Abstract: A polyherbal preparation for the prevention of atherosclerosis and hyperlipidemia comprising a mixture of Commiphora mukul, Boswellia serrata, Semecarpus anacardium Strychnox nux vomica, Terminalia arjuna and Shankha Bhasma.

Abstract: A dimer of phenazine-1-carboyxlic acid natural products from fluorescent pseudomonad bacterium and a method of preparing a dimer of phenazine-1-carboxylic acid natural product are disclosed herein. The method comprises growing the bacterium in a water based liquid medium under favorable pH and temperature with continuous agitation, extracting the dimer of phenazine-1-carboyxlic acid natural product from the medium by centrifugation using organic solvents, filtering the resultant emulsion to separate the aqueous layer in a separation funnel, isolating the crude dimer of phenazine-1-carboyxlic acid natural product from the organic layer by evaporating the organic solvent, and purifying the dimer of phenazine-1-carboxylic acid natural product by chromatography.

Abstract: A vaccine composition for humans and animals against Japanese encephalitis virus infection is a composition which comprises a chimeric synthetic peptide consisting of a B cell epitope linked to a T-helper cell epitope from Japanese encephalitis proteins, wherein the chimeric peptide is in an amount sufficient to induce protective immunity against Japanese encephalitis virus infection. For example, the B cell epitope may be SEQ ID NO:46, 84 or 85; and the T-helper cell epitope may be SEQ ID NO:77, 82 or 83.

Abstract: The present invention provides compounds and methods for the detection of anti-leishmanial antibodies in individuals suspected of infection with the protozoan parasite of the genus Leishmania, where the infectious agent is an Indian strain and similar or closely related to Indian Leishmania strains. The compounds provided include polypeptides as shown in SEQ ID NO: 5 or SEQ ID NO: 6 which are useful for the detection of anti-leishmanial antibodies in individuals where the immune responses are elicited against Leishmania species of Indian strains and similar or closely related to Indian Leishmania strains, the compounds are also useful as a vaccine and therapeutic agent to prevent and treat leishmaniasis. The present invention further provides a diagnostic kit consisting of antibody raised against polypeptides as shown in SEQ ID NO: 5 or SEQ ID NO: 6 for detecting leishmanial antigens.

Abstract: A simple easy to manufacture analytical device capable of performing membrane based immunoassays on batch of samples within 3 to 10 minutes wherein the method permits focused application of samples, costly labeled immunoassay and signal amplification reagents, said device includes an antibody-immobilized micro porous membrane, breadth corner layer of which is directly attached to a semi-rigid liquid-impervious body with water insoluble adhesive; absorbent body is provided separately and is not attached to analytical device during manufacture, absorbent body is wetted and is placed proximal to the lower surface of the membrane thereby forming networks of capillary channels with the absorbent body; flow of samples or reagents is always kept downwards and focused without application of any force to the absorbent body and the use of disposable adsorbent body permits stepwise addition of signal amplification reagents for ultra sensitive detection of diagnostically important molecules by visual examination of the m

Abstract: The present invention provides a novel pharmaceutical composition consisting of a combination of three coumarinolignoids of formula 1, 2 and 3 isolated from the seeds of the plant Cleome viscose along with a pharmaceutically acceptable carrier useful as a immunomodulator. The invention also describes the ability of the compounds to modulate humorral and cell mediated immune response. It further provides a process for the preparation of a novel pharmaceutical composition of the said three coumarinolignoids in an optimized ratio to modulate humorral and cell mediated immune response.

Abstract: The present invention relates to a PPE family antigenic protein Rv2430c of SEQ ID No. 1; a set of three high antigenic index peptides of SEQ ID Nos. 2 to 4; an antigenic ORF Rv2430c of SEQ ID No. 5 and lastly a method of inducing immune response against Mycobacterium tuberculosis in a subject in need thereof, said method comprising step of: introducing PPE antigenic protein Rv2430c of SEQ ID No. 1 into the subject and inducing immune response against Mycobacterium tuberculosis.

Abstract: The present invention relates to a novel oligonucleotide primers having SEQ ID NO: 1, SEQ ID No: 2, SEQ ID NO: 3 and SEQ ID NO: 4 for amplification of the kinesin-related gene of Leishmania species. The invention also provides a method for detecting and differentiating visceral leishmaniasis (VL) and post kala-azar-dermal leishmaniasis (PKDL) causing strains of Leishmania donovani in a sample, comprising isolating DNA from a sample; amplifying the target region from the DNA using novel oligonucleotide primers and heat stable DNA polymerase to obtain amplified fragments; separating the amplified fragments and analyzing the fragments to detect and differentiate VL and PKDL causing strains of Leishmania donovani based on the banding pattern of the amplified fragments. In addition, the invention provides a diagnostic kit for detection and differentiation of VL and PKDL causing strains of the Leishmania donovani.

Abstract: The present invention provides an oligonucleotide primer pair having SEQ ID NO: 3 and SEQ ID NO: 4 for amplification of Early Secretory Antigenic Target (esat)-6-gene of Mycobacterium species. The invention also provides a method for detecting M .tuberculosis in a sample based on the amplification of esat-6 gene, comprising isolating DNA template from the sample, amplifying with the above oligonucleotide primer pair and subjecting the amplified DNA product to separation and staining to detect the presence of amplified DNA product for identifying Mycobacterium tuberculosis in the sample. The invention further provides a diagnostic kit for detection of Mycobacterium tuberculosis.

Abstract: A novel polymer support for solid phase peptide synthesis comprising polystyrene backbone and propoxylate function of hexanedioldiacrylate crosslinks having optimum hydrophilic/hydrophobic balance and a process of preparation thereof.

Abstract: The present invention relates to an adipocyte Insulin adpInsl with Insulin A and B chains of SEQ ID Nos. 1 and 2, a effective method of treating type 2 diabetes in a subject using adipocyte insulin, said method comprising steps of administering the insulin to a diabetic intraperitoneally, an Insulin gene of SEQ ID No. 3, a process of isolating protein Insulin from the adipocytes of the Carp, said method comprising steps of reverse transcripting RNA of adipocytes to obtain cDNA, using oligonucleotide primers of SEQ ID Nos. 5 and 6 to identify AdpInsl gene from cDNA, and deducing amino acid sequence from cDNA to obtain protein Insulin, and an adipocyte of Catla Catla useful for producing the said Insulin.

Abstract: A process for obtaining a substance with growth promoting activity that includes the step of isolating perivitelline fluid from a fertilized egg of a horseshoe crab. Also, a process for proliferating cells including the steps of isolating perivitelline fluid from a fertilized egg of a horseshoe crab and growing the cells in the presence of the isolated perivitelline fluid.

Abstract: A simple easy to manufacture analytical device capable of performing membrane based immunoassays on batch of samples within 3 to 10 minutes wherein the method permits focused application of samples, costly labeled immunoassay and signal amplification reagents, said device includes an antibody-immobilized micro porous membrane, breadth corner layer of which is directly attached to a semi-rigid liquid-impervious body with water insoluble adhesive; absorbent body is provided separately and is not attached to analytical device during manufacture, absorbent body is wetted and is placed proximal to the lower surface of the membrane thereby forming networks of capillary channels with the absorbent body; flow of samples or reagents is always kept downwards and focused without application of any force to the absorbent body and the use of disposable adsorbent body permits stepwise addition of signal amplification reagents for ultra sensitive detection of diagnostically important molecules by visual examination of the m

Abstract: The present invention relates to a process for the cure and control of Diabetes mellitus using natural products isolated from Perna viridis.

Abstract: Oligonucleotide primers for specific amplification of the hupB gene of Mycobacterium species selected from the group consisting of Seq ID No. 1, Seq ID No. 2, Seq ID No. 3, Seq ID No. 4, Seq ID No. 5 and a method for differentiating Mycobacterium species based on target gene encoding for histone like proteins such as hupB comprising of (a) obtaining DNA from culture or from clinical samples, b) amplifying a part of the target gene encoding for histone like proteins such as hupB of Mycobacterium species using DNA as a template in a polymerise chain reaction with a pair of oligonucleotide primers, c) detecting said amplified fragment of the hupB gene to detect the presence of Mycobacterial species or not and differentiating Mycobacterium tuberculosis from Mycobacterium bovis based on the size of the amplified fragment.

Abstract: The present invention relates to process for increased yield of the amino acid arginine from bacterial cultures by employing strains that have been genetically manipulated for both increased arginine biosynthesis and increased level of the Escherichia coli protein YggA or a protein that is substantially similar to Escherichia coli YggA. Two strains of this invention have been deposited at MTCC, Chandigarh. The strains are GJ4894/pHYD952 (MTCC 5127) and GJ4536/pHYD953 (MTCC 5128).

Abstract: The present disclosure relates to methods and compositions for in vitro cultivation of species of Swertia, e.g. Swertia chirata (Ham.). The disclosure provides culture media comprising Murashige and Skoog (MS) basal culture medium, plant hormones preferably selected from the group consisting of benzyladenine (BAP), gibberellic acid (GA3), and auxins, and other additives, e.g. sucrose and agar. Preferably, auxins are selected from the group consisting of indole acetic acid (IAA), indole butyric acid (IBA), and naphthalene acetic acid (NAA). Individual plant hormone concentrations are preferably from about 0.5 mg/L to about 5.0 mg/L.

Abstract: The present invention relates to the use of Indian Green Mussel (Perna viridis) as a source of anti-HIV activity. More particularly, the present invention relates to the use of an extract of Indian Green Mussel (Perna viridis) as a source of anti-HIV activity in vitro.

Abstract: The present invention relates to disinfectant and cleansing compositions for cleaning the skin of humans and for cleaning surface such as floors, and the invention also provides process for the preparation of the said composition.

Abstract: The present invention relates to the development of a novel multiutility vigorously growing robust mint plant ‘Ganga’ of Mentha spicata L. var. viridis producing essential oil exhibiting anti-insect and anti-microbial activities and useful for agrochemical and pharmaceutical purposes.