Abstract: A multifunctional chemical agents comprising functional agents Fn1, Fn2 and linkers, for the linchpin directed (LDM), protein directed (PDPM) modifications of proteins, and Fn1 accelerated kinetic labeling by Fn2.

Abstract: The invention discloses nanoparticles comprising compounds of calcium with anions such as phosphate, pyrophosphate, sulphate, silicate, carbonate, molybdate, or phosphosilicate that are doped with various ions. The nanoparticles are configured to produce heat (hyperthermia) under radio-wave (1 KHz-1000 GHz) exposure together with magnetism suitable for contrast imaging in MRI, X-ray absorption for computed tomography, near-infrared optical fluorescence for optical imaging, and/or radio-isotope emission for nuclear imaging or therapy. The nanoparticles can also be incorporated into micro-beads or other 3 dimensional scaffolds for image-guided (MRI, CT, NIR, nuclear) tissue regeneration, immunotherapy, vascular or tumor embolization, and/or chemo/radio-embolization.

Abstract: The invention relates to an ergonomic foot pedal and to apparatuses for manual ventilation. In an embodiment, the invention provides a compact and integrated foot pedal that enables a care provider to provide positive pressure ventilation to a subject's airways and lungs, and to optionally apply suction for the purpose of aspirating mucous, secretions, meconium, blood, fluids or other such materials from a patient—specifically from airways.

Abstract: In accordance with the present subject matter, there is provided a process for preparing a furan derivative, the process comprising the steps of contacting a sugar with a monophasic organic solvent to obtain a reaction mixture; and subjecting the reaction mixture to a temperature in the range from 100° C. to 180° C., in presence of an acid catalyst, for a time period in the range of 0.5 min to 4.0 h to obtain at least 70% conversion of the sugar to a single furan derivative, wherein the acid catalyst is selected from the group consisting of homogenous acid catalyst, heterogenous solid acid catalyst, and combinations thereof. There is also provided a process for preparation of a heterogenous solid acid catalyst.

Abstract: This invention relates to a simple end point assay for detection of transient intracellular Ca2+ with broad applicability to many Ca2+ channel proteins comprising, Generation of expression constructs for the fusion proteins having the Ca2+/calmodulin dependent protein kinase II (CaMKII) phosphorylation sites of NR2A or NR2B subunits of N-methyl-D-aspartate receptor (NMDAR) or the voltage gated potassium channel of Drosophila (Eag) or any protein sequence which binds to the T-site of CaMKII similar to NR2B, conjugated to mitochondrial localizing signal sequence, or mutants of these sequences as described herein. Generation of mammalian expression constructs of ?-CaMKll as a chimera with green fluorescent protein (GFP-?-CaMKII) or its mutants as described herein.

Abstract: The present invention provides a modified bacterial strain capable of fermenting both hexose and pentose sugars for production of bioalcohol wherein a promoter of pyruvate dehydrogenase operon (PDH) is replaced with a promoter of a gene that is expressed under anaerobic conditions. The present invention further provides a method of obtaining modified bacterial strain capable of fermenting both hexose and pentose sugar for production of bioalcohol. The present invention also provides a method of fermenting lignocellulosic biomass having hexose and pentose sugar using the modified bacteria for production of biomass.

Abstract: The present invention relates to a simple and convenient process for preparing solid lipid sustained release nanoparticles for delivery of drugs/vitamins, preferably fat soluble vitamins and more specifically Vitamin D3 and retinoic acid (RA). The process involves microemulsion technique. The nanoparticles of Vitamin D3 and RA obtained by the process of the present invention have utility in treatment of diseases like tuberculosis. Use may be extended to other diseases like AMD, diabetic retinopathy, cancers, hyperpigmentation, acne, and osteoporosis.

Abstract: The present invention relates to the continuous process of sequestration of nutrients from waste effluents released from gas fermentation plants or green-house gases emission managing plants by novel Thraustochytrids. Particularly this invention relates to the methods and systems to enhance sequestration rate and productivity of the process. This invention also relates to rapid biotransformation of nutrients present in waste effluents into high value omega-3 fatty acids like Docosahexaenoic acid (DHA), Docosapentaenoic acid (DPA), Eicosapentaenoic acid (EPA) and lipids for biodiesel. This disclosure is about means of processing of waste streams and producing value added products out of it.

Abstract: The present invention provides a process for enzyme mediated hydrolysis of biomass for production of soluble sugars, wherein the said process comprises of steady addition of small portions of biomass to enzyme solution, enabling rapid solubilization of biomass. The process used for enzymatic saccharification allows for increased biomass loading, enzyme recycle and mitigation of substrate and product inhibitory effect. The recycling of unhydrolysed biomass along with soluble enzyme ensures complete reuse of the said enzyme for effective repeated hydrolysis thereby increasing the overall productivity of enzyme used.

Abstract: The present invention mainly relates to knee joint and more particularly to the polymeric composite or nanocomposites based polycentric knee joint.

Abstract: The present invention provides a modified bacterial strain capable of fermenting both hexose and pentose sugars for production of bioalcohol wherein a promoter of pyruvate dehydrogenase operon (PDH) is replaced with a promoter of a gene that is expressed under anaerobic conditions. The present invention further provides a method of obtaining modified bacterial strain capable of fermenting both hexose and pentose sugar for production of bioalcohol. The present invention also provides a method of fermenting lignocellulosic biomass having hexose and pentose sugar using the modified bacteria for production of biomass.

Abstract: This invention relates to a high affinity recombinant humanized antibody fragment (scFv) specific for hepatitis B surface antigen having unique inter/intra chain bonding interaction because of 28 altered amino acid residues from the original mouse (5S) antibody and its chimeric Fab form, wherein fine tuning of the vernier zone residue makes it closer to the human sequence without any structural constraints.

Abstract: The present invention demonstrates for the first time that FAT1 plays an important role in modulating PDCD4 expression, which in turn regulates AP-1 dependent transcription, controls processes crucial for migration and invasion in cancer cells, controls induction of a pro-inflammatory micro environment in cancer cells. The study illustrates a link between inflammation and cancer in cells or in a subject. This work highlights the importance of FAT1 in the induction of the cellular pathways of migration and invasion, proteolysis of the ECM and the expression of pro-inflammatory molecules leading to a favorable micro environment for tumor and cancer progression.

Abstract: According to an embodiment, the present subject matter describes a device for delivery of one or more fluids in to a target site. The fluid delivery device (100) includes a housing (105, 205), a shaft (110), which may 125 be disposed inside the housing (105, 205) to form at least one fluid chamber (115, 210) therebetween. Further, the fluid chamber (115, 210) is adapted to receive the one or more fluids. The fluid delivery device (100) further includes a plunger (120, 225) provided at a first end (125) of the housing (105, 205). The plunger (120, 225) may be coupled to the shaft (110) and may be adapted to move inside the housing (105, 205) to deliver the one or more fluids to the target site (405).

Abstract: The present invention relates to a mutant of L-asparaginase enzyme characterized in having high thermostability, pH stability and no glutaminase activity useful for therapeutics and the process of preparing the same. The present invention specifically relates to mutants MTCC 5580, MTCC 5581 and MTCC 5582 characterized in having higher stability, no glutaminase activity etc., to allow their usage in the form of improved protein therapeutics.

Abstract: A recombinant microorganism is provided herein, in particular, a recombinant microorganism of the Azotobacteraceae family. The recombinant Azotobacter microorganism is capable of fixing atmospheric nitrogen continuously in the presence of oxygen and externally fixed nitrogen sources. The present invention further provides a process for production of the recombinant microorganism and a composition comprising the recombinant microorganism for use as biofertilizers and/or for use in the preparation of a fertilizer composition. The recombinant microorganism produced by this invention is an environmental friendly, highly beneficial microorganism.

Abstract: This invention relates to a novel non-obturation, regenerative technique “SealBio” of endodontic treatment involving regenerative potential of stem cells and signaling molecules, locally available in the peri-radicular region of teeth, wherein they are stimulated to induce healing and deposition of a natural barrier (seal) at the root apex.

Abstract: A process for designing of PCR-based detection method for Chlamydia trachomatis comprising designing of PCR primers from the genome sequence of Chlamydia trachomatis selecting DNA sequence of genes for PCR based diagnostic of Chlamydia trachomatis, optimizing the PCR conditions of the PCR primers; subjecting the said genes and primers to the step of characterization.

Abstract: This invention is a process for the preparation of talc based formulation for LDPE-degrading bacterial consortia. The process comprises preparing an active consortium. The active consortium is divided into four parts in centrifuge tubes. The tubes are spun at 5000 rpm. A supernatant is decanted from the tubes. The tubes are vortexed. Talc is added to each tube. The tubes with talc are again vortexed for some time to produce a homogeneous mixture. The mixture is poured into glass dishes. The dishes are kept at room temperature as aseptically for drying.