Abstract: The present disclosure provides methods of treating and/or preventing inflammatory bowel disease (IBD) and graft-versus-host disease (GVHD) using salt-inducible kinase (SIK) inhibitors, such as macrocyclic SIK inhibitors of Formula (I), imidazolyl SIK inhibitors of Formula (II), and urea and carbamate SIK inhibitors of Formula (III-A) (e.g., urea and carbamate SIK inhibitors of Formula (III)).

Abstract: The invention provides a novel method of preparing a capture phase for detecting and/or quantifying a target biological entity, said capture phase including a biological ligand for the biological entity, said biological ligand being covalently bonded to an amphiphilic polymer and being immobilized on a solid support, the method being characterized in that the biological ligand is immobilized on the solid support by bringing the solid support into contact with a dispersion of micelles formed by a plurality of chains of the amphiphilic polymer, said micelles carrying a plurality of molecules of the biological ligand on the surface thereof. The invention also provides corresponding capture phases and associated detection methods and kits.

Abstract: The invention relates to a device for cleaning an optical sensor (2) of an optical detection system of a motor vehicle, which comprises spray means (4) for spraying a cleaning liquid onto an exterior surface (20) of this optical sensor (2). The device comprises suction means (7) of which a chamber (5) opens onto at least a portion of the periphery of this optical sensor (2).

Abstract: Clip (15) for a wiper blade (10), which clip is configured to be interposed between an end-piece (22) of the blade (10) and an aerodynamic spoiler (20) of a longitudinal cover member of the blade (10), characterized in that the said clip (15) comprises first means (25) able to collaborate by friction and/or anchorage with the end-piece (22) and second means (27) able to collaborate by friction and/or anchorage with the spoiler (20).

Abstract: A knee brace with a connection mechanism that enables quick and easy secure attachment and detachment of a plastic cuff shell to struts of the brace without the need for separate fasteners and the tools required for them via the use of a novel snap connector which will connect by a simple plug in motion, and which is configured to firmly hold the connected strut and prevent it from rotating relative to the cuff shell once connected while also enabling a quick and easy tool-free disconnection of the strut for exchanging of one cuff for another. The thigh and tibia shells can be interchange without removing any screws, rivets or traditional connectors providing a modular construction with the ability to mix and match different size thigh and calf shells, making it possible for a customer to order the product in kit form, or as separate components thereby enabling easy customization.

Abstract: Materials and methods for preventing gastrointestinal obstruction are provided. A peptide comprising between about 7 amino acids and about 32 amino acids in a solution may be introduced to a target site. The peptide may undergo self-organization under physiological conditions and/or in the presence of a cation.

Abstract: A method is provided for fabricating a thin film solid-state Li-ion battery comprising a first electrode layer, a solid electrolyte layer, and a second electrode layer. The method comprises depositing, on a substrate, an initial layer stack comprising a first layer comprising a first electrode material compound, and a second layer comprising an electrolyte material compound; and afterwards performing a lithiation step comprising incorporating Li in the first layer and in the second layer, thereby forming a stack of a first electrode layer and a solid electrolyte layer. The initial layer stack may further comprise a third layer comprising a second electrode material compound. By performing the lithiation step, Li is also incorporated in the third layer, such that a stack of a first electrode layer, a solid electrolyte layer, and a second electrode layer is formed. One or more of the first, second, or third layers may be Li-free.

Abstract: This method of calibration comprising the reconstruction of a 3D mapping of 3D landmarks of an environment on the basis of digital images of the environment captured by the computer-based vision system (10) during the movement of the craft (2) along a trajectory. It comprises the optimization of at least one 3D mapping corresponding to a first sequence of images by considering at least one extrinsic parameter and/or at least one intrinsic parameter and/or at least one parameter of poses and/or one parameter of 3D landmarks as constant and the optimization of at least one 3D mapping corresponding to a second sequence of images, longer than the first image sequence and including the first image sequence, by considering said at least one extrinsic parameter and/or said at least one intrinsic parameter and/or said at least one parameter of poses and/or said at least one parameter of 3D landmarks as variable so as to estimate it.

Abstract: A method is provided for determining the dominant eye of a person using equipment designed to acquire at least one image of the face of the person, then process the image, and finally return information enabling the person to know which eye is the dominant eye thereof. The method uses a sighting device that is identifiable and locatable in relation to the equipment, with the viewing being carried out through a window with both eyes open. The size of the window is such that it does not allow the person to see said target with both eyes at the same time. The equipment acquires at least one image for viewing the position of both eyes of the person, processing the image by performing calculations while taking into account the position of a central point located between both eyes, the position of the target and the position of the window.

Abstract: Systems, methods and aspects, and embodiments thereof relate to unsupervised or semi-supervised features learning using a quantum processor. To achieve unsupervised or semi-supervised features learning, the quantum processor is programmed to achieve Hierarchal Deep Learning (referred to as HDL) over one or more data sets. Systems and methods search for, parse, and detect maximally repeating patterns in one or more data sets or across data or data sets. Embodiments and aspects regard using sparse coding to detect maximally repeating patterns in or across data. Examples of sparse coding include L0 and L1 sparse coding. Some implementations may involve appending, incorporating or attaching labels to dictionary elements, or constituent elements of one or more dictionaries. There may be a logical association between label and the element labeled such that the process of unsupervised or semi-supervised feature learning spans both the elements and the incorporated, attached or appended label.

Abstract: Achieving orthogonal control of non-orthogonal qubit parameters of a logical qubit allows for increasing the length of a qubit chain thereby increasing the effective connectivity of the qubit chain. A hybrid qubit is formed by communicatively coupling a dedicated second qubit to a first qubit. By tuning a programmable parameter of the second qubit of a hybrid qubit, an effective programmable parameter of the hybrid qubit is adjusted without affecting another effective programmable parameter of the hybrid qubit thereby achieving orthogonal control of otherwise non-orthogonal qubit parameters. The length of the logical qubit may thus be increased by communicatively coupling a plurality of such hybrid qubits together.

Abstract: Disclosed is a pyrazole amide compound of a novel structure as represented by general formula I, wherein, each substituent group is as defined in the specification. The compound of general formula I has good insecticidal activity, and can be used for pest control.

Abstract: In one aspect, the invention relates to compounds having the formula: where R1-R6, a, b, Z, and X are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and processes and intermediates for preparing such compounds.

Abstract: A method and system for identifying a given geometrical feature of an optical component or semi-finished ophthalmic lens blank, where an optical component is made of an organic material that can emit light at an emission wavelength ?e when being lighten at an illumination wavelength ?i different from the emission wavelength ?e, a surface of the optical component is illuminated with an incident light beam including at least light at the illumination wavelength but devoid from light at the emission wavelength, light emitted at the emission wavelength by the illuminated surface is collected to build an image of the surface, and the surface image is processed to apply metrics to compare the image with reference data specific to the given geometrical feature.

Abstract: The present invention is dedicated to a method for the manufacture of an optical article comprising the following steps: providing a substrate having two main faces and bearing —OH functions on at least one of its faces, successively exposing one face of the substrate bearing —OH functions to at least 2 distinct materials named M1 and M2, M1 having a weight average molecular weight higher than M2, in a vacuum chamber under conditions resulting in the deposit of those materials on the surface of the substrate, and wherein: M1 is a substituted silane comprising: at least one function X1 bonded to a silicon atom, wherein the Si—X1 group is capable of forming a covalent bond with a —OH group of the substrate and/or a covalent bond with M2, and at least one fluorine containing group, M2 is a substituted silane having a number average molecular weight inferior or equal to 900 g/mol, comprising: at least one function X2 bonded to a silicon atom, wherein the Si—X2 group is capable of forming a covalent bond with a —O

Abstract: The invention provides compounds of formula (I): wherein the variables are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are inhibitors of JAK kinases. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat inflammatory bowel diseases, and processes and intermediates useful for preparing such compounds.

Abstract: Wastewater pump comprising a reversible motor (110) driving a rotor (160) equipped with blades (170). The rotor (160) is a disc (165) bearing pivoting blades (170) each mounted on a radial spindle (167) borne by the rotor. Each blade (170) is composed of a plate (171) bearing an articulation node (175) engaged on the spindle and a cutter (172) on the back of the plate forming a prop supporting the plate in the active position when the rotor (160) is rotating in the forward direction (D), and the cutter (172) projecting in the peripheral direction when the rotor (160) turns in the reverse direction (R), the plate (171) being applied against the disc (165). A fixed ring surrounds the disc and bears at least one cutter (135).

Abstract: A bidirectional voltage differentiator circuit comprises start-up circuitry, sensing circuitry, and output circuitry coupled to logic circuitry. The start-up circuitry acts to start-up the sensing circuitry when the circuit is powered on, and accelerates the response of the sensing circuitry thereafter. The sensing circuitry senses variation in an input voltage applied to an input node. Responsive to the voltage variation sensed by the sensing circuitry, the output circuitry produces a state change at a first or second output node. The logic circuitry receives the states of the output nodes and produces a logic output signal to indicate the occurrence of the variation sensed in the input voltage. The voltage sensing circuit is operable to sense variation of the input voltage regardless of whether the voltage is rising or falling and without regard to the DC value of the input voltage.

Abstract: Analog processors for solving various computational problems are provided. Such analog processors comprise a plurality of quantum devices, arranged in a lattice, together with a plurality of coupling devices. The analog processors further comprise bias control systems each configured to apply a local effective bias on a corresponding quantum device. A set of coupling devices in the plurality of coupling devices is configured to couple nearest-neighbor quantum devices in the lattice. Another set of coupling devices is configured to couple next-nearest neighbor quantum devices. The analog processors further comprise a plurality of coupling control systems each configured to tune the coupling value of a corresponding coupling device in the plurality of coupling devices to a coupling. Such quantum processors further comprise a set of readout devices each configured to measure the information from a corresponding quantum device in the plurality of quantum devices.