Patents Assigned to DEVELOPMENT FOUNDATION
  • Patent number: 7790455
    Abstract: A cell culture comprising human foreskin cells, the human foreskin cells being capable of maintaining stem cells in an undifferentiated state when co-cultured therewith.
    Type: Grant
    Filed: July 6, 2007
    Date of Patent: September 7, 2010
    Assignee: Technion Research & Development Foundation Ltd.
    Inventors: Michal Amit, Joseph Itskovitz-Eldor
  • Patent number: 7790153
    Abstract: The present invention provides a method of treating auto-immune diseases in an animal comprising the step of orally administering a type one interferon to said animal. Also provided is a method of reducing inflammation associated with an auto-immune disease in an animal comprising the step of orally administering a type one interferon to said animal. Further provided is a method of decreasing the levels of a cytokine in an individual having multiple sclerosis, comprising the step of orally administering a type one interferon to said individual, wherein said cytokine is selected from the group consisting of TGF-?, IL-2, IL-10, IFN-? and the inflammatory soluble serum marker ICAM-1. In addition, the present invention provides a method of decreasing the incidence of insulin-dependent diabetes mellitus in at-risk populations, comprising the step of orally administering INF-? to individuals of said at-risk population.
    Type: Grant
    Filed: March 16, 2004
    Date of Patent: September 7, 2010
    Assignee: Research Development Foundation
    Inventor: Staley Brod
  • Publication number: 20100221735
    Abstract: The present invention relates to molecular markers for detection, prognosis and follow up of Parkinson's disease (PD), wherein said molecular markers are one or more genes with altered expression pattern, or gene products thereof (RNA or protein). Genes which expression is upregulated or downregulated in PD patients are tools for early diagnosis od PD, for monitoring the progress of the disease and can serve as targets for screening new agents for treatment of PD.
    Type: Application
    Filed: March 3, 2010
    Publication date: September 2, 2010
    Applicant: Technion Research & Development Foundation Ltd.
    Inventors: Moussa B.H. YOUDIM, Silvia A. Mandel, Edna Grünblatt, Peter Riederer
  • Publication number: 20100221829
    Abstract: Well-defined, xeno-free culture media which comprise a TGF-beta isoform or the chimera formed between IL6 and the soluble IL6 receptor (IL6RIL6), which are capable of maintaining stem cells, and particularly, human embryonic stem cells, in an undifferentiated state are provided. Also provided are cell cultures comprising the culture media and the stem cells and methods of expanding and deriving embryonic stem cells in such well-defined, xeno-free culture media. In addition, the present invention provides methods of differentiating ESCs or EBs formed therefrom for the generation of lineage specific cells.
    Type: Application
    Filed: August 29, 2006
    Publication date: September 2, 2010
    Applicant: Technion Research & Development FOUNDATION lTD.
    Inventors: Michal Amit, Joseph Itskovitz-Eldor
  • Publication number: 20100214312
    Abstract: A method of deforming a geometric object. The method comprises providing a data segment representing a geometric object, defining a contour enclosing the geometric object in the data segment, calculating a plurality of barycentric coordinates having a plurality of complex coefficients according to the enclosing contour, receiving user input to manipulate the enclosing contour to a target contour, and using the plurality of barycentric coordinates according to the target contour for mapping the geometric object to a target geometric object.
    Type: Application
    Filed: February 25, 2009
    Publication date: August 26, 2010
    Applicant: Technion Research & Development Foundation Ltd.
    Inventors: Ofir Weber, Mirela Ben-Chen, Craig(Chaim) Gotsman
  • Patent number: 7780974
    Abstract: The invention provides novel compositions and methods related to stents, such as coronary stents, comprising avicins, which are triterpene saponin compositions. In particular aspects of the invention, the avicins have growth-inhibiting properties and/or anti-inflammatory properties. In specific embodiments of the invention, the stent comprising the avicin reduces at least in part restenosis, such as that associated with stent procedures.
    Type: Grant
    Filed: September 20, 2005
    Date of Patent: August 24, 2010
    Assignee: Research Development Foundation
    Inventor: Jordan U. Gutterman
  • Patent number: 7777790
    Abstract: A method for electronic imaging includes controlling an image sensor to capture a first sequence of first input images at a first frame rate having a first spatial resolution, and to capture a second sequence of second input images, interleaved with the first sequence and having a second spatial resolution lower than the first spatial resolution. The first and second sequences of the input images are processed to generate an third sequence of output images at a second frame rate higher than the first frame rate and having a third spatial resolution higher than the second spatial resolution.
    Type: Grant
    Filed: January 27, 2005
    Date of Patent: August 17, 2010
    Assignee: Technion Research & Development Foundation Ltd.
    Inventors: Arie Feuer, Nir Maor
  • Publication number: 20100204576
    Abstract: An ultrasound cardiac stimulation system comprising: a spatially selective ultrasound source comprising at least one ultrasound transducer located outside the circulatory system; and a controller; where the controller generates an electrical response in the heart by directing the ultrasound source to transmit a high enough power level of ultrasound to one or more locations in the heart.
    Type: Application
    Filed: April 19, 2010
    Publication date: August 12, 2010
    Applicant: Technion Research & Development Foundation Ltd.
    Inventor: Dan ADAM
  • Publication number: 20100205171
    Abstract: A method and apparatus for resolving conjunctive queries, comprising relational predicates and external predicates, such as XML predicates. The method and apparatus obtain results from a relational engine or from an external engine, and then use the obtained results as input for the other engine, so as to optimize the activity of the other engine. The process may repeat further times, with the results obtained by the other engine being input to the first engine. The method and apparatus further disclose handling value, being isomorphic hierarchical subtrees.
    Type: Application
    Filed: September 28, 2008
    Publication date: August 12, 2010
    Applicant: TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD.
    Inventors: Oded Shmueli, Royi Ronen
  • Publication number: 20100202285
    Abstract: An algorithm is presented, which may be used to generate LSPs for path-oriented virtual circuit networks. The algorithm maximizes throughput of traffic-flow through the network according to certain constraints which may selected to suit various scenarios and recovery schemes. The algorithm may be used by network operators to maximize financial profit from existing networks which has a predetermined bandwidth capacity.
    Type: Application
    Filed: April 14, 2009
    Publication date: August 12, 2010
    Applicant: TECHNION RESEARCH & DEVELOPMENT FOUNDATION LTD.
    Inventors: Reuven Cohen, Gabi Nakibly
  • Publication number: 20100196910
    Abstract: A method of generating cells predominantly displaying at least one characteristic associated with a cardiac phenotype is disclosed. The method comprises (a) partially dispersing a confluent cultured population of human stem cells, thereby generating a cell population including cell aggregates; (b) subjecting the cell aggregates to culturing conditions suitable for generating embryoid bodies; (c) subjecting the embryoid bodies to culturing conditions suitable for inducing cardiac lineage differentiation in at least a portion of the cells of the embryoid bodies, the culturing conditions suitable for inducing cardiac lineage differentiation including adherence of the embryoid bodies to a surface, and culture, medium supplemented with serum, thereby generating cells predominantly displaying at least one characteristic associated with a cardiac phenotype.
    Type: Application
    Filed: February 8, 2010
    Publication date: August 5, 2010
    Applicant: Technion Research & Development Foundation Ltd.
    Inventors: Lior GEPSTEIN, Izhak Kehat, Joseph Itskovitz-Eldor, Michal Amit
  • Publication number: 20100194439
    Abstract: A complementary logic circuit contains a first logic input, a second logic input, a first dedicated logic terminal, a second dedicated logic terminal, a first logic block, and a second logic block. The first logic block consists of a network of p-type transistors for implementing a predetermined logic function. The p-type transistor network has an outer diffusion connection, a first network gate connection, and an inner diffusion connection. The outer diffusion connection of the p-type transistor network is connected to the first dedicated logic terminal, and the first network gate connection of the p-type transistor network is connected to the first logic input. The second logic block consists of a network of n-type transistors which implements a logic function complementary to the logic function implemented by the first logic block. The n-type transistor network has an outer diffusion connection, a first network gate connection, and an inner diffusion connection.
    Type: Application
    Filed: April 12, 2010
    Publication date: August 5, 2010
    Applicant: Technion Research & Development Foundation Ltd.
    Inventors: Arkadiy MORGENSHTEIN, Alexander Fish, Israel A. Wagner
  • Publication number: 20100192678
    Abstract: A method of focusing a plurality of discrete particles. The method comprises establishing a flow of a fluid medium carrying a plurality of discrete particles within a capillary having a plurality of separate walls and a longitudinal axis. The method further includes vibrating the plurality of separate walls to apply an acoustic field having a central axis substantially along the longitudinal axis to focus the plurality of discrete particles substantially along the longitudinal axis.
    Type: Application
    Filed: February 2, 2010
    Publication date: August 5, 2010
    Applicant: Technion Research & Development Foundation Ltd.
    Inventors: Peter VAINSHTEIN, Michael Shapiro
  • Publication number: 20100198521
    Abstract: The present invention provides an electronic nose device based on chemically sensitive field effect transistors. In particular, the sensors of the electronic nose device are composed of non-oxidized, functionalized silicon nanowires which can detect volatile organic compounds with very high sensitivity. Methods of use in diagnosing diseases including various types of cancer are disclosed.
    Type: Application
    Filed: July 24, 2008
    Publication date: August 5, 2010
    Applicant: TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD.
    Inventor: Hossam Haick
  • Publication number: 20100191474
    Abstract: Electronic nose device having a plurality of sensors composed of nanowires of columnar discotic liquid crystals, the device having low sensitivity to humidity. The device is designed to determine the composition and concentration of volatile organic compounds in a sample with very high sensitivity. Methods for use of the device in applications such as diagnosis of disease and food quality control are disclosed.
    Type: Application
    Filed: October 23, 2008
    Publication date: July 29, 2010
    Applicant: TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD.
    Inventor: Hossam Haick
  • Publication number: 20100189291
    Abstract: An optical pin-point microphone has a light source for directing a sensing beam to an object of interest so as to be reflected thereby as a reflected signal beam, a detector having multiple detector elements for receiving the reflected signal beam, and a summer for receiving signals from at least two of the detector elements and detecting, rectifying, amplifying and summing the received signals to generate a non-vanishing signal representative of an acoustic signal.
    Type: Application
    Filed: September 25, 2009
    Publication date: July 29, 2010
    Applicant: TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD.
    Inventors: Abraham Aharoni, Mordechai Segev, Zvi Katz
  • Patent number: 7764426
    Abstract: An apparatus for providing a light beam with spatially varying polarization. The apparatus includes: two circumferentially curved reflectors positioned substantially opposite each other, a polarizer positioned in an optical path between the two reflectors, for polarizing light reflected from one reflector before it reaches the other. A non-polarized light beam incident along a given axis on one of the reflectors is radially reflected off that reflector, acquires predetermined polarization from the polarizer and is then reflected off the second reflector to a light beam of spatially varying polarization.
    Type: Grant
    Filed: April 4, 2004
    Date of Patent: July 27, 2010
    Assignee: Technion Research and Development Foundation Ltd.
    Inventors: Stephen Geoffrey Lipson, Amir Shoham
  • Publication number: 20100183654
    Abstract: The present invention concerns gp36 immunoreactive compositions for E. canis and gp 47 immunoreactive compositions for E. chaffeensis. In particular, epitopes for E. canis gp36 and E. chaffeensis gp 47 are disclosed. In certain embodiments, the immunoreactive compositions comprise tandem repeats having carbohydrate moieties.
    Type: Application
    Filed: June 15, 2006
    Publication date: July 22, 2010
    Applicant: Research Development Foundation
    Inventors: Jere W. McBride, Christopher Kuyler Doyle
  • Patent number: 7759091
    Abstract: The present invention relates to targeted killing of a cell utilizing a chimeric polypeptide comprising a cell-specific targeting moiety and a signal transduction pathway factor. In a preferred embodiment, the signal transduction pathway factor is an apoptosis-inducing factor, such as granzyme B, granzyme A, or Bax.
    Type: Grant
    Filed: February 29, 2008
    Date of Patent: July 20, 2010
    Assignee: Research Development Foundation
    Inventors: Michael G. Rosenblum, Yuying Liu
  • Publication number: 20100179133
    Abstract: Articles of manufacturing (such as tobacco products), methods, devices and compositions for preventing or reducing tobacco-associated damage and/or disorders associated with oxidative stress in a subject, and which utilize a TSPO receptor ligand (such as diazepam), are disclosed.
    Type: Application
    Filed: July 2, 2008
    Publication date: July 15, 2010
    Applicant: Technion Research & Development Foundation Ltd.
    Inventors: Moshe Gavish, Rafael M. Nagler