Abstract: A method for creating a metabolic map of metabolic reactions by selecting metabolic reactions active in cancer cells. A core set of metabolic reactions occurring in the cancer cells is designated. For each permutation, whether inhibition of the k-th non-core reaction together with inhibition of all previously deleted non-core reactions results in inhibition of any of the core reactions or results in inhibition of the flux of biomass metabolites to biomass is determined. If inhibition of the k-th non-core reaction and inhibition of all previously deleted non-core reactions does not result in inhibition of any core reactions and does not result in inhibition of the flux of biomass metabolites to biomass, then the k-th non-core reaction is deleted from the set of non-core reactions. The number of permutations for which the k-th non-core reaction is not deleted is determined and a metabolic map is then created based on that number.

Abstract: A successive approximation register (SAR) analog-to-digital converter (ADC) is disclosed. A first and second capacitor DACs receive a first and second input signals respectively. A first coarse comparator compares an output of the first capacitor DAC with a window reference voltage, a second coarse comparator compares an output of the second capacitor DAC with the window reference voltage, and a fine comparator compares the output of the first capacitor DAC with the output of the second capacitor DAC. A SAR controller receives outputs of the first and second coarse comparators to determine whether the outputs of the first and second capacitor DACs are within a predictive window determined by the window reference voltage. The SAR controller bypasses at least one phase of analog-to-digital conversion of the SAR ADC when the outputs of the first capacitor DAC and the second capacitor DAC are determined to be within the predictive window.

Abstract: The present invention provides a method of creating a building structure to be installed on a basin floor wherein the base for erecting the structure would be an element of such a block and this block would be placed on the basin floor in such a way, and would be fixed in position relative to it in such a manner, that this base could be used as a foundation for stationary, large-sized heavy structures and also to ensure the possibility of using the block elements as members of the structure being erected and thus to increase the economic efficiency of the method.

Abstract: Processes for forming quantum well structures which are characterized by controllable nitride content are provided, as well as superlattice structures, optical devices and optical communication systems based thereon.

Abstract: A method of remotely viewing a video from a selected viewpoint selected by the viewer from a continuous segment, including, receiving a recording of a video of a subject recorded using a first depth video camera that records a video comprising a sequence of picture frames and additionally records a depth value for pixels of the picture frames; receiving a recording of a video of the subject recorded using a standard video camera or a second depth video camera positioned to record a video at a viewpoint that differs from the viewpoint of the depth video camera; using the recordings to render a viewable video from the selected viewpoint; and display the rendered viewable video to the viewer.

Abstract: Methods of generating and expanding proliferative, multipotent connective tissue progenitor cells from adult stem cells are provided. Also provided are methods of generating functional tendon grafts in vitro and bone, cartilage and connective tissues in vivo using the isolated cell preparation of connective tissue progenitor cells.

Abstract: A method for determining similarity between a non-planar probe surface and a non-planar model surface is disclosed. The method comprises calculating an extremal value of an objective function describing embedding of the probe surface into an embedding space having a non-constant sectional curvature; and determining similarity between the probe surface and the model surface based on the extremal value.

Abstract: A method and system for determining the subjective state of mind of a human subject presented with a test audible or visual stimulus. An an electroencephalogram (EEG) recording unit is connected to the human subject, recording the subject's EEG when presented with one or more test stimuli. The recorded EEG signal is then transformed to a 3-D map in order to visualize the brain areas that were active when presenting the test stimuli. The given 3-D map of the test stimuli is then compared with reference 3-D maps of neutral and subjectively significant stimuli.

Abstract: The present invention provides a system and method for diagnosing, monitoring or prognosing Alzheimer's disease using at least one sensor comprising carbon nanotubes coated with cyclodextrin or derivatives thereof and/or at least one sensor comprising metal nanoparticles coated with various organic coatings in conjunction with a learning and pattern recognition algorithm.

Abstract: The present invention provides a system and method for diagnosing, monitoring, prognosing or staging Parkinson's disease using at least one sensor comprising carbon nanotubes coated with cyclodextrin or derivatives thereof or metal nanoparticles coated with various organic coatings in conjunction with a learning and pattern recognition algorithm.

Abstract: A method for Space-variant polarization manipulation of enhanced nondirectional thermal emission in a narrow spectral peak is disclosed, comprising providing a subwavelength grating irradiating non-directional thermal emission on the grating and discretely controlling the local orientation of the grating.

Abstract: System and method for active detection of asymmetry in a rotating structure, the method comprises: imparting harmonic mechanical excitation on the rotating structure that is asynchronous to the speed of rotation of the structure; obtaining a response from the excited rotating body; and analyzing the response to determine a presence of modulation of the imparted harmonic mechanical excitation, that causes vibration at a frequency that is a combination of both the harmonic mechanical excitation and the modulation speed of rotation.

Abstract: Disclosed are polypeptides that are analogs of urocortin 2 that have pharmacological activity similar to urocortin 2 but have improved water solubility compared to urocortin 2, and pharmaceutical compositions of the polypeptides of the present invention. Also disclosed are polynucleotides encoding the polypeptides, and methods of treating pathophysiological states employing pharmaceutical compositions of the polypeptides and polynucleotides of the present invention. In addition, disclosed are vectors and host cells that include a nucleic acid encoding a polypeptide of the present invention, and kits that include pharmaceutical compositions of the present invention.

Abstract: A light-emitting-diode (LED) array includes a first LED unit having a first electrode and a second LED unit having a second electrode. The first LED unit and the second LED unit are positioned on a common substrate and are separated by a gap. Two or more polymer materials form a multi-layered structure in the gap. A first polymer material substantially fills a lower portion of the gap and at least one additional polymer material substantially fills a remainder of the gap above the first polymer material. A kinematic viscosity of the first polymer material is less than a kinematic viscosity of the at least one additional polymer material. An interconnect, positioned on top of the at least one additional polymer material, electrically connects the first electrode and the second electrode.

Abstract: Propargylamine, propargylamine derivatives N-propargyl-1-aminoindan and analogs thereof, and pharmaceutically acceptable salts thereof, are useful for administration to a subject at high risk for or suffering from acute renal failure (ARF).

Abstract: A semiconductor, room-temperature, electrically excited, two-photon device with thick optically active layer is provided. The intrinsic AlGaAs active layer is sandwiched between two intrinsic graded waveguide layers having increased aluminum concentration at increased distance from the active layer. The waveguide structure is sandwiched between two cladding layers of high aluminum concentration, n and p doped respectively. The structure is epitaxially grown on a substrate and further comprises other layers such as buffer, graded layers and contact layers. An etched ridge provides lateral confinement for light. The device provides two-photons gain and may be used in light sources, optical amplifiers, pulse compressors and lasers.

Abstract: The present invention is directed to compositions and methods related to soluble G-protein coupled receptors (sGPCR). In certain aspects the invention includes compositions and methods related to a soluble corticotropin releasing factor receptor related protein, sCRFR2, as well as its effects on CRFR signaling and interaction between CRF family ligand and CRFR receptors, including but not limited to CRFR2, CRFR1 and functional or signaling capable variants thereof.

Abstract: A ultra high speed photonic Analog to Digital Converted (ADC) for sampling and quantizing an electrical voltage signal, internally enabled by photonics uses coherent optical detection architectures for photonic quantization. Coherent light is phase modulated by the test signal. Using an interferometer, or an array of interferometers the phase of modulated light is compared with a reference light. Flash ADC, successive approximation ADC and delta-sigma ADC configurations are presented.

Abstract: A light-emitting-diode (LED) array includes a first LED device having a first electrode and a second LED device having a second electrode. The first LED device and the second LED device are positioned on a common substrate. At least one polymer material is between the first LED device and the second LED device. A plurality of microsctructures are in the at least one polymer material. An interconnect is formed on top of the at least one polymer material to electrically connect the first electrode and the second electrode.

Abstract: The present invention is of methods of establishing and propagating human embryonic stem cell lines using feeder cells-free, xeno-free culture systems and stem cells which are capable of being maintained in an undifferentiated, pluripotent and proliferative state in culture which is free of xeno contaminants and feeder cells.