Abstract: The present invention concerns a compound having the following formula (I): as well as its use as a medicament, especially for its use for treating viral infections.

Abstract: The present invention relates to an improved process for the preparation of 4-({(1R)-2-[5-(2-fluoro-3-methoxy phenyl)-3-{[2-fluoro-6-(trifluoro methyl) phenyl] methyl}-4-methyl-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl]-1-phenylethyl}amino) butanoic acid of formula (I) or its pharmaceutically acceptable salts.

Abstract: Disclosed is a composition comprising C16:2-C18:2 soap; and C16:1-C18:1 soap; wherein a weight ratio of C16:2-C18:2 soap to C16:1-C18:1 soap in the composition is higher than 0.7. Also contemplated are end use compositions comprising the same.

Abstract: A round trip container includes a container body having a receiving cavity and an opening. A proximal end of a closure flap is operably coupled with the container body and the closure flap is configured to extend over the opening. A first adhesive receiving area is located on one of the closure flap and the container body and receives adhesive to adhere the closure flap to the container body when the container is placed in a closed “outbound” configuration. An adhesive portion is located on one of the closure flap and the container body. A removable covering is placed over the second adhesive portion. After the package has been received and opened, and any desired contents inserted into the receiving cavity, the covering can be removed and the second adhesive adheres the closure flap to the container body placing the container in a closed “return” configuration.

Abstract: Biomarkers are provided that are predictive of a subject's responsiveness to a therapy comprising lenvatinib or a pharmaceutically acceptable salt thereof (e.g., lenvatinib mesylate). The biomarkers, compositions, and methods described herein are useful in selecting appropriate treatment modalities for a subject having cancer (e.g., thyroid cancer, kidney cancer), suspected of having cancer, or at risk of developing cancer.

Abstract: A timepiece, that includes a display mechanism arranged to control the movements of a display organ with respect to an indication scale including different indications having at least two different widths and being separated from one another by corresponding separation spaces, where the separation spaces all have substantially one and the same width.

Abstract: A method of welding a support on a slide profile, which comprises: a) providing a support having a wall with an inner face, and providing a profile having a wall with an outer face, b) positioning the interface support with the inner face of its wall against the outer face of the wall of the profile, c) creating a welding joint between the wall of the support and the wall of the profile by moving a laser beam relative to the wall of the profile, while keeping the laser beam in a position such that it successively passes through, from an emitting source: the wall of the profile, then the wall of the support, while remaining within the material of the wall of the support.

Abstract: The present invention concerns synthetic polynucleotides encoding a human fukutin-related protein (FKRP) wherein the synthetic polynucleotides contain at least a mutation avoiding supplementary transcript(s) generated from frameshift start codon(s). The synthetic polynucleotides are useful, especially for treating a pathology linked to a FKRP deficiency or induced by a defect in ?-dystroglycan (?-DG) glycosylation, such as LGMD2I.

Abstract: Compositions disclosed herein, and methods of use thereof included those for treating or preventing sepsis in a subject in need, including methods of extending of the survival of a subject suffering from sepsis, and reduction of organ dysfunction or failure due to sepsis. Methods of treating or preventing sepsis in a subject in need includes administering compositions comprising early apoptotic cells or early apoptotic cell supernatants. Compositions and methods of use thereof may reduce the negative proinflammatory effect accompanying sepsis. Further, anti-inflammatory cytokine release may be reduced. In certain instances, compositions may include additional agents.

Abstract: A diagnostically useful carrier includes a means for specifically capturing an antibody to a polypeptide from the group including squid MLC1 or squid MLC2 or a variant thereof in a sample from a subject. A method includes the step detecting in a sample from a subject the presence or absence of an antibody to squid MLC1 or squid MLC2. The polypeptide or the carrier or a polypeptide binding specifically to an IgE antibody from the sample of a patient to squid MLC1 or squid MLC2 are useful for the manufacture of a diagnostic kit, preferably for the diagnosis of allergy.

Abstract: The invention provides a crystalline hydrochloride salt of 4-[2-(2,4,6-trifluorophenoxymethyl)phenyl]piperidine. This invention also provides pharmaceutical compositions comprising the crystalline salt, processes and intermediates for preparing the crystalline salt, and methods of using the crystalline salt to treat diseases.

Abstract: A method for manufacturing a covering system for a motor vehicle seat member includes the steps of: providing a support, a cover and a pad; associating the support with the cover, the pad being left free between the support and the cover; and creating longitudinal seam lines, one on either side of the pad. The longitudinal seam lines join together the support and the cover. The longitudinal seam lines form straight segments, extending in a transverse direction towards the first pad, and join together the support, the cover, and the first pad.

Abstract: A system and method operable to facilitate preparing of an advertising project are disclosed herein. The method, in an embodiment, includes a plurality of steps related to preparing an advertising project before any ads are published based on the advertising project. The steps include processing rule data associated with at least one rule; processing goal data associated with at least one goal factor; determining a plurality of ad spot sets depending at least partially on the at least one rule; determining which ones of the eligible ad spot sets either reaches the at least one goal factor or reaches a designated proximity to the at least one goal factor, resulting in a plurality of spot set candidates; and processing heuristic logic that includes at least one control setting and a plurality of optimization steps. The method also includes identifying at least one of the modified sets that results from the optimization steps.

Abstract: An adapter (1) for securing a wiper on an arm of a wiper system, the adapter (1) extending in a longitudinal direction (L), the adapter (1) being configured to be fitted such as to rotate on a connector of the wiper around an axis of rotation transverse to the longitudinal direction (L), the adapter (1) comprising at least one lateral wall (10) and one upper wall (12), the lateral wall (10) and the upper wall (12) participating in defining an inner volume of the adapter (1), the adapter (1) comprising an inner wall (20) extending at least partly into the inner volume of the adapter (1), the adapter (1) comprises a locking device (22) which is designed to render the adapter integral longitudinally relative to the arm of the wiper system, the locking device being fitted such as to pivot on the upper wall around an axis of pivoting.

Abstract: A copper treatment additive and methods are provided for applying copper to base metal effectively and efficiently while requiring a reduced frequency of replacing a treatment bath of copper sulfate solution. The copper treatment additive comprises an acidic, liquid mixture for use with a solution of copper sulfate and sulfuric acid to produce a strongly adherent, uniform metallic copper coating on steel. The copper treatment additive includes a first portion of Polyethylene Glycol 3350, a second portion of 4,4?-Methylene Dianiline; and a third portion of 31.45% Hydrochloric Acid. The copper coating has been observed to facilitate wire drawing processes and enhance characteristics associated with welding and decorative wire.

Abstract: A cleaning method (1) for cleaning a glazed surface (20) of a vehicle (2), said vehicle (2) comprising a cleaning device (21) comprising a wiping system (210) with at least one spray device for spraying a liquid (Lq), characterized in that said cleaning method (1) involves verifying (E1) a first condition (C1) that the current season (sc) is spring or summer, verifying (E2) a second condition (C2) which is the probability (pb) of there being insect strike (is) on said glazed surface (20), and verifying (E3) a third condition (C3) that said vehicle (2) is stopped. If all of the conditions (C) are met, then activating (E4) the cleaning device to begin a cleaning cycle (Cy), and executing (E5) the cleaning cycle (Cy) using said cleaning device (21).

Abstract: A process (1) for de-icing a glazed surface (20) of a vehicle (2) is disclosed. A de-icing device (21) includes a wiper system (210) with at least one device for spraying a liquid (L, Lq), and is used to perform a method involving verification (E1) of a primary condition (C1) according to which the ignition (Cc) of the said vehicle (2) is activated, verification (E2) of a secondary condition (C2) according to which the exterior temperature (t) is below a temperature threshold (Th1), verification (E3) of a tertiary condition (C3) according to which a demisting function (fd) is activated; and when all of the conditions are fulfilled, then activation (E4) of the de-icing device (21) in order to start a de-icing cycle (Cy). The de-icing cycle (Cy) comprising spraying by the device for spraying of the liquid (L, Lq) onto the glazed surface (20).

Abstract: A current-averaging audio amplifier for vehicles. The current averaging audio amplifier is connectable to a DC power source and a load, and may generally comprise a power input to receive a DC electrical power from the DC power source. The system may further include a voltage converter, such as a boost converter, connected to the power input, such that the voltage converter can receive electrical power from the DC power source. The system also includes a rechargeable battery coupled to the voltage converter, such that the voltage converter charges the rechargeable battery. An audio amplifier can be powered by the rechargeable battery and connectable to supply power to the load, wherein the average power supplied by the rechargeable battery to the audio amplifier in a finite time interval differs from the average power supplied by the DC power source to the voltage converter.