Abstract: The invention concerns a pumping device that includes a pump having a pumping chamber with a variable volume, an inlet that communicates with the pumping chamber and a valve, an outlet that communicates with the pumping chamber and a valve, and an actuator adapted to change the volume of the pumping chamber. A fluidic pathway in the pumping device includes the inlet, the pumping chamber, the outlet, and a downstream line situated downstream of the outlet valve. The pumping device also includes a pressure sensor for measuring the pressure between the valves of the pathway, and a processing means for processing the received pressure data from the pressure sensor. The invention also concerns a method for detecting a dysfunction in the pumping device.

Abstract: Method for detecting failure including possible under or over delivery of a micropump having at least an inlet valve, a pumping chamber with an inner pressure sensor and an outlet valve, said method comprising the determination of the pump tightness via the measurement of the pressure by said inner pressure sensor in said pumping chamber at least at certain intervals when the pump is inactive and the comparison with a value of reference.

Abstract: The invention relates to a connector/cap assembly comprising locking means and coupling means allowing the cap to be removed from the connector using only one hand and preferably without the cap coming into contact with the hand of the practitioner.

Abstract: A system for performing fluid administration on a patient, the system including a flexible membrane forming a valve of a port having a valve seat, and an actuator having an actuator head, wherein the flexible membrane includes a membrane actuator clip configured to removably connect to the actuator head, the connection between the membrane actuator clip and the actuator head allowing the actuator to push the flexible membrane towards the valve seat to close the valve, and to pull the flexible membrane away from the valve seat to open the valve.

Abstract: The invention relates to a system for treating blood, which includes a single cassette capable of carrying out the various CRRT treatments.

Abstract: A medical device for administering a solution, the device including a pump, a reservoir, and a communication structure for connecting the reservoir and the pump, and a line for connecting the medical device to the patient, wherein the medical device is adapted to use a mathematical model in order to determine at any moment a physical or chemical characteristics of the solution, which is contained in the reservoir, wherein the mathematical model takes account of a modification of the solution in the reservoir over the course of time as a function of an exposure to temperature, to humidity, or to pressure of the solution, or ageing or permeability of the reservoir; and the medical device is adapted to inform the patient about refilling the solution or changing the reservoir depending on the modification of the characteristics of the solution.

Abstract: The present invention describes the improvements due to alternated actuation cycles to reduce the delivery errors related to the pumping chamber elasticity, the actuator relaxation or hysteresis. The method actuates a pumping device with an optimal driving voltage profile, wherein the pumping device comprises a pumping chamber including a pumping membrane and a voltage controlled actuator connected to said membrane; the movement of said membrane being defined by three positions, namely a rest, a bottom and a top position. The method includes the actuation of the membrane with a pumping pattern including at least two different cycles: Cycle A: rest-bottom-rest-top-rest Cycle B: rest-top-rest-bottom-rest. The invention also relates to a device to carry out the method.

Abstract: A sampling system performs an automatic dialysis sampling at specific time intervals of a dialysis treatment. The system includes a fluidic pathway in which a dialysis solution flows, a series of sampling containers, and a valve system. The valve system is arranged in the fluidic pathway. The sampling system includes an electronic system that controls automatically the valve system in order to direct a certain quantity of each fluid sample to a specific sampling container.

Abstract: An adjustable passive flow regulator may be used in the field of drug delivery (liquid or gaseous, e.g. for pain management) or for draining cerebrospinal fluid (CSF) for hydrocephalus patient.

Abstract: The invention concerns a medical assembly which insures a secured communication between a medical device (like a insulin pump) and its remote control which manages the medical device. To this effect, said assembly use an external microcontroller (MCU) which contains the secured data and uses a cryptographic mechanism to communicate with the medical device. One single external microcontroller (MCU) is paired with only one medical device in such a way the patient can change several times of remote device although aware that the remote device, in which said external protected MCU is inserted, is the single remote device paired with the medical device. In said assembly, said medical device and said external microcontroller (MCU) comprise secured memories which contain the wireless communication configuration in such a way the devices know in advance the good configuration.

Abstract: Sensor for dynamically detecting the residual fluid volume Vres of a collapsible reservoir (1,3) characterized by the fact that it is adapted to detect a threshold pressure Pth which corresponds to a phase within said reservoir (1,3) when only said residual fluid volume Vres remains, said residual volume Vres corresponding to a safety volume sufficient to ensure a safety margin to alert the user before the reservoir (1,3) is empty.

Abstract: The present invention describes a valve for controlling the passage of a microfluidic system. Said valve comprises a first valve element (103) and a second valve element (104, 105) with respective first and second contact surfaces which are placed opposite to each other in such a way as to control a fluid flow through said passage. Said first valve element comprising a flexible part and a rigid part.

Abstract: The present invention concerns a medical pump comprising: a. A hard housing comprising a top (24) and bottom (1) hard shells, within which a rigid wall (3) and a movable membrane (2) create three distinct chambers; wherein i. said movable membrane tightly separates said second (29) and third (22) chambers ii. said first and third chambers have a watertight interface iii. said second chamber (29) is designed to contain a fluid iv. said first chamber (23) comprises a first venting mean (20) which is arranged to provide a fluidic communication between said first chamber (23) and the external environment; v. said third chamber (22) comprises a second venting mean which is arranged to provide a fluidic communication between said third chamber (22) and the external environment b. A pumping element (4) located in the first chamber (23) c. A least one pressure sensor which measure the pressure gradient between the first chamber (23) and the second chamber (29) d. A fluid pathway which permits: i.

Abstract: The invention concerns a flow regulator, made of a stack of 3 plates, respectively a top plate including a flexible membrane (1), a middle plate (2) with pillars and through holes and a bottom plate (3) with fluidic ports, micro channels and through holes (8,9,12). The principle is based on the deformation of the membrane due to the pressure of the liquid. The membrane goes in contact with the pillars of the middle plate, obstructing gradually the through holes of the pillars. The device is designed to keep the flow constant in a predefined range of pressure. The device is dedicated to ultra low flow rate up to 1 ml per day or below, typically for drug infusion. Plastic flow regulators comprise preferably several independent valves coupled in parallel. The membrane plate is therefore made of several flexible membranes obstructing gradually the flow by increasing the pressure. Stress limiters are used to avoid plastic deformation of the membrane.

Abstract: The invention relates to an assembly that includes an infusion set and a patch intended for receiving a pump for the transcutaneous administration of a product, said patch including an adhesive portion and a non-adhesive portion, the assembly being characterized in that said set includes patch-guiding elements and sliding elements intended for sliding along the guiding elements.

Abstract: A device for inserting at least one hollow needle for the injection or withdrawal of a solution into/from a tissue, said device comprising a casing (1), a plunger (2) movably mounted inside the casing, and propulsion means (3 and 4) suitable for driving the plunger towards the distal end (1a) of the device by applying a force F1(t). The propulsion means and/or the plunger comprise retaining means (3a) for joining the propulsion means and the plunger while the latter is moving, said retaining means releasing the plunger from the propulsion means when a force F2(t) is exerted in the opposite direction to F1(t). Pressure means hold the needle in the tissue and allow a controlled withdrawal of the plunger at least while the solution is being injected.

Abstract: A micropump in the form of a stack comprising, in succession, a flexible diaphragm, a pumping chamber and a closing-off plate, said pumping chamber communicating with the outside, for example via the flexible diaphragm; said diaphragm being furthermore secured to an actuator arranged outside the micropump, characterized in that said diaphragm is secured to the actuator by way of at least one element in the form of a strip, which is rigid along its main axis and flexible in the direction perpendicular to its main axis.

Abstract: A dialysis system comprises a filtration means, a pump and a sorbent device for performing a dialysis treatment and/or for regenerating a dialysate solution.

Abstract: Out-of-plane microneedle manufacturing process comprising the simultaneous creation of a network of microneedles and the creation of a polygonal shaped hat (2) above each microneedle (1) under formation, said process comprising the following steps: providing bridges (3) between the hats (3), maintaining the bridges (3) during the remaining microneedle manufacturing steps, removing the bridges (3), together with the hats (2), when the microneedles (1) are formed.

Abstract: The invention relates to a method for prescribing a dialysis treatment comprising the following steps: collecting patient specific data, determining at least one target, defining a series of values of the type [V;t] which allow to achieve said target wherein V represents the volume of dialysate used and t the duration of treatment, based on said patient specific data, displaying said series of values on a map. The invention also relates to a system using this method.