Abstract: Fused grain having the following chemical composition: more than 10% and less than 50% of alumina Al2O3; more than 10% and less than 50% of titanium oxide TiO2; more than 21% and less than 50% of zirconia; more than 1% and less than 10% of a compound chosen from the group constituted by MgO, CaO, Fe2O3, Cr2O3, MnO2, La2O3, Y2O3, Ga2O3 and mixtures thereof; less than 20% of silica SiO2; less than 10% of a compound chosen from the group constituted by alkali metal oxides, alkaline-earth metal oxides and mixtures thereof; less than 2% of other oxide species; the percentages being percentages by weight on the basis of the oxides. Application in the melting of metals.

Abstract: The present invention relates to a process for manufacturing an electrochromic article comprising the following successive steps: (a) the deposition of a layer of an electrochromic compound on the surface of a transparent or translucent electrically conductive substrate, said layer of electrochromic compound covering only one portion of the surface of said electrically conductive substrate and leaving free at least one other portion thereof, (b) the deposition of a redox agent which is a reducing agent or an oxidizing agent for the electrochromic compound, on the portion of the surface of the electrically conductive substrate not covered by the layer of electrochromic compound, (c) the contacting of the layer of electrochromic compound, deposited in step (a), and of the layer of redox agent, deposited in step (b), with a liquid electrolyte for a sufficient time to enable the reduction or the oxidation of the electrochromic compound by the redox agent, and (d) the removal of the electrolyte by rinsing and/or d

Abstract: A device and method for detecting a short circuit in an electrical component during a start-up routine. In an embodiment, a device may have a problematic display having a short circuit that may result in damage to other components of the device if the device were allowed to fully startup during a normal start-up routine. Thus, power supplied to the panel may be initiated in stages so as to monitor any current that may be flowing through the panel, which in turn, may be indicative of a short circuit in the panel. If enough “leakage” current is detected through the panel during this staged startup routine, then a short-circuit detection circuit may interrupt the startup routine and lock out the operation of the device until the detected short circuit in the panel can be addressed.

Abstract: A device is provided for supporting a magnetic reading head. The device includes a guide for guiding and cushioning the reading head. The guide is mounted between a base of the reading head and a bearing surface parallel to the base, and includes at least one part made of a material, the Young's modulus of which is greater than 200 N/mm2.

Abstract: The present invention provides a method for calibrating a spot color comprising: determining a target value for the spot color; and calibrating a printing device in an enumeration cycling manner, so that a spot color measurement value of a color block output by the printing device approximates the target value. The present invention further provides an apparatus for calibrating a spot color, comprising: a target module used for determining a target value for the spot color; a calibrating module used for calibrating a printing device in an enumeration cycling manner, so that a spot color measurement value of a color block output by the printing device approximates the target value. The present invention precisely calibrates the spot color of the printing device.

Abstract: The present invention relates to a skin lightening composition and a method of lightening skin. The skin lightening is achieved using siRNA oligonucleotides which are able to achieve this using much lower concentration as compared to known chemical actives.

Abstract: OX40 is a potent immune stimulating target. Provided herein is a method of treating cancer, which includes administering to a subject in need of treatment an OX40 agonist and a common gamma chain (yc) cytokine or an active fragment, variant, analog, or derivative thereof. In certain aspects the common gamma chain (yc) cytokine is interleukin-2 (IL-2) or an active fragment, variant, analog, or derivative thereof. Combined treatment with an agonist anti-OX40 mAb and IL-2 synergized to augment tumor immunotherapy against multiple tumor types. Dual therapy was also able to restore the function of anergic tumor-reactive CD8+ T cells.

Abstract: The present invention is concerned with novel 4-substituted 1,3-dihydro-2H-benzimidazol-2-one derivatives substituted with heterocycles having formula (I) tautomers and stereoisomeric forms thereof, and the pharmaceutically acceptable addition salts, and the solvates thereof, wherein R4, R5, Z and Het have the meaning defined in the claims. The compounds according to the present invention are useful as inhibitors on the replication of the respiratory syncytial virus (RSV). The invention further concerns the preparation of such novel compounds, compositions comprising these compounds, and the compounds for use in the treatment of respiratory syncytial virus infection.

Abstract: Aspects of the invention provide single stranded oligonucleotides for activating or enhancing expression of PTEN. Further aspects provide compositions and kits comprising single stranded oligonucleotides for activating or enhancing expression of PTEN. Methods for modulating expression of PTEN using the single stranded oligonucleotides are also provided. Further aspects of the invention provide methods for selecting a candidate oligonucleotide for activating or enhancing expression of PTEN.

Abstract: A method includes receiving, at a network device in a shared network that includes a plurality of PLMNs, a request from an inbound roaming user device to connect to a home network of the inbound roaming user device. The method also includes identifying, by the network device, a PLMN selected by the inbound roaming user device, and accessing a listing of allowed PLMNs and disallowed PLMNs for roaming in the shared network. The method includes determining whether the selected PLMN is an allowed PLMN and blocking the connection to the home network in response to a determination that the selected PLMN is not an allowed PLMN.

Abstract: A previously obtained location of a fixed wireless device is stored and available for processing of a call or the like from the device when a location determination may be desirable. In some circumstances, the previously obtained location of the fixed wireless device may be retrieved to provide information to a public-safety answering point (PSAP) during handling of an emergency call initiated by the fixed wireless device over a wireless network.

Abstract: In one aspect, the invention relates to compounds having the formula: where R1, R2, R3, R4, and R5 are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.

Abstract: Aspects of the invention provide single stranded oligonucleotides for activating or enhancing expression of ATP2A2. Further aspects provide compositions and kits comprising single stranded oligonucleotides for activating or enhancing expression of ATP2A2. Methods for modulating expression of ATP2A2 using the single stranded oligonucleotides are also provided. Further aspects of the invention provide methods for selecting a candidate oligonucleotide for activating or enhancing expression of ATP2A2.

Abstract: The present invention provides a beverage preparation machine for forming a beverage by contacting an aqueous medium with one or more beverage ingredients, the beverage preparation machine comprising a tube forming at least a part of an outlet path for discharging the beverage to a receptacle; wherein the tube has an upstream end for receiving the beverage and a downstream end for discharging the beverage; wherein the upstream end has a characteristic internal dimension of at least 8 mm and the downstream end has a characteristic internal dimension of at least 10 mm.

Abstract: A method includes attaching to a Packet Data Network (PDN) supporting services over a long term evolution (LTE) network to establish a first network connection. The method includes connecting to a wireless local area network, e.g. a WiFi network, to establish a second network connection. The method further includes launching an application accessing at least one of the supported services and receiving a request from the application to switch between the first and second network connections, according to the supported service, e.g. a policy associated with the service. Switching from the first network connection to the second network connections includes connecting to the PDN via an evolved Packet Data Gateway (ePDG).

Abstract: A user device may be configured to generate a multipart message (e.g., a multimedia messaging service (“MMS”) message). A message part of the multipart message may include conversation metadata that includes information regarding a messaging conversation between the user device and at least one other user device. The message part may include a multipart type indicator (e.g., a Multipurpose Internet Mail Extensions (“MIME”) type indicator) that indicates that a type of the at least one part is a type associated with conversation metadata. The user device may output the multipart message to the other user device.

Abstract: Systems and methods for message timestamp re-alignment for message thread consistency across multiple devices are disclosed. In some implementations, an outbound message originating at a mobile phone is received at an integrated messaging server. The outbound message is associated with a messaging protocol. A timestamp representing a send time for the outbound message associated with the messaging protocol at the mobile phone is determined, at the integrated messaging server, by receiving an indication of the send time from the mobile phone. The outbound message and the timestamp are stored at the integrated messaging server. The outbound message and the timestamp representing the send time for the outbound message are provided from the integrated messaging server to a client computing device different from the mobile phone.

Abstract: Exemplary embodiments provide a system and method for uploading large files to a remote server faster. The system and method divide the file into smaller file chunks and utilize parallel thread execution to prepare and upload the file chunks to the remote server. The uploading may further utilize a plurality of HTTP connections. Once all chunks have been uploaded to the remote server, the chunks may be consolidated into the original file by using content tokens and chunk numbers associated with the uploaded chunks.

Abstract: To allow a user to temporarily move access to premium content to another location, e.g. outside the vicinity of the home, while adequately protecting the rights of a broadcast content provider, the various examples implement a transfer of an object for an identified right of content usage between premium content reproduction devices and a mobile device. The mobile device enables such transfer to support viewing of the premium content by a user outside of the user's home.