Abstract: The present invention provides a method of fabricating a device having hollow nanoneedles which extend through a supporting membrane. The device can be used as a molecular delivery system.

Abstract: A system for measuring one or more characteristics of light of a photon energy Eph from a light source, that can be determined from measuring three-photon absorption events, the system comprising: a) a detector having a band gap material characterized by gap energy between 2.1 and 3 times Eph; b) an optical element configured to concentrate a beam of light from the light source on the detector; c) a signal amplifier that amplifies an output signal indicative of when three photons produced by the light source undergo a three-photon absorption event in the band gap material; and d) an analyzer that analyzes the output signal to count or measure a rate of the three-photon absorption events, and determines the one or more characteristics of the light from the light source.

Abstract: Compositions comprising liposomes composed of whole cell membrane fraction are provided. The liposomes may be attached to, or encapsulate a pharmaceutical agent. Also provided are methods of generating and using these lipospmes.

Abstract: Methods and compositions suitable for modulating angiogenesis in a mammalian tissue are provided. Further provided are methods suitable for inhibiting metastasis and fibrosis in a mammalian tissue and for assessing the malignancy of colon cancer tumors.

Abstract: A method of generating cells predominantly displaying at least one characteristic associated with a cardiac phenotype is disclosed. The method comprises (a) partially dispersing a confluent cultured population of human stem cells, thereby generating a cell population including cell aggregates; (b) subjecting the cell aggregates to culturing conditions suitable for generating embryoid bodies; (c) subjecting the embryoid bodies to culturing conditions suitable for inducing cardiac lineage differentiation in at least a portion of the cells of the embryoid bodies, the culturing conditions suitable for inducing cardiac lineage differentiation including adherence of the embryoid bodies to a surface, and culture, medium supplemented with serum, thereby generating cells predominantly displaying at least one characteristic associated with a cardiac phenotype.

Abstract: Provided are methods of isolating pericyte progenitor cells from pluripotent stem cells such as embryonic stem cells and induced pluripotent stem cells, by isolating CD105+, CD73+ and/or CD105+/CD73+ cells from embryoid bodies and optionally by enriching the cells with CD31? cells. Also provided are methods of isolating endothelial cells and co-derivation of pericyte and endothelial cells progenitor cells from embryoid bodies, and methods of differentiating same for various therapeutic applications. In addition, the invention provides an isolated pericyte progenitor cell having an expression marker signature of CD105+/CD73+CD31?/alpha SMA?/CD133?/Flk-1?.

Abstract: A method of separating a mixture of a plurality of molecular analytes having different isoelectric points (pIs). The method comprises placing a solution containing a mixture of a plurality of molecular analytes in a separation volume, generating a pH profile having a plurality of pH zones across an axis of the separation volume, and adjusting a profile of the pH profile to induce a migration of a first molecular analyte along the axis apart from a second molecular analyte. The first and second molecular analytes having different pIs.

Abstract: Cripto, a developmental oncoprotein, antagonizes activin and TGF-b signaling by forming a complex with activin and TGF-b and their type II receptors. This complex precludes the formation of a functional activin/TGF-b•type II•type I complex, thereby blocking the signaling of activin and TGF-b. Cripto may be generally capable of blocking antiproliferative Smad2/3 signals and provides a novel mechanism of oncogenic action with multiple therapeutic implications. Inhibiting the formation of Cripto and activin/TGF-b complex may enhance antiproliferative effects of activin and TGF-b.

Abstract: A device for isoelectric focusing. The device comprises a focusing container configured to contain an electrolyte solution and having a longitudinal axis and at least one electrolysis unit mounted in a close proximity to the longitudinal axis. Each electrolysis unit injects an ion flow into the focusing container so as to create a pH gradient having a plurality of steps in the electrolyte solution, along the longitudinal axis. Each step has a substantially uniform pH level and the pH gradient is defined by at least one pH ramp between every two sequential steps of the plurality of steps.

Abstract: Disclosed is a novel family of macrocyclic compounds, coined calixurenes, which comprises linear and cyclic oligomers composed of alternating moieties of an aromatic unit and a ureatic unit, linked to one another via a bridging moiety. The disclosed calixurenes feature multiple heteroatom-containing groups, and can be designed so as to feature other functionalities, and can thus be used in a variety of applications. Further disclosed are processes of preparing the calixurenes, articles containing same and uses thereof.

Abstract: A complementary logic circuit contains a first logic input, a second logic input, a first dedicated logic terminal, a second dedicated logic terminal, a high-voltage terminal configured for connection to a high constant voltage a low-voltage terminal configured for connection to a low constant voltage, a p-type transistor, and an n-type transistor. The p-type transistor has an outer diffusion connection, a gate connection, an inner diffusion connection, and a bulk connection. The n-type transistor has an outer diffusion connection, a gate connection, an inner diffusion connection, and a bulk connection.

Abstract: The present invention relates to a hierarchical system and method for task assignment (TA), coordination and communication of multiple Unmanned Aerial Vehicles (DAV's) engaging multiple attack targets and conceives an ad-hoc routing algorithm for synchronization of target lists utilizing a distributed computing topology. Assuming limited communication bandwidth and range, coordination of UAV motion is achieved by implementing a simple behavioral flocking algorithm utilizing a tree topology for target list routing. The TA algorithm is based on a graph-theoretic approach, in which a node locates all the detectable targets, identifies them and computes its distance to each target. The node then produces an attack plan that minimizes the sum of distances of the UAV's in the subtree of a given node to the targets.

Abstract: A source driving circuit adapted to drive a display panel is provided herein. The source driving circuit includes a first output buffer and a second output buffer responsible for enhancing signals with different polarities respectively. As for the first output buffer, the first output buffer includes a first differential input stage, a first output stage and a second output stage. The first output stage includes a first level adjustment circuit and a first self-bias providing circuit. The first level adjustment circuit provides a first level voltage according to input signals received by the first differential input stage, such that the second output stage thereby provides a first charge current and a second charge current to output a first output signal based on the first level voltage. The first self-bias providing circuit provides a first biased voltage associated with one input signal to control the first level adjustment circuit to operate.

Abstract: A computerized method of mapping a plurality of model fragments covering a selected object. The method comprises receiving a representation of an object, generating a parameterized data model of the object according to said representation, the parameterized data model having a plurality of elements, setting a plurality of model fragments each cover a portion of the parameterized data model, applying, using a processor, a set cover algorithm to identify a subgroup of the plurality of model fragments so that a union of a plurality of members of the subgroup covers said parameterized data model, and outputting the subgroup.

Abstract: A process for producing hydrogen from natural gas, said process comprises the steps of: (i) providing an autothermal heat exchanger packed-bed membrane reformer (APBMR) comprising: (a) an elongated external gas oxidation compartment comprising an inlet, an outlet and packed oxidation catalyst particles, said inlet and outlet being located each at one extremity of said external gas oxidation compartment; (b) an elongated internal gas steam-reforming compartment comprising an inlet, an outlet and packed steam-reforming catalyst particles, said inlet and outlet being located each at one extremity of said internal gas steam-reforming compartment; (c) one or more hydrogen-separating membrane(s) positioned in said steam-reforming compartment substantially parallel to the longitudinal axis of said steam-reforming compartment; (d) one insulation layer surrounding said external compartment; and, optionally, (e) one or more elongated internal gas oxidation compartment(s) positioned in said steamreforming compartment su

Abstract: A complementary logic circuit, comprising: a first and second logic input; a first and second dedicated logic terminal; a p-type transistor network comprising multiple p-type transistors, for implementing a predetermined logic function, and having an outer diffusion connection connected to the first dedicated logic terminal, a first network gate connection connected to the first logic input, and an inner diffusion connection; and an n-type transistor network comprising multiple n-type transistors, for implementing a logic function complementary to the predetermined logic function, and having an outer diffusion connection connected to the second dedicated logic terminal, a first network gate connection connected to the second logic input, and an inner diffusion connection; the inner diffusion connections of the p-type transistor network and of the n-type transistor network being connected to form a common diffusion logic terminal.

Abstract: A method for producing a Barium Titanate layer, the method includes: receiving or preparing an aqueous solution that comprises water and Barium Titanate; wherein the aqueous solution is characterized by a high positive zeta potential, low conductivity and a high pH value; electrophoretically depositing Barium Titanate from the aqueous solution on a base metal cathode while substantially preventing oxidation of the base metal cathode; drying the deposited Barium Titanate; and sintering the deposited Barium Titanate while substantially preventing the oxidation of the base metal cathode.

Abstract: A method for error detection includes storing in an associative memory (24, 50, 70) multiple data entries (30), each data entry including a data item (28) together with one or more check symbols (40) computed with respect to the data item. A predetermined sequence of search keys (32) is applied to the memory, thereby causing the memory to generate, in parallel, match results with respect to the data entries. The match results are processed in order to identify an error in at least one of the data entries.

Abstract: Methods are disclosed for predicting a patient response to anti-Her2 therapy or anti-aromatase therapy. In certain embodiments, the methods involve the identification of low molecular weight cyclin E (LMW-E) in cancers, such as breast cancer cells, as a predictive and prognostic marker. In further embodiments, LMW-E expression by a cancerous or pre-cancerous cell may be used to predict response to an aromatase inhibitor and/or CDK2 inhibitor, and determination of LMW-E expression may be used in the personalization of cancer therapies.

Abstract: An activated carbon cloth-supported bimetallic Pd—Cu nanocatalyst is disclosed comprising about 1 wt % Pd and about 0.35-0.45 wt % Cu and having a surface Cu/Pd metal ratio of about 8-10 m2/m2. The nanocatalyst is capable of removing nitrate and/or nitrite from wastewater with a high selectivity to nitrogen.