Abstract: The present invention relates to a class of novel isothiazolo[4,3-b]pyridine derivatives and a method for their preparation, as well as to pharmaceutical compositions comprising one or more of said isothiazolo[4,3-b]pyridine derivatives and one or more pharmaceutically acceptable excipients. The present invention further relates to the use of said novel isothiazolo[4,3-b]pyridine derivatives as biologically active ingredients, more specifically as medicaments for the treatment of disorders and pathologic conditions such as, but not limited to, cell-proliferative and neurodegenerative diseases.

Abstract: The problem of the invention is to provide a resin composite electrolytic copper foil having further improved heat resistance and improved plate adhesion strength when plated after desmear treatment in the work process of an additive method. The solution is to form a roughened surface having a plurality of minute projections, a surface roughness (Rz) within a range of 1.0 ?m to 3.0 ?m and a lightness value of not more than 30 on one surface of an electrolytic copper foil (A), and form a layer of a resin composition (B) containing a block copolymerized polyimide resin (a) having a structure that imide oligomers of a first structural unit and a second structural unit are bonded alternately and repeatedly on the roughened surface.

Abstract: A voltage regulator includes a feedback regulation loop and a drive transistor configured to source current to a regulated output. A transient recovery circuit is coupled to the voltage regulator circuit and includes a first transistor coupled to source current into a control terminal of the drive transistor, wherein the source current is in addition to current sourced in response to operation of the feedback regulation loop. The first transistor is selectively actuated in response to a drop in voltage at the regulated output. The transient recovery circuit further includes a second transistor coupled to sink current from the regulated output. The sink current has a first non-zero magnitude in the quiescent operating mode of the regulator circuit. In response to an increase in voltage at the regulated output, the operation of the second transistor is modified to increase the sink current to a second, greater, non-zero magnitude.

Abstract: A guided mode resonance device, comprising—a substrate,—a waveguide,—a grating structure associated with said waveguide, said grating structure being arranged to an incident surface of said substrate, said incident surface being intended to receive an incident light beam provided by at least one light source, said incident light beam having an incident angle, defined relative to the normal of said waveguide, said grating structure comprising at least one elementary structure comprising at least a first-type grating structure and at least a second-type grating structure,—wherein:—said waveguide is arranged to transfer light from_the first-type grating structures to the second-type grating structure and also to transfer light from the second-type grating structures to the first-type grating structure,—said first-type grating structure is arranged to couple out a first light beam,—said second-type grating structure is arranged to couple out a second light beam,—said first light beam having a different spectral d

Abstract: This invention relates to riluzole for use in the treatment or prevention of adverse effects associated with the administration of anticancer agents having neurotoxic effects, such as, for example, platinum salts, taxanes and periwinkle alkaloids.

Abstract: To provide an electronic device in which a CPU unit and an arbitrary number of IO units can be connected by stacking without the ineffective size increase of the entire device, and the easy unlocking is possible. The CPU unit 13 and the IO unit 15 are connected by inserting a pair of edge connecters 63, 65 formed at both ends of a riser board 61 into an edge-connector socket 33 formed in a first board 31 of the CPU unit 13 and into an edge-connector socket 57 formed in a second board 51 of the CPU unit 13, and the first board 31 and the second board 51 are electrically connected through the riser board 61.

Abstract: An annular gasket for an electrical connection of the kind comprising a socket-outlet casing (6) and a plug casing (7), said gasket extending in an axial direction (X) and comprising a cylindrical base (2) surmounted by a skirt (3) extending axially from the base (2), the skirt (3) presenting an inner wall (3b), an outer wall (3a), and a rounded free edge (4), each of the inner wall (3b) and of the outer wall (3a) presenting, a continuously curved shape in radial section view, the thickness of the skirt (3) decreasing in continuous and non-linear manner from the base (2) towards the free edge (4), the skirt (3) presenting a concavity oriented towards the inside of the gasket, whereby the skirt (3) folds over onto itself when axial stress is exerted on the free edge (4).

Abstract: Embodiments of the present invention have left and right guide links that are pivotally attached to the frame, typically to an upper part of the frame, and left and right foot support links each having a mid-portion pivotally interconnected with a lower end of the respective guide link. Reciprocal motion of the guide links causes the foot support links to move along a path having a horizontal component of motion (i.e. fore and aft). Left and right vertical control links are coupled to a vertical cam drive such that the vertical cam drive reciprocates the vertical control links. The vertical control links are each coupled to a forward portion of the respective foot support link such that the reciprocating control links cause foot receiving areas at the rear of the respective foot support links to reciprocate along a path having a vertical component of motion (i.e. upwardly and downwardly).

Abstract: A method for manufacturing a corrective ophthalmic glasses lens personalized for a wearer, includes defining and digitally recording the configuration parameters of the lens, calculating modeling data of the refractive faces of the lens, and manufacturing the lens in accordance with the configuration parameters.

Abstract: An oil pump is provided. The oil pump comprises a shell, a rotor mounting part disposed at an end of the shell, and a rotor mechanism disposed on the rotor mounting part. The shell has an inlet and an outlet and defines a low-pressure oil chamber and a high-pressure oil chamber therein. The high-pressure oil chamber and the low-pressure oil chamber are located at the same side of a periphery of the rotor mounting part. An engine cover comprising the oil pump and an engine comprising the engine cover are also provided.

Abstract: An elliptical exercise device has a frame and guide link pivotally attached thereto. A foot support link is pivotally connected to a lower attachment point of each guide link so that when the guide links pivot relative to the frame, foot receiving areas of the foot support links move in a path of travel having a horizontal component of motion. Vertical control tracks are pivotally connected to the frame and support the foot support links. A vertical drive is coupled to the forward portion of the frame and vertical control elements connect the vertical drive to the vertical control tracks.

Abstract: A molded funnel shaped cone joined with a base molded of compress crumb rubber has a pair of peripheral, outside flanges spaced apart and in contact with upper and lower surfaces of the base. The body has a pair of opposing apertures adjacent to the top end for placement of a barrier marking tape and for other uses.

Abstract: A mthod of metalizing a surface of an insulation substrate includes: applying an ink composition onto the surface to form an ink layer; subjecting the insulation substrate to heat treatment at a temperature of about 500 to 1000 degrees Celsius in a non-reactive atmosphere; plating a metal layer on the ink layer. The ink composition comprises a metal compound and an ink vehicle. The metal compound includes at least one selected from a group consisting of a nano-copper oxide, a nano-cuprous oxide, a compound of formula I, and a compound of formula II, TiO2-?(I), M1M2pOq (II), 0.05??<1.8, where, M1 is at least one element selected from a group consisting of groups 2, 9-12 of the periodic table, M2 is at least one element selected from a group consisting of groups 3-8, 10 and 13 of the periodic table, 0<p?2, and 0<q<4.

Abstract: Reinforced section piece comprising a metal section piece and a reinforcing spacer piece, said section piece having a generally U-shaped cross-section with a base portion, said section piece comprising side wings extending perpendicularly on each side from the transverse ends of the base portion, with inner surfaces facing each other at an inside distance, the reinforcing spacer piece comprising a body having a width that is slightly less than the inner distance, and being configured to prevent the lessening of the distance between the two side wings, the reinforcing spacer piece additionally comprising protuberances projecting outwards from the body in the transverse direction, facing the curved surfaces of the male section piece.

Abstract: The present invention concerns subject matter connected to or making use of lgLON5, lgLON5 fragments and variants of lgLON5 and lgLON5-fragments. In particular the present invention relates to a use of a polypeptide comprising one or more sequences of IgLON5, an lgLON5-fragment or a variant thereof for the diagnosis of a disease, in vitro methods for diagnosing such a disease, a polypeptide comprising one or more sequences of lgLON5, an lgLON5-fragment or a variant thereof or a nucleic acid encoding said polypeptide for use in the treatment of a disease, a pharmaceutical composition comprising such polypeptide, a method for treating such a disease, an autoantibody binding to IgLON5, an lgLON5-fragment or a variant thereof, a method for isolating such autoantibody, a medical or diagnostic device comprising such autoantibody or such polypeptide and a test kit for the diagnosis of a disease, which test kit comprises such autoantibody and/or such polypeptide.

Abstract: The present invention relates to a zero-phosphate machine dish wash composition in unit dose format comprising non-phosphate builder, alkali percarbonate, a manganese bleach catalyst in relatively low amounts and one or more polycarboxylate polymers. The builder comprises one or more from methylglycine-N,N-diacetic acid and/or one or more salts thereof, citric acid and/or one or more salts thereof, and glutamic acid-N,N-diacetic acid and/or one or more salts thereof. The polycarboxylate polymers have a weight average molecular weight of between 1000 and 100,000, the polymers comprising at least 20 mol-% of acrylate monomers and from 0 to 40 mol-% of maleate monomers. The composition provides improved tea stain removal upon use.

Abstract: A method of managing video signals utilizes non-reference quality analysis to select versions of the video which are of at least a desired quality to process and distribute from among versions which are not of a desired quality.

Abstract: A method for optical detection of residual soil on articles (such as medical instruments and equipment), after completion of a washing or a rinsing operation by a washer. A soil detection system provides an indication of soil on the articles by detecting luminescent radiation emanating from the soil in the presence of ambient light.

Abstract: The invention relates to an end joining piece (1) for a wiper of a window of a vehicle, comprising at least one flexible support (3) as well as a friction blade (4) which is designed to be applied against the window. The end joining place (1) comprises a receptacle (5) which can receive an end part (28) of the flexible support (3). The end joining piece (1) is provided with at least one means (7) for locking the end part (28) of the flexible support (3) in the engaged position inside the receptacle (5). The locking means (7) comprise an orifice (10) which equips the end joining piece (1) and a stud (8) which is equipped with a finger (9).