin, and for treating conditions associated with reduced endogenous production of erythropoietin such as anemia and like conditions, as well as pharmaceutical compositions comprising such a compound and a pharmaceutical carrier.

Abstract: A nanogel comprising a self-organizing peptide, a chitosan, and polyethylene glycol.

Abstract: A clamp and a clamp with light are disclosed for attachment to a work area such as a vehicle hood. The clamp with light includes a clamp having an upper arm with one or more bumpers, a lower arm with one or more bumpers connected to the upper arm, a rotating arm for vertical movement of the light, and a light connected to the clamp.

Abstract: A median filter device is provided with a reordered circuit, a comparison circuit and a data refresh circuit on the basis of the conventional data buffer circuit and data register circuit. The reorder circuit re-sorts the signal data stored in the data buffer circuit in a preceding clock cycle according to their numerical values. The comparison circuit compares the new signal datum entered in the current clock cycle with the signal data already stored to generate a median. The data refresh circuit updates the signal codes stored in the data register circuit with the signal codes corresponding to the new signal data, for calculation of the median in a following clock cycle. The length of the data buffer circuit and data register circuit can be reduced from N signal data to N-1 signal data, which achieves less data storage capacity, smaller circuit area, easier data processing and higher operation efficiency.

Abstract: A cutting tool for cutting sheets of materials, such as, for example, sheets of building materials. The cutting tool includes a working table with a support surface. The working table includes a slot extending through the support surface. The cutting tool further includes a handle and blade pivotally engaged with respect to the working table between an open position and a closed position. The cutting tool further includes a guide rail that can be connected to the base in a plurality of positions relative to a cutting plane of the blade include a parallel position and a perpendicular position.

Abstract: The invention provides compounds of formula (I): wherein the variables are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are inhibitors of JAK kinases. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat gastrointestinal and other inflammatory diseases, and processes and intermediates useful for preparing such compounds.

Abstract: The invention relates to a process for the manufacture of a coated frozen confection, the process comprising the steps of (a) manufacturing a frozen confection, followed by; (b) imparting thermal energy to the surface of the frozen confection, sufficient to cause at least partial melting of the surface of the frozen confection, followed by; (c) allowing the surface of the frozen confection to refreeze, followed by; (d) coating the frozen confection in a liquid coating, which subsequently solidifies to provide a solid coating.

Abstract: An anhydrous antiperspirant stick or soft solid composition comprising an antiperspirant active system, thickening agent, and non-aqueous carrier oil, characterised in that the particulate antiperspirant active system comprises an aluminium sesquichlorohyrate of formula AI2OH44CI1.6 to AI2OH4.9CI1.1 activated with a water soluble calcium salt.