Patents Assigned to DEVELOPMENT FOUNDATION
  • USE OF ELECTROSPUN MICROTUBES FOR DRUG DELIVERY
    Publication number: 20110028834
    Abstract: Provided is a method of delivering a medicament or a diagnostic agent to a subject in need thereof by (a) introducing a microtube configured to deliver the medicament or the diagnostic agent into the subject, said microtube comprises an electrospun shell and an electrospun coat over an internal surface of said shell, and (b) administering the medicament or the diagnostic agent through said microtube, thereby delivering the medicament or the diagnostic agent to the subject. Also provided are kits for delivering a medicament or a diagnostic agent.
    Type: Application
    Filed: February 12, 2009
    Publication date: February 3, 2011
    Applicant: TECHNION RESEARCH & DEVELOPMENT FOUNDATION LTD.
    Inventor: Eyal Zussman
  • METHODS FOR IDENTIFICATION AND SELECTION OF HUMAN EMBRYONIC STEM CELL DERIVED CELLS
    Publication number: 20110027234
    Abstract: A nucleic acid construct is disclosed, the nucleic acid comprising a polynucleotide comprising a nucleic acid sequence encoding a detectable expression product, the nucleic acid sequence being operably linked to a human tissue specific promoter. A method of lineage tracing of human stem cells and isolated human embryonic stem cell comprising the nucleic acid construct are also disclosed.
    Type: Application
    Filed: April 10, 2008
    Publication date: February 3, 2011
    Applicant: Technion Research & Development Foundation Ltd.
    Inventors: Lior Gepstein, Irit Huber
  • METHOD AND DEVICE FOR TACTILE PRESENTATION
    Publication number: 20110025602
    Abstract: A method for a tactile presentation of perceivable content. The method comprises receiving a data representing perceivable content, selecting a plurality of electric currents according to the data, each the electric current is associated with at least one of a plurality of regions of a solution having a plurality of macromolecules, and changing a level of acidity (pH) of at least one of the plurality of regions by applying a respective the electric current thereto. A proton concentration in the plurality of regions tactilely presents the perceivable content.
    Type: Application
    Filed: March 25, 2009
    Publication date: February 3, 2011
    Applicant: Technion Research & Development Foundation Ltd.
    Inventors: Uri Sivan, Elad Brod
  • METHOD AND SYSTEM FOR MANIPULATING FLUID MEDIUM
    Publication number: 20110023973
    Abstract: A system for manipulating a fluid medium is disclosed. The system comprises a plurality of particles suspended in the fluid medium, and a light source configured for irradiating the particles by light to induce nonlinear optical effects. The particles are constituted such that the nonlinear optical effects result in drag forces exerted by the particles on the fluid medium. The magnitude of the drag forces is sufficient to establish hydrodynamic flow of the fluid medium.
    Type: Application
    Filed: March 25, 2009
    Publication date: February 3, 2011
    Applicant: Technion Research & Development Foundation Ltd.
    Inventors: Mordechai Segev, Demetrios N. Christodoulides, Carmel Rotschild
  • METHOD OF DYNAMICALLY CULTURING EMBRYONIC STEM CELLS
    Publication number: 20110027887
    Abstract: The present invention is of a method of dynamically generating human embryoid bodies which can be used for generating lineage specific cells and cell lines. Specifically, the present invention can be used to generate ESC-differentiated cells for cell-replacement therapy.
    Type: Application
    Filed: October 18, 2010
    Publication date: February 3, 2011
    Applicant: TECHNION RESEARCH & DEVELOPMENT FOUNDATION LTD.
    Inventors: SHARON GERECHT-NIR, JOSEPH ITSKOVITZ-ELDOR
  • PHOTOGRAMMETRIC TEXTURE MAPPING USING CASUAL IMAGES
    Publication number: 20110025690
    Abstract: A method for photogrammetric texture mapping using casual images is provided. The method may include the following steps: estimating, for each vertex of at least a portion of a three dimensional (3D) mesh representing a model, projection parameters associated with a virtual camera that is unique for each vertex; mapping pixels from a two dimensional (2D) image to the vertices, such that each mapping of a pixel is based on the estimated respective virtual camera parameters; and texturing the portion of the mesh with corresponding mapped pixels wherein vertices on the textured portion are selected such that they are visible from a specified viewpoint associated with the 3D mesh.
    Type: Application
    Filed: July 26, 2010
    Publication date: February 3, 2011
    Applicant: TECHNION RESEARCH & DEVELOPMENT FOUNDATION LTD.
    Inventors: Yochay TZUR, Ayellet TAL
  • Output buffer with high driving ability
    Patent number: 7880514
    Abstract: An output buffer including a first differential input stage, a primary output stage, and a secondary output stage is provided herein. The first differential input stage respectively receives a first and a second input signals via a first and a second input terminals. The primary output stage includes a first and a second output stages. The first output stage provides at least one first level voltage according to the first and the second input signals, and the second output stage controlled by the first level voltage drives an output terminal of the output buffer to a target level. The secondary output stage includes a comparator and a third output stage. The comparator compares the induced currents in the first differential input stage, and thereby generates a control voltage. The third output stage controlled by the control voltage drives the output terminal of the output buffer to the target level.
    Type: Grant
    Filed: January 8, 2009
    Date of Patent: February 1, 2011
    Assignees: Himax Technologies Limited, NCKU Research & Development Foundation
    Inventors: Chien-Hung Tsai, Jia-Hui Wang, Jing-Chuan Qiu, Chen-Yu Wang
  • MODELING MICRO-SCAFFOLD-BASED IMPLANTS FOR BONE TISSUE ENGINEERING
    Publication number: 20110022174
    Abstract: A new conceptual biomedical method is presented for designing scaffold-based bone implants and using these implants in treating deteriorated bones. These implants have micro-architectural bone structures that are capable of mimicking the stochastic micro-structure as in natural bone bio-mineral structures. Moreover, they can be adapted as specific tailor-made compatible bone-repair mediator implants to be used as effective substitutes for natural damaged bone fracture structures.
    Type: Application
    Filed: January 11, 2009
    Publication date: January 27, 2011
    Applicant: TECHNION - RESEARCH & DEVELOPMENT FOUNDATION LTD
    Inventors: Yaron Holdstein, Anat Fischer
  • ANTI HUMAN IMMUNODEFICIENCY ANTIBODIES AND USES THEREOF
    Publication number: 20110020357
    Abstract: Provided are antibodies comprising an antigen recognition domain capable of binding an MHC molecule being complexed with a human immunodeficiency virus (HIV) peptide, wherein the antibody does not bind the MHC molecule in an absence of the complexed peptide, and wherein the antibody does not bind the peptide in an absence of the MHC molecule. Also provided are methods of using same for diagnosing HIV infection and treating AIDS.
    Type: Application
    Filed: April 5, 2009
    Publication date: January 27, 2011
    Applicant: Technion Research & Development Foundation Ltd.
    Inventors: Yoram Reiter, Maya Haus-Cohen
  • BUS ENHANCED NETWORK ON CHIP
    Publication number: 20110022754
    Abstract: A system that includes multiple modules of an integrated circuit; a network on chip that is coupled to the multiple modules; a bus, coupled in parallel to the network on chip to the multiple modules; wherein a latency of the bus is lower and more predictable than an average latency of the network of chip.
    Type: Application
    Filed: December 7, 2008
    Publication date: January 27, 2011
    Applicant: TECHNION RESEARCH & DEVELOPMENT FOUNDATION LTD
    Inventors: Israel Cidon, Avinoam Kolodny, Walter Zigmond Isask'har
  • Synthetic binding pairs comprising cucurbituril derivatives and polyammonium compounds and uses thereof
    Patent number: 7875713
    Abstract: Derivatized cucurbiturils and cucurbituril assemblies formed thereby are disclosed. Also disclosed are binding pairs of the disclosed cucurbituril assemblies and polyamine structures, which are highly advantageous over the presently known affinity pairs and therefore can be efficiently utilized in a myriad of applications.
    Type: Grant
    Filed: September 5, 2004
    Date of Patent: January 25, 2011
    Assignee: Technion Research & Development Foundation Ltd.
    Inventor: Ehud Keinan
  • ADHERING COMPOSITION AND METHOD OF APPLYING THE SAME
    Publication number: 20110015759
    Abstract: A method of in-situ adhering including providing pre-gel including phenolic compound and water miscible polymers like carbohydrates, salts of anionic polysaccharide, spreading layer of pre-gel onto a surface, adding solid support, comprising cross linking agents capable of interacting with the polymer, to pre-gel, and allowing pre-gel to cure and adhere onto surface.
    Type: Application
    Filed: November 5, 2008
    Publication date: January 20, 2011
    Applicant: TECHNION-RESEARCH & DEVELOPMENT FOUNDATION LTD
    Inventors: Havazelet Bianco-Peled, Ohad Kimhi
  • ADHESIVES AND METHODS OF APPLYING THE SAME
    Publication number: 20110015125
    Abstract: A composition including pre-gel including at least one phenol-based compound, excluding phloroglucinol and derivatives, at least one water miscible polymer, at least one cross linking agent capable of interacting with the polymer. The polymer is selected from one or more natural and/or synthetic carbohydrate, and salt of an anionic polysaccharide.
    Type: Application
    Filed: November 5, 2008
    Publication date: January 20, 2011
    Applicant: TECHNION-RESEARCH & DEVELOPMENT FOUNDATION LTD
    Inventors: Havazelet Bianco-Peled, Ohad Kimhi
  • CHEMICAL SENSORS BASED ON CUBIC NANOPARTICLES CAPPED WITH AN ORGANIC COATING FOR DETECTING EXPLOSIVES
    Publication number: 20110015872
    Abstract: The present application describes a sensor apparatus, especially an electronic nose, based on 2D films or 3D assemblies of cubic nanoparticles capped with an organic coating. The organic coating is modified with unique compositions of functional moieties, e.g. cyclodextrins, to provide the detection of volatile and non-volatile compounds derived from explosive materials, e.g. PETN, RDX, TNT etc. with very high sensitivity. The nose employs pattern recognition algorithms and methods, e.g. PCA, for detecting and quantifying specific explosive compounds.
    Type: Application
    Filed: March 26, 2009
    Publication date: January 20, 2011
    Applicant: TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD.
    Inventors: Hossam Haick, Ekaterina Dovgolevsky
  • CORE-ALLOYED SHELL SEMICONDUCTOR NANOCRYSTALS
    Publication number: 20110006285
    Abstract: The invention relates to a core-alloyed shell semiconductor nanocrystal comprising: (i) a core of a semiconductor material having a selected band gap energy; (ii) a core-overcoating shell consisting of one or more layers comprised of an alloy of the said semiconductor of (i) and a second semiconductor; (iii) and an outer organic ligand layer, provided that the core semiconductor material is not HgTe. In certain embodiments, the core semiconductor material is PbSe and the alloy shell semiconductor material has the PbSexS1-x structure; or the core semiconductor material is CdTe and the alloy shell semiconductor material has either the CdTexSe1-x or CdTexS1-x structure.
    Type: Application
    Filed: May 14, 2010
    Publication date: January 13, 2011
    Applicant: Technion Research & Development Foundation Ltd.
    Inventors: Efrat LIFSHITZ, Ariel Kigel, Maya Brumer-Gilary, Aldona Sashchiuk, Lilac Amirav, Viktoria Kloper, Dima Cheskis, Ruth Osovsky
  • CRIPTO ANTAGONISM OF ACTIVIN AND TGF-B SIGNALING
    Publication number: 20110009319
    Abstract: Cripto, a developmental oncoprotein, antagonizes activin and TGF-b signaling by forming a complex with activin and TGF-b and their type II receptors. This complex precludes the formation of a functional activin/TGF-b•type II•type I complex, thereby blocking the signaling of activin and TGF-b. Cripto may be generally capable of blocking antiproliferative Smad2/3 signals and provides a novel mechanism of oncogenic action with multiple therapeutic implications. Inhibiting the formation of Cripto and activin/TGF-b complex may enhance antiproliferative effects of activin and TGF-b.
    Type: Application
    Filed: September 21, 2010
    Publication date: January 13, 2011
    Applicant: RESEARCH DEVELOPMENT FOUNDATION
    Inventors: Wylie Vale, Craig A. Harrison, Peter C. Gray
  • Structure-based modulators of B1 G-protein coupled receptors
    Patent number: 7869958
    Abstract: The present invention relates to a method for identifying modulators of B1 G-protein coupled receptors. The present invention also relates to a method for identifying an antagonist or agonist of the corticotropin-releasing factor receptor 2 (CRFR2). The present invention also relates to a method for improving antagonists or agonists of CRFR2. The present invention also relates to the three-dimensional structure of CRFR2 as representative of the B1 GPCR subfamily and its use as a basis for rational drug design of antagonist or agonists of B1 GPCRs.
    Type: Grant
    Filed: August 9, 2005
    Date of Patent: January 11, 2011
    Assignee: Research Development Foundation
    Inventors: Grace Christy Rani Royappa, Marilyn H. Perrin, Jean E. Rivier, Wylie W. Vale, Jr., Roland Riek
  • Cavity Plasmon Resonance Biosensing Device, Method And System
    Publication number: 20110001975
    Abstract: The current invention provides a devices methods and systems for efficient biosensing using the Surface Plasmon Resonance (SPR) and Cavity Plasmon Resonance (CPR) phenomena. The miniature biosensor comprises a stratified structure having a channel for analyte form between a substrate and thin metallic absorber layer in which plasmon are resonantly excited. Presence of analyte in the channel, changes the resonance conditions, thus changing the energy absorbed by the biosensor. Bolometric signal from the absorber; layer or detection of the radiation not absorbed by the biosensor is used to detect, measure the concentration of, or monitor the analyte.
    Type: Application
    Filed: September 4, 2007
    Publication date: January 6, 2011
    Applicant: Technion Research & Development Foundation Ltd.
    Inventors: Daniel Razansky, Pinchas Einziger, Dan Adam
  • SYSTEM AND METHOD FOR SYNCHRONIZING MULTI-CLOCK DOMAINS
    Publication number: 20100322365
    Abstract: A universal synchronizer for preventing signals from first clock domain from causing metastability in sampling registers operating in a second clock domain. A first synchronization flip-flop receives a primary signal from the first clock domain and a second synchronization flip-flop generates a secondary signal synchronized with the second clock domain. Notably, logic is applied to intermediate signals passed between the first synchronization flip-flop and the second synchronization flip-flop.
    Type: Application
    Filed: June 18, 2009
    Publication date: December 23, 2010
    Applicant: TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD.
    Inventors: Rostislav (Reuven) Dobkin, Ran Ginosar
  • NITROGEN OXIDE SENSITIVE FIELD EFFECT TRANSISTORS FOR EXPLOSIVE DETECTION COMPRISING FUNCTIONALIZED NON-OXIDIZED SILICON NANOWIRES
    Publication number: 20100325073
    Abstract: An apparatus for detecting volatile compounds derived from explosive materials with very high sensitivity. The apparatus is composed of field effect transistors of non-oxidized silicon nanowires modified with specific functional groups including, in particular, amine, imine and/or carboxyl moieties. Further a system is provided comprising the apparatus in conjunction with learning and pattern recognition algorithms and methods of use thereof for detecting and quantifying specific explosive compounds.
    Type: Application
    Filed: February 18, 2009
    Publication date: December 23, 2010
    Applicant: TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD.
    Inventor: Hossam Haick