Abstract: The invention relates to a device for inserting needles, including a body defined by a proximal end and a distal end, a mounting movably mounted inside the body, at least one needle secured to the mounting, a drive means suitable for driving the mounting towards said distal end, said mounting comprising a distal surface onto which the needle projects, said distal end comprising a contact area intended for contacting the tissue, the mounting being configured so as to reach a position, after activating the driving means, in which the distal surface thereof, relative to said proximal end, is more distant than said contact area, wherein the device is further configured so as to enable a gradual passive return movement of the mounting once said position has been reached.

Abstract: A micro-needle (4) comprising a sharp tip (31), an elongated body (32) and a head (36) containing at least two parallel independent lumens (5, 6), each of said lumens (5, 6) communicating with a distal side opening (7, 8) of the head (36); said openings (7, 8) being essentially oriented in a direction which is perpendicular with respect to its lumen (5, 6) main direction and wherein the distal top end (33, 34) of said lumen (5, 6) is in the head (36) of the micro-needle (4).

Abstract: A method actuates a pumping device that has an optimal driving voltage. The pumping device includes a pumping chamber that has a pumping membrane, an inlet and an outlet chamber, a voltage controlled actuator connected to the pumping membrane, a stop position defined by a mechanical stop, and a sensor for determining whether the pumping membrane has reached the mechanical stop. The method performs a learning and working phase. The learning phase is adapted to determine the optimal driving voltage.

Abstract: The present invention concerns a medical pump comprising: a. A hard housing comprising a top (24) and bottom (1) hard shells, within which a rigid wall (3) and a movable membrane (2) create three distinct chambers; wherein i. said movable membrane tightly separates said second (29) and third (22) chambers ii. said first and third chambers have a watertight interface iii. said second chamber (29) is designed to contain a fluid iv. said first chamber (23) comprises a first venting mean (20) which is arranged to provide a fluidic communication between said first chamber (23) and the external environment; v. said third chamber (22) comprises a second venting mean which is arranged to provide a fluidic communication between said third chamber (22) and the external environment b. A pumping element (4) located in the first chamber (23) c. A least one pressure sensor which measure the pressure gradient between the first chamber (23) and the second chamber (29) d. A fluid pathway which permits: i.

Abstract: An out-of-plane microneedle manufacturing process comprises the simultaneous creation of a network of microneedles and the creation of a polygonal shaped hat above each microneedle under formation. The process comprises the following steps: providing bridges between the hats, maintaining the bridges during the remaining microneedle manufacturing steps, removing the bridges, together with the hats, when the microneedles are formed.

Abstract: A fluid container for a medical fluid dispensing device, comprises a rigid body (3) for delimiting with the inside part of its wall a volume of the medical fluid, and a membrane (5) that covers at least an opening of the rigid body thereby creating a fluid tight lid, the opening corresponding to a measurement area, and the membrane further covers a portion of an outside part of the rigid body's wall. The membrane comprises a flexible measurement part (11) corresponding to the opening of the rigid body, an attachment part (13) that is fixed to the rigid body, and a second part (12) that connects the flexible measurement part to the attachment part, and which comprises a rigid part (14), an upper part of which is connected to the flexible measurement part, and the rigid part further comprising a sealing surface (18), and a deformable part (15) which connects the rigid part to the attachment part.

Abstract: The present invention relates to a coating for medical implants. The coating contains an active agent that is intended to have an effect on the surrounding tissue after placement of the implant. This effect is activated in the presence of cells. The active agent is released from the coating under the direct influence of the cells.

Abstract: The invention concerns a pumping device that includes a pump having a pumping chamber with a variable volume, an inlet that communicates with the pumping chamber and a valve, an outlet that communicates with the pumping chamber and a valve, and an actuator adapted to change the volume of the pumping chamber. A fluidic pathway in the pumping device includes the inlet, the pumping chamber, the outlet, and a downstream line situated downstream of the outlet valve. The pumping device also includes a pressure sensor for measuring the pressure between the valves of the pathway, and a processing means for processing the received pressure data from the pressure sensor. The invention also concerns a method for detecting a dysfunction in the pumping device.

Abstract: The invention relates to a peritoneal dialysis sampling system to be used together with a peritoneal dialysis system which is programmed to deliver fluid to a peritoneal cavity of a patient and to drain the fluid from the cavity, said peritoneal dialysis system comprising a supplying line and supplying means for supplying dialysis fluid to the peritoneal cavity, a draining line and draining means for draining the fluid from the cavity, said peritoneal dialysis sampling system comprising an automatic sampling system which is able to automatically sample volumic fractions of the dialysate contained in the peritoneum of the patient at specific time intervals in order to evaluate the peritoneal membrane characteristics and/or improve the peritoneal dialysis for a given patient.

Abstract: Device for determining the characteristics of peritoneal membrane comprising means for measuring glucose in the fluid drainage and a processing unit comprising means for determining the characteristics of the membrane as a function of that rate of glucose measured at different times. The invention also relates to a method for determining the characteristics of peritoneal membrane including the consideration of glucose measured at different moments in the liquid drainage.

Abstract: Cannula inserter comprising a casing with a distal end, intended to be placed in proximity to the skin of a patient, and an opposite proximal end, a piston fixed at least temporarily by retaining means, drive means designed to exert a propulsion force of the piston in the direction counter to the trigger, and release means intended to release the piston; the inserter additionally comprising a needle fixed to a support; the piston being mounted in the casing in such a way that, once released, it reaches and remains temporarily in a first position, then a second position; the needle and its support also being arranged so as to be able to be driven by the piston in a direction corresponding to the main orientation of the casing, before the piston reaches said first position, and so as to be able to effect an automatic rotation about an axis perpendicular to said main orientation during the movement of the piston between said first position and said second position.

Abstract: Out-of-plane microneedle manufacturing process comprising the simultaneous creation of a network of microneedles and the creation of a polygonal shaped hat (2) above each microneedle (1) under formation, said process comprising the following steps: providing bridges (3) between the hats (3), maintaining the bridges (3) during the remaining microneedle manufacturing steps, removing the bridges (3), together with the hats (2), when the microneedles (1) are formed.

Abstract: Sensor for dynamically detecting the residual fluid volume Vres of a collapsible reservoir (1,3) characterized by the fact that it is adapted to detect a threshold pressure Pth which corresponds to a phase within said reservoir (1,3) when only said residual fluid volume Vres remains, said residual volume Vres corresponding to a safety volume sufficient to ensure a safety margin to alert the user before the reservoir (1,3) is empty.

Abstract: The regulator comprises at least a cylinder (2) with a fluid inlet connector (1) for receiving fluid at an inlet pressure and a fluid outlet connector (4) for delivering fluid, at least one chamber (3), a rod (5) in said cylinder with one side submitted to the inlet pressure and the other side submitted to the outlet pressure generating a net force counter-balanced by at least one spring means (7) acting on one side of said rod (5) against said inlet pressure, wherein a fluidic pathway is formed between said rod (5) and said cylinder (2) as the major fluidic resistance of the device, wherein a change of the inlet pressure induces a move of the rod along the axis of the cylinder thereby modifying the fluidic resistance of said fluidic pathway, wherein the fluidic resistance of said pathway varies with the applied pressure at the inlet in a predefined range of pressure, inducing a regulated flow rate in the considered range of pressure.

Abstract: The invention relates to a device for inserting needles, including a body defined by a proximal end and a distal end, a mounting movably mounted inside the body, at least one needle secured to the mounting, a drive means suitable for driving the mounting towards said distal end, said mounting comprising a distal surface onto which the needle projects, said distal end comprising a contact area intended for contacting the tissue, the mounting being configured so as to reach a position, after activating the driving means, in which the distal surface thereof, relative to said proximal end, is more distant than said contact area, wherein the device is further configured so as to enable a gradual passive return movement of the mounting once said position has been reached.

Abstract: The invention relates to a method for prescribing a dialysis treatment comprising the following steps: collecting patient specific data, determining at least one target, defining a series of values of the type [V;t] which allow to achieve said target wherein V represents the volume of dialysate used and t the duration of treatment, based on said patient specific data, displaying said series of values on a map. The invention also relates to a system using this method.

Abstract: The invention concerns a flow regulator, made of a stack of 3 plates, respectively a top plate including a flexible membrane (1), a middle plate (2) with pillars and through holes and a bottom plate (3) with fluidic ports, micro channels and through holes (8,9,12). The principle is based on the deformation of the membrane due to the pressure of the liquid. The membrane goes in contact with the pillars of the middle plate, obstructing gradually the through holes of the pillars. The device is designed to keep the flow constant in a predefined range of pressure. The device is dedicated to ultra low flow rate up to 1 ml per day or below, typically for drug infusion. Plastic flow regulators comprise preferably several independent valves coupled in parallel. The membrane plate is therefore made of several flexible membranes obstructing gradually the flow by increasing the pressure. Stress limiters are used to avoid plastic deformation of the membrane.

Abstract: The invention concerns a system and a method of use of said system for performing fluid administration on a patient, the system comprising: a liquid pump (1), a liquid distribution system (2) connected to said pump (1) in such a way that liquid can flow from the liquid distribution system (2) to the pump (1) and vice versa, liquid supply means (3) for supplying liquid to a patient (4) via said liquid distribution system (2) and said pump (1), a patient conduit (5) adapted for connecting said liquid distribution system (2) to a patient (4), the system being characterized by the fact that said liquid distribution system (2) comprises two distinct hub chambers (7,8), the first hub chamber (7) including at least one liquid supply port with dedicated valve means (9), one patient port with dedicated valve means (10) and one pump inlet (26), the second hub chamber (8) including at least, one patient port (18) or warmer port (16) with dedicated valve means and one pump outlet (27), said system furthermore comprisi

Abstract: The present invention describes the improvements due to alternated actuation cycles to reduce the delivery errors related to the pumping chamber elasticity, the actuator relaxation or hysteresis. The method actuates a pumping device with an optimal driving voltage profile, wherein the pumping device comprises a pumping chamber including a pumping membrane and a voltage controlled actuator connected to said membrane; the movement of said membrane being defined by three positions, namely a rest, a bottom and a top position. The method includes the actuation of the membrane with a pumping pattern including at least two different cycles: Cycle A: rest-bottom-rest-top-rest Cycle B: rest-top-rest-bottom-rest. The invention also relates to a device to carry out the method.

Abstract: A polymeric container for storing a drug such as insulin which comprises a hard shell (2) and a flexible film (1), wherein both elements are made from the same material.