Patents Assigned to DEVELOPMENT FOUNDATION
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Publication number: 20140119628Abstract: A method of projection domain processing based on a local transform and shrinkage for use in reconstructing digital images from a set of projections, the method including providing a target image of a target object, providing projection data of the target object, producing filtered projection data by applying a sparsifying transform and a shrinkage function to the projection data, followed by an inverse of the sparsifying transform, producing a restored image by applying a reconstruction transform to the filtered projection data, comparing the restored image to the target image, and producing an optimized projection domain shrinkage function by adapting the shrinkage function to minimize differences between the restored image and the target image. Related apparatus and methods are also described.Type: ApplicationFiled: October 23, 2013Publication date: May 1, 2014Applicant: Technion Research & Development Foundation LimitedInventors: Michael ELAD, Joseph Shtok, Michael Zibulevsky
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Patent number: 8710179Abstract: Methods for concentrating microorganisms in a liquid sample or depleting microorganisms therefrom, utilizing polymeric compounds having affinity to microbial cells that are composed of a plurality of positively charged amino acid residues and two or more hydrophobic moieties are disclosed. Also disclosed are devices for concentrating and methods for detection and identification microorganisms in a liquid sample.Type: GrantFiled: December 13, 2007Date of Patent: April 29, 2014Assignee: Technion Research & Development Foundation LimitedInventors: Amram Mor, Shahar Rotem, Yechezkel Kashi, Nili Raz
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Patent number: 8709480Abstract: A method of in-situ adhering including providing pre-gel including phenolic compound and water miscible polymers like carbohydrates, salts of anionic polysaccharide, spreading layer of pre-gel onto a surface, adding solid support, comprising cross linking agents capable of interacting with the polymer, to pre-gel, and allowing pre-gel to cure and adhere onto surface.Type: GrantFiled: November 5, 2008Date of Patent: April 29, 2014Assignee: Technion Research and Development Foundation Ltd.Inventors: Havazelet Bianco-Peled, Ohad Kimhi
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Publication number: 20140113358Abstract: Provided is a method of focusing particles. The method includes: providing a suspension of the particles in a suspending medium; and flowing the suspension along a channel, such that the flowing suspension occupies a certain volume that has at least one cross-sectional dimension smaller than 100 ?m. The suspending medium has such viscoelastic properties, that flowing the suspension in the channel directs at least some of the particles towards a focus region, enclosed in said certain volume.Type: ApplicationFiled: December 23, 2013Publication date: April 24, 2014Applicant: Technion Research & Development Foundation Ltd.Inventors: Alexander Leshansky, Avishay Bransky, Korin Natanel
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Publication number: 20140113927Abstract: Hydrophobic weak base compounds such as hydrophobic weak base chemotherapeutic agents (which are not an anthracycline) for use in the treatment of medical conditions such as proliferative disease or disorder in a subject, in combination with illumination of a region in a body of the subject which is characterized by the presence of proliferating cells, are disclosed. The hydrophobic weak base compound and a wavelength of illumination are selected such that the hydrophobic weak base compound acts as a therapeutically effective photosensitizer when exposed to the illumination.Type: ApplicationFiled: January 2, 2014Publication date: April 24, 2014Applicant: Technion Research & Development Foundation LimitedInventors: Yehuda G. ASSARAF, Yamit Adar Turgeman, Andrzej M. Skladanowski, Arjan W. Griffioen, Henk Verheul, Kristy Gotink, Hubert Van Den Bergh, Patrycja Nowak-Sliwinska
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Patent number: 8693780Abstract: A computerized method of image processing to form a collage within a predetermined outline from a plurality of images, the method comprising: processing each image to assign a saliency measure to each pixel, said processing utilizing a dissimilarity measure which combines an appearance component and a distance component; finding a first patch of said image and comparing with other patches at different distances from said first patch using said dissimilarity measure, thereby to obtain a score; applying to each pixel of said first patch said obtained score; continuing said comparing and scoring with additional patches of said image until each pixel obtains a score; from said scored pixels providing for each image a region of interest, by setting an initial boundary that encloses a predetermined set of highest scored pixels, and propagating a curve around said initial boundary in such a way as to minimize length and maximize included saliency; and combining said regions of interest into said collage by: orderingType: GrantFiled: June 22, 2010Date of Patent: April 8, 2014Assignee: Technion Research & Development Foundation LimitedInventors: Ayellet Tal, Lihi Zelnik-Manor, Stas Goferman
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Publication number: 20140090976Abstract: A radiation conversion device is presented comprising at least one radiation conversion cell. The radiation conversion cell comprises a photo-absorber unit having a predetermined absorption spectrum for absorbing radiation of a certain wavelength range thereby converting the absorbed radiation into charge carriers, and at least partially reflective layer structure configured to be substantially reflective for said certain wavelength range.Type: ApplicationFiled: May 10, 2012Publication date: April 3, 2014Applicant: TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD.Inventors: Avner Rotschild, Hen Dotan, Ofer Kfir, Elad Sharlin
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Patent number: 8685955Abstract: Novel iron chelators exhibiting neuroprotective and good transport properties are useful in iron chelation therapy for treatment of a disease, disorder or condition associated with iron overload and oxidative stress, e.g., a neurodegenerative or cerebrovascular disease or disorder, a neoplastic disease, hemochromatosis, thalassemia, a cardiovascular disease, diabetes, an inflammatory disorder, anthracycline cardiotoxicity, a viral infection, a protozoal infection, a yeast infection, retarding aging, and prevention and/or treatment of skin aging and skin protection against sunlight and/or UV light. The iron chelator function is provided by a 8-hydroxyquinoline, a hydroxypyridinone or a hydroxamate moiety. The neuroprotective function is imparted to the compound, e.g., by a neuroprotective peptide. A combined antiapoptotic and neuroprotective function is provided by a propargyl group.Type: GrantFiled: November 14, 2011Date of Patent: April 1, 2014Assignees: Technion Research and Development Foundation Ltd., Yeda Research and Development Co. Ltd.Inventors: Moussa B. H. Youdim, Matitiyahu Fridkin, Hailin Zheng, Rivka Warshawsky
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Patent number: 8685962Abstract: Articles of manufacturing (such as tobacco products), methods, devices and compositions for preventing or reducing tobacco-associated damage and/or disorders associated with oxidative stress in a subject, and which utilize a TSPO receptor ligand (such as diazepam), are disclosed.Type: GrantFiled: July 2, 2008Date of Patent: April 1, 2014Assignee: Technion Research & Development Foundation LimitedInventors: Moshe Gavish, Rafael M. Nagler
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Publication number: 20140086953Abstract: Novel attenuating deletions of Chikungunya virus E2 polypeptides are provided as are attenuated viruses comprising the deletions. Also provided are immunogenic compositions comprising the attenuated viruses and methods of producing such viruses in cells (such as insect cells). Viruses of the embodiments can be used for immunization of animals to provide protection from the pathogenic effects of Chikungunya virus infection.Type: ApplicationFiled: September 26, 2013Publication date: March 27, 2014Applicant: Research Development FoundationInventors: Dennis T. BROWN, Raquel HERNANDEZ
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Patent number: 8683388Abstract: A method for restricting the number of consequential interactions to further virtual objects having a relationship with a first virtual object, resulting from an interaction with said first virtual object. The method comprises: defining a maximum number of consequential interactions, counting consequential interactions, and stopping further interaction when the maximum number of consequential interactions is reached.Type: GrantFiled: July 8, 2008Date of Patent: March 25, 2014Assignee: Technion Research & Development Foundation LimitedInventors: Gershon Elber, Orit Shaked, Oded Shmueli
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Patent number: 8679493Abstract: Methods and compositions involving polypeptides having an aglycosylated antibody Fc domain. In certain embodiments, polypeptides have an aglycosylated Fc domain that contains one or more substitutions compared to a native Fc domain. Additionally, some embodiments involve an Fc domain that is binds some Fc receptors but not others. For example, polypeptides are provided with an aglycosylated Fe domain that selectively binds Fc?RI at a level within 2-fold of a glycosylated Fc domain, but that is significantly reduced for binding to other Fc receptors. Furthermore, methods and compositions are provided for promoting antibody-dependent cell-mediated toxicity (ADCC) using a polypeptide having a modified aglycosylated Fc domain and a second non-Fc binding domain, which can be an antigen binding region of an antibody or a non-antigen binding region. Some embodiments concern antibodies with such polypeptides, which may have the same or different non-Fc binding domain.Type: GrantFiled: June 30, 2010Date of Patent: March 25, 2014Assignee: Research Development FoundationInventors: George Georgiou, Sang Taek Jung, Sai Reddy
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Patent number: 8672145Abstract: A sorbent polymer is provided that interacts or reacts with aqueous urea to aid the regeneration of a dialysate liquid. The sorbent polymer may include one or more specific functional groups bonded thereto. Such specific functional groups are selected from carboxylic acids, carboxylic acid esters, carboxylates, amides, dicarboxylic acids, dicarboxylic acid esters, and dicer boxylates to produce the desired urea sorbent.Type: GrantFiled: July 29, 2013Date of Patent: March 18, 2014Assignees: Fresenius Medical Care Holdings, Inc., The Technion Research and Development Foundation, Ltd.Inventor: Moris S. Eisen
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Patent number: 8673354Abstract: A composition including pre-gel including at least one phenol-based compound, excluding phloroglucinol and derivatives, at least one water miscible polymer, at least one cross linking agent capable of interacting with the polymer. The polymer is selected from one or more natural and/or synthetic carbohydrate, and salt of an anionic polysaccharide.Type: GrantFiled: November 5, 2008Date of Patent: March 18, 2014Assignee: Technion Research and Development Foundation Ltd.Inventors: Havazelet Bianco-Peled, Ohad Kimhi
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Patent number: 8668897Abstract: The present invention relates to compositions and methods for producing hydrogen from water involving reacting metal particles with water in the presence of an effective amount of activator. In particular the invention pertains to compositions and methods for producing hydrogen upon reaction of metal particles selected from the group consisting of aluminum (Al), magnesium (Mg), boron (B), silicon (Si), iron (Fe), and zinc (Zn) with water, in the presence of an effective amount of an activator catalyst, wherein the activator is selected from the group consisting of: alkali metals, earth alkali metals, hydrides of alkali metals, hydrides of earth alkali metals, hydroxides of alkali metals, and hydroxides of earth alkali metals.Type: GrantFiled: January 5, 2009Date of Patent: March 11, 2014Assignee: Technion Research & Development Foundation LimitedInventors: Valery Rosenband, Alon Gany
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Patent number: 8669512Abstract: A system for measuring one or more characteristics of light of a photon energy Eph from a light source, that can be determined from measuring three-photon absorption events, the system comprising: a) a detector having a band gap material characterized by gap energy between 2.1 and 3 times Eph; b) an optical element configured to concentrate a beam of light from the light source on the detector; c) a signal amplifier that amplifies an output signal indicative of when three photons produced by the light source undergo a three-photon absorption event in the band gap material; and d) an analyzer that analyzes the output signal to count or measure a rate of the three-photon absorption events, and determines the one or more characteristics of the light from the light source.Type: GrantFiled: December 28, 2011Date of Patent: March 11, 2014Assignee: Technion Research & Development Foundation LimitedInventors: Amir Nevet, Alex Hayat, Meir Orenstein
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Patent number: 8669119Abstract: A system for manipulating a fluid medium is disclosed. The system comprises a plurality of particles suspended in the fluid medium, and a light source configured for irradiating the particles by light to induce nonlinear optical effects. The particles are constituted such that the nonlinear optical effects result in drag forces exerted by the particles on the fluid medium. The magnitude of the drag forces is sufficient to establish hydrodynamic flow of the fluid medium.Type: GrantFiled: March 25, 2009Date of Patent: March 11, 2014Assignee: Technion Research & Development Foundation LimitedInventors: Mordechai Segev, Demetrios N. Christodoulides, Carmel Rotschild
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Patent number: 8669092Abstract: A search of the public human genome database identified a human EST, GenBank accession number AW293249, which has high homology to known pufferfish urocortin sequences. The full length sequence was amplified from human genomic DNA and sequenced. Sequence homology comparisons of the novel sequence with human urocortin I and urocortin II revealed that the sequence encoded a novel human urocortin, which was designated urocortin III (UcnIII). While urocortin III does not have high affinity for either CRF-R1 or CRF-R2, the affinity for CRF-R2 is greater than the affinity for CRF-R1. Urocortin III is capable stimulating cyclic AMP production in cells expressing CRF-R2? or ?. Thus, the affinity is high enough that urocortin III could act as a native agonist of CRF-R2. However, it is also likely that urocortin III is a stronger agonist of a yet to be identified receptor.Type: GrantFiled: May 1, 2013Date of Patent: March 11, 2014Assignee: Rsearch Development FoundationInventors: Wylie W. Vale, Jr., Kathy A. Lewis, Marilyn H. Perrin, Koichi Kunitake, Jean E. F. Rivier, Jozsef Gulyas
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Publication number: 20140065402Abstract: The present invention relates to hybrid electrically conducting systems comprising a matrix of a conducting polymer (polyaniline-PANI), and highly conducting carbonaceous nanoparticles, e.g., carbon nanotubes (CNT) or graphenes. The PANI/carbon nano-composites are prepared by a novel process comprising the steps of (a) polymerizing aniline and carbonaceous nanoparticles by inverse emulsion polymerization conducted under sonication, so as to obtain PANI/carbon nano-composites; (b) de-doping the PANI/carbon nano-composites obtained in step (a); (c) re-doping the PANI/carbon nano-composites obtained in step (b); and (d) forming a film from the re-doped PANI/carbon nano-composites. The PANI/carbon nano-composites are used for the preparation of thin, transparent, and conductive films which can be applied to a variety of substrates and used for commercial applications.Type: ApplicationFiled: September 3, 2013Publication date: March 6, 2014Applicant: Technion Research and Development Foundation Ltd.Inventors: Ran Yosef SUCKEVERIENE, Moshe NARKIS
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Publication number: 20140061650Abstract: An electronic device is presented, such as a thin film transistor. The device comprises a patterned electrically-conductive layer associated with an active element of the electronic device. The electrically-conductive layer has a pattern defining an array of spaced-apart electrically conductive regions. This technique allows for increasing an electric current through the device.Type: ApplicationFiled: September 16, 2013Publication date: March 6, 2014Applicant: TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD.Inventors: Nir TESSLER, Moti MARGALIT, Oded GLOBERMAN, Roy SHENHAR