Abstract: Provided are methods and systems for parallel analysis of a single cell's nucleic acid.

Abstract: The present invention provides a process for the preparation of organic bromides, by a radical bromodecarboxylation of carboxylic acids with a bromoisocyanurate.

Abstract: A new class of pseudo-trisaccharide aminoglycosides having an alkyl group at the 5? position, exhibiting efficient stop codon mutation readthrough activity, low cytotoxicity and high selectivity towards eukaryotic translation systems are provided. Also provided are pharmaceutical compositions containing the same, and uses thereof in the treatment of genetic disorders, as well as processes of preparing these aminoglycosides. The disclosed aminoglycosides can be represented by the general formula I: or a pharmaceutically acceptable salt thereof, wherein R1 is selected from the group consisting of alkyl, cycloalkyl and aryl; and all other variables and features are as described in the specification.

Abstract: A single-exposure ptychography system is presented. The system comprises an optical unit defining an light input plane, an imaging plane, and an object plane between the light input and output planes. The optical unit comprises at least a first focusing assembly, whose front focal plane defines a location of the light input plane; and a diffraction arrangement at a predetermined position with respect to the light input plane. The diffraction arrangement is configured to create from input plane wave light structured light in the form of an array of illuminating beams forming a predetermined illumination pattern in the object plane; thereby providing that each of the illuminating beams creates a different intensity pattern in a known region at the light output plane.

Abstract: A multiple-write enabled flash memory system, comprising: a flash memory comprising at least two planes, wherein each plane comprises multiple blocks, and wherein each block comprises multiple pages; an FTL memory manager configured: to reference one or more clean active blocks on each plane for a first write, wherein the first-write comprises writing one logical page of unmodified data to one physical page, and to reference one or more recycled active block on each plane for a second write, wherein each page of each recycled active block stores data from a previous first-write; and an encoder configured to encode a page of data via a write-once-memory (WOM) code to produce WOM-encoded data, wherein a combination of a target page of each recycled active block is configured to store the WOM-encoded data via a second write.

Abstract: A method includes receiving a signal, which includes reflections of multiple pulses from one or more targets (24). A Doppler focusing function, in which the reflections of the multiple pulses from each target accumulate in-phase to produce a respective peak associated with a respective delay and a respective Doppler frequency of the target, is evaluated based on the received signal. Respective delays and Doppler frequencies of the targets are estimated based on the Doppler focusing function.

Abstract: Cell-targeted serine protease constructs are provided. Such constructs can be used in methods for targeted cell killing such as for treatment cell of proliferative diseases (e.g., cancer). In some aspects, recombinant serine proteases, such as Granzyme B polypeptides, are provided that exhibit improved stability and cell toxicity. Methods and compositions for treating lapatinib or trastuzumab-resistant cancers are also provided.

Abstract: Well-defined, xeno-free culture media which comprise a TGF-beta isoform or the chimera formed between IL6 and the soluble IL6 receptor (IL6RIL6), which are capable of maintaining stem cells, and particularly, human embryonic stem cells, in an undifferentiated state are provided. Also provided are cell cultures comprising the culture media and the stem cells and methods of expanding and deriving embryonic stem cells in such well-defined, xeno-free culture media. In addition, the present invention provides methods of differentiating ESCs or EBs formed therefrom for the generation of lineage specific cells.

Abstract: A method comprising, in a cloud computing system: receiving a new job at the cloud computing system; sampling VMs (Virtual Machines) of the cloud computing system for the load currently handled by each of the VMs; if the load currently handled by the VMs is within operational bounds, sending the new job to one of the VMs which currently handles the highest load compared to other ones of the VMs; and if the load currently handled by the VMs is beyond operational bounds, sending the new job to one of the VMs which currently handles the lowest load compared to other ones of the VMs.

Abstract: Methods and systems that remove impurities from phosphogypsum (PG), including from radium and heavy metal salts, and produce gypsum binders and products. In one embodiment, PG is reacted with a chloride solution in an acidic environment under mechanical manipulation and/or heat followed by galvanic and/or zeolite absorption removal of impurities.

Abstract: A novel method to reduce B-cell lymphoma cell migration to and engraftment of the spleen in patients with JAM-C positive B-cell lymphomas is described. In certain aspects, a method for identifying and treating JAM-C positive B-cell lymphoma patients with anti-JAM-C antibodies is provided. Recombinant antibody molecules that specifically bind to JAM-C are also disclosed.

Abstract: A fluid pumping system may include an electroosmotic pump; and a separation member provided at least one end of the electroosmotic pump, and configured to separate the fluid and a transfer target fluid. The electroosmotic pump may include: a membrane that allows a fluid to move therethrough; and a first electrode and a second electrode which are respectively provided at two opposite sides of the membrane, and each of which is formed of a porous material or has a porous structure to allow a fluid to move therethrough; each of the first electrode and the second electrode may be made of porous carbon only; and an electrochemical reaction of the first electrode and the second electrode may take place as a cation is moved in a direction whereby a charge balance is established.

Abstract: A method for reducing disk read rate by managing dataset mapping of virtual machine (VM) guest memory, comprising: monitoring a plurality of disk read write operations of a VM guest; updating a dataset mapping between disk blocks allocated to the VM guest and corresponding physical addresses of memory pages of the VM guest containing replica of data stored in the disk blocks, based on the plurality of disk read write operations; when identifying writing to one of the memory pages, removing a mapping of corresponding disk block and corresponding physical address of memory page; when reclaiming a mapped memory page of the VM guest by a host of the VM guest, discarding data contained in the memory page; and when the data is requested by the VM guest after it was reclaimed by said host, retrieving the data from corresponding disk block according to the mapping.

Abstract: A fragment of a virulent peptide named phenol-soluble modulin (PSM) having anti-bacterial activity and methods for eliminating bacteria are provided.

Abstract: The present disclosure relates to salts of the compound (I), polymorphic forms thereof, methods for preparation and use thereof, and pharmaceutical compositions thereof.

Abstract: A method of macro placement includes partitioning an entire region of a semiconductor chip into sub-regions; determining a packing sequence of a plurality of movable macros in the sub-region; extracting search points of a plurality of placed blocks in the sub-region with respect to one of the movable macros; determining a feasible region associated with the search point; packing said movable macro in the feasible region; evaluating a legalizing cost function; and determining whether a value of the evaluated legalizing cost function is less than a predetermined threshold value.

Abstract: According to an aspect of some embodiments, an apparatus for isolation and cytometric analysis of cells from a liquid medium is provided. The apparatus comprises a cell reservoir, for receiving a liquid medium containing a suspension of cells. The apparatus further comprises a cell cage array between the cell reservoir and an enclosed reservoir, each cell cage comprising a large opening adjacent to the first cell reservoir, a cell cage, and one or more small opening adjacent to the enclosed reservoir. A connected liquid medium pump may move the suspended cells into cell cages by flowing the liquid medium from the cell reservoir to the enclosed reservoir. The apparatus further comprises a mechanical element which when actuated, pushes the cell cage array against a gel layer, forming a contiguous barrier to isolate each cell in a cell cage, and allowing cytometric analysis of isolated cells.

Abstract: A detection arrangement and method for directing the sensitivity of an optical knife-edge detection system to its optimal operating point. This is referred to as an increase in the detection dynamic range of the system with advantageous applications for detecting motion of a surface such as for Atomic Force Microscopy as well as detecting acoustic vibrations on unstable surfaces. A pair of parallel reflecting surfaces, such as an optical slab waveguide, serve to reflect the sensing beam back onto the knife-edge detector once it is shifted off its sensing range. Allowing multiple reflections, the sensing beam is maintained on the knife-edge detector even at large angular offsets from the optimal operating point of the basic knife-edge detector. Use of a modified arrangement, with two knife-edge detectors at quadrature ensures near-optimal sensitivity at a detection dynamic range up to forty-fold larger than that of the basic knife-edge system.

Abstract: Memory circuitry comprises memory cells having two terminals and a feedback path connected between the two terminals. The feedback path is used to adaptively amplify identical programming pulses that serve to change memory states of the memory cell, and the amplification is based on a current resistive level of the memory cell, which may for example be a multi-level memory cell.

Abstract: A new class of pseudo-trisaccharide aminoglycosides having an alkyl group at the 5? position, exhibiting efficient stop codon mutation readthrough activity, low cytotoxicity and high selectivity towards eukaryotic translation systems are provided. Also provided are pharmaceutical compositions containing the same, and uses thereof in the treatment of genetic disorders, as well as processes of preparing these aminoglycosides. The disclosed aminoglycosides can be represented by the general formula I: or a pharmaceutically acceptable salt thereof, wherein R1 is selected from the group consisting of alkyl, cycloalkyl and aryl; and all other variables and features are as described in the specification.