Patents Assigned to DEVELOPMENT FOUNDATION
  • Transistor structures and methods of fabrication thereof
    Patent number: 8552422
    Abstract: An electronic device is presented, such as a thin film transistor. The device comprises a patterned electrically-conductive layer associated with an active element of the electronic device. The electrically-conductive layer has a pattern defining an array of spaced-apart electrically conductive regions. This technique allows for increasing an electric current through the device.
    Type: Grant
    Filed: November 2, 2012
    Date of Patent: October 8, 2013
    Assignee: Technion Research and Development Foundation Ltd.
    Inventors: Nir Tessler, Moti Margalit, Oded Globerman, Roy Shenhar
  • Methods and compositions relating to improved lentiviral vectors and their applications
    Patent number: 8551773
    Abstract: The present invention provides HIV-derived lentivectors which are safe, highly efficient, and very potent for expressing transgenes for human gene therapy, especially, in human hematopoietic progenitor cells as well as in all other blood cell derivatives. The lentiviral vectors comprise a self-inactivating configuration for biosafety and promoters such as the EF1? promoter as one example. Additional promoters are also described. The vectors can also comprise additional transcription enhancing elements such as the wood chuck hepatitis virus post-transcriptional regulatory element. These vectors therefore provide useful tools for genetic treatments such as inherited and acquired lympho-hematological disorders, gene-therapies for cancers especially the hematological cancers, as well as for the study of hematopoiesis via lentivector-mediated modification of human HSCs.
    Type: Grant
    Filed: September 18, 2012
    Date of Patent: October 8, 2013
    Assignee: Research Development Foundation
    Inventors: Didier Trono, Patrick Salmon
  • MULTIPLE DELIVERY SLING-LOAD SYSTEM AND METHOD
    Publication number: 20130259634
    Abstract: An add-on sling-load system (100, 200, 300, 400, 600) capable of being attached to a host that comprises a load (120, 230) provided with at least two slices arranged in a predetermined configuration and preferably a stack and a controlled coupling mechanism (130, 620) configured to attach and release at least one slice from the arranged configuration. The sling load system is used for multiple deliveries.
    Type: Application
    Filed: December 7, 2011
    Publication date: October 3, 2013
    Applicant: TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD.
    Inventors: Reuben Raz, Aviv Rosen
  • Albumin fibers and fabrics and methods of generating and using same
    Patent number: 8546333
    Abstract: Provided are method of generating a fiber from a globular protein such as albumin. Also provided are albumin fibers and fabrics and methods of using same for bonding a damaged tissue or for ex vivo or in vivo formation of a tissue.
    Type: Grant
    Filed: January 31, 2008
    Date of Patent: October 1, 2013
    Assignee: Technion Research & Development Foundation Limited
    Inventors: Eyal Zussman, David Simhon, Shmuel Chervinsky, Abraham Katzir, Zvi Nevo, Yael Dror
  • Posts in glue layer for group-III nitride LEDs
    Patent number: 8546829
    Abstract: A semiconductor light emitting device and a method for making the semiconductor light emitting device are described. The semiconductor light emitting device includes an epitaxial structure having a first type doped layer, a light emitting layer, and a second type doped layer. The epitaxial structure may further include an undoped layer. A substrate is bonded to at least one surface of the epitaxial structure with an adhesive layer. One or more posts are located in the adhesive layer. The posts may have different widths depending on the location of the posts and/or the posts may only be located under certain portions of the epitaxial structure.
    Type: Grant
    Filed: July 19, 2011
    Date of Patent: October 1, 2013
    Assignees: Phostek, Inc., NCKU Research and Development Foundation
    Inventors: Ray-Hua Horng, Heng Liu, Yi-An Lu
  • METHODS OF GENERATING CORNEAL CELLS AND CELL POPULATIONS COMPRISING SAME
    Publication number: 20130251692
    Abstract: A method of generating a population of corneal epithelial cells is disclosed. The method comprises culturing human pluripotent stem cells in corneal fibroblast-conditioned medium on a solid surface comprising an extracellular matrix component thereby generating the population of corneal epithelial cells. Isolated cell populations and corneal tissues are also disclosed, as well as uses thereof.
    Type: Application
    Filed: December 1, 2011
    Publication date: September 26, 2013
    Applicants: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE, TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED
    Inventors: Joseph Itskovitz-Eldor, Daniel Aberdam, Ruby Shalom-Feuerstein
  • MEDIA FOR CULTURING STEM CELLS
    Publication number: 20130252329
    Abstract: Well-defined, xeno-free culture media which comprise a TGF-beta isoform or the chimera formed between IL6 and the soluble IL6 receptor (IL6RIL6), which are capable of mainataining stem cells, and particularly, human embryonic stem cells, in an undifferentiated state are provided. Also provided are cell cultures comprising the culture media and the stem cells and methods of expanding and deriving embryonic stem cells in such well-defined, xeno-free culture media. In addition, the present invention provides methods of differentiating ESCs or EBs formed therefrom for the generation of lineage specific cells.
    Type: Application
    Filed: June 4, 2013
    Publication date: September 26, 2013
    Applicant: Technion Research & Development Foundation Limited
    Inventors: Michal AMIT, Joseph Itskovitz-Eldor
  • Heterocyclic derivatives, pharmaceutical compositions and methods of use thereof
    Patent number: 8541428
    Abstract: The present invention relates to novel quinoxaline, quinazoline and phthalazine derivatives as well as multimeric derivatives, methods for their preparation, pharmaceutical compositions including such compounds, and methods of using these compounds for the treatment and prevention of brain damage resulting from brain injury, especially secondary brain damage due to traumatic brain injury (TBI). The compounds of the invention are also useful in treating and preventing neurodegenerative diseases.
    Type: Grant
    Filed: August 22, 2006
    Date of Patent: September 24, 2013
    Assignee: Technion Research and Development Foundation Ltd.
    Inventors: Moshe Gavish, Jehuda Arieh Veenman, Alex Shterenberg, Ilan Marek
  • Method of predicting responsiveness to autologous adoptive cell transfer therapy
    Patent number: 8541185
    Abstract: A method of determining responsiveness to cancer treatment is disclosed. The method comprises analyzing a frequency of tumor infiltrating lymphocytes (TILs) having a CD8+CD28?CD152? signature in a sample of the subject, wherein a frequency of TILs having the CD8+CD28?CD152? signature above a predetermined level is indicative of a positive responsiveness to cancer treatment. Other signatures reflecting responsiveness to cancer treatment are also disclosed. In addition, methods of treating cancer based on these signatures are also disclosed.
    Type: Grant
    Filed: September 15, 2008
    Date of Patent: September 24, 2013
    Assignees: Technion Research & Development Foundation Limited, Tel HaShomer Medical Research Infrastructure and Services Ltd.
    Inventors: Kfir Oved, Eran Eden, Martin Akerman, Roy Noy, Michal Besser, Yoram Reiter
  • Methods of generating tendon tissue in vitro from connective tissue progenitor cells
    Patent number: 8541234
    Abstract: Methods of generating and expanding proliferative, multipotent connective tissue progenitor cells from adult stem cells are provided. Also provided are methods of generating functional tendon grafts in vitro and bone, cartilage and connective tissues in vivo using the isolated cell preparation of connective tissue progenitor cells.
    Type: Grant
    Filed: June 19, 2012
    Date of Patent: September 24, 2013
    Assignee: Technion Research & Development Foundation Limited
    Inventors: Joseph Itskovitz-Eldor, Shahar Cohen
  • Method and system for processing an image according to deterministic and stochastic fields
    Patent number: 8537172
    Abstract: A method of assembling an image. The method comprises receiving an image depicting a pattern, identifying a stochastic field and a deterministic field of the pattern, separately increasing resolution of each the stochastic and deterministic fields, and assembling the resolution increased stochastic and deterministic fields to create an additional image of the pattern. The pattern in the additional image having a higher spatial resolution than in the image.
    Type: Grant
    Filed: January 30, 2009
    Date of Patent: September 17, 2013
    Assignee: Technion Research & Development Foundation Limited
    Inventors: Shira Nemirovsky, Moshe Porat
  • FILTRATION MODULE
    Publication number: 20130233799
    Abstract: The present invention provides a filtration module having at least one membrane layer and a spacer layer, wherein the spacer includes: a polymeric matrix; and a biocide physically embedded into or attached to the polymeric matrix. Moreover, the invention provides a method for reducing the concentration of bacteria in water, by contacting water with the filtration module.
    Type: Application
    Filed: February 20, 2013
    Publication date: September 12, 2013
    Applicant: TECHNION RESEARCH & DEVELOPMENT FOUNDATION LTD.
    Inventor: TECHNION RESEARCH & DEVELOPMENT FOUNDATION LTD.
  • Detection Of Chronic Kidney Disease And Disease Progression
    Publication number: 20130236981
    Abstract: The present invention provides a sensor or a system comprising gold nanoparticles coated with specific organic coatings for diagnosing, staging or monitoring chronic kidney disease.
    Type: Application
    Filed: March 11, 2013
    Publication date: September 12, 2013
    Applicant: Technion Research and Development Foundation Ltd.
    Inventors: Hossam Haick, Ophir Marom
  • SCAFFOLD FOR GROWING NEURONAL CELLS AND TISSUE
    Publication number: 20130236503
    Abstract: The present invention provides a composition based on poly-1-lactic acid (PLLA) and polylactic-co-glycolic-acid (PLGA) scaffold on which neuronal tissue can ex-vivo grow. Further, more the invention provides a method for making cellular vasculature networks and a method for treating a neuronal injury in a subject, by implanting the current composition.
    Type: Application
    Filed: February 25, 2013
    Publication date: September 12, 2013
    Applicant: TECHNION RESEARCH & DEVELOPMENT FOUNDATION LTD.
    Inventor: TECHNION RESEARCH & DEVELOPMENT FOUNDATION LTD.
  • AMINOGLYCOSIDES AND USES THEREOF IN TREATING GENETIC DISORDERS
    Publication number: 20130237489
    Abstract: A new class of pseudo-trisaccharide aminoglycosides having an alkyl group at the 5? position, exhibiting efficient stop codon mutation readthrough activity, low cytotoxicity and high selectivity towards eukaryotic translation systems are provided. Also provided are pharmaceutical compositions containing the same, and uses thereof in the treatment of genetic disorders, as well as processes of preparing these aminoglycosides. The disclosed aminoglycosides can be represented by the general formula I: or a pharmaceutically acceptable salt thereof, wherein R1 is selected from the group consisting of alkyl, cycloalkyl and aryl; and all other variables and features are as described in the specification.
    Type: Application
    Filed: November 17, 2011
    Publication date: September 12, 2013
    Applicant: Technion Research & Development Foundation Limited
    Inventors: Timor Baasov, Dana Atia-Glikin, Jeyakumar Kandasamy, Valery Belakhov
  • Memory Diodes
    Publication number: 20130234098
    Abstract: A memory cell (32C), including a first non-insulator (34C) and a second non-insulator (40C), different from the first non-insulator. The second non-insulator forms a junction (46C) with the first non-insulator. The cell further includes a first electrode (48C) which is connected to the first non-insulator and a second electrode (50C) which is connected to the second non-insulator. At least one of the first and second non-insulators is chosen from a group consisting of a solid electrolyte and a mixed ionic electronic conductor and has an ionic transference number less than 1 and greater than or equal to 0.5.
    Type: Application
    Filed: September 18, 2011
    Publication date: September 12, 2013
    Applicant: TECHNION RESEARCH & DEVELOPMENT FOUNDATION LTD.
    Inventor: Avner Rothschild
  • NOVEL METHODS AND CULTURE MEDIA FOR CULTURING PLURIPOTENT STEM CELLS
    Publication number: 20130236961
    Abstract: Provided is an isolated population of human pluripotent stem cells comprising at least 50% human pluripotent stem cells characterized by an OCT4+/TRA1-60?/TRA1-81?/SSEA1+/SSEA4? expression signature, and novel methods of generating and maintaining same in a pluripotent, undifferentiated state a suspension culture devoid of cell clumps. Also provided are novel culture media, cell cultures and methods for culturing pluripotent stem cells in a suspension culture or a two-dimensional culture system while maintaining the cells in a proliferative, pluripotent and undifferentiated state. The novel culture media comprise interleukin 11 (IL11) and Ciliay Neurotrophic Factor (CNTF); bFGF at a concentration of at least 50 ng/ml and an IL6RIL6 chimera; or an animal contaminant-free serum replacement and an IL6RIL6 chimera. Also provided are methods for generating lineage-specific cells from the pluripotent stem cells.
    Type: Application
    Filed: September 7, 2011
    Publication date: September 12, 2013
    Applicant: TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED
    Inventors: Michal Amit, Joseph Itskovitz-Eldor
  • Apparatus and method for finding visible points in a cloud point
    Patent number: 8531457
    Abstract: The subject matter discloses a method of determining whether a point in a computerized image is visible from a viewpoint; said image is represented as a point cloud, the method comprising: performing inversion on a the vicinity of the point thus creating a computerized inversed object, each point in the vicinity of the point is related to a parallel point in the computerized inversed object and obtaining a convex hull of the inversed object; the point is likely to be visible from the viewpoint in case it belongs to the point set composing the convex hull. The method is also useful for shadow casting and for determining the location of an image-capturing device within a volume.
    Type: Grant
    Filed: May 24, 2009
    Date of Patent: September 10, 2013
    Assignee: Technion Research and Development Foundation Ltd.
    Inventors: Sagi Katz, Ayellet Tal
  • Therapeutic agents comprising pro-apoptotic proteins
    Patent number: 8530225
    Abstract: The present invention relates to targeted killing of a cell utilizing a chimeric polypeptide comprising a cell-specific targeting moiety and a signal transduction pathway factor. In a preferred embodiment, the signal transduction pathway factor is an apoptosis-inducing factor, such as granzyme B, granzyme A, or Bax.
    Type: Grant
    Filed: October 25, 2011
    Date of Patent: September 10, 2013
    Assignee: Research Development Foundation
    Inventors: Michael G. Rosenblum, Yuying Liu
  • Automatic remeshing by mapping a 2D grid on 3D genus-G meshes based on topological analysis
    Patent number: 8531456
    Abstract: The present invention provides a novel remeshing approach for genus-g meshes that overcomes distortion problems. The proposed approach is based on continuous mapping of a 2D grid on the 3D meshed model. The criteria of the new mesh can be defined directly on the 2D grid. The remeshing is invariant to the original mesh. Due to topological analysis, the mapping of the 2D grid onto the 3D mesh minimizes distortion and guarantees continuity. The 2D grid, the element shapes and the density (multiresolution) can be changed straightforwardly, thus generating a modular approach.
    Type: Grant
    Filed: April 20, 2006
    Date of Patent: September 10, 2013
    Assignee: Technion Research and Development Foundation Ltd.
    Inventors: Anath Fischer, Dvir Steiner