Abstract: A method of calculating an optical system (OS) of an ophthalmic lens according to a given spectacle frame, said ophthalmic lens comprising a back surface (BS) and a front surface (FS) arranged to deliver an ophthalmic vision image (VI), a light-guide optical element having a proximal surface (PS) and a distal surface (DS), said light-guide optical element being arranged to output a supplementary image (SI), wherein the method comprises the steps of: providing at least a morpho-geometrical parameter data of the frame or of the light-guide optical element; optimizing the optical system (OS) according to at least the morpho-geometrical parameter data as a target.

Abstract: The disclosure is directed to a method for designing a lithographic mask to print a pattern of structural features, wherein an OPC-based methodology may be used for producing one or more simulated patterns as they would be printed through the optimized mask. A real mask is then produced according to the optimized design, and an actual print is made through the mask. To evaluate the printed pattern and the PW on wafer more accurately, experimental contours are extracted from the CD-SEM measurements of the printed pattern. The verification of the mask is based on a comparison between on the one hand the contour obtained from the printed pattern, and on the other hand the intended pattern and/or the simulated contour. A direct comparison can be made between simulation and experiment, without losing all the pieces of info contained in each single CD-SEM picture.

Abstract: A device for detecting radiation particles comprising at least one sensor for sensing radiation particles, capable of supplying an electrical pulse when it is traversed by at least one radiation particle, and at least one detection circuit comprising a voltage-controlled oscillator to which said electrical pulse originating from the sensor is supplied as the control voltage. The voltage-controlled oscillator is a ring oscillator.

Abstract: In one aspect, the invention relates to compounds having the formula: where R1-R5 and X are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and processes and intermediates for preparing such compounds.

Abstract: Element (26) for a connection system between a windscreen wiper brush and a driving arm of said brush, said element being configured to be fixed selectively to terminal pieces of a plurality of arms, such that the element comprises at least one first bearing surface (48a, 48b) and one first locking means (27) configured to cooperate with a first arm, and it further comprises at least one second bearing surface (60a) and one second locking means (27?) configured to cooperate with a second arm.

Abstract: Disclosed is a device for measuring ocular refraction and a geometric-morphological parameter of an individual, including: a gaze-stimulating target placed so as to stimulate the gaze of the individual in a posture associated with a proximity value and a sight axis; an illuminating system able to generate at least one illuminating beam in the direction of the eyes of the individual; an image-capturing system; and a computer able to receive at least one first image captured by the image-capturing system. According to the invention, the image-capturing system is able to acquire an image of part of the face surrounding the eyes of the individual, and the computer is able to extract, from the acquired image, a first measurement of a glazing parameter and a first measurement of objective ocular refraction by refraction of the illuminating beam on the eyes of the individual in the given posture.

Abstract: This invention relates to a composition comprising an anti-HIV treatment and a treatment for side effects of said anti-HIV treatment in an HIV-infected patient. This invention is, for example, very useful in the treatment of side effects caused by certain anti-HIV treatments, for example premature aging and lipodystrophy, which can be caused by protease inhibitors or reverse transcriptase inhibitors. The composition of this invention includes at least one hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor, at least one farnesyl-pyrophosphate synthase inhibitor, and at least one anti-HIV agent. One of the processes for treating an HIV-infected patient includes, in any order, the following steps: (i) administration of a mixture including at least one hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor and at least one farnesyl-pyrophosphate synthase inhibitor and (ii) administration of an anti-HIV agent, in which the administrations are concomitant, successive or alternative.

Abstract: An active interface device including a transducer or sensor array having a plurality of transducers or sensors arranged to transform a cell activity into an electrical signal, at least one detection unit for detecting the electrical signal(s), at least one recording unit for recording the electrical signal(s), comprising a plurality of recording channels arranged for being routed to the transducers or sensors, and at least one control unit. The control unit is arranged for addressing the transducers or sensors to the detection unit(s), for activating transducers or sensors, and for routing the recording channels to activated transducers or sensors.

Abstract: In the field of active phase-control antennas, a method is provided for calibrating the phase center of an active antenna including a plurality of sub-elements able to receive a useful signal emitted by a satellite, the calibration being defined as a function of the reception characteristics of a reference signal at the level of each sub-element, the reference signal being emitted by the same satellite on a frequency band substantially equal to the frequency band of the useful signal and whose theoretical reception characteristics are known.

Abstract: A positive pressure gas supply system configured to supply positive pressure gas to a patient includes a CPAP unit configured to generate a flow of positive pressure gas. A humidifier base is positioned to receive the flow of positive pressure gas from the CPAP unit. A receiving portion of the humidifier base is configured to removably receive a refilling module. The refilling module is configured to hold a volume of water, complete a gas flow path partially defined by the humidifier base, and humidify the positive pressure gas. In addition, a respiration tube connecting portion is positioned to remain in communication with a gas discharge passage of the humidifier base when the refilling module is removed from the humidifier base. The respiration tube connecting portion is configured to be connected to a respiration tube and deliver the humidified positive pressure gas to the respiration tube.

Abstract: A method of blocking a lens member having a surface to be manufactured on a lens holding unit, the method comprising: a lens member providing step during which a lens member comprising engraved markings is provided, a contrast providing step during which contrast elements are placed on the engraved markings, a taping step during which the marked surface of the lens member is taped with an adhesive tape over the contrast elements, and a blocking step during which the lens member is blocked on a lens holding unit via the taped surface.

Abstract: Quantum processor architectures employ unit cells tiled over an area. A unit cell may include first and second sets of qubits where each qubit in the first set crosses at least one qubit in the second set. Angular deviations between qubits in one set may allow qubits in the same set to cross one another. Each unit cell is positioned proximally adjacent at least one other unit cell. Communicatively coupling between qubits is realized through respective intra-cell and inter-cell coupling devices.

Abstract: Wrench (1) for providing a maximum torque to an external part, characterized in that it comprises at least one elongated metal part (3) provided with a fixed end (4) and a pusher end (5), and which also comprises a torque-applying head (6) upon which the pusher end (5) acts, wherein the elongated metal part (3) is capable of bending when a torque is applied with the wrench, and wherein the elongated metal part (3) reaches a maximum bending point that determines the maximum torque provided by the wrench (1). The inventive wrench (1) is easier to use than conventional spring-based wrenches as the force required to adjust the torque is minimal and independent of the torque value to which the wrench is adjusted. It is also capable of providing higher torque values.

Abstract: A connector for a windscreen wiper of a motor vehicle, the connector being configured to allow the wiper to be articulated to an arm for driving the wiper in a rotational movement about an axis of rotation Y. The connector includes one or more projecting shapes which are configured to be guided in rotation by an adaptor for the wiper on the arm in various angularly distant regions about the axis of rotation Y, so as to allow the movement in rotation.

Abstract: A humidifier assembly for a CPAP includes a base housing with a gas inlet configured to receive respiratory gas from the CPAP unit. The base housing includes a first connecting device located at a sidewall of the base housing and configured to directly, removably connect the base housing to the CPAP unit. The base housing also includes a second connecting device configured to be coupled to an air delivery hose. The humidifier assembly further includes a liquid storage container that is removably received in the base housing. The liquid storage container includes a liquid storage space configured to store liquid and a humidifying region configured to receive the respiratory gas from the gas feed opening and receive a partial amount of the liquid stored in the liquid storage space to enrich the respiratory gas with moisture.

Abstract: A timepiece pallet fork for a mechanical oscillator including an arbor allowing the timepiece pallet fork to oscillate about a pivot axis, first and second pallets configured to alternatively engage with an escapement wheel when the timepiece pallet fork oscillates, the first pallet being displaceable with respect to the arbor by absorption of energy, the first pallet being displaceable from a first upstream waiting position to a first downstream stopping end position which is offset compared to the first upstream waiting position, and a first arm having an intermediate section including an elastic bend, one end of the arm being fixed with respect to the arbor to form a first fixed end, the intermediate section of the first arm being located between the first fixed end and the first pallet and returning the first pallet towards the first upstream waiting position by the intermediate section being elastically deformable from a first configuration into a second configuration.

Abstract: The invention relates to a method for determining an ophthalmic lens wherein: a first and a second reference axes are determined, the first reference axis is comprised between [?T?20°, ?T+20° ] with ?T being the mean axis of astigmatism over a first temporal portion, and the second reference axis is comprised between [?N?20°, ?N+20° ] with ?N being the mean axis of astigmatism over a second nasal portion; a combined reference axis is determined as a linear combination of the first and second reference axes; over the first portion, the sphere value along the combined reference axis is greater than the sphere value along a perpendicular axis to the combined reference axis; and over the second portion, the sphere value along the combined reference axis is greater than the sphere value along a perpendicular axis to the combined reference axis.

Abstract: The present invention relates to a method for detecting and optionally quantifying at least one molecule comprising at least one protonated group such as an amine function immobilized at the surface of the solid substrate, said method being a reversible, direct and colorimetric method that uses a coloring agent. The present invention also relates to various uses of said method and the solutions used during said method.

Abstract: A monolithic honeycomb element includes a collection of adjacent ducts of mutually parallel axes separated by walls made of a porous material, the element having, in transverse cross section, a polygonal, notably quadratic cross section delimited by exterior wall elements, wherein at least one corner of the polygon, has, along the bisector of the angle at the corner, an additional thickness, such that the total thickness of the external wall, likewise measured along the bisector of the angle at the corner, is greater than the mean thickness of the exterior walls by a factor of at least 1.43, the additional thickness being obtained at least in part by an additional quantity of porous material on the external face of the corner.

Abstract: One aspect of the invention relates to a method for reducing salt content in an aqueous cadaverine salt composition comprising adjusting the pH of the aqueous cadaverine salt composition to provide a first composition comprising an aqueous cadaverine composition and a solid composition, wherein the pH of the aqueous cadaverine composition is at least about 12; and removing the solid composition from the first composition to provide the aqueous cadaverine composition. Another aspect of the invention relates to a method for the purification of cadaverine from an aqueous cadaverine salt composition using the salt-reducing method described herein; and obtaining cadaverine from the aqueous cadaverine composition.