Abstract: This invention provides compounds of formula I: wherein a, b, c, d, m, n, p, s, t, W, Ar1, R1, R2, R3, R4, R6, R7, and R8 are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.

Abstract: A system for cleaning at least one glazed surface (21) comprises at least two devices (100 to 111) for projecting a cleaning product onto an associated glazed surface. The projection devices each include an electronic control module (120) configured to drive the operation of the corresponding projection device depending on control instructions, and the cleaning system includes a powerline bus common to the at least two projection devices (100 to 111), which are linked electrically to the powerline bus (11) independently of one another and in successive areas (90, 92) of said powerline bus.

Abstract: The present invention provides for a method and structure for forming three-dimensionally routed dielectric wires between discrete points on the two or more parallel circuit planes. The wires may be freely routed in three-dimensional space as to create the most efficient routing between the two arbitrarily defined points on the two or more parallel circuit planes. Metalizing the outer surfaces of these three dimensional dielectric wires electrically coupling the discrete wires to their respective discrete contact points. Two or more of these wires may be in intimate contact to one another electrically coupling to each other as well as to two or more discrete contact pads. These electrically coupled contact pads may be on opposite sides or on the same side of the structure and the formed metalized wires may originate on one side and terminate on the other or originate and terminate from the same side.

Abstract: An electrolytic cell for generating hydrogen through the electrolysis of water, including an anodic compartment and a cathodic compartment separated by a solid polymeric electrolyte alkaline membrane. The anodic compartment includes a positive electrode or anode at least partially submerged in a layer of water, and the cathodic compartment includes a negative electrode or cathode. The cell is arranged between a first closing plate and a second closing plate. A tie-rod, provided in the central portion of the first closing plate, passes through the first closing plate, the cell and the second closing plate. A central collector for conveying the hydrogen generated in the cathodic compartment is arranged coaxially to the tie-rod and is in communication with the cathodic compartment through an opening formed in the tie-rod.

Abstract: The invention relates to a system for controlling a device (1) for cleaning a vehicle window (2), said device (1) being arranged to perform a first cleaning function, suitable for example for standard cleaning of dust, and at least one second cleaning function, intended for clearing the window (2) of a specific material, in particular frost, snow or insects, adhering to the outer surface of said window, comprising at least one sensor (19) arranged to provide information on the presence of said material on at least one portion of the outer surface of the window (2) and a first electronic means (20) arranged to receive commands for executing functions of the cleaning device (1) and communicating with the latter, characterised in that it is arranged so that the first electronic means (20) responds to a first command for executing the second function by performing, with the data of said at least one sensor (19), an identification of the presence or the absence of said material and not activating the second functi

Abstract: A system for detecting a person being interested in a target includes a camera configured to capture an image of a location in front of a target area, a memory configured to store instructions and position information with respect to the target area, and a processor that executes the instructions to perform operations including receiving the image from the camera, detecting a face of person within the image, detecting a face direction in accordance with the detected face, and determining whether the person looks at the target area in accordance with the detected face direction and the stored position information with respect to the target area.

Abstract: A system (2) for cleaning at least one glazed surface (20, 21) of a vehicle (1) comprises a hydraulic distribution bus (3), able to allow a cleaning product to flow from a storage tank, and at least two devices (100 to 111) for projecting the cleaning product onto the at least one glazed surface (20, 21). According to the invention, the at least two projection devices (100 to 111) are linked by hydraulic connection elements to the hydraulic distribution bus (3), independently of one another and in successive areas of said hydraulic distribution bus (3).

Abstract: The present invention relates to compounds of the following general formula (I): wherein: R1 is notably a group —NRaRb, Ra and Rb forming together with the nitrogen atom onto which they are bound, a heterocycle comprising from 5 to 30 atoms, R2 is notably an aryl comprising from 5 to 30 atoms, and R3 is notably an alkenyl comprising from 1 to 20 carbon atoms.

Abstract: The invention relates to a cleaning arrangement (40) for the cleaning of vehicle windows, wherein the cleaning arrangement (40) has a base body (131) with at least one spray opening (42, 43), wherein the base body (131) is able to be connected to a wiper arm (10), and wherein the base body (131) has a supply connection (51) for a cleaning fluid, which supply connection (51) is hydraulically connected to the spray opening (42, 43) via a connecting duct (121). According to the invention, it is provided that a feed connection (141) branches off from the connecting duct (121), which feed connection (141) opens in a connecting chamber (140) of the base body (131), and that the connecting chamber (140) is able to be closed by means of a closure cap (95).

Abstract: The present invention relates to a transparent optical article comprising at least one dye at least partially inhibiting light having a wavelength ranging from 400 to 460 nm and at least one selective optical brightener that emits light by fluorescence at a wavelength ranging from 400 to 460 nm. The optical brightener acts as a means for at least partially balancing the color imparted to the transparent optical article by the dye, thus allowing for perception of said optical article as less yellow, and even colorless to an user or an observer.

Abstract: The present invention provides an in vitro method for determining the prognosis in a patient suffering a heart failure disease, the method comprising the step of determining the level of soluble neprilysin (NEP) in a test sample of the patient.

Abstract: A cavitation device is provided for use in a method for the treatment of water by cavitation. The water to be treated passes through an annular cavitation zone which exists between two mutually opposite annular structures which rotate relative to one another and which have teeth directed substantially axially towards one another. Here, the water flows along cavitation surfaces which are provided on the face sides of the teeth of a first of the two annular structures and which are inclined in the circumferential direction such that, viewed in the relative direction of rotation of the other, second annular structure, the spacings between said teeth and said second annular structure increase.

Abstract: The invention relates to a chop saw for a cutting machine, having an axis of rotation (2) and comprising a circular first sawtooth disk (4) and a first carrier (3) holding the first sawtooth disk (4), wherein the first saw tooth disk (4) has a plurality of sawteeth (5) over the circumference thereof and/or on the flat surfaces thereof, and wherein the first carrier (3) is symmetrical along the axis of rotation (2), and wherein the first carrier (3) has, on a first carrier surface (7), a retaining mandrel (9) for holding the chop saw (1) in a machine chuck of the cutting machine, and wherein the first sawtooth disk (4) is positioned on a second carrier surface (8) of the first carrier (3), which faces away from the first carrier surface (7), and wherein the chop saw (1) has a second sawtooth disk (11), which is arranged parallel to the first sawtooth disk (4).

Abstract: The invention provides a detachable wind guard for a flute-type instrument comprising an elongate, arcuate cover configured to wrap over a flute barrel. The cover has a center section with a radius larger than the radius of the flute barrel and includes a tapered, recessed facing edge configured to leave an embouchure hole uncovered when the wind guard is attached to the flute barrel. End sections taper to a radius sized to conform to the flute barrel. An elongate, arcuate holder positioned opposite the cover has a radius sized to conform to the flute barrel. A connector pin passes through knuckles on both the cover and holder to form a hinge that allows the wind guard to open in a clamshell manner. Torsion springs around the connector pin bias the holder in a closed position.

Abstract: Provided is a mutated hyperthermophilic PTE having a lactonase activity derived from a hyperthermophilic phosphotriesterase corresponding to the consensus sequence of SEQ ID NO: 1, the mutated PTE including the at least one mutation chosen amongst 55 putative positions and the mutated PTE having enhanced properties. Also provided are compositions including the mutated hyperthermophilic PTE and the uses thereof, notably as bioscavenger of organophosphate compounds or as quorum quencher of the bacteria using lactones to communicate.

Abstract: The invention relates to an in vitro method for determining in an isolated sample of a subject the presence of one or more Human Hepatitis C Virus (HCV) sequence variants comprising reverse transcription and amplifying HCV RNAs molecules using specific sets of primers allowing the amplification of the HCV regions named 5?-UTR-Core and NS5B. The method includes an step for purifying the amplified regions and a sequencing step of the amplified fragments. The invention also includes specific oligonucleotides than are used as primers in the method, as well as kits including one or more of these oligonucleotides as sets of primers.

Abstract: The present relates to interleukin 15 (IL-15) antagonists and uses thereof, in particular for the treatment of autoimmune diseases and inflammatory diseases. In particular, the present invention relates to an IL-15 mutant polypeptide having the amino acid sequence as set forth in SEQ ID NO:1 wherein the leucine residue at position 45 is substituted by an aspartic acid residue, the asparagines residue at position 65 is substituted by a lysine residue and the leucine residue at position 69 is substituted by an arginine residue.