Abstract: The present invention provides a pharmaceutical composition for treating bacterial infections in patients comprising an effective amount of 3,5-dihydroxy-4-pent-4′-enoyl-1′-oxymethylbenzoic acid (Oenostacin) isolated from Oenothera biennis.
Type:
Grant
Filed:
September 21, 2000
Date of Patent:
April 2, 2002
Assignees:
Council of Scientific and Industrial Research, Department of Biotechnology
Abstract: As per the World Health organization (WHO) requirement, the water for drinking purposes should be 100% virus free. This invention reports a polymer impregnated porous substrate membrane and method for the preparation of said membrane for capturing viruses from water. The water filtered through the membrane prepared by the process of the present invention has been tested to be virus free and fully potable based on the tests carried out at the Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India and Sriram Institute for Industrial Research (an ISO 9001 R&D Organization), New Delhi, India. The invention will be of immense use especially for the developing countries and third world countries which are subjected to the problem of unsafe drinking water. This invention is useful also for the developed countries for use in water treatment plants due to highly industrialized nature and existence of a variety of manufacturing units like chemicals and fertilizers.
Type:
Grant
Filed:
March 30, 1999
Date of Patent:
December 5, 2000
Assignees:
Council of Scientific and Industrial Research and Department of Biotechnology, Government of India
Abstract: A process for the isolation of nontoxinogenic V. cholerae strain and a process for preparing a cholera vaccine from said V. cholerae strain, said process comprising (a) isolating V. cholerae from the stool of a patient suffering from cholera by spreading the stool on a selector medium specific for V. cholerae, (b) separating the non-toxinogenic V. cholerae strain from the population of the V. cholerae strains isolated in step (a), and (c) incorporating immunogenic cholera toxin (ctx) B subunit gene into the chromosome of the strain by conventional methods to produce the vaccine.
Type:
Grant
Filed:
February 3, 1999
Date of Patent:
August 22, 2000
Assignees:
Council of Scientific & Industrial Research, National Institute of Cholera and Enteric Diseases, Department of Biotechnology
Abstract: A universal polymer support containing an organic aliphatic molecule of structure ##STR1## having at least a pair of cis-hydroxyl groups where one of the hydroxyl groups is attached to the polymer support through a covalent linkage and the other hydroxyl group is protected by an acid labile group.
Type:
Grant
Filed:
July 24, 1998
Date of Patent:
July 18, 2000
Assignees:
Council of Scientific & Industrial Research, Department of Biotechnology, Ministry of Science and Technology, Government of India
Abstract: A process for preparing oligoribo- or oligodeoxyribonucleotides comprising treating an alkanediol or alkanetriol of formula I ##STR1## wherein R.sup.1 =H--(CH.sub.2).sub.n --; andR.sup.2 =--CH.sub.2 OH or --(CH.sub.2).sub.n --Hn=1-4;with 4,4'-dimethoxytrityl chloride to generate a monosubstituted tritylated compound of formula II ##STR2## wherein R.sup.3 =H--(CH.sub.2).sub.p --; andR.sup.4 =-CH.sub.2 OH or --(CH.sub.2).sub.p --H;R.sup.5 is 4,4'-dimethoxytrityl and concommitantly R.sup.6 is hydrogen, orR.sup.5 is hydrogen and concommitantly R.sup.6 is 4,4'-dimethoxytrityl;p=1-4;and treating the compound of formula II with one equivalent of a homobifunctional alkanedioic acid halide, and contacting the resulting mixture with a polymer support bearing hydroxyl or aminoalkyl functionalities.
Type:
Grant
Filed:
March 31, 1997
Date of Patent:
August 24, 1999
Assignee:
Council of Sciemtific & Industrial Research and Department of Biotechnology