Abstract: A cryogenic oil-free direct drive turbogenerator for gas liquefaction plant applications is described. The pressure energy from cryogenic gas is expanded through a turbine and the power generated is converted into electricity through a directly driven generator and a power electronics arrangement. The machinery can withstand very cold temperature operation (e.g., <?425° F.) by isolating the cold turbine side from the warmer side of the machine turbine end and has a hermetically sealed design wherein the process gas is fully contained from leaking at operating pressures. A unique gas injection scheme uses seal gas segregation, thrust bearing cooling and pressure balance for thrust control which is accomplished through a pressure regulator arrangement. Also described is an algorithm for speed control and overspeed protection through the power electronics system. The rotating components of the turbogenerator are supported on foil gas bearings for oil-free operation eliminating extraneous lubrication.

Abstract: A LIDAR-type device for a remote spectroscopy of a matter includes an optical emission channel that includes a laser source and an optical waves frequency generator to generate a first comb, a second comb, and a local comb. Each comb includes at least one stripe. A transmit telescope emits an emission signal. A reception channel includes a receive telescope that receives a signal reflected by the matter traversed by the emission signal and a detection system that detects a first beat signal of the at least one stripe of the local comb with the corresponding first stripe of the first reflected comb, a second beat signal of the at least one stripe of the local comb with the corresponding second stripe of the second reflected comb, and a third beat signal of the at least one first beat signal with the at least one second beat signal.

Abstract: Collaborative filtering systems based on variational autoencoders (VAEs) are provided. VAEs may be trained on row-wise data without necessarily training a paired VAE on column-wise data (or vice-versa), and may optionally be trained via minibatches. The row-wise VAE models the output of the corresponding column-based VAE as a set of parameters and uses these parameters in decoding. In some implementations, a paired VAE is provided which receives column-wise data and models row-wise parameters; each of the paired VAEs may bind their learned column- or row-wise parameters to the output of the corresponding VAE. The paired VAEs may optionally be trained via minibatches. Unobserved data may be explicitly modelled. Methods for performing inference with such VAE-based collaborative filtering systems are also disclosed, as are example applications to search and anomaly detection.

Abstract: A headrest for a vehicle seat includes: a support surface for the head of an occupant; at least one lateral edge extending along an edge of the support surface; and a sound diffusion system arranged in a cavity in the edge and including a speaker configured to emit sound waves in front of the support surface and at least one passive radiator configured to emit low frequency sound waves in front of the support surface.

Abstract: A movable anchorage system for a seat belt, having a lockable slide mechanism comprising a slide extending in a longitudinal direction of adjustment, a slider system comprising at least one body configured to move in translation along the slide while being guided by the slide, the body incorporating an anchorage device for the seat belt, an actuator configured to ensure the movement of the slider system along the slide, a mechanism for locking the position of the slider system in the slide.

Abstract: A container with a lid includes at least one thread on a neck of the container; at least one thread on the lid; a bump at the lower part of the lid; an end stop on a lower end of the neck; and an engagement portion of the neck corresponding to an area where the bump of the lid will engage the neck when the lid is in a fully engaged position. The engagement portion is arranged such that audible feedback and tactile feedback are produced when the lid moves into a fully engaged position.

Abstract: Computer-implemented systems and methods are provided for tracking user activity and managing quests. By way of example, a method may include receiving, from a website server, first identity data representing an identity of a user and data identifying a quest activated by the user, the quest comprising one or more activities to be performed at a physical location, and receiving, from at least one reporting device, second identity data representing the identity of the user at the physical location, and activity tracking data in response to the user performing an activity associated with the quest at the physical location. The method may also include identifying the user and the quest activated by the user based on the first identity data and data identifying the quest, further identifying the user and activity data related to the quest based on the second identity data and activity tracking data, and monitoring a progress of the user.

Abstract: Described herein are aptamers that bind to the transferrin receptor (e.g., CD71) and can be used, in part, for depleting transferrin receptor-expressing cells from a population of therapeutic cells. These aptamer compositions can be used in methods for isolating and/or enriching cells expressing CD71 or depleting cell populations of cells expressing CD71, including for example, tumor cells. Further provided are methods of using the aptamers or cell populations generated using them in the methods disclosed herein for therapies and/or drug delivery.

Abstract: A refill cartridge and a bottle to contain the cartridge. The refill includes at least two sealed openings, one at the top and one at the bottom. They may be sealed by an in mold label. The bottle is suitable for including the cartridge and may also include a pump and a dip tube. The dip tube is used to pierce the top and bottom seals of the cartridge when the bottle closure is screwed onto the bottle. Piercing the bottom seal releases product into the water filled interior of the body of the bottle. Typically the product will be a concentrate such as a body wash or hand washing concentrate. The bottle preferably includes an aperture or window through which at least a portion of the cartridge can be seen so that the consumer can determine which variation of product is present in the refill in the bottle.

Abstract: The present invention relates to a water filter comprising: a water filter cartridge including a water filter cartridge body, a water filter cartridge outlet cap having a water filter cartridge outlet, and a water filter cartridge sealing cap. The water filter cartridge body in a hollow cylinder form with a central hollow space, one end of the water filter cartridge body is coupled with the water filter cartridge outlet cap so that communicating with the water filter cartridge outlet, and the another end of the water filter cartridge body is coupled with the water filter cartridge sealing cap. The water filter cartridge outlet in a hollow cylinder form protruding from one surface of the water filter cartridge outlet cap.

Abstract: A corneal device comprising a base surface and a top surface, and having a water content ranging from about 78%-92% (w/w), inclusive. The corneal device can be used to treat, for example without limitation, ectatic corneal disease by supporting corneal structure weakened by the disease and/or changing an anterior curvature of the cornea.

Abstract: The invention is directed to a hydratable concentrated surfactant composition. The composition is pourable, easy to dilute, substantially free of sulfate and oil, comprises a C6-C14 acid, alcohol or both, an anionic surfactant comprising acyl isethionate and an amphoteric surfactant, zwitterionic surfactant or both. The composition is in lamellar phase and thickens and transforms to an isotropic phase upon dilution. The composition can be used as a concentrate in small volumes and diluted as used and needed or can be diluted with water in refill packaging to ensure a reduction in plastic waste.

Abstract: A method for determining, by reanalysis, a vibratory environment of a coupled vehicle/passenger system. A vehicle is subjected to external forces Fext and is coupled to a new passenger including multiple payloads (e.g., x=I, . . . N payload(s)). At the level of vehicle/passenger interfaces Ix, the method comprising a step DET1) for determining, based on reference interfacial acceleration ?x_ref of a reference passenger, the interfacial acceleration ?x? relative to the new passenger.

Abstract: The present invention is related to a method for treating cancer by using siRNA nanocomplex consisting of a nucleic acid molecule, a monocationic drug and a biocompatible polymer surfactant. The present nanocomplex can deliver an active ingredient (for example, a nucleic acid molecule and monocationic drug) into a cell/tissue of interest in a stable manner, and may be effectively applied for treating or detecting diverse disorders (practically, cancers).

Abstract: The invention relates to a recombinant adenovirus comprising an albumin-binding moiety on the outer surface of the adenoviral hexon protein, pharmaceutical compositions containing it and its medical use. Particularly, the invention relates to an oncolytic adenovirus comprising a sequence encoding an albumin-binding moiety inserted in the hypervariable region 1 (HVR1) of the hexon protein coding sequence and its use in the prevention and/or treatment of cancer.

Abstract: Sarcomas are rare malignant tumors arising from the mesenchymal tissues at all body sites. The inventors show that in a mouse model of p16/p19 deficiency prone to tumor development, the absence of the mouse pantetheinase Vnn1 enhances the frequency of aggressive fibrosarcomas. They also show that reintroduction of a catalytically active form of the Vnn1 pantetheinase limits tumor growth in vivo. Interestingly, VNN1 expression in human sarcomas is associated with reduced aggressiveness and lower risk of metastatic relapse in patients. In conclusion, Vnn1 represents a novel marker of sarcoma and may modulate tumor aggressiveness by sustaining myofibroblast cell differentiation, thereby limiting evolution towards undifferentiated tumors. The present invention relates to the use of Vnn1 as a biomarker and a therapeutic target in sarcomas.

Abstract: A splitboard fastening system is disclosed herein. The splitboard fastening system comprises a crossbar comprising a shear bushing interface and a hook, an eccentric post coupled to a lever and configured to engage an inside edge of the hook in response to rotation of the lever, and a shear bushing configured to engage the shear bushing interface, wherein the crossbar is configured to be coupled to a first splitboard ski, and wherein the eccentric post and the shear bushing are configured to be independently coupled to a second splitboard ski.

Abstract: Provided herein are antibodies that specifically bind Tau and methods of using the same.

Abstract: Sintered product having a relative density of greater than 90%, with, to more than 80% of the volume thereof, a stack of flat ceramic platelets, the assembly of the platelets having a mean thickness of less than 3 ?m, having a width of greater than 50 mm, and including more than 20% of alumina, as a percentage on the basis of the weight of the product. The width of the product is the largest dimension measured in the plane in which the length of the product is measured, along a direction perpendicular to the direction of the length. The length of the product is the largest dimension thereof in a plane parallel to the general plane in which the platelets extend.