Abstract: Provided herein, in some embodiments, are antibodies, antigen-binding antibody fragments, chimeric antigen receptors (CARs) and bispecific T cell engagers (BiTEs) that bind specifically to B7 homolog 6. Also provided herein are methods of using the same and cells comprising the same.

Abstract: A multiphase composite, formed by freeze-casting, lyophilization, and sintering, has sintered particles forming a scaffold having at least one region of aligned porosity; and a second phase formed in pores of the scaffold. In a particular embodiment, the second phase is a nuclear fuel, in another, the first phase is a nuclear fuel, and in others, both phases are nuclear fuels. In some embodiments, the first phase is a ceramic, and in other embodiments a metal such as stainless steel. In other embodiments, the second phase is a metal, and in other embodiments a ceramic. In some embodiments the second phase is positioned in a subset of pores of the scaffold, at least some additional pores being filled with a third phase. In embodiments, the second phase is also sintered.

Abstract: We disclose transconductor-capacitor classical dynamical systems that emulate quantum dynamical systems and quantum-inspired systems by composing them with 1) a real capacitor, whose value exactly emulates the value of the quantum constant ? termed a Planck capacitor; 2) a ‘quantum admittance’ element, which has no classical equivalent, but which can be emulated by approximately 18 transistors of a coupled transconductor system; 3) an emulated ‘quantum transadmittance element’ that can couple emulated quantum admittances to each other; and 4) an emulated ‘quantum transadmittance mixer element’ that can couple quantum admittances to each other under the control of an input. We describe how these parts may be composed together to emulate arbitrary two-state and discrete-state quantum or quantum-inspired systems including stochastics, state preparation, probability computations, state amplification, state attenuation, control, dynamics, and loss compensation.

Abstract: We disclose transconductor-capacitor classical dynamical systems that emulate quantum dynamical systems and quantum-inspired systems by composing them with 1) capacitors that represent ? termed Planck capacitors; 2) a ‘quantum admittance’ element, which can be emulated efficiently via coupled transconductors; 3) an emulated ‘quantum transadmittance element’ that can couple emulated quantum admittances to each other; and 4) an emulated ‘quantum transadmittance mixer element’ that can couple emulated quantum admittances to each other under the control of an input. We describe a ‘Quantum Cochlea’, a biologically-inspired quantum traveling-wave system with coupled emulated quantum two-state systems for efficient spectrum analysis that uses all of these parts.

Abstract: We disclose transconductor-capacitor classical dynamical systems that emulate quantum dynamical systems and quantum-inspired systems by composing them with 1) capacitors that represent ? termed Planck capacitors; 2) a ‘quantum admittance’ element, which can be emulated efficiently via coupled transconductors; 3) an emulated ‘quantum transadmittance element’ that can couple emulated quantum admittances to each other; and 4) an emulated ‘quantum transadmittance mixer element’ that can couple emulated quantum admittances to each other under the control of an input. We describe a ‘Quantum Cochlea’, a biologically-inspired quantum traveling-wave system with coupled emulated quantum two-state systems for efficient spectrum analysis that uses all of these parts.

Abstract: Pyridyl analogs of 1-(2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl) imidazole and pharmaceutical compositions containing the same are provided.

Abstract: Embodiments of the present disclosure pertain to conductive textiles that include a textile component with a plurality of fibers; and metal-organic frameworks associated with the fibers of the textile component in the form of a conductive network. Metal-organic frameworks may have a two-dimensional structure and a crystalline form. Metal-organic frameworks may be conformally coated on the fibers of the textile component. Additional embodiments of the present disclosure pertain to methods of sensing an analyte in a sample by exposing the sample to a conductive textile; and detecting the presence or absence of the analyte by detecting a change in a property of the conductive textile, and correlating the change in the property to the presence or absence of the analyte. The analyte in the sample may reversibly associate with the conductive textile. The association may also result in filtration, pre-concentration, and capture of the analyte by the conductive textile.

Abstract: The present invention features methods for stimulating clearance of misfolded or aggregated proteins or peptides in microglia or neurons, and treating neurodegenerative diseases associated with such pathology in brain by selectively inhibiting the expression or activity of Acyl-CoA: Cholesterol Acyltransferase 1, but not Acyl-CoA: Cholesterol Acyltransferase 2.

Abstract: Pyridyl analogs of 1-(2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl) imidazole and pharmaceutical compositions containing the same are provided.

Abstract: A technique performs a security operation. The technique includes receiving first activity data from a mobile device, the first activity data identifying activity by a user that is currently using the mobile device. The technique further includes receiving second activity data from an electronic wearable apparatus, the second activity data identifying physical activity by a wearer that is currently wearing the electronic wearable apparatus. The technique further includes, based on the first activity data received from the mobile device and the second activity data received from the electronic wearable apparatus, performing an assessment operation that provides an assessment result indicating whether the user that is currently using the mobile device and the wearer that is currently wearing the electronic wearable apparatus are the same person. With such a technique, authentication may be continuous but without burdening the user to repeatedly re-enter a password.

Abstract: This disclosure relates to preserving a quantum state in a quantum memory. A controller of the quantum memory determines based on a characteristic of noise that causes deterioration of the quantum state a dynamical decoupling base sequence. The duration of the base sequence is shorter than or equal to an access latency time of the quantum memory to allow access to the quantum state within the access latency time. Further, the deterioration of the quantum state is bounded to an upper deterioration limit when the base sequence is repeatedly applied to the quantum system. This provides acceptable access times while simultaneously allowing long term storage of data in the quantum state with low error rates. Repeatedly applying the base sequence to the quantum system will first yield an increasing deterioration but that deterioration will eventually reach the upper limit. As a result, over time the error rates will not exceed that upper limit and the quantum state is stable.

Abstract: The present invention a method for producing a human immunoglobulin G (IgG) antibody using a prime-boost regime in a Bone Marrow Liver Thymic (BLT) mouse.

Abstract: The present invention provides for the manipulation of carbon flux in a recombinant host cell to increase the formation of desirable products. The invention relates to cellulose-digesting organisms that have been genetically modified to allow the production of ethanol at a high yield by redirecting carbon flux at key steps of central metabolism.

Abstract: The present invention includes an expression cassette containing a polynucleotide encoding a polypeptide; and a host cell, transgenic plant (e.g., a dicot or monocot), transformed seed, and transgenic rootstock containing said expression cassette. Methods for desensitizing a plant to endogenous cytokinin; increasing seed, embryo or cotyledon size or weight; increasing the seed yield of a plant; and/or increasing the size of the root or root meristem or formation of lateral or adventitious roots are provided. In some embodiments, expression of the polypeptide is under control of a seed-preferred, embryo-preferred or root-preferred promoter.

Abstract: The present invention provides attenuated Toxoplasma gondii mutants for use as vaccines in the prevention or treatment of cancer.

Abstract: Improved anti-CD154 antibodies are provided herein which have ablated FcR binding and/or complement binding/activation. The use of these antibodies for inducing tolerance and treating immune diseases including autoimmunity, inflammation and allergic disorders is disclosed herein.

Abstract: Systems and methods for monitoring a range of motion of a joint are described. For example, in one embodiment, a first set of sensors may sense accelerations of a first body portion located on a first side of the joint and a second set of sensors may sense accelerations of the second body portion located on a second opposing side of the joint. The acceleration data may then be used to compute the relative motion of the first and second body portions to determine movement of the joint. This joint movement may then be used to determine one or more range of motion movement metrics which are output for viewing by a subject or medical practitioner.

Abstract: The present invention relates to a method for diagnosing neuroendocrine cancers via detecting the presence of N-methyl D-asparate-associated (NMDA) glutamate receptors type 1 and/or type 2. Methods for preventing and treating neuroendocrine cancers are also disclosed.

Abstract: Methods for treating breast and bladder cancer patients based upon E2F4 regulatory activity as a predictor of relapse of a patient with estrogen receptor positive breast cancer and in bladder cancer stratification are provided. The methods involve determining gene expression profiles for substances linked to activity of E2F4 in cancer cells and tissue. Signature gene expression profiles are provided for identifying breast cancer samples and bladder cancer samples that would be responsive to certain therapies and also provide for prognosis based on these profiles.

Abstract: The present invention provides triterpenoids produced from natural compounds such as oleanolic acid, ursolic acid, betulinic acid, and hederagenin.