Abstract: An isolating system and method for dampening vibrations between vibration-generating or vibration-sensitive equipment and a support structure. The isolating system includes first and second housing sections connected to one another via a vibration dampening assembly. The first housing section is secured to the support structure and includes a frame and first isolator assembly. The second housing section includes a second isolator assembly positioned between the frame and first isolator assembly. The vibration dampening assembly connects the first and second isolating assemblies to one another and prevents direct physical contact between them. One of a flange assembly and flange assembly of an attachment assembly is engaged with a connector region of the second isolator assembly and is used to secure the equipment to the second isolator assembly.

Abstract: The invention provides process for preparing a heat-treated intermediate vegetable and/or meat matter preparation.

Abstract: The present invention is in the field of antiperspirant compositions, in particular, compositions comprising antiperspirant actives. Disclosed is an antiperspirant composition free from aluminium and/or zirconium salt comprising an oil in water emulsion comprises oil phase and a nonionic emulsifier, has an HLB value of 10 or lower and a melting point higher than 37° C.; wherein said composition comprises at least 4 wt % of said nonionic emulsifier; wherein said oil phase comprises a lipophilic material having a melting point greater than 37° C.

Abstract: A vibration dampening device, a mounting assembly including a vibration dampening device, and a method of dampening vibration in a vibration-sensitive component using the same. The vibration dampening device includes a first member that rests upon or is operatively engaged with a support surface; a second member that is operatively engaged with the vibration-sensitive component; and at least one isolator assembly interposed between the first member and the second member, wherein the first member and the second member are decoupled from one another by the at least one isolator assembly. The at least one isolator assembly includes a first isolator that is at least partially embedded in the first member and a second isolator that is at least partially embedded in the second member, and an isolator insert that extends between the first isolator and second isolator. The isolator insert creates a gap between the first and second members.

Abstract: This invention relates to a soap bar composition which provides enhanced delivery of water soluble skin benefit agents such that the desired activity of the benefit agent is observed for a long time post the wash. This is achieved by absorbing/coating the benefit agent on to specific clays followed by further coating with a hydrophobic material selected from wax or petrolatum.

Abstract: The present invention relates to novel compounds having the general formula: and pharmaceutical compositions thereof, and methods for inhibiting the activity of SHP2 phosphatase with the compounds and compositions of the invention. The present invention further relates to, but is not limited to, methods for suppressing tumor cell growth, ameliorating the pathogenesis of systemic lupus erythematosus, and the treatment of various other disorders, including Noonan syndrome, diabetes, neutropenia, neuroblastoma, melanoma, juvenile leukemia, juvenile myelomonocytic leukemia, chronic myelomonocytic leukemia, acute myeloid leukemia, and other cancers associated with SHP2 deregulation with the compounds and compositions of the invention, alone or in combination with other treatments.

Abstract: An inner drum cover is provided at a drum opening of an inner drum of a washing machine, the inner drum cover is used to open or close the drum opening, so that the inner drum forms a closed container after the drum opening is closed by the inner drum cover. The inner drum can perform washing after the inner drum cover is correspondingly fastened to the drum opening, so that clothes only come into contact with washing water in the sealed inner drum in a washing process. In this way, a case in which the clothes are contaminated because washing water between the inner drum and an outer drum flows into the inner drum is avoided, washing cleanliness of the washing machine is greatly improved, and incomplete washing of the clothes caused by contamination of the washing water between the inner drum and the outer drum is avoided.

Abstract: A method of erecting a carton from a blank, including: engaging the blank with a punch head against which the carton is formed, folding side portions of the blank against the punch head to form sides of the carton; folding outer portions of the side portions of the blank away from the punch head and against an external side of the carton; folding end portions of the blank against the punch head to form end portions of the carton; folding outer portions of the end portions of the blank away from the punch head and against an external end of the carton; and securing corner gussets formed between the side and end portions against sides or ends of the carton.

Abstract: Cellular biological activities are tightly controlled by intracellular signaling processes initiated by extracellular signals. Protein tyrosine phosphatases, which remove phosphate groups from tyrosine phosphorylated signaling molecules, play equally important tyrosine roles as protein kinases in signal transduction. SHP-2, a cytoplasmic SH2 domain containing protein tyrosine phosphatase, is involved in the signaling pathways of a variety of growth factors and cytokines. Recent studies have clearly demonstrated that this phosphatase plays an important role in transducing signal relay from the cell surface to the nucleus, and is a critical intracellular regulator in mediating cell proliferation and differentiation.

Abstract: A linear actuator is configured to be connected between a platform and a structure or ground for displacement of the platform relative to the structure or the ground. The actuator comprises a base, and an output displaceable linearly relative to the base. A first plurality of idlers are on the base, and a second plurality of idlers are on the output. An actuator unit has a reciprocating rotational output. A tensioning member has a first end connected to the rotational output of the actuator unit, and a second end connected to an anchor point on one of the output and the base, the tensioning member being routed from the rotational output, through the first plurality of idlers and the second plurality of idlers and to the anchor point for converting a winding/unwinding of the tensioning member into a translation of the output.

Abstract: The present disclosure concerns a warning device comprising a warning body having a longitudinal axis and comprising a light-emitting assembly; and a collapsible stand configurable in a compacted configuration and in a warning configuration in which the light-emitting assembly is at least partially visible. The collapsible stand comprises a handle sleeve mounted to and slidable along the warning body and legs pivotably mounted to the handle sleeve, the legs being juxtaposed against the warning body when the collapsible stand is in the compacted configuration to cover the warning body and the legs extending outwardly and downwardly when the collapsible stand is in the warning configuration, the collapsible stand being configurable between the compacted configuration and the warning configuration by sliding the handle sleeve along the warning body. The disclosure also concerns a warning assembly comprising such a warning device and a method of emitting a warning light signal.

Abstract: The present invention provides compositions, kits, and method for determining the levels of expression of human polyoma or papillomavirus species and RNA transcripts. These levels can be used for the prognosis of risk of developing virally-induced cancers. The ratio (R) between early and late transcripts is indicative of HPV infections associated with higher risk of developing genital neoplasia and cancer.

Abstract: A method of manufacturing a connector device suitable for making an inter or intra static electrical energy converter connection. The device includes at least two flat conductors and at least one insulating material. The said method includes: preparing each flat conductor individually; applying at least one coat of enamel varnish to each conductor, which is thinner than a desired final thickness; carrying out cross-linking of the enamel coating; and repeating the depositing of a layer of enameling resin and the cross-linking until the chosen thickness is reached. The varnish coated conductors of the connector device are assembled by using a template and connecting elements.

Abstract: Machine learning classification models which are robust against label noise are provided. Noise may be modelled explicitly by modelling “label flips”, where incorrect binary labels are “flipped” relative to their ground truth value. Distributions of label flips may be modelled as prior and posterior distributions in a flexible architecture for machine learning systems. An arbitrary classification model may be provided within the system. The classification model is made more robust to label noise by operation of the prior and posterior distributions. Particular prior and approximating posterior distributions are disclosed.

Abstract: A parallel assembly (2; 11; 51) of chromatography column modules (3a,b,c; 13a,b,c; 53a,b,c, 90a, b) connected in a rigid housing (21; 61), the assembly having one common assembly inlet (15; 55) and one common assembly outlet (17; 57), each column module comprising a bed space (29) filled with chromatography medium and each column module comprises integrated fluid conduits which when the column module is connected with other column modules in the rigid housing are adapted to connect the bed space (29) of the column module with the assembly inlet (15; 55) and the assembly outlet (17; 57), wherein the total length and/or volume of the fluid conduit from the assembly inlet to one bed space together with the length and/or volume of the fluid conduit from the same bed space to the assembly outlet is substantially the same for all bed spaces and modules installed in the parallel assembly.

Abstract: A fabric softener composition comprising: a. 1 to 20 wt. % ionic compound of general formula I: (I) wherein b. 0.1 to 20 wt. % fatty co-softener; and c. Water.

Abstract: The present disclosure provides pharmaceutical combinations comprising at least one spliceosome modulator and at least one inhibitor chosen from BCL2, BCL2/BCLxL, and BCLxL inhibitors. Also provided are methods of treating cancer comprising administering a therapeutically effective amount of at least one spliceosome modulator and a therapeutically effective amount of at least one inhibitor chosen from BCL2, BCL2/BCLxL, and BCLxL inhibitors.