Abstract: A method for treating an individual who has been identified as having Alzheimer's disease by administering orally to the individual a therapeutically effective amount of ladostigil or a pharmaceutically active salt thereof, wherein the therapeutically effective amount is 70 mg per day, 140 mg per day, or 200 mg per day. Also, a unit dosage form of ladostigil or a pharmaceutically active salt thereof in an amount of 50 mg, 70 mg, 80 mg or 100 mg.

Abstract: A method of preparing neural precursor cells by exposing pluripotent stem cells or neural stem cells to a differentiation agent. The agent is a pyridine analog, which in preferred embodiments is a phenylethynyl-substituted or phenylazo-substituted pyridine. In other embodiments, a method of enhancing neural precursor cell survival is provided in which the survival is enhanced by exposure to the pyridine analog. In further embodiments, a method of preparing neuronal cells is provided in which pluripotent or neural stem cells exposed to the pyridine analog are then incubated without the pyridine analog, resulting in differentiation into neurons, astrocytes and oligodendrocytes. These methods may be used in toxicological screens, e.g., to evaluate the neurotoxicity of a test compound.

Abstract: Polymeric foams and elastomer/hydrogel bicontinuous composite structures derived from high internal phase emulsions and possessing shape-memory characteristics are disclosed, as well as processes for forming the same and uses thereof in, for example, manufacturing of various articles.

Abstract: A method for determining an optimal location for positioning an image capturing device within a volume, the method including, obtaining a plurality of points to be visible from the image capturing device, performing inversion on points located in the vicinity of the plurality of points thus creating a computerized inversed object, each point in the vicinity of the plurality of point is translated to a corresponding point in the computerized inversed object, defining a convex hull of the inversed object, determining if a point of the plurality of points is visible from the viewpoint according to the position of its corresponding point on the convex hull relative to its neighbor points, repeating said determining for multiple locations within the volume, determining whether a predetermined set of points is visible from each location, selecting the optimal location of the image capturing device based on the results of said repeated determining.

Abstract: A set of volatile organic compounds is provided, comprising at least butylated hydroxy toluene or 4,6-di (1,1-dimethylethyl)-2-methyl-phenol for breath analysis. Methods of use thereof in diagnosing, monitoring or prognosing lung cancer are also disclosed.

Abstract: A sorbent polymer is provided that interacts or reacts with aqueous urea to aid the regeneration of a dialysate liquid. The sorbent polymer may include one or more specific functional groups bonded thereto. Such specific functional groups are selected from carboxylic acids, carboxylic acid esters, carboxylates, amides, dicarboxylic acids, dicarboxylic acid esters, and dicer boxylates to produce the desired urea sorbent.

Abstract: The present invention concerns gp36 immunoreactive compositions for E. canis and gp 47 immunoreactive compositions for E. chaffeensis. In particular, epitopes for E. canis gp36 and E. chaffeensis gp 47 are disclosed. In certain embodiments, the immunoreactive compositions comprise tandem repeats having carbohydrate moieties.

Abstract: A semiconductor light emitting component including an epitaxial structure, a first electrode, a second electrode, a first cutout structure and a second cutout structure is provided. The epitaxial structure includes a first type doped layer, a light emitting portion and a second type doped layer. The first electrode is formed on a surface of the first type doped layer. The second electrode is formed on a surface of the second type doped layer. The first cutout structure is formed in the first type doped layer to expose at least a portion of the first electrode. The second cutout structure is formed in the first type doped layer, the light emitting portion and the second type doped layer so as to expose at least a portion of the second electrode.

Abstract: The invention provides compositions and methods for ameliorating renal dysfunction induced by renal hypoperfusion or acute kidney injury, resulting for example from increased intra-abdominal pressure, using phosphodiesterase inhibitors, more particularly phosphodiesterase type inhibitors, or pharmaceutically acceptable salts or solvates thereof.

Abstract: A method for forming a plurality of semiconductor light emitting devices includes forming an epitaxial layer having a first type doped layer, a light emitting layer, and a second type doped layer on a first temporary substrate. The epitaxial layer is separated into a plurality of epitaxial structures on the first temporary substrate. A second temporary substrate is coupled to the epitaxial layer with a first adhesive layer and the first temporary substrate is removed from the epitaxial layer. A permanent semiconductor substrate is coupled to the epitaxial layer with a second adhesive layer. The second temporary substrate and the first adhesive layer are removed from the epitaxial layer. The permanent semiconductor substrate is separated into a plurality of portions with each portion corresponding to at least one of the plurality of epitaxial structures to form a plurality of semiconductor light emitting devices.

Abstract: A non transitory computer readable medium and a method of detecting excavation of an underground tunnel, the method includes: propagating a light pulse through an underground optic fiber; generating detection signals responsive to Brillion scattered light resulting from the propagating of the light pulse through the underground optic fiber; wherein the detection signals represent tension values at multiple locations along the underground optic fiber; and processing the detection signals to detect excavation of the underground tunnel.

Abstract: In a data storage and retrieval system wherein data arranged in nodes is stored and retrieved in pages, each page comprising a cluster of nodes, a method comprising: monitoring ongoing data retrieval to find retrieval patterns of nodes which are retrieved together and to identify changes in said retrieval patterns over time; and periodically reclustering the data nodes among said pages dynamically during usage of the data to reflect said changes, so that nodes more often retrieved together are migrated to cluster together and nodes more often required separately are migrated to cluster separately, thereby to keep small an overall number of page accesses of said data storage and retrieval system during data retrieval despite dynamic changes in patterns of data retrieval.

Abstract: A method and apparatus for resolving conjunctive queries, comprising relational predicates and external predicates, such as XML predicates. The method and apparatus obtain results from a relational engine or from an external engine, and then use the obtained results as input for the other engine, so as to optimize the activity of the other engine. The process may repeat further times, with the results obtained by the other engine being input to the first engine. The method and apparatus further disclose handling value, being isomorphic hierarchical sub-trees.

Abstract: A floorplanning method for an analog integrated circuit layout is disclosed. A first-type block is defined as a movable and deformable block with rectangle constraint, and a second-type block is defined as a fixed-size block without rectangle constraint. Each block in the floorplan is classified to the first-type or the second-type block. In a shape determination stage, a target shape is determined among candidates of the first-type block, the first-type block accordingly being modified to the target shape, resulting in at least one overlap in the floorplan. In an overlap elimination stage, neighboring blocks of each said overlap are analyzed, the overlap being then eliminated by utilizing surrounding space, resulting in unused space in the floorplan. In an enlargement stage, the unused space is utilized for enlarging the first-type block.

Abstract: Disclosed are methods for controlling molecular interactions where at least one member of a pair of chemical entities having a pH-dependent affinity is immobilized on the surface of an electrode. By changing the potential difference between the electrode and a counter electrode, the affinity of the pair of chemical entities is changed, changing the tendency of the pair to bind or to dissociate. Disclosed are also devices useful for implementing the methods of the present invention.

Abstract: A method of stimulating neurons present in a living body is disclosed. The method comprises directing light to an artificial light absorbing medium implanted extracellularly at a target location having the neurons therein, wherein wavelengths and intensities of the light are selected so as to heat the light absorbing medium by light absorption. The heating is sufficient to stimulate neurons nearby the light absorbing medium. In some embodiments, the light is spatially modulating so as to encode a stimulation pattern therein.

Abstract: The present invention is of methods of establishing and propagating human embryonic stem cell lines using feeder cells-free, xeno-free culture systems and stem cells which are capable of being maintained in an undifferentiated, pluripotent and proliferative state in culture which is free of xeno contaminants and feeder cells.

Abstract: A system for stabilizing a single-track vehicle including a front assembly and a rear assembly, said system comprising a robust controller including an inner loop which closes on a roll angular rate {dot over (?)} of said rear assembly and reduces parametric uncertainty associated with said vehicle, and an outer loop which closes on a roll angle ? of said rear assembly, and wherein the robust controller outputs a steering torque signal for controlling a steering angle in said front assembly; a roll angle sensor for measuring the roll angle in the rear assembly; a roll rate gyro for measuring the roll angular rate in the rear assembly; and a motor for applying the steering angle to said front assembly responsive to the steering torque signal.

Abstract: The present invention introduces a new technique allowing the fabrication of high-aspect ratio nanoscale semiconductor structures and local device modifications using FIB technology. The unwanted semiconductor sputtering in the beam tail region prevented by a thin slow-sputter-rate layer which responds much slower and mostly to the high-intensity ion beam center, thus acting as a saturated absorber funnel-like mask for the semiconductor. The protective layer can be deposited locally using FIB, thus enabling this technique for local device modifications, which is impossible using existing technology. Furthermore, such protective layers allow much higher resolution and nanoscale milling can be achieved with very high aspect ratios, e.g. Ti layer results in aspect ratio higher than 10 versus bare semiconductor milling ratio of about 3.

Abstract: Provided are method of generating a fiber from a globular protein such as albumin. Also provided are albumin fibers and fabrics and methods of using same for bonding a damaged tissue or for ex vivo or in vivo formation of a tissue.