Abstract: A snap hook that includes a body, a gate, a connection link and a breakable fastener is provided. A central portion of the body is positioned between an upper portion and a lower portion. The gate is pivotally coupled proximate the central portion of the body. The gate and the body selectively forming a closed configuration that defines a hook connection passage and an open configuration that provides access to the hook connection passage. An upper end of the connection link is pivotally coupled proximate the central portion of the body. A lower end of the connection link includes a body connection aperture. The breakable fastener couples the lower end of the connection link proximate the lower portion of the body. The breakable fastener is configured to break when a select amount of force is applied to the lower end of the connection link to transfer the force from the lower portion of the body to the central portion of the body.

Abstract: Peptides with a sequence length from 13 to 50 amino acids, the N-terminal region of said peptides consisting in the sequence HXaa1EGTFTSDXaa2SXaa3Xaa4 (SEQ ID NO: 1) wherein: Xaa1 is an amino acid selected from alanine and glycine; Xaa2 is an amino acid selected from valine and leucine; Xaa3 is an amino acid selected from serine and lysine; Xaa4 is an amino acid selected from tyrosine and glutamine; and Hystidine is the N-terminal residue; for use in the topical treatment and/or prevention of retinal neurodegenerative diseases, in particular diabetic retinopathy are described. Pharmaceutical topical compositions for use in the topical treatment and/or prevention of these diseases are also described.

Abstract: The invention relates to a wiper system (1) comprising: a driving arm (3) comprising a rod (30) extended by an end portion (31) that is able to be connected to a windscreen wiper (2); a windscreen wiper (2) fitted on said end portion (31) and comprising at least one ramp (10) that is able to channel a cleaning and/or deicing fluid; characterized in that said wiper system (1) comprises: a transporting pipe (5) for said fluid, which passes at least in part along said rod (30), said pipe (5) helping to channel said fluid towards said ramp (10); a connecting means (8) that helps to provide a removable connection between said pipe (5) and said ramp (10) and helping to channel said fluid from said pipe (5) towards said ramp (10); a retaining means (9) that is able to ensure fastening of said connecting means (8) to said rod (30).

Abstract: The present invention relates to a method for transforming an initial progressive ophthalmic surface which has to be manufactured by a manufacturing method, the transformation method comprising: a step of selecting a manufacturing method intended to be implemented, in which said manufacturing method introduces a reproducible surface defect, a step of selecting a predictive model of said reproducible surface defect, a step of selecting an initial progressive ophthalmic surface S intended to be manufactured, a step of determining (S1), during which there is determined, by means of said predictive model, a surface defect value D which would be introduced if the initial progressive ophthalmic surface S were produced by said manufacturing method, a transformation step (S2), during which said initial progressive ophthalmic surface S is transformed into a transformed progressive ophthalmic surface S* by compensating the defect value D determined during the step (S1), such that the subsequent manufacture of the tr

Abstract: An apparatus for implementing a method for determining the dominant eye of a spectacle wearer (1), includes a target (2), an element (3, 4) for occulting at least one eye, and a sighting device (5, 50) equipped with an optical window (6). The principal feature of the apparatus is that the sighting device (5, 50) includes an electronic sensor making it possible to identify the direction of movement of the sighting device (5, 50), during the method during various steps of viewing the target (2).

Abstract: The present invention is drawn to an optical article comprising: (a) a transparent optical polymer substrate, (b) a transparent intermediate abrasion-resistant coating obtained from at least one epoxysilane by a sol-gel process, and (c) a transparent outer coating comprising a polythiolene matrix obtained by curing a liquid monomer mixture comprising at least one polyfunctional thiol and at least one polyfunctional allyl monomer, said cured polythiol-ene matrix having a glass transition temperature comprised in the range from 40° C. to 70° C. and a thickness from 3.5 ?m to less than 10 ?m. It is also drawn to a method for preparing such an optical article and to a method for repairing scratches in such an optical article by heating.

Abstract: The present invention provides a solution formulation for inhalation comprising: a liquid phase; an active ingredient containing a carboxylic ester in which the oxygen atom is covalently bound to a quaternary nitrogen-containing heterocycle, dissolved in the liquid phase; and a magnesium or calcium salt, dissolved in the liquid phase. The formulation is particularly suited to pMDIs and nebulizers.

Abstract: A temperature sensing assembly for measuring the temperature of an inner wall of a high temperature vessel includes a thermocouple assembly having multiple junction points to provide indications of temperature. The assembly further includes support structures for supporting the thermocouple assembly in the interior space of the vessel and to maintain the junction points proximate the inner wall of the vessel.

Abstract: In one aspect, the invention relates to a compound of the structure: or a pharmaceutically acceptable salt thereof, and a crystalline form of this compound, having neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising this compound; methods of using this compound; and processes for preparing this compound.

Abstract: Casing (20?) for a windscreen wiper drive rod, in particular of a motor vehicle, said casing being configured to cover et least a portion of said drive rod and comprising means for fixing to said drive rod and/or to at least one element (42) linked to said drive rod, characterised in that it further comprises support and guiding means (70) which are configured to cooperate with at least one electric cable (63) and/or at least one fluid line (64) of said windscreen wiper.

Abstract: A luminaire includes an excitation light source which emits excitation light. A first fluorescent plate includes a first principle surface disposed across the optical axis of the excitation light. A first phosphor layer is arranged discretely along the first principle surface. A second fluorescent plate is arranged at the downstream side of the excitation light with respect to the first fluorescent plate. The second fluorescent plate includes a second principle surface disposed across the optical axis. A second phosphor layer is arranged discretely along the second principle surface. The second phosphor layer has a wavelength conversion characteristic different from a wavelength conversion characteristic of the first phosphor layer. A support supports the first fluorescent plate and the second fluorescent plate such that at least one of relative positions and rotations of the first fluorescent plate and the second fluorescent plate are adjustable.

Abstract: A method of producing a metal-organic framework (MOF) film on a substrate is disclosed, the method comprising providing a substrate having a main surface and forming on said main surface a MOF film using an organometallic compound precursor and at least one organic ligand, wherein each of said organometallic compound precursor and said at least one organic ligand is provided only in vapour phase.

Abstract: The positioning receiver according to the invention comprises means for storing configuration information and information on its reception conditions, which is processed in order to calculate a current and/or predicted precision of the positioning calculation. Advantageously, at least some of this information is integrated into a variation model of a Kalman filter integrated into the receiver. The invention notably allows a more rapid convergence on a reference precision in a mono-frequency operating mode and transitions between a mono-frequency and bi-frequency mode to be smoothed. Advantageously, the precision information is delivered graphically or in numerical form to the user.

Abstract: Adaptor (112) for connecting a windscreen wiper unit (10) to a driving arm (26), the adaptor comprising two substantially parallel walls (28) connected together by means of at least one connecting element (30), the said walls having first, inner, side faces (28a) between which the said at least one connecting element extends, and outer side faces (28b), the said adaptor further having at least one stop element which is mounted on one of the said walls and which projects at least partially from the said outer side face of this wall, characterized in that the said at least one element (150) is movable between an operational stop position and a non-operational position.

Abstract: In an annual or perpetual calendar mechanism, a day-of-the-month wheel includes a notch. At each actuation of a lever, a first pawl finger effects an actuation of one step, on one of the teeth of the day-of-the-month wheel. Upon actuation of the lever at the end of a month of fewer than 31 days, a second pawl finger effects, in the notch, an actuation of the day-of-the-month wheel by a whole number of steps. The notch is positioned between two consecutive teeth among the teeth of the day-of-the-month wheel. The day-of-the-month wheel has a peripheral edge which forms the profiles of its teeth as well as the notch.

Abstract: Modular shelving systems and display shelves for modular shelving systems are disclosed. In one embodiment, a modular shelving system includes a shelf support frame comprising a back plane portion and a base portion. At least one display shelf module is removably coupled to the back plane portion of the shelf support frame such that the display shelf module is vertically and horizontally positionable on the back plane portion of the shelf support frame. The display shelf module may include a top and bottom panels, and side panels that define an interior volume. A display panel may be affixed to a front of the display shelf module. A projector may be disposed in the interior volume of the display shelf module. The projector projects an optical signal onto a rear surface of the display panel such that image data is visible on a front surface of the display panel.

Abstract: The present invention concerns an oligonucleotide modified by substitution at the 3? or the 5? end by a moiety comprising at least one ketal functional group, wherein the ketal carbon of said ketal functional group bears two saturated or unsaturated, linear or branched, hydrocarbon chains comprising from 1 to 22 carbon atoms, and the use therefore as a medicament, in particular for use for treating cancer.

Abstract: The active optical coupling system generally has: a photonic die having a photonic integrated circuit (PIC) waveguide element disposed thereon, the PIC waveguide element having an intermediate coupling element disposed on the PIC waveguide element; a liquid crystal refractive element (LCRE) being optically coupled to the PIC waveguide element of the photonic die via the intermediate coupling element, the LCRE having a first face for receiving light, a second face opposite the first face for outputting the received light, a liquid crystal layer between the first and second faces, and an electrode system arranged to act on the liquid crystal layer; and a controller being electrically connected to the electrode system of the LCRE and being operable to actively control the propagation of the outputted light upon action of the electrode system, said active control allowing coupling of the outputted light into the PIC waveguide element.

Abstract: A dry bulk commodities cargo fluidizing system which is substantially flat and foldable for use in shipping container liner-bags used for transporting bulk commodities and may be built into or secured to liner-bags. The system is composed of a first floor layer and a second floor layer which covers the first floor layer. The first and second floor layers are thermally joined together about woven plastic mesh to form connected chambers for receiving deliver of fluid evenly throughout the system with the second floor layer having multiple pinholes of various size and number density over its surface in relation to the fluid source to the system. The plastic mesh strips between the first and second floor layers create fluid flow bridges for fluid flow even when bulk commodities cargo is loaded onto the second floor layer and is pressing the second floor layer against the first floor layer.

Abstract: An assembly for analyzing a light pattern caused by refraction and reflection at a precious stone, comprising a light source for illuminating the precious stone, a retaining device for retaining the precious stone, a diffusing screen for imaging the light pattern, and a camera for recording the light pattern imaged on the diffusing screen. The assembly comprises a semi-transmitting optical element for deflecting, in a direction of the precious stone, light emitted by the light source and transmitting the light refracted and reflected at the precious stone.