Abstract: A device for ex situ magnetic resonance analysis is disclosed. The device comprises a static magnetic field unit (12) for generating a generally cylindrically symmetric static magnetic field outside the static magnetic field unit, and a radiofrequency unit (14) for generating a generally cylindrically symmetric radiofrequency field outside the radiofrequency unit. The radiofrequency field is perpendicular to the static magnetic field. A spatial inhomogeneity of the magnetic field substantially matches a spatial inhomogeneity of the radiofrequency field.

Abstract: A method of resistor matching in analog integrated circuit layout is disclosed. Shapes of mismatching resistor blocks are analyzed to obtain geometrical information for deforming the mismatching resistor blocks. The mismatching resistor blocks are deformed into centrosymmetrical blocks according to the obtained geometrical information, each mismatching resistor block being decomposed to a plurality of unit-resistors. The unit-resistors are placed into matching resistor blocks to return a resulting layout with improved matching quality by reducing centroid offset between a centroid of the unit-resistors and a centroid of the matching resistor block.

Abstract: Methods and devices for detecting and collection analytes fractionated based on pI, separating analytes via electrophoresis and pI, and purifying a target molecule using pI focusing and subsequent crystallization are provided.

Abstract: The present invention provides methods of identifying a genetic abnormality such as mutation in EGFR or KRAS or ALK which is associated with the management of lung cancer or diagnosing, prognosing or monitoring the treatment of pre-cancerous conditions of the lung, such as bronchial dysplasia or atypical alveolar hyperplasia (AAH), through the detection of at least one volatile organic compound indicative of these states.

Abstract: Provided are methods for treating diabetes comprising administering to a patient a GLP-1 agonist and an iron chelator. In various embodiments, methods are provided for culturing pancreatic beta islet cells comprising contacting the beta cells with a GLP-1 agonist and an iron chelator in an amount effective to promote survival of the beta cells.

Abstract: An optical flow estimation process based on a spatio-temporal model with varying coefficients multiplying a set of basis functions at each pixel. The benefit of over-parameterization becomes evident in the smoothness term, which instead of directly penalizing for changes in the optic flow, accumulates a cost of deviating from the assumed optic flow model. The optical flow field is represented by a general space-time model comprising a selected set of basis functions. The optical flow parameters are computed at each pixel in terms of coefficients of the basis functions. The model is thus highly over-parameterized, and regularization is applied at the level of the coefficients, rather than the model itself. As a result, the actual optical flow in the group of images is represented more accurately than in methods that are known in the art.

Abstract: A method of assaying a solid or liquid material, the method comprising: illuminating a sample of the material with pulses of light at a plurality of different wavelengths at which atoms and/or molecules in the material are ionized in multiphoton ionization (MPI) process; generating a value responsive to charge produced in the ionization process for each wavelength to provide an MPI spectrum for the material; and processing the MPI spectrum to assay an atom or molecule in the material.

Abstract: A clock and data recovery (CDR) architecture which includes a frequency detector, a phase detector, a phase charge pump circuit, a frequency charge pump circuit and a voltage controlled oscillator is provided. The phase detector is configured to only include four AND gates to receive and evaluate the intermediate signals, generated by the frequency detector, and accordingly generate a phase control signal. The voltage controlled oscillator is configured to output a plurality of clock signals with different phases according to the current signals outputted from the phase and frequency charge pump circuits, and select at least one of the plurality of clock signals with different phases for sampling a data signal.

Abstract: A method for signal processing includes distributing an analog input signal to a plurality of processing channels. In each processing channel, the input signal is mixed with a respective periodic waveform including multiple spectral lines, so as to produce a respective baseband signal in which multiple spectral slices of the input signal are superimposed on one another. The baseband signal produced in each of the processing channels is digitized, to produce a set of digital sample sequences that represent the input signal.

Abstract: An immuno-molecule which comprises a soluble human MHC class I effector domain; and an antibody targeting domain which is linked to the soluble human MHC class I effector domain, methods of making same and uses thereof.

Abstract: A method for generating induced pluripotent stem (iPS) cells from isolated hair follicles is disclosed. The method comprises: a. culturing isolated hair follicle keratinocytes on a layer of feeder cells, so as to generate colonies of hair follicle keratinocytes; b. detaching the colonies of hair follicle keratinocytes from the feeder cells so as to generate detached keratinocytes; c. infecting the detached keratinocytes with a virus comprising a nucleic acid molecule encoding at least one dedifferentiation factor so as to generated infected keratinocytes; and d. culturing the infected keratinocytes on a layer of feeder cells in a culture medium until iPS cells are formed, thereby generating iPS cells. Populations and uses of the iPS cells are also disclosed.

Abstract: A search of the public human genome database identified a human EST, GenBank accession number AW293249, which has high homology to known pufferfish urocortin sequences. The full length sequence was amplified from human genomic DNA and sequenced. Sequence homology comparisons of the novel sequence with human urocortin I and urocortin II revealed that the sequence encoded a novel human urocortin, which was designated urocortin III (UcnIII). While urocortin III does not have high affinity for either CRF-R1 or CRF-R2, the affinity for CRF-R2 is greater than the affinity for CRF-R1. Urocortin III is capable stimulating cyclic AMP production in cells expressing CRF-R2? or ?. Thus, the affinity is high enough that urocortin III could act as a native agonist of CRF-R2. However, it is also likely that urocortin III is a stronger agonist of a yet to be identified receptor.

Abstract: A method of applying a nondestructive mechanical force on one or more cells in aqueous environment by inducing heat generated acoustic pressure pulses. The method comprises providing an energy transmission pattern to induce the applying of a desired nondestructive mechanical force on a at least one cell by forming a plurality of heat generated acoustic pressure pulses in an aqueous environment and instructing the radiation of a target area in proximity to the at least one cell in the aqueous environment with light energy according to the energy transmission pattern.

Abstract: Provided are isolated complexes comprising a major histocompatibility complex (MHC) class II and a type I diabetes-associated GAD autoantigenic peptide, the isolated complex having a structural conformation which enables isolation of a high affinity entity which comprises an antigen binding domain capable of specifically binding to a native conformation of a complex composed of the MHC class II and the type I diabetes-associated GAD autoantigenic peptide; and isolated high affinity entities comprising an antigen binding domain capable of specifically binding the complex, wherein the isolated high affinity entity does not bind to the MHC class II in an absence of the diabetes-associated GAD autoantigenic peptide, wherein the isolated high affinity entity does not bind to the diabetes-associated GAD autoantigenic peptide in an absence of the MHC class II; and methods and kits using same for diagnostic and therapeutic purposes.

Abstract: System and method for converting energy; the system comprising: an acoustic resonator; a phase-exchange device configured for forming across a section of said resonator a concentration gradient of a first substance in a gaseous medium contained by said resonator, to thereby generate a pressure wave within said resonator; and a conversion device for converting mechanical energy constituted by said pressure wave to non-mechanical energy.

Abstract: The present invention provides HIV-derived lentivectors which are safe, highly efficient, and very potent for expressing transgenes for human gene therapy, especially, in human hematopoietic progenitor cells as well as in all other blood cell derivatives. The lentiviral vectors comprise a self-inactivating configuration for biosafety and promoters such as the EF1? promoter as one example. Additional promoters are also described. The vectors can also comprise additional transcription enhancing elements such as the wood chuck hepatitis virus post-transcriptional regulatory element. These vectors therefore provide useful tools for genetic treatments such as inherited and acquired lympho-hematological disorders, gene-therapies for cancers especially the hematological cancers, as well as for the study of hematopoiesis via lentivector-mediated modification of human HSCs.

Abstract: A method for reconstructing a holographic projection including providing a single hologram, providing at least one cyclic shift of at least a portion of the single hologram in the space domain, and reconstructing a cyclically shifted hologram by applying said cyclic shift on said portion and providing at least one cyclic shift comprises computing the cyclic shift; wherein computing at least one cyclic shift includes creating an array of shifting points in a g-h plane of the single hologram and calculating a distance vector from an origin of the plane to the shifting point.

Abstract: Methods and compositions are provided for stimulating insulin production, increasing beta cell mass, or decreasing beta cell loss in a subject. For example, methods of the embodiments can comprise administration of a corticotropin-releasing factor (CRF)1 receptor agonist and a CRF2 receptor agonist. Also provided are pharmaceutical compositions comprising a selective CRF1 receptor agonist and a selective CRF2 receptor agonist.

Abstract: A clock and data recovery (CDR) architecture which includes a frequency detector, a phase detector, a phase charge pump circuit, a frequency charge pump circuit and a voltage controlled oscillator is provided. The phase detector is configured to only include four AND gates to receive and evaluate the intermediate signals, generated by the frequency detector, and accordingly generate a phase control signal. The voltage controlled oscillator is configured to output a plurality of clock signals with different phases according to the current signals outputted from the phase and frequency charge pump circuits, and select at least one of the plurality of clock signals with different phases for sampling a data signal.

Abstract: An isolated primate embryonic cell is provided as well as cell cultures and cell lines derived therefrom. Also provided are methods of generating and using such cells.