Patents Assigned to DEVELOPMENT FOUNDATION
  • Methods of determining cellular phenotypes
    Patent number: 10281463
    Abstract: Methods of determining a phenotype of cells in a biological sample are provided. The methods are based measuring a refractive index of said cells based on a diffraction pattern received from a diffraction grating having a plurality of compartments having lateral dimensions such that said cells can fit therein.
    Type: Grant
    Filed: March 9, 2016
    Date of Patent: May 7, 2019
    Assignee: TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED
    Inventors: Ester Segal, Nadav Ben-Dov
  • Pure memristive logic gate
    Patent number: 10284203
    Abstract: According to an embodiment of the invention there is provided a device and method. The device may include a pure memristive logic gate, wherein the pure memristive logic gate consists essentially of at least one input memristive device and an output memristive device that is coupled to and differs from the at least one memristive device; wherein the pure memristive device is controlled by a single control voltage.
    Type: Grant
    Filed: June 14, 2017
    Date of Patent: May 7, 2019
    Assignee: TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD.
    Inventors: Shahar Kvatinsky, Dmitry Belousov, Slavik Liman, Nimrod Wald, Guy Satat
  • Methods of isotachophoresis detection
    Patent number: 10281427
    Abstract: An isotachophoresis (ITP) apparatus, a kit comprising same and method of use thereof for the detection and/or separation of analytes of interest.
    Type: Grant
    Filed: May 28, 2015
    Date of Patent: May 7, 2019
    Assignee: TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED
    Inventors: Moran Bercovici, Merav Karsenty, Tally Rosenfeld
  • POLYHIPES BY INTERFACIAL STEP-GROWTH POLYMERIZATION
    Publication number: 20190127546
    Abstract: A polyHIPE-templated composition-of-matter afforded by interfacial polymerization, comprising a polymer of alternating residues of hydrophobic and hydrophilic monomers. The described composition-of-matter is characterized by an open-, quasi-closed- or a truly closed-cell microstructure, whereas the latter is capable of non-releasably or releasably encapsulating an organic or aqueous composition therein for extended periods of time, as well as various uses thereof.
    Type: Application
    Filed: December 24, 2018
    Publication date: May 2, 2019
    Applicant: Technion Research & Development Foundation Limited
    Inventors: Michael S. SILVERSTEIN, Liraz Avraham
  • SYSTEMS AND METHODS FOR GENERATING VOLUMETRIC MODELS
    Publication number: 20190130642
    Abstract: There is provided a method of design and analysis of a geometric object comprising: receiving an initial definition of the geometric object in a coordinate system; generating a volumetric model according to the initial definition, the volumetric model comprises: volumetric cells each represented by one or more multivariate of three variables or more functions, and intra object general border surfaces in general orientation each defines topological adjacency between at least two of said plurality of volumetric cells.
    Type: Application
    Filed: May 24, 2017
    Publication date: May 2, 2019
    Applicant: Technion Research & Development Foundation Limited
    Inventors: Gershon ELBER, Fady MASSARWI
  • RECOMBINANT FILAGGRIN POLYPEPTIDES FOR CELL IMPORTATION
    Publication number: 20190127430
    Abstract: Disclosed are recombinant polypeptides that include (a) a filaggrin amino acid sequence and (b) a cell importation signal sequence that includes a motif of two to fifteen amino acids, wherein the motif includes at least one arginine residue and at least one methionine residue. Also disclosed are nucleic acids encoding the recombinant polypeptides of the present invention, and compositions that include the recombinant polypeptides and nucleic acids of the present invention. Methods of treating or preventing a skin disease or skin disorder using the compositions of the present invention are also included, as well as kits that include a sealed containing that includes a recombinant polypeptide of the present invention.
    Type: Application
    Filed: January 8, 2019
    Publication date: May 2, 2019
    Applicant: Research Development Foundation
    Inventors: J. Timothy STOUT, Binoy APPUKUTTAN, Trevor McFARLAND
  • CONTROL SYSTEM FOR NANO-SATELLITES
    Publication number: 20190118979
    Abstract: A nanosatellite with an illumination element, and an arrangement of nanosatellites in low earth orbit (LEO) arranged to controllably apply their illumination to be visible on the ground. The nanosatellites may be coordinated to provide illumination events visible on the ground at particular locations and particular times.
    Type: Application
    Filed: December 13, 2018
    Publication date: April 25, 2019
    Applicant: Technion Research & Development Foundation Limited
    Inventors: Oded SHMUELI, Ehud BEHAR
  • SMART GROUND SYSTEM FOR MONITORING OF NANO-SATELLITES
    Publication number: 20190118980
    Abstract: A ground-based satellite control station to control an array of nanosatellites in low earth orbit to produce an illumination event visible at a predetermined ground location. The nanosatellites in the array may have an illumination element, and array of nanosatellites in low earth orbit (LEO) may controllably apply their illumination to be visible on the ground. The nanosatellites may be coordinated by the control station to provide illumination events visible on the ground at particular locations and particular times.
    Type: Application
    Filed: December 13, 2018
    Publication date: April 25, 2019
    Applicant: Technion Research & Development Foundation Limited
    Inventors: Oded SHMUELI, Ehud BEHAR
  • HEPARANASE-NEUTRALIZING MONOCLONAL ANTIBODIES
    Publication number: 20190112391
    Abstract: The present invention relates to heparanase-neutralizing monoclonal antibodies (m Abs), pharmaceutical composition comprising same, and use thereof for treating a disease or disorder associated with heparanase activity, including but not limited to cancer, inflammation, diabetes and related complications. The present invention further provides combined therapies comprising the heparanase-neutralizing m Ab and an anti-cancer treatment such as chemotherapy or radiation, for treating a proliferative disease in a subject.
    Type: Application
    Filed: October 13, 2016
    Publication date: April 18, 2019
    Applicant: Technion Research & Development Foundation Limited
    Inventors: Israel VLODAVSKY, Marina WEISSMANN, Neta ILAN, Gil ARVATZ
  • Methods for treating insulin resistance and for sensitizing patients to GLP1 agonist therapy
    Patent number: 10258639
    Abstract: Methods for treatment of insulin resistance and type II diabetes by administration of inhibitors of the PKI pathway are provided. In some aspects, inhibitors of the PKI pathway, such as inhibitors of PIKB, HIF1 and/or mTOR, can be used to treat subject having insulin resistance who are refractory to GLP1 agonist therapy.
    Type: Grant
    Filed: May 6, 2015
    Date of Patent: April 16, 2019
    Assignee: Research Development Foundation
    Inventors: Marc Montminy, Sam Van De Velde, Emilie Blanchet
  • Field effect transistor device
    Patent number: 10263068
    Abstract: A transistor device is described, the transistor comprising: a channel region in contact with the gate insulator and source and drain electrodes in contact with the channel region and arranged in a spaced-apart relationship. The channel region is configured with discontinuity in a material path of the channel, located between the source and drain electrodes. The channel being formed by a plurality of discrete semiconductor particles, distributed irregularly within the channel region, and a plurality of electrically conducting particles. The electrically conducting particles connect at least some of said semiconducting particles to one another to provide continuous path for electric coupling between said at least some semiconductor particles, forming an electrical path between the source and drain electrodes.
    Type: Grant
    Filed: March 31, 2016
    Date of Patent: April 16, 2019
    Assignee: Technion Research & Development Foundation Limited
    Inventors: Yoav Eichen, Nir Tessler, Pramod Kumar, Yulia Gerchikov
  • LIPOSOMAL FORMULATIONS AND METHODS OF USING SAME IN AGRICULTURE
    Publication number: 20190098895
    Abstract: Provided is a formulation including an agriculturally acceptable carrier and liposomes including a lipid membrane and an intraliposomal aqueous core. The liposome has a diameter in the range of between 100 nm to 300 nm and the lipid membrane includes at least one liposome forming phospholipid. The lipid membrane may include two or more phospholipids. At least one of the two or more phospholipids may be a liposome forming lipid. Further, at least one of the two or more phospholipids may be characterized by one or more of the following features: (a) it has an unsaturated lipid tail; (b) it includes a polar head group; (c) it includes an acidic head group. Further provided are methods of using the formulation for agricultural treatment and kits for preparing and using such formulations.
    Type: Application
    Filed: March 8, 2017
    Publication date: April 4, 2019
    Applicant: TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD.
    Inventors: Avi SCHROEDER, Avishai KARNY
  • INFILTRATING IMMUNE CELL PROPORTIONS PREDICT ANTI-TNF RESPONSE IN COLON BIOPSIES
    Publication number: 20190094223
    Abstract: Provided are methods of predicting responsiveness of a subject having an inflammatory bowel disease (IBD) to a tumor necrosis factor (TNF)-alpha inhibitor, by analyzing a frequency of at least one subpopulation of immune cells in a tissue biopsy of the subject. Also provided are methods of selecting a treatment for a subject and kits for determining responsiveness of the subject to treatment with a TNF-alpha inhibitor.
    Type: Application
    Filed: April 6, 2017
    Publication date: March 28, 2019
    Applicants: Technion Research & Development Foundation Limited, The Board of Trustees of the Leland Stanford Junior University
    Inventors: Shai S. SHEN-ORR, Elina STAROVETSKY, Naama MAIMON, Purvesh KHATRI, Renaud GAUJOUX, Francesco VALLANIA
  • MEDIUM COMPRISING TRANSFORMING GROWTH FACTOR BETA 1 AND BASIC FIBROBLAST GROWTH FACTOR
    Publication number: 20190093078
    Abstract: The present invention is of methods of establishing and propagating human embryonic stem cell lines using feeder cells-free, xeno-free culture systems and stem cells which are capable of being maintained in an undifferentiated, pluripotent and proliferative state in culture which is free of xeno contaminants and feeder cells.
    Type: Application
    Filed: September 3, 2018
    Publication date: March 28, 2019
    Applicant: Technion Research & Development Foundation Limited
    Inventors: Michal AMIT, Joseph ITSKOVITZ-ELDOR
  • Composition and method for treating androgen-dependent disorders
    Patent number: 10240132
    Abstract: Chimeric polypeptides comprising a dihydrotestosterone (DHT) reductase moiety, such as 3 alpha-hydroxysteroid dehydrogenase (3?-HSD), fused to a signal peptide moiety, polynucleotides encoding same, and compositions comprising at least one microorganism cell capable of secreting the chimeric polypeptide, are provided. Further provided are methods and kits for treating, preventing or ameliorating androgen-dependent disorders, including but not limited to androgenic alopecia.
    Type: Grant
    Filed: March 28, 2017
    Date of Patent: March 26, 2019
    Assignee: TECHNION RESEARCH & DEVELOPMENT FOUNDATION LTD.
    Inventors: Roee Amit, Alexey Tomsov, Orna Atar, Liron Abrahami, Yael Annis, Roni Cohen, Alexandra Ereskovsky, Noa Katz, Lior Levy, Maayan Lufton, Tal Ofek, Sagi Sheinkman, Nitzan Shmuel, Inbal Vaknin, Ruth Veksler, Adi Yannai
  • DISINFECTION AND REMOVAL OF NITROGEN SPECIES FROM SALINE AQUACULTURE SYSTEMS
    Publication number: 20190082661
    Abstract: Provided are physico-chemical processes for continuous and simultaneous water disinfection, oxidation of off flavor agents, minimization of trihalomethane (THM) production, reduction of nitrate and nitrite production and oxidation of ammonia so as to remove nitrogen species, in saline (for example, seawater) based aquaculture systems. The aquaculture system may be any handling/storage/transport system, for example, recirculated aquaculture systems (RAS), for fish or other aquaculture species.
    Type: Application
    Filed: March 8, 2017
    Publication date: March 21, 2019
    Applicant: TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED
    Inventors: Ori LAHAV, Raz BEN-ASHER, Youri GENDEL, Liat BIRNHACK
  • CREATING A SYNTHETIC MODEL WITH ORGANIC VERACITY
    Publication number: 20190080510
    Abstract: A method of creating a real time synthetic model tracking a dynamic physical entity, comprising: a) Receiving multiple points extracted from a sequence of 3D information depicting a dynamic physical entity, each point is associated with position and photometric information. b) Identifying, within the multiply of points, a cloud point which includes multiple entity representative points which portray a surface of the dynamic physical entity. c) Generating a points-surface for a synthetic model by creating spatial presentation of the entity representative points through calculation of principal curvatures for each entity representative point according to the respective position information. d) Generating a continuous surface for the synthetic model by texturing ellipsoidal shapes created for each entity representative point according to the respective photometric information.
    Type: Application
    Filed: November 12, 2018
    Publication date: March 14, 2019
    Applicant: Technion Research & Development Foundation Limited
    Inventors: Miriam Reiner, Tatiana Gelfeld
  • Methods and compositions relating to improved lentiviral vectors and their applications
    Patent number: 10226538
    Abstract: The present invention provides HIV-derived lentivectors which are safe, highly efficient, and very potent for expressing transgenes for human gene therapy, especially, in human hematopoietic progenitor cells as well as in all other blood cell derivatives. The lentiviral vectors comprise a self-inactivating configuration for biosafety and promoters such as the EF1? promoter as one example. Additional promoters are also described. The vectors can also comprise additional transcription enhancing elements such as the wood chuck hepatitis virus post-transcriptional regulatory element. These vectors therefore provide useful tools for genetic treatments such as inherited and acquired lympho-hematological disorders, gene-therapies for cancers especially the hematological cancers, as well as for the study of hematopoiesis via lentivector-mediated modification of human HSCs.
    Type: Grant
    Filed: July 31, 2017
    Date of Patent: March 12, 2019
    Assignee: Research Development Foundation
    Inventors: Didier Trono, Patrick Salmon
  • Structured light generation and processing on a mobile device
    Patent number: 10225533
    Abstract: A system comprising: a handheld mobile device comprising: a projector unit configured to project an image; a camera; and a prism configured to reflect the image projected by the projector such that the camera can capture the projected image.
    Type: Grant
    Filed: April 7, 2015
    Date of Patent: March 5, 2019
    Assignee: Technion Research and Development Foundation Limited
    Inventors: Aaron Wetzler, Ron Kimmel
  • NOVEL AMINOGLYCOSIDES AND USES THEREOF IN THE TREATMENT OF GENETIC DISORDERS
    Publication number: 20190060340
    Abstract: A new class of paromomycin-derived aminoglycosides, which exhibit efficient stop-codon mutation suppression activity, low toxicity and high selectivity towards eukaryotic cells are provided. Also provided are chemical and chemo-enzymatic processes of preparing these paromomycin-derived aminoglycosides and intermediates thereof, as well as pharmaceutical compositions containing the same, and uses thereof in the treatment of genetic disorders.
    Type: Application
    Filed: November 14, 2018
    Publication date: February 28, 2019
    Applicant: Technion Research & Development Foundation Limited
    Inventors: Timor Baasov, Tamar Ben-Yosef, Igor Nudelman, Annie Rebibo-Sabbah, Dalia Shallom-Shezifi, Mariana Hainrichson