Patents Assigned to Dako
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Publication number: 20110235172Abstract: A holding device for retaining a number of slides with tissue specimens, wherein the surfaces of the microscope slides in retained position are located in a common plane, comprises an elongated hanger having a clamping means for releasable clamping of microscope slides in a hanging position with the surfaces in said plane, the microscope slides being clamped at their upper end and by release from the clamping means being free to fall from the hanger because of their own weight. The clamping means preferably is arranged to cooperate with a loading rack having a supporting surface for support of the current microscope slides in said plan, the hanger being able to be introduced into the rack and the clamping means being able to actuated so that all microscope slides placed on the supporting surface are clamped in the holding device.Type: ApplicationFiled: April 25, 2011Publication date: September 29, 2011Applicant: Dako Instrumec ASInventors: Oystein LJUNGMANN, Torstein Ljungmann
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Publication number: 20110200497Abstract: An apparatus for heat treatment of tissue specimens, comprising a pressure cooker (1) for cooking of tissue specimens, a temperature sensor (5) and a pressure sensor (6) connected to the pressure cooker, and a control unit (15) for time-controlled heat treatment of the tissue specimens in the pressure cooker (1). The control unit is arranged to control a programmed step-by-step heating course, with a programmed time duration on each temperature step, from a chosen start temperature up to a chosen maximum temperature. The apparatus preferably comprises a vent valve (8) coupled to the pressure cooker, and the control unit (15) then is also arranged to control a programmed step-by-step cooling course, from the chosen maximum temperature down to a chosen final temperature.Type: ApplicationFiled: April 27, 2011Publication date: August 18, 2011Applicant: Dako Instrumec ASInventors: Torstein Ljungmann, Oystein Ljungmann
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Patent number: 7998408Abstract: An apparatus for automatic execution of different treatment operations in connection with staining of tissue specimens on microscope slides, wherein the apparatus (1) comprises an assembly of vessels (4) for receiving different liquids for staining of the tissue specimens, a loading station (2) for microscope slides (28), a conveyor (5) for transfer of carriers with microscope slides from vessel to vessel in accordance with a treatment program, an unloading station (8) for treated microscope slides, and a control unit (18) for controlling the treatment operations in accordance with a data program. The apparatus comprises different levels (I, II) having units for execution of the relevant treatment operations.Type: GrantFiled: December 22, 2005Date of Patent: August 16, 2011Assignee: Dako Instrumec ASInventors: Øystein Ljungmann, Torstein Ljungmann
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Publication number: 20110177500Abstract: The invention provides compositions and methods for the detection of targets in a sample; in particular, an immunohistochemistry (IHC) sample. Probes and detectable labels may be provided in multiple layers in order to increase the flexibility of a detection system, and to allow for amplification to enhance the signal from a target. The layers may be created by incorporating probes and detectable labels into larger molecular units that interact through nucleic acids base-pairing, including peptide-nucleic acid (PNA) base-pairing. Optional non-natural bases allow for degenerate base pairing schemes. The compositions and methods are compatible with immunohistochemistry (IHC), but also could be used in immunocytochemistry (ICC), in situ hybridization (ISH), flow cytometry, enzyme immuno-assays (EIA), enzyme linked immuno-assays (ELISA), blotting methods (e.g.Type: ApplicationFiled: June 30, 2006Publication date: July 21, 2011Applicant: DAKO DENMARK ASInventors: Lars Winther, Jesper Lohse, Susanne Gabs, Kenneth Heesche Petersen
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Publication number: 20110177077Abstract: The present invention relates to novel anti-human PAX 5 antibodies capable of binding to one or more epitopes located within the C-terminal regulatory domain of PAX 5. In particular the invention relates to an antibody, antigen binding fragment or recombinant protein thereof, which is capable of specific binding to an epitope located within the C-terminal fragment of human PAX 5 protein, wherein said epitope comprises from 3 to 17 amino acid residues of amino acid sequence GSPYYYSAAARGAAPPA (SEQ ID NO:2). The invention also relates to immunogenic peptide sequences for the production of the antibodies, diagnostic and therapeutic applications comprising using the antibodies and formulations comprising thereof.Type: ApplicationFiled: June 25, 2009Publication date: July 21, 2011Applicant: DAKO DENMARK A/SInventors: Kirsten Damgaard Hoff, Jakob O. Gjørret, Kurt Pii, Sussie Steen Jensen, Henrik Winther
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Patent number: 7972789Abstract: The present disclosure provides compounds that may be used as chromogens, fluorochromes, or as both. Said compounds may further be used as substrate for at least one enzyme, wherein said enzyme is capable of processing an aromatic amine group (—NH2), an aromatic hydroxyl group (—OH), or an aromatic phosphate group (—PO4). Furthermore, the present disclosure also provides methods for precipitating said compounds as well as methods for detecting a target using said compounds. Even further, kits comprising said compounds are disclosed. Said compounds may be used in any method utilizing a fluorochrome, a chromogen, or both.Type: GrantFiled: November 24, 2006Date of Patent: July 5, 2011Assignee: Dako Denmark A/SInventor: Kenneth H. Petersen
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Publication number: 20110144047Abstract: The invention provides methods for predicting the response to a topoisomerase Il? inhibitor therapy in an individual having cancer, wherein the methods comprise the steps of determining TIMP-I DNA aberration/TIMP-1 protein aberration in combination with determining DNA aberration in TOP2A/HER2 amplicon on chromosome 17q21 including TOP2A and HER2 or aberrations of TOP2A and ErbB2 protein expression. Further provided are methods of treating cancer by using said topoisomerase Il? inhibitor therapy. The invention also comprises a kit for the application of the methods for predicting the response to a topoisomerase Il? inhibitor therapy in an individual having cancer.Type: ApplicationFiled: May 20, 2009Publication date: June 16, 2011Applicant: DAKO DENMARK A/SInventors: Nils Aage Brünner, Kristen Vang Nielsen
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Patent number: 7960178Abstract: A sample processing system 101 that may be automated and methods are disclosed where sample(s) 198 are arranged on a carrier element 197 and a process operation control system 171 automatically processes the sample(s) perhaps robotically according to an desired aggregation of event dictated by an input 173. Alteration of an initial aggregated event topology may be accepted while the system is processing an initial aggregation and varied-parameter robotic control simulation functionalities 606 may be accomplished to determine an enhanced sequence for processing. Suggested operator actions may be displayed that might further enhance the scheduling of the altered aggregated event topology together with an automatic operator need prompt 608 that may inform an operator of a need for a particular action in order to accomplish the desired tasks.Type: GrantFiled: December 19, 2003Date of Patent: June 14, 2011Assignee: DAKO Denmark A/SInventors: Marc Key, Gordon Feingold, Rosanne Welcher
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Patent number: 7952798Abstract: A holding device for retaining a number of microscope slides with tissue specimens, wherein the surfaces of the slides in retained position are located in a common plane. The holding device has an elongated hanger with a clamp for releasably clamping the microscope slides in a hanging position with the surfaces of the slides in the common plane. The microscope slides are clamped at their upper end and are free to fall from their own weight from the hanger by release from the clamp. The clamp preferably is arranged to cooperate with a loading rack having a supporting surface for support of the microscope slides, in which the hanger can be introduced into the rack and the clamp can be actuated so that all microscope slides placed on the supporting surface are clamped in the holding device.Type: GrantFiled: December 22, 2005Date of Patent: May 31, 2011Assignee: Dako Instrumec ASInventors: Øystein Ljungmann, Torstein Ljungmann
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Patent number: 7937228Abstract: A sample processing system that may be automated and methods are disclosed where samples are arranged on a carrier element and a process operation control system automatically processes the samples perhaps robotically with an operationally-influential exteriorly-consequential information monitor or a data capture element. Significant process details as well as operationally-influential exteriorly-consequential information may be monitored and an automatic notice element may cause notification of a person at some display that may be remote. Various people may be notified, such as an administrator, a supplier, or a manufacturer of an opportunity for some action such as reagent reordering or the like. A simulated motion display may be included to “watch” simulated operation in real time or long after completion of the actual processing.Type: GrantFiled: March 19, 2008Date of Patent: May 3, 2011Assignee: DAKO Denmark A/SInventors: Gordon Feingold, Marc Key, Rosanne Welcher, John Favuzzi
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Patent number: 7901634Abstract: An apparatus for processing at least one biological sample accommodated on at least one carrier member (15) in a chamber includes at least one reservoir (18) able to accommodate a fluid arranged on a surface inside the chamber adjacent to and/or facing a substantial part of the at least one biological sample. The apparatus may comprise a bottom member (12) arranged to support at least one carrier member (15) carrying at least one biological sample and a lid (14) including at least one fluid reservoir (18). The reservoir filled with water provides humidity to the chamber and impedes drying out of the sample.Type: GrantFiled: January 7, 2005Date of Patent: March 8, 2011Assignee: Dako Denmark A/SInventors: Gregory A. Testa, Tim Svenstrup Poulsen, Steen Hauge Matthiesen, Ole Feldballe Rasmussen, Lars Winther
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Publication number: 20110027777Abstract: A first exemplary method for performing a prognosis for a breast cancer patient, comprises the steps of determining the status of an aberration of the TOP2A gene in a tissue sample taken from the patient; and estimating the probability of either recurrence-free survival or of overall survival of the patient at a later time based upon a pre determined Hazard Ratio corresponding to the determined status. A second such exemplary method comprises the steps of determining the status of an aberration of the TOP2A gene in a tissue sample taken from the patient; and estimating the probability of either recurrence-free survival or of overall survival of the patient at a later time based upon a pre-determined Kaplan-Meier plot corresponding to the determined status.Type: ApplicationFiled: March 30, 2007Publication date: February 3, 2011Applicant: DAKO DENMARKInventors: Jan Trøst Jørgensen, Bent Ejlertsen, Henning Mouridsen, Kirsten Vang Nielsen
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Patent number: 7875245Abstract: The present invention concerns a method and apparatus for automatic processing a biological sample on a carrier, perhaps robotically, by applying predetermined amounts of reagents in a predetermined sequence according to a processing protocol, the processing including pre-treatment steps, under the control of an adaptive processing control system using a sample process parameter input that may be independent and an independent process parameter memory that does not interrupt process operation when being used, such that samples may be added or removed without interrupting the processing of other samples. Also included is an image capture function for sample and reagent identification and process monitoring, as well as temperature regulation and environmental control functions.Type: GrantFiled: June 20, 2005Date of Patent: January 25, 2011Assignee: DAKO Denmark A/SInventors: John A. Favuzzi, Kristopher S. Buchanan, Michael T. Barber, Loren L. Bland, Dawn M. Rohrbacker, Robert M. Clark, Gordon A. Feingold, Benno M. Guggenheimer, Marc E. Key, Merritt M. Martin, Jr., Robert L. Lathrop, Jeffery L. Rau, Jonathan R. Sweda, Douglas F. Sweet, John E. Van Bosch, Lars Winther, Rosanne Welcher
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Patent number: 7867443Abstract: The present invention concerns a method and apparatus for automatic staining or other processing of a biological sample on a slide, perhaps robotically, by applying predetermined amounts of reagents in a predetermined sequence according to a processing protocol, the processing including pre-treatment steps, under the control of an adaptive processing control system. Further provided is a method of antigen retrieval, the method comprising contacting, within a heated processing tank of an automated staining apparatus, at least one biological sample with at least one composition for antigen retrieval comprising at least one chelating agent, at least one detergent and at least 50% by volume of at least one liquid that facilitates antigen retrieval.Type: GrantFiled: July 7, 2005Date of Patent: January 11, 2011Assignee: DAKO Denmark A/SInventors: Marc E. Key, Scott A. Devore, Loren L. Bland, Uffe Lovborg
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Patent number: 7850912Abstract: A method and apparatus for continuous workflow processing of biological samples. In one embodiment, the apparatus includes a probe for dispensing one or more reagents from one or more reagent containers onto one or more biological sample carriers. The method and apparatus includes processing each biological sample according to a respective sequence of protocol steps which may be ordered by a scheduler protocol. The method and apparatus also includes network capability for connectivity with additional equipment for receiving or transmitting pertinent data via the network.Type: GrantFiled: September 16, 2005Date of Patent: December 14, 2010Assignee: DAKO Denmark A/SInventors: John A. Favuzzi, Marc E. Key, Robert L. Lathrop, Gordon A. Feingold, Rosanne Welcher
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Publication number: 20100285467Abstract: The present invention relates to a method of biological labeling that occurs via a free radical chain reaction. The labeling occurs due to deposition of a detectable reporter molecule from a media comprising a substance comprising at least two moieties of a peroxidase enzyme substrate (termed herein ‘cross-linker’) in a target site comprising peroxidase activity and a biological marker. The labeling reaction described herein may generally be used to detect targets in a host of experimental schemes for detecting and visualizing a biological or chemical target, including immunohistochemistry (IHC), in situ hybridization (ISH), antibody-based staining methods such as ELISA, Southern, Northern, and Western blotting, and others.Type: ApplicationFiled: September 16, 2008Publication date: November 11, 2010Applicant: DAKO DENMARK A/SInventors: Jesper Lohse, Kenneth Heesche Petersen
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Publication number: 20100248257Abstract: The present invention relates to the fields of analysis, diagnostics, prognostics, standardization, characterization and enumeration of entities such as biological cells, as well as therapeutical applications. Accordingly, the present invention in preferred aspects is directed to methods for the detection and/or analysis and/or isolation and optionally further manipulation of entities, such as cells, particles, and supra-molecular structures.Type: ApplicationFiled: December 28, 2009Publication date: September 30, 2010Applicant: DAKO DENMARK A/SInventors: Kivin Jacobsen, Henrik Pedersen, Liselotte Brix, Jesper Lohse, Jørgen Schøller, Tina Jakobsen
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Publication number: 20100226854Abstract: Novel compounds carrying ligands capable of binding to counter receptors on relevant target cells are disclosed. The compounds possess a number of advantageous features, rendering them very suitable for a wide range of applications, including use as detection systems, detection of relevant target cells as well as a number of other methods. In particular, novel MHC complexes comprising one or more MHC molecules are disclosed. The affinity and specificity of the MHC-peptide complexes are surprisingly high. The possibility of presenting to the target cells a plurality of MHC-peptide complexes makes the MHC complexes according to the present invention an extremely powerful tool e.g. in the field of therapy and diagnosis. The invention generally relates to the field of therapy, including therapeutic methods and therapeutic compositions. Also comprised by the present invention is the sample-mounted use of MHC complexes and MHC multimers.Type: ApplicationFiled: November 16, 2009Publication date: September 9, 2010Applicant: DAKO DENMARK A/SInventors: Jørgen Schøller, Henrik Pedersen, Liselotte Brix
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Patent number: 7758809Abstract: The present invention concerns a method and an apparatus for automatic staining of at least one tissue sample accommodated on a slide by applying reagents. The system may include at least one slide provided in a slide rack, a fluid containment element, a slide holder, a vertical slide positioner to pivot the slides to a vertical position, and a slide immerser element to immerse the vertical slide into a fluid containment element or even a dip tank. By pivoting the slides from a horizontal to a vertical position, an automated method and apparatus for carrying out a pretreatment in an automated staining apparatus may be provided. The pivoting of slides may ensure an appropriate orientation of the slides for both the pretreatment and the staining processes.Type: GrantFiled: December 3, 2009Date of Patent: July 20, 2010Assignee: Dako Cytomation Denmark A/SInventors: John Favuzzi, Benno Guggenheimer, Jeff Rau, Marc Key, Robert Lathrop, Rosanne Welcher
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Patent number: 7754147Abstract: A Staining machine for treatment of tissue specimens on slides placed in baskets (9) includes a number of baths (7, 12) placed successively in a row (6 resp. 11), and a device for successive transport of the baskets in a transport path from one bath to the next one, the baskets (9) being transported from an input station (5) to an output station (14) in accordance with a predetermined treatment program. The machine includes at least two bath rows (6 resp. 11) placed juxtaposed and parallel with each other, the first bath row (6) extending from the input station (5) to an opposite end of this row, and second path row (11) extending from the output station (14) to an opposite end of this row.Type: GrantFiled: December 17, 2002Date of Patent: July 13, 2010Assignee: Dako Instrumec ASInventors: Oystein Ljungmann, Torstein Ljungmann