Abstract: Multifunctional compounds are provided, comprising two or more functional moieties selected from: (i) a moiety that imparts an iron chelator function; (ii) a moiety that imparts a neuroprotective function; (iii) a moiety that imparts combined antiapoptotic, neuroprotective and/or neurorestorative functions; (iv) a moiety that imparts brain MAO inhibition, preferably with little or no MAO inhibition in liver and small intestine; (v) a moiety that imparts cholinesterase inhibitory function; and (vi) a moiety that imparts an N-methyl-D-aspartic acid receptor (NMDAR) inhibition, and pharmaceutically acceptable salts and optical isomers thereof. The multifunctional compounds are useful in the treatment or prevention of diseases, disorders or conditions that can be prevented and/or treated by iron chelation therapy, and/or neuroprotection and/or neurorestoration, and/or apoptosis inhibition and/or MAO inhibition and/or cholinesterase inhibition and/or NMADR inhibition.
Type:
Application
Filed:
January 31, 2010
Publication date:
February 16, 2012
Applicants:
TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD., YEDA RESEARCH AND DEVELOPMENT CO., LTD.
Inventors:
Moussa B. H. Youdim, Mati Fridkin, Hailin Zheng
Abstract: The present invention relates to methods for detecting, prognosing and staging cancers, in particular cancers of the gastrointestinal tract. The methods of the invention comprise detecting specific protein markers in a tissue of interest, wherein the detected levels thereof may be indicative of pre-cancerous or cancerous tissue, or the stage or prognosis of a cancer. Further provided are methods of treating cancer, and cancer detection kits.
Type:
Application
Filed:
April 27, 2010
Publication date:
February 16, 2012
Applicant:
Technion Research And Development Foundation LTD.
Inventors:
Arie Admon, Eilon Barnea, Ilan Beer, Tamar Ziv
Abstract: An apparatus arranged for examining particles, comprising: a cartridge having at least one microchannel, a viscoelastic fluid flowing in the microchannel, the fluid comprising a suspension of particles, thereby effecting alignment of the particles in at least one-dimensional array parallel to the fluid flow, and an optical magnifying means generating an image of the particles in the microchannel.
Type:
Application
Filed:
October 1, 2009
Publication date:
February 9, 2012
Applicants:
TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD., PIXCELL MEDICAL TECHNOLOGIES LTD.
Abstract: A process for electroplating high adhesion copper layer on a surface of a highly oxidizable metal in an invariable container, and products produced by this process are provided.
Type:
Application
Filed:
February 11, 2010
Publication date:
February 2, 2012
Applicant:
Technion Research & Development Foundation Ltd.
Inventors:
Yair Ein-Eli, Nina Sezin, David Starosvetsky
Abstract: A method of forming an image of a target that comprises illuminating a target with light, maneuvering an optical unit having at least one diffractive element in front of the target through a plurality of positions, capturing, during the maneuvering, a plurality of spectrally encoded frames each from a portion of the light that is scattered from a different of a plurality of overlapping segments along a track traversing an image plane of the target, and combining the plurality of spectrally encoded frames to form a composite multispectral image of at least a portion of said target.
Type:
Application
Filed:
July 27, 2011
Publication date:
February 2, 2012
Applicant:
Technion Research & Development Foundation Ltd.
Abstract: A device of estimating a dose of ionizing radiation absorbed in an intra bone volume. The device comprises a static magnetic field source adapted to generate a substantially static magnetic field in a probing space having a volume of less than 2 cubic millimeter (mm3), the probing space being placed in front of a distal end of static magnetic field source, a micro resonator mounted in adjacent to the distal end, and at least one transmission line which feeds the resonator so as to generate an microwave magnetic field at the probing space and to transmit a signal returned from said microwave magnetic field and indicative of radiation induced paramagnetic defects in said probing space so as to allow a spectrometer to compute a dose of ionizing radiation absorbed in a portion of a bone placed in the probing space according to an analysis of the signal. The static magnetic field source being sized and shaped to maneuver the probing space to overlap with an intra bone volume of the bone.
Type:
Application
Filed:
April 15, 2010
Publication date:
February 2, 2012
Applicant:
Technion Research & Development Foundation Ltd.
Abstract: Articles of manufacturing, methods, devices and compositions for preventing or reducing tobacco-associated damage in a subject, and which utilize a metal ion chelating agent, a copper chelating agent, a penicillamine and/or a structural analog of penicillamine, with and without an additional antioxidant, are disclosed.
Type:
Application
Filed:
September 21, 2011
Publication date:
January 19, 2012
Applicant:
Technion Research & Development Foundation Ltd.
Abstract: Propargylamine, propargylamine derivatives including N-propargyl-1-aminoindan, enantiomers and analogs thereof, and pharmaceutically acceptable salts thereof, are useful for prevention or treatment of cardiovascular disorders, diseases and conditions.
Type:
Grant
Filed:
June 9, 2006
Date of Patent:
January 17, 2012
Assignees:
Technion Research and Development Foundation Ltd., Rappaport Family Institute
Inventors:
Moussa B. H. Youdim, Ofer Binah, Zaid A. Abassi, Yaron Barac
Abstract: A complementary logic circuit contains a first logic input, a second logic input, a first dedicated logic terminal, a second dedicated logic terminal, a high-voltage terminal configured for connection to a high constant voltage a low-voltage terminal configured for connection to a low constant voltage, a p-type transistor, and an n-type transistor. The p-type transistor has an outer diffusion connection, a gate connection, an inner diffusion connection, and a bulk connection. The n-type transistor has an outer diffusion connection, a gate connection, an inner diffusion connection, and a bulk connection.
Type:
Application
Filed:
July 7, 2011
Publication date:
January 5, 2012
Applicant:
Technion Research & Development Foundation Ltd.
Abstract: Methods and compositions concerning mutant flaviviruses with host-range phenotypes are provided. Nucleotide sequences that encode mutant flavivirus proteins are also provided. In certain aspects, viruses comprising these sequences display reduced replication in mammalian cells. In further aspects of the invention, flavivirus vaccine compositions and methods for vaccination against flavivirus infection are provided.
Abstract: An immuno-molecule which comprises a soluble human MHC class I effector domain; and an antibody targeting domain which is linked to the soluble human MHC class I effector domain, methods of making same and uses thereof.
Type:
Application
Filed:
September 19, 2011
Publication date:
January 5, 2012
Applicants:
Teva Pharmaceutical Industries Ltd., Technion Research & Development Foundation Ltd.
Abstract: A CMOS integrated circuit for multi-channel neuronal recording with twelve true-differential channels, band separation and digital offset calibration. The recorded signal is separated into 2 bands: a low-frequency, local field potential (LFP); and high-frequency spike data. Digitally programmable gains for the LFP and spike bands are provided. A mixed-signal front-end processor for multi-channel neuronal recording is also described. It receives twelve differential-input channels of implanted recording electrodes. A programmable cutoff HPF blocks DC and low frequency input drift at about 1 Hz. The signals are band-split at about 200 Hz to low-frequency local field potential (LFP) and high-frequency spike data (SPK), which is band limited by a programmable-cutoff LPF. The analog signals are converted into digital form, and streamed out over a serial digital bus at up to 8 Mbps.
Type:
Grant
Filed:
July 6, 2005
Date of Patent:
January 3, 2012
Assignee:
Technion Research and Development Foundation, Ltd.
Abstract: A search of the public human genome database identified a human EST, GenBank accession number AW293249, which has high homology to known pufferfish urocortin sequences. The full length sequence was amplified from human genomic DNA and sequenced. Sequence homology comparisons of the novel sequence with human urocortin I and urocortin II revealed that the sequence encoded a novel human urocortin, which was designated urocortin III (UcnIII). While urocortin III does not have high affinity for either CRF-R1 or CRF-R2, the affinity for CRF-R2 is greater than the affinity for CRF-R1. Urocortin III is capable stimulating cyclic AMP production in cells expressing CRF-R2? or ?. Thus, the affinity is high enough that urocortin III could act as a native agonist of CRF-R2. However, it is also likely that urocortin III is a stronger agonist of a yet to be identified receptor.
Type:
Grant
Filed:
November 6, 2008
Date of Patent:
December 27, 2011
Assignee:
Research Development Foundation
Inventors:
Wylie W. Vale, Jr., Kathy A. Lewis, Marilyn H. Perrin, Koichi S. Kunitake, Jean E. Rivier, Jozsef Gulyas
Abstract: A method for increasing intestinal function is provided. The method comprising orally and/or enterally administering to a subject in need thereof a therapeutically effective amount of insulin, thereby increasing intestinal function.
Type:
Application
Filed:
August 19, 2011
Publication date:
December 15, 2011
Applicant:
TECHNION RESEARCH & DEVELOPMENT FOUNDATION LTD.
Inventors:
Igor Sukhotnik, Naim Shehadeh, Raanan Shamir
Abstract: A composition-of-matter comprising an antibody or antibody fragment including an antigen-binding region capable of specifically binding an antigen-presenting portion of a complex composed of a human antigen-presenting molecule and an antigen derived from a pathogen is disclosed.
Type:
Application
Filed:
November 19, 2009
Publication date:
December 1, 2011
Applicant:
Technion Research & Development Foundation Ltd.
Abstract: The invention provides novel saponin mixtures and compounds which are isolated from the species Acacia victoriae and methods for their use. These compounds may contain a triterpene moiety, such as acacic or oleanolic acid, to which oligosaccharides and monoterpenoid moieties are attached. The mixtures and compounds have properties related to the regulation of apoptosis and cytotoxicity of cells and exhibit potent anti-tumor effects against a variety of tumor cells.
Type:
Application
Filed:
June 14, 2011
Publication date:
December 1, 2011
Applicant:
RESEARCH DEVELOPMENT FOUNDATION
Inventors:
Charles J. Arntzen, Mary E. Blake, Jordan U. Gutterman, Joseph J. Hoffmann, Gamini S. Jayatilake, David T. Bailey
Abstract: A macroporous hydrogel sponge is provided selected from: (i) a synthetic polymer hydrogel sponge, and (ii) a synthetic polymer-polypeptide conjugate hydrogel sponge, the macroporous hydrogel sponge being at least 20% porous and having a pore diameter of 50-1000 ?m, wherein said synthetic polymer is crosslinked to an extent determined by effecting the crosslinkig of the synthetic polymer or synthetic polymer-polypeptide conjugate in the presence of at least about 30% by weight crosslinking agent.
Type:
Application
Filed:
December 6, 2009
Publication date:
December 1, 2011
Applicant:
TECHION RESEARCH AND DEVELOPMENT FOUNDATION LTD.
Abstract: A method for signal processing includes distributing an analog input signal to a plurality of processing channels. In each processing channel, the input signal is mixed with a respective periodic waveform including multiple spectral lines, so as to produce a respective baseband signal in which multiple spectral slices of the input signal are superimposed on one another. The baseband signal produced in each of the processing channels is digitized, to produce a set of digital sample sequences that represent the input signal.
Type:
Application
Filed:
February 15, 2010
Publication date:
December 1, 2011
Applicant:
TECHNION RESEARCH & DEVELOPMENT FOUNDATION LTD.
Abstract: ESR imaging probe, system, and method are described. The probe is an ex-situ probe, the system comprises the probe and configured for operating the probe, and the method comprises detecting ESR from outside a resonator of the probe. An exemplary embodiment of a probe according to the invention comprises a cooled dielectric resonator, and one sided gradient coils. An exemplary embodiment of the system comprises source current that is configured to supply to the gradient coils currents of up to 100 A in pulses shorter than 1 ?sec.
Type:
Grant
Filed:
June 14, 2007
Date of Patent:
November 29, 2011
Assignee:
Technion Research & Development Foundation Ltd.
Abstract: Methods and compositions for the screening and isolation of ligand-binding polypeptides, such as antibodies. In some aspects, methods of the invention enable the isolation of intact soluble antibodies comprising a constant domain. Screening methods that employ genetic packages such as bacteria and bacteriophages enable high through-put identification of ligand binding molecules.