Abstract: The disclosed apparatus, systems and methods relate a failover and internet connection monitoring system featuring a cloud server running an API, a probe, a firewall and a policy routing system. The failover connection monitoring system is capable of gathering and analyzing performance data and controlling the flow of packets to and from the internet over one or more connections to optimize performance of the network.

Abstract: A hybrid computing system for solving a computational problem includes a digital processor, a quantum processor having qubits and coupling devices that together define a working graph of the quantum processor, and at least one nontransitory processor-readable medium communicatively coupleable to the digital processor which stores at least one of processor-executable instructions or data. The digital processor receives a computational problem, and programs the quantum processor with a first set of bias fields and a first set of coupling strengths. The quantum processor generates samples as potential solutions to an approximation of the problem. The digital processor updates the approximation by determining a second set of bias fields based at least in part on the first set of bias fields and a first set of mean fields that are based at least in part on the first set of samples and coupling strengths of one or more virtual coupling devices.

Abstract: The invention relates to a method and apparatus for image compression, particularly to an improved block-coding apparatus and method for image compression. Image compression systems such as JPEG and JPEG2000 are known and popular standards for image compression. Many of the advantageous features of JPEG2000 derive from the use of the EBCOT algorithm (Embedded Block-Coding with Optimized Truncation). One drawback of the JPEG2000 standards is computational complexity. This application discloses a relatively fast block-coding algorithm, particularly as compared with the standard JPEG2000 EBCOT algorithm. Computational complexity is reduced.

Abstract: The present disclosure provides inhibitors of activin receptor-like kinase 5 (ALK5). Also disclosed are methods to modulate the activity of ALK5 and methods of treatment of disorders mediated by ALK5.

Abstract: A vehicle seat support comprising two rails extending in a longitudinal direction, a central module slidably mounted on the rails and suitable for supporting the vehicle seat, a footrest slidably mounted on the rails in front of the central module and suitable for receiving the feet of an occupant seated on the seat, a first actuation system able to cause the central module to slide along the rails, and a second actuation system able to cause the footrest to slide along the rails independently of the central module.

Abstract: Detergent composition (F) for domestic or industrial use including, as thickener, a self-invertible inverse latex including an aqueous phase including: a) a crosslinked anionic polyelectrolyte (P) consisting of: at least one monomer unit derived from 2-methyl-2-[(1 -oxo-2-propenyl)amino]-1-propanesulfonic acid in free acid form or partially or totally salified form; —at least one monomer unit derived from at least one monomer chosen from the elements of the group consisting of acrylamide, N,N-dimethylacrylamide, ethacrylamide, N-isopropylacrylamide, N-tert-butylacrylamide; and at least one monomer unit derived from a polyethylenic crosslinking monomer (AR), b) ethylenediaminedisuccinic acid in trisodium salt form.

Abstract: The present disclosure relates to compounds of formula (I) and pharmaceutical compositions thereof and methods for inhibiting the activity of SHP2 phosphatase with the compounds and compositions of the disclosure. The present disclosure further relates to, but is not limited to, methods for treating disorders associated with SHP2 deregulation with the compounds and compositions of the disclosure.

Abstract: Disclosed are a new composition of lipoamino acids and alkanediols, a process for the preparation thereof, and a cosmetic or pharmaceutical composition resulting therefrom.

Abstract: Systems and methods for scheduling usage time for programs that can be executed on a hybrid computing system including a quantum processing unit (QPU) and a central processing unit (CPU). Programs can comprise both QPU-executable tasks and CPU-executable tasks. Some programs can be considered high performance programs that are intolerant of interruptions to QPU-executable tasks and some programs can be considered low performance programs that are tolerant of interruptions to QPU-executable tasks. After a high performance program finishes executing QPU-executable tasks on a QPU, a low performance program may execute QPU-executable tasks on the QPU while the high performance program executes CPU-executable tasks on a CPU. Execution of QPU-executable tasks of a low performance program on a QPU can pause or stop if a high performance program is queued.

Abstract: The present invention relates to a wiping device for a detection system of a vehicle, including a wiper blade, a wiper arm, a motor unit and a drive unit. The drive unit includes a guidance block which carries the wiper arm, and which is inserted in a guidance frame, and a plurality of belt wheels. At least one drive belt wheel is driven in a rotational motion by the motor unit. The drive unit further includes a belt which is driven by the belt wheels and moves the guidance block according to a rectilinear motion.

Abstract: The present invention relates to an apparatus and method for near-simultaneous and integrated delivery of bone graft material during the placement of surgical cages or other medical implants in a patient's spine, and methods for using same. The integrated fusion cage and graft delivery device according to various embodiments delivers and disperses biologic material through a fusion cage to a disc space and, without withdrawal from the surgical site, may selectively detach the fusion cage for deposit to the same disc space. The integrated fusion cage and graft delivery device is formed such that a hollow tube and plunger selectively and controllably place bone graft material and a fusion cage in or adjacent to the bone graft receiving area. In one embodiment, the integrated fusion cage is an expandable integrated fusion cage. In another embodiment, the bone graft material is loaded into a breech area in the hollow tube.

Abstract: The present disclosure relates to circuits, systems, and methods of operation for a memory device. In an example, a memory device includes a memory array including a plurality of memory cells, each memory cell having an impedance that varies in accordance with a respective data value stored therein; and a tracking memory cell having an impedance based on a tracking data value stored therein; and a read circuit coupled to the memory array, the read circuit configured to determine an impedance of a selected memory cells with respect to the impedance of the tracking memory cell; read a data value stored within the selected memory cell based upon a voltage change of a signal node voltage corresponding to the impedance of the selected memory cell.

Abstract: A method involves detecting in a sample an autoantibody binding specifically to one or more from Gluk1, Gluk2, Gluk3, Gluk4 and Gluk5, preferably Gluk2. An autoantibody binds specifically to one or more from Gluk1, Gluk2, Gluk3, Gluk4 and Gluk5, preferably Gluk2. A diagnostically useful carrier with a solid phase with an immobilized polypeptide contains one or more from Gluk1, Gluk2, Gluk3, Gluk4 and Gluk5, preferably Gluk2 or a variant thereof. The autoantibody can be used for diagnosing a neurological autoimmune disease or a cancer.

Abstract: The invention related to high glycerol compositions comprising blends of alkyl isethionate and alkyl taurate. Selecting specific ratios of isethionate to taurate allows preparation of high glycerol liquids while minimizing amphoteric, all while retaining clear, isotropic liquid.

Abstract: Wiper blade for a wiping system, in particular for wiping a camera of a motor vehicle, the wiper blade comprising a connection device suitable for releasable connection to a drive shaft of the wiper blade, said connection device comprising a first orientation which allows mounting/dismounting relative to a drive shaft, and a second orientation which does not allow such mounting/dismounting.

Abstract: Provided herein are methods of treating cancer (e.g., RCC), which comprise administering to a human patient in need thereof: (a) a PD-1 antagonist; (b) an ILT4 antagonist; and (c) lenvatinib represented by Formula (I), or a pharmaceutically acceptable salt thereof. Also provided are kits containing such agents and uses of therapeutic combinations of such agents for the treatment of cancer.

Abstract: The present invention relates to a neuromorphic circuit suitable for implementing a neural network, the neuromorphic circuit comprising: lines of words, pairs of complementary bit-lines, source lines, a set of elementary cells, an electronic circuit implementing a neurone having an output and including: a set of logic components, a counting unit, a comparison unit comprising a comparator and a comparison voltage generator, the comparator being suitable for comparing the output of the counting unit with the comparison voltage generated by the comparison voltage generator in order to output a signal dependent on the comparison and corresponding to the output of the electronic circuit which implements a neurone.

Abstract: An autonomous guided vehicle comprising a platform adapted to carry a load thereon in a working position; a plurality of suspension devices connected to the platform, each suspension device having a sensor and an actuator; and a plurality of wheels associated with the suspension devices; wherein a first wheel is associated with a first suspension device such that the sensor of the first suspension device is adapted to provide a signal when a relative position of the first wheel and the platform is altered.

Abstract: An ultra-wideband-based system and method for detecting properties associated with a movable object in an environment such as an indoor environment. The method includes transmitting ultra-wideband radar signals to an environment, using an ultra-wideband transmitter, and receiving signals reflected from the environment as a result of the transmission of the first ultra-wideband radar signals using an ultra-wideband receiver. The method also includes processing the reflected signals and determining properties associated with a movable object in an environment based on the processed reflected signals, using the processor.