Patents Assigned to Dako
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Publication number: 20100168390Abstract: The present invention describes novel methods to generate MHC multimers and methods to improve existing and new MHC multimers. The invention also describes improved methods for the use of MHC multimers in analysis of T-cells in samples including diagnostic and prognostic methods. Furthermore the use of MHC multimers in therapy are described, e.g. anti-tumour and anti-virus therapy, including isolation of antigen specific T-cells capable of inactivation or elimination of undesirable targeT-cells or isolation of specific T-cells capable of regulation of other immune cells.Type: ApplicationFiled: December 22, 2009Publication date: July 1, 2010Applicant: DAKO DENMARK A/SInventors: Liselotte Brix, Henrik Pedersen, Tina Jakobsen, Jorgen Scholler, Jesper Lohse, Katja Brunstedt, Kivin Jacobsen
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Patent number: 7718435Abstract: This invention describes a cartridge pump and dispensing assembly for applications where cartridges containing liquid reagents are interchanged often. The cartridge pump has a reagent reservoir which directly empties into a metering chamber. A valve is at each end of the metering chamber. The two valves are aligned in the same direction so as to allow unidirectional liquid flow. The metering chamber is made of a compressible material, such as flexible tubing, so that when an external compression is applied to the chamber, the liquid contained therein is forcibly expelled. As the compression is removed, the metering chamber resumes its former shape and draws liquid into the chamber from the reagent reservoir. A dispensing assembly with electromechanical actuators for compression of the metering chamber and a sensor for sensing the amount of liquid contained within the reagent reservoir are also shown.Type: GrantFiled: October 31, 2000Date of Patent: May 18, 2010Assignee: DAKO Denmark A/SInventors: Steven A. Bogen, Herbert H. Loeffler
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Publication number: 20100105145Abstract: The present invention relates to optionally automated methods that may be used to qualitatively and/or quantitatively detect at least one, or for example, two or more different targets in a sample, and kits associated with such methods. The two or more different targets may be detected and distinguished by adding at least one cross-linking agent to the sample in between different steps of a detection procedure. The addition of a cross-linking agent may allow for drastic changes in buffer conditions (i.e. solvent, pH, salt concentration, etc.) or temperature in order to refine a detection procedure with minimal loss of signal. The instant invention is compatible with a variety of detection systems, including immunohistochemistry (IHC), immunocytochemistry (ICC), in situ hybridization (ISH), flow cytometry, enzyme immuno-assays (EIA), enzyme linked immuno-assays (ELISA), blotting methods (e.g.Type: ApplicationFiled: June 30, 2006Publication date: April 29, 2010Applicant: DAKO DENMARK A/SInventor: Lars Winther
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Publication number: 20100105030Abstract: The invention relates to non-natural bases and base pairs that expand the normal DNA-based encoding system. Compositions herein may comprise at least one non-natural base that may interact with another base via a Watson Crick-type hydrogen bonding geometry and/or a Hoogsteen-type hydrogen bonding geometry. The bases may be used in a molecular entity, such as an oligomer or any other entity wherein the bases are attached to a backbone. For example, they may be comprised in DNA, RNA, or PNA, or a variety of other nucleic acid-type systems.Type: ApplicationFiled: June 30, 2006Publication date: April 29, 2010Applicant: DAKO DENMARK A/SInventors: Jesper Lohse, Kenneth Heesche Petersen
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Patent number: 7648678Abstract: The present invention concerns a method and an apparatus for automatic staining of at least one tissue sample accommodated on a slide by applying reagents. The system may include at least one slide provided in a slide rack, a fluid containment element, a slide holder, a vertical slide positioner to pivot the slides to a vertical position, and a slide immerser element to immerse the vertical slide into a fluid containment element or even a dip tank. By pivoting the slides from a horizontal to a vertical position, an automated method and apparatus for carrying out a pretreatment in an automated staining apparatus may be provided. The pivoting of slides may ensure an appropriate orientation of the slides for both the pretreatment and the staining processes.Type: GrantFiled: December 8, 2003Date of Patent: January 19, 2010Assignee: DAKO Denmark A/SInventors: John Favuzzi, Benno Guggenheimer, Jeff Rau, Marc Key, Robert Lathrop, Rosanne Welcher
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Patent number: 7642057Abstract: A novel method for detecting chromosome aberrations is disclosed. More specifically, chromosome aberrations are detected by in situ hybridisation using at least two sets of hybridisation probes, at least one set comprising one or more peptide nucleic acid probes capable of hybridising to specific nucleic acid sequences related to a potential aberration in a chromosome, and at least one set comprising two or more peptide nucleic acid probes capable of hybridising to specific nucleic acid sequences related to another potential aberration in a chromosome. In particular, the method may be used for detecting chromosome aberrations in the form of breakpoints.Type: GrantFiled: February 19, 2008Date of Patent: January 5, 2010Assignee: Dako Denmark A/SInventors: Jacobus Johannus Maria Van Dongen, Karl-Johan Pluzek, Kristen Vang Nielsen, Kim Adelhorst
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Patent number: 7603201Abstract: Systems and methods allowing for the automatic control and scheduling of a staining apparatus for biological samples on slides present within the apparatus. In some embodiments, the actions of a robot coupled to the staining apparatus, which performs some of the staining tasks on the individual slides in accordance with their respective protocols, may be prioritized and scheduled. In some embodiments, the scheduling may result in increasing or maximizing the throughput of slides. In some embodiments, robot scheduling ensures that the individual slides are processed substantially within the tolerances specified by their respective protocols. In some embodiments, the robot scheduler may respond to spontaneous user actions and adaptively schedule or re-schedule robot actions.Type: GrantFiled: January 23, 2006Date of Patent: October 13, 2009Assignee: Dako Denmark A/SInventors: Gordon Alan Feingold, James B. Gilmartin, Mark Richard Holbrook, John A. Favuzzi, Marc E. Key
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Patent number: 7593787Abstract: Systems and methods allowing for the automatic control and scheduling of a staining apparatus for biological samples on slides present within the apparatus are provided. In some embodiments, the actions of a robot coupled to the staining apparatus, which performs some of the staining tasks on the individual slides in accordance with their respective protocols, may be prioritized and scheduled. In some embodiments, the scheduling may result in increasing or maximizing the throughput of slides. In some embodiments, robot scheduling ensures that the individual slides are processed substantially within the tolerances specified by their respective protocols. In some embodiments, the robot scheduler may respond to spontaneous user actions and adaptively schedule or re-schedule robot actions.Type: GrantFiled: January 23, 2006Date of Patent: September 22, 2009Assignee: Dako Denmark A/SInventors: Gordon Alan Feingold, James B. Gilmartin, Mark Richard Holbrook, John A. Favuzzi, Marc E. Key
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Patent number: 7584019Abstract: Systems and methods allowing for the automatic control and scheduling of a staining apparatus for biological samples on slides present within the apparatus. In some embodiments, the actions of a robot coupled to the staining apparatus, which performs some of the staining tasks on the individual slides in accordance with their respective protocols, may be prioritized and scheduled. In some embodiments, the scheduling may result in increasing or maximizing the throughput of slides. In some embodiments, robot scheduling ensures that the individual slides are processed substantially within the tolerances specified by their respective protocols. In some embodiments, the robot scheduler may respond to spontaneous user actions and adaptively schedule or re-schedule robot actions.Type: GrantFiled: September 16, 2005Date of Patent: September 1, 2009Assignee: Dako Denmark A/SInventors: Gordon Alan Feingold, James B. Gilmartin, Mark Richard Holbrook, John A. Favuzzi, Marc E. Key
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Patent number: 7553672Abstract: An automated slide stainer with slides mounted in a horizontal position on a rotary carousel. Reagents and rinse liquids are automatically dispensed onto tissue sections or cells mounted on slides for the purpose of performing chemical or immunohistochemical stains. The rinse liquids are removed by an aspiration head connected to a source of vacuum. Individual slides or groups of slides are supported on flat heating stations for heating to individual temperatures. Temperature control electronics on the carousel are controlled by a user interface off of the carousel.Type: GrantFiled: May 14, 2007Date of Patent: June 30, 2009Assignee: Dako Denmark A/SInventors: Steven A. Bogen, Herbert H. Loeffler, John A. Purbrick
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Publication number: 20080187934Abstract: A novel method for detecting chromosome aberrations is disclosed. More specifically, chromosome aberrations are detected by in situ hybridisation using at least two sets of hybridisation probes, at least one set comprising one or more peptide nucleic acid probes capable of hybridising to specific nucleic acid sequences related to a potential aberration in a chromosome, and at least one set comprising two or more peptide nucleic acid probes capable of hybridising to specific nucleic acid sequences related to another potential aberration in a chromosome. In particular, the method may be used for detecting chromosome aberrations in the form of breakpoints.Type: ApplicationFiled: February 19, 2008Publication date: August 7, 2008Applicant: Dako A/SInventors: Jacobus Johannus Maria Van Dongen, Karl-Johan Pluzek, Kirsten Vang Nielsen, Kim Adelhorst
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Patent number: 7400983Abstract: A sample processing system (101) that may be automated and methods are disclosed where samples) (198) are arranged on a carrier element (197) and a process operation control system (171) automatically processes the samples) perhaps robotically with an operationally-influential exteriorly-consequential information monitor (402) or a data capture element (414). Significant process details as well as operationally-influential exteriorly-consequential information may be monitored and an automatic notice element (404) may cause notification of a person at some display (415) that may be remote. Various people may be notified, such as an administrator, a supplier, or a manufacturer of an opportunity for some action such as reagent reordering or the like. A simulated motion display may be included to “watch” simulated operation in real time or long after completion of the actual processing.Type: GrantFiled: December 19, 2003Date of Patent: July 15, 2008Assignee: Dako Denmark A/SInventors: Gordon Feingold, Marc Key, Rosanne Welcher, John Favuzzi
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Patent number: 7368245Abstract: A novel method for detecting chromosome aberrations is disclosed. More specifically, chromosome aberrations are detected by in situ hybridisation using at least two sets of hybridisation probes, at least one set comprising one or more peptide nucleic acid probes capable of hybridising to specific nucleic acid sequences related to a potential aberration in a chromosome, and at least one set comprising two or more peptide nucleic acid probes capable of hybridising to specific nucleic acid sequences related to another potential aberration in a chromosome. In particular, the method may be used for detecting chromosome aberrations in the form of breakpoints.Type: GrantFiled: September 8, 2005Date of Patent: May 6, 2008Assignee: Dako Denmark A/SInventors: Jacobus Johannus Maria Van Dongen, Karl-Johan Pluzek, Kirsten Vang Nielsen, Kim Adelhorst
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Patent number: 7306916Abstract: The present invention relates to methods for detecting a change in chromosomal structure. These methods employ labeled probes that bind nucleic acids. For example, these probes may be comprised of nucleic acids or nucleic acid analogs and a detectable label.Type: GrantFiled: May 3, 2005Date of Patent: December 11, 2007Assignee: Dako Denmark A/SInventors: Tim Svenstrup Poulsen, Susan Medom Poulsen, Kenneth Heesche Petersen
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Publication number: 20060259253Abstract: A flow cytometry apparatus and methods to process information incident to particles or cells entrained in a sheath fluid stream allowing assessment, differentiation, assignment, and separation of such particles or cells even at high rates of speed. A first signal processor individually or in combination with at least one additional signal processor for applying compensation transformation on data from a signal. Compensation transformation can involve complex operations on data from at least one signal to compensate for one or numerous operating parameters. Compensated parameters can be returned to the first signal processor for provide information upon which to define and differentiate particles from one another.Type: ApplicationFiled: March 31, 2006Publication date: November 16, 2006Applicant: Dako Colorado, Inc.Inventors: Carl Ellison, Paul Purcell, George Malachowski, Matthias Ottenberg
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Patent number: 7135563Abstract: The present invention relates to methods, kits and compositions suitable for the improved detection, quantitation and analysis of nucleic acid target sequences using probe-based hybridization assays.Type: GrantFiled: September 10, 2001Date of Patent: November 14, 2006Assignees: Boston Probes, Inc., Dako A/SInventors: Kyriaki Stefano, James M. Coull, Henrik Stender, Jens J. Hyldig-Nielsen, Kenneth H. Peterson
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Patent number: 7110192Abstract: A lens system for collecting and focusing light emanating from an object has a cuvette housing the object and having a wall of thickness not greater than 1.5 millimeters; a plano-convex lens having a planar surface affixed to the wall; a sequence of at least three meniscus lenses, each meniscus lens having a concave surface toward the object and a convex surface, each successive meniscus lens receiving the light from the immediately preceding meniscus lens and having radii of curvature of its concave and convex surfaces greater than corresponding radii of the preceding meniscus lens; and at least one compound lens that may be a doublet lens or a triplet lens, the compound lens receiving the light from a last meniscus lens, wherein an image of a geometrical point on the object has a root-mean square spot size equal to or less than 63 ?m.Type: GrantFiled: January 12, 2005Date of Patent: September 19, 2006Assignee: Dako Denmark A/SInventors: Megan Lynne Sauter, Johnathan Charles Sharpe, Sean B. Pieper
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Patent number: 7105294Abstract: A novel method for detecting chromosome aberrations is disclosed. More specifically, chromosome aberrations are detected by in situ hybridisation using at least two sets of hybridisation probes, at least one set comprising one or more peptide nucleic acid probes capable of hybridising to specific nucleic acid sequences related to a potential aberration in a chromosome, and at least one set comprising two or more peptide nucleic acid probes capable of hybridising to specific nucleic acid sequences related to another potential aberration in a chromosome. In particular, the method may be used for detecting chromosome aberrations in the form of breakpoints.Type: GrantFiled: August 27, 2002Date of Patent: September 12, 2006Assignee: Dako Denmark A/SInventors: Jacobus Johannus Maria Van Dongen, Karl-Johan Pluzek, Kirsten Vang Nielsen, Kim Adelhorst
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Publication number: 20060160106Abstract: A novel method for detecting chromosome aberrations is disclosed. More specifically, chromosome aberrations are detected by in situ hybridisation using at least two sets of hybridisation probes, at least one set comprising one or more peptide nucleic acid probes capable of hybridising to specific nucleic acid sequences related to a potential aberration in a chromosome, and at least one set comprising two or more peptide nucleic acid probes capable of hybridising to specific nucleic acid sequences related to another potential aberration in a chromosome. In particular, the method may be used for detecting chromosome aberrations in the form of breakpoints.Type: ApplicationFiled: September 8, 2005Publication date: July 20, 2006Applicant: Dako A/SInventors: Jacobus Van Dongen, Karl-Johan Pluzek, Kirsten Nielsen, Kim Adelhorst
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Patent number: D591864Type: GrantFiled: December 10, 2007Date of Patent: May 5, 2009Assignee: Dako Denmark A/SInventor: Peter O. Schmidt