Abstract: The invention provides compounds which are prodrugs of a JAK inhibitor agent for the targeted delivery of the JAK inhibitor to the gastrointestinal tract of a mammal. The invention also provides pharmaceutical compositions comprising the compounds, methods of using the compounds to treat gastrointestinal inflammatory diseases, and processes and intermediates useful for preparing the compounds.

Abstract: The invention provides crystalline forms of biphenyl-2-ylcarbamic acid 1-(2-{[4-(4-carbamoylpiperidin-1-ylmethyl)benzoyl]methylamino}ethyl)piperidin-4-yl ester, and pharmaceutically acceptable solvates thereof. The crystalline form can be a freebase, or a salt such as a diphosphate, monosulfate or dioxalate salt. The invention also provides pharmaceutical compositions comprising these crystalline compounds or prepared using these compounds; processes and intermediates for preparing the crystalline compounds; and methods of using these compounds to treat a pulmonary disorder.

Abstract: The disclosure concerns an infrared emitter is provided comprising a metalized membrane emitting infrared light in operation. The membrane comprises a two dimensional array of infrared wavelength sized through-holes and to each side a thin metal layer comprising also an array of through-holes. The through-holes are arranged as a two-dimensional periodic array and each of said through-holes have a cross section having a maximum and a minimum dimension of less than any wavelength of the emitted infrared light. The peak wavelength of the emitted infrared light is proportional to the periodicity of the through-holes. At least one of the metal layers is connected to an electrical current source that provides an electrical current that heats at least one of the metal layers so that a narrow bandwidth and highly directive light beam of infrared light is emitted. The membrane is arranged on a membrane support and both are made of a material that resists to temperatures higher than 400°.

Abstract: This invention relates to a solution formulation containing a tiotropium salt, 12-20% ethanol, 0.1-1.5% of water, 0.05-0.10% citric acid (or other organic acid) and an HFA propellant, wherein the percentages are percentages by weight based on the total weight of the formulation. The invention also provides a pMDI comprising a canister containing the formulation.

Abstract: The invention relates to a screen wiper (1) for a motor vehicle screen (6) comprising a support frame (2) of principal longitudinal orientation, having lower means exhibiting a wiper blade (4), the said support frame (2) being intended to be caused to move between two end positions along a predetermined trajectory in a wiping cycle of the screen (6), and a device (7, 8) for spraying cleaning liquid comprising at least one first set of spraying orifices aligned in the said principal longitudinal orientation for at least one part of a first side of the wiper in such a way as to permit the spraying of washing liquid in front of the wiper in relation to the wiping movement.

Abstract: An ophthalmic lens that can be edged, includes a main front surface and a main rear surface, obtained by successive deposition on at least one of the main surfaces of the lens, of a first hydrophobic layer that has a thickness of between 6 and 16 nm and is obtained by deposition of a composition including a constituent A selected from fluorosilanes having a number average molar mass that is higher than, or equal to, 2000 g/mol, of a second hydrophobic layer that has a thickness of between 3 and 20 nm and is obtained by the deposition of a composition including a constituent B selected from the fluorosilanes having a number average molar mass than is lower than, or equal to, 900 g/mol, and of a layer including a metal fluoride having a thickness of between 22 and 50 nm.

Abstract: A method of controlling a programmable lens device comprising a programmable lens and an optical function controller, the programmable lens having an optical function and extending between at least one eye of the wearer and the real world scene when the device is used by the wearer, and the optical function controller being arranged to control the optical function of the programmable lens, the method comprising: —an optical function data receiving step during which optical function data relating to the optical function of the programmable lens is received by the optical function controller, —an activity data receiving step during which activity data relating to the activity of the wearer are received by the optical function controller, —an optical function modifying step during which the optical function of the programmable electronic lens device is modified by the optical function controller based on the optical function data and the activity data.

Abstract: A pictures positioning system and method for positioning pictures on display elements of a binocular displaying device is described. The binocular displaying device comprises a right and a left display element to be placed in front of corresponding eyes of a wearer, and to display right and left pictures. The binocular displaying device comprises a measurement means. The method comprises a providing step during which at least one wearer related parameter is provided, the providing step including a measurement operation. The measurement operation may be performed by using the measurement means embedded in the binocular displaying device. The method includes a display positioning determination step during which a right display positioning of the right picture on the right display element is determined and a left display positioning of the left picture on the left display element is determined. The display positioning determination step is performed based on at least one wearer related parameter.

Abstract: The invention discloses a polypeptide capable of binding immunoglobulins or immunoglobulin-containing proteins, which polypeptide comprises six or more domains of protein Z or the C domain of protein A or a functional variant thereof. It also discloses separation matrices comprising the polypeptide and methods of using the separation matrices for separation of immunoglobulins or immunoglobulin-containing proteins.

Abstract: A driving apparatus configured to drive a light emitting device includes a driving current source module operable to supply current to the light emitting device via a node during operation. A protection module coupled to the node and the driving current source module selectively injects current to the node during operation. The driving current source module is controlled based on a detection result of a voltage on the node.

Abstract: The present invention relates to recombinant microorganisms comprising an isobutanol producing metabolic pathway and methods of using said recombinant microorganisms to produce isobutanol. In various aspects of the invention, the recombinant microorganisms may comprise one or more modifications resulting in the reduction in the expression and/or activity of an endogenous transporter protein. In various embodiments described herein, the recombinant microorganisms may be microorganisms of the Saccharomyces clade, Crabtree-negative yeast microorganisms, Crabtree-positive yeast microorganisms, post-WGD (whole genome duplication) yeast microorganisms, pre-WGD (whole genome duplication) yeast microorganisms, and non-fermenting yeast microorganisms.

Abstract: An inspection pouch for housing and providing hands-free access to electronic testing equipment, meters, lights, tools and other implements needed by inspectors, installers and other workers. The pouch has a main compartment forming a tray with a cover therefor, the main compartment capable of being suspended from the cover at angles between zero and ninety degrees to enable viewing of equipment staged in the main compartment.

Abstract: The invention relates to a method for deflecting space debris comprising steps of: launching (E2) a thruster (2) by means of a sounding rocket (1) at a target altitude close to that of the one or more debris to be deflected. generating (E3) by the thruster a gas cloud (G) above the sounding rocket.

Abstract: A high torque axial gap electric motor includes rotor and stator disks containing magnets fixed to their respective faces, where the magnets contain triangular ridges arranged in concentric circles. The face of each rotor magnet ridge is parallel to the face of a stator magnet ridge, creating an air gap with a cross-section that has a zigzag appearance. The preferred embodiment uses a three-phase motor design with multiple rotors and stators and permanent magnets.

Abstract: Adapter (126) for a windscreen wiper, particularly a motor vehicle windscreen wiper, the said adapter being intended to connect a wiper blade to a first end piece of a first driving arm of the lateral locking type and secured to a cylindrical rod defining an axis (Y) of articulation of the adapter with respect to the said blade, as well as a substantially U-shaped second end piece of a second driving arm, the said adapter comprising a longitudinal body comprising first and second lateral longitudinal walls (142a, 142b) that are substantially parallel and connected together by a transverse wall (144), the said body comprising at least one through-orifice (156) configured to accommodate the said cylindrical rod, characterized in that it further comprises rotation blocking means (170b) configured to collaborate with the said first end piece in order to secure the latter and the adapter in terms of rotation about the said axis (Y).

Abstract: The invention relates to a cover 20 intended to lock a shaft 2a securely to a driving arm and a connector 8 that carries a wiper 1, the cover 20 extending along a main longitudinal axis X and having at least two longitudinal flanks 25, each longitudinal flank 25 having an open slot 29 delimited at a first longitudinal end by an end wall 29e and at a second longitudinal end by an opening 29c for receiving the shaft 2a, said cover 20 being characterized in that said opening 29c is formed opposite said end wall 29e. Application to motor vehicles, in particular to the wiping of a rear window.

Abstract: A child-resistant storage case has a lid hinged to a base to define an interior storage space. Two side latches are spaced apart from one another on opposing side aspects of the storage case. A front latch mechanism includes a horizontal tab extending forward from the front aspect of the case. To open the storage case, the user must simultaneously press inward on the side latches, press downward on the horizontal tab, and lift the lid upward. The required downward actuation of the front latch mechanism is counter-intuitive for most people, and in combination with the side latches, is very difficult for most small children.