Patents Assigned to Diagnostics, Inc.
  • MACHINE LEARNING SYSTEM AND METHOD FOR SOMATIC MUTATION DISCOVERY
    Publication number: 20240321390
    Abstract: A machine learning system and method for somatic mutation discovery are provided that provides improved identification of tumor-specific mutations. The improved identification of tumor-specific mutations may affect discovery of alterations and therapeutic management of cancer patients.
    Type: Application
    Filed: March 28, 2024
    Publication date: September 26, 2024
    Applicant: Personal Genome Diagnostics Inc.
    Inventors: Samuel V. Angiuoli, Derrick Wood
  • SITE-SPECIFIC ADAPTATION OF AUTOMATED DIAGNOSTIC ANALYSIS SYSTEMS
    Publication number: 20240320962
    Abstract: Methods of characterizing a sample container or a biological sample in an automated diagnostic analysis system using an artificial intelligence (AI) algorithm include retraining of the AI algorithm in response to characterization confidence levels determined to be unsatisfactory. The AI algorithm is retrained with data (including image data and/or non-image data) having features prevalent at the site where the automated diagnostic analysis system is operated, which were not sufficiently or at all included in training data used to initially train the AI algorithm. Systems for characterizing a sample container or a biological sample using an AI algorithm are also provided, as are other aspects.
    Type: Application
    Filed: July 6, 2022
    Publication date: September 26, 2024
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventors: Venkatesh NarasimhaMurthy, Vivek Singh, Yao-Jen Chang, Benjamin S. Pollack, Ankur Kapoor, Rayal Raj Prasad Nalam Venkat
  • Compositions, kits, and methods for multiplex assays to correct for biotin interference in target analyte measurements
    Patent number: 12099063
    Abstract: Kits containing a multiplexed chemiluminescent detection system and microfluidics devices and methods for detecting the presence and/or concentration of biotin and at least one target analyte in a sample are disclosed. The kits, microfluidics devices, and methods utilize singlet oxygen-activatable chemiluminescent compounds in combination with two or more fluorescent molecules that emit light at different wavelengths.
    Type: Grant
    Filed: February 10, 2022
    Date of Patent: September 24, 2024
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventor: Tie Wei
  • Methods and compositions for removing biotin interference from assays using conjugated molecular traps
    Patent number: 12099055
    Abstract: The present invention relates to methods and compositions to remove or reduce biotin interference from certain assays.
    Type: Grant
    Filed: March 18, 2022
    Date of Patent: September 24, 2024
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventor: Tie Wei
  • DIAGNOSTIC LABORATORY SYSTEMS AND METHODS OF OPERATING
    Publication number: 20240310395
    Abstract: Methods of operating a diagnostic laboratory system include providing a module configured to perform a function on an item in the diagnostic laboratory system; providing a plurality of sensors, each of the plurality of sensors configured to monitor the function or the item and generate sensor data in response to the monitoring; checking an operational status of a first sensor of the plurality of sensors; receiving sensor data from at least one of the plurality of sensors; and scaling sensor data from the first sensor in response to the operational status and the sensor data to generate revised sensor data. Systems including a middleware server configured to carry out the methods are provided as are other aspects.
    Type: Application
    Filed: February 17, 2022
    Publication date: September 19, 2024
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventors: Yao-Jen Chang, Rayal Raj Prasad Nalam Venkat, Benjamin S. Pollack, Vivek Singh, Venkatesh NarasimhaMurthy, Ankur Kapoor
  • Diffractometer-based global in situ diagnostic system for animals
    Patent number: 12094609
    Abstract: An animal-tissue analysis and communication system produces a quantitative-diagnostic indicator for animal-tissue analyzed by the system. The system includes an animal-tissue-analyzer subsystem with at least one animal-tissue analyzer constructed to analyze animal tissue and to produce an quantitative-diagnostic indicator. The system also includes a two-way communication subsystem constructed to allow the animal-tissue-analyzer subsystem to send and receive information relevant to the quantitative-diagnostic indicator. The animal-tissue-analyzer subsystem includes at least one tissue diffractometer operatively coupled to a computer database over a network, and is configured for acquisition and transfer of animal-tissue data, and transfer to the computer database over the network.
    Type: Grant
    Filed: September 26, 2021
    Date of Patent: September 17, 2024
    Assignee: Arion Diagnostics, Inc.
    Inventors: Alexander Lazarev, Pavel Lazarev, Delvin Tai Wai Yuk
  • Electrocardiography patch
    Patent number: 12089943
    Abstract: An apparatus is provided. A strip has first and second end sections, and a first surface and second surface. Two electrocardiographic electrodes are provided on the strip with one of the electrocardiographic electrodes provided on the first surface of the first end section of the strip and another of the electrocardiographic electrodes positioned on the first surface on the second end section of the strip. A flexible circuit is mounted to the second surface of the strip and includes a circuit trace electrically coupled to each of the electrocardiographic electrodes. A wireless transceiver is affixed on one of the first or second end sections, and a battery is positioned on one of the first or second end sections. A processor is positioned on one of the first or second end sections and is housed separate from the battery.
    Type: Grant
    Filed: April 26, 2024
    Date of Patent: September 17, 2024
    Assignee: Bardy Diagnostics, Inc.
    Inventors: Jason Felix, Jon Mikalson Bishay, Gust H. Bardy
  • Real-time ECG report generation
    Patent number: 12094585
    Abstract: A method includes receiving, by a first computing system, a first package of electrocardiogram (ECG) data and metadata associated with the ECG data. The method further includes generating, by the first computing system, a report simulation page including strips of the ECG data and a summary of patient data based on the ECG data and the metadata. The method further includes displaying the report simulation page in a user interface (UI) and displaying a report build page in the UI. The report build page includes the ECG data and the metadata. The method further includes modifying the metadata in the report build page and automatically updating the report simulation page in response to the modifying the metadata.
    Type: Grant
    Filed: April 14, 2023
    Date of Patent: September 17, 2024
    Assignee: Boston Scientific Cardiac Diagnostics, Inc.
    Inventors: Jan Hagenbrock, David Engebretsen, David Will, Riley Ellis, Jake Matras, Tim McClanahan
  • READY TO USE ANALYZER CONTROL PRODUCT FOR CUA URINALYSIS INSTRUMENTS
    Publication number: 20240299946
    Abstract: An analyzer control product provided with a sealed rack tube containing a preconfigured volume of analyzer control fluid is described. In particular, the rack tube is provided with a base portion; a top portion; and a sidewall extending from the base portion to the top portion, the sidewall having an inner peripheral surface and an outer peripheral surface, at least one of the inner peripheral surface and the outer peripheral surface in contact with the base portion to form a control fluid void. The analyzer control fluid is within the control fluid void. The analyzer control fluid has a preconfigured volume. A sealing member is attached to the top portion to seal the control void.
    Type: Application
    Filed: March 28, 2022
    Publication date: September 12, 2024
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventor: Lloyd Schulman
  • SAMPLE LYSIS REAGENT COMPOSITIONS AND METHODS OF PRODUCTION AND USE THEREOF
    Publication number: 20240302370
    Abstract: Methods of utilizing sample lysis reagent compositions in the handling of samples containing viruses, such as (but not limited to) severe acute respiratory syndrome coronavirus 2 (SARS-COV-2), are disclosed. Kits containing the sample lysis reagent compositions are also disclosed.
    Type: Application
    Filed: January 14, 2022
    Publication date: September 12, 2024
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventors: Sai Patibandla, Krishna Singh, Geraldine Arrode-Bruses
  • Pulmonary analysis using transpulmonary pressure
    Patent number: 12086980
    Abstract: A method for analyzing a patient based on a volumetric pulmonary scan includes receiving volumetric pulmonary scan data representative of a patient's pulmonary structure. This method also includes determining a level of transpulmonary pressure defining an effort metric based on one or more characteristics from the received volumetric pulmonary scan data. This method further includes determining one or more physiological or anatomical parameters associated with the transpulmonary pressure based on the received volumetric pulmonary scan data and the effort metric. A non-transitory computer readable medium can be programmed with instructions for causing one or more processors to perform the method for analyzing a patient based on a volumetric pulmonary scan.
    Type: Grant
    Filed: October 27, 2021
    Date of Patent: September 10, 2024
    Assignee: VIDA Diagnostics, Inc.
    Inventors: Samuel Peterson, Juerg Tschirren, Xia Huang, John D. Newell, Jr.
  • Enhanced chloride selective membrane
    Patent number: 12085532
    Abstract: There is provided a chloride selective membrane including an epoxide-based matrix reacted with a stoichiometric amount of an amino compound and an activator such that the epoxide-based matrix comprises a number of quaternary ammonium groups.
    Type: Grant
    Filed: July 24, 2023
    Date of Patent: September 10, 2024
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Bo Peng, David Thompson
  • Login token management
    Patent number: 12086228
    Abstract: Techniques for securing user data in a healthcare data management system are described. A client system receives a request to authenticate a user. A login token relating to an authenticated user is maintained at the client system. A role is selected for the user, and an authorization token relating to the selected role is maintained at the client system. A session for the user is initiated. This includes generating an encrypted session cookie relating to the user and the session, storing the encrypted session cookie at the client system, and periodically updating a timestamp for the session cookie.
    Type: Grant
    Filed: January 3, 2023
    Date of Patent: September 10, 2024
    Assignee: Boston Scientific Cardiac Diagnostics, Inc.
    Inventors: Savy Vath, Gale G. McFarland, Kevin W. Kirkeby, Michael S. Butterbrodt
  • Mobile connected autonomous refrigerator
    Patent number: 12085579
    Abstract: A method and system for replenishing refrigerated consumables by a mobile connected autonomous refrigerator includes receiving a notification triggered by a laboratory instrument that a refrigerated consumable used by the laboratory instrument is depleted; autonomously navigating to a refrigerated storage; retrieving the refrigerated consumable and placing it in the mobile refrigerated unit: autonomously moving to the laboratory instrument that triggered the notification; and alerting an operator to retrieve the refrigerated consumable from mobile refrigerated unit and load it into the laboratory instrument.
    Type: Grant
    Filed: September 29, 2022
    Date of Patent: September 10, 2024
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventor: Michael Heydlauf
  • REMOTE AMBULATORY CARDIAC MONITORING SYSTEM FOR ACQUIRING ECG SIGNALS
    Publication number: 20240293038
    Abstract: A system and method for a multi-function remote ambulatory cardiac monitoring system. The system includes a housing and a microprocessor disposed within the housing. The microprocessor controls the remote ambulatory cardiac monitoring system. The system also includes an electrode for sensing ECG signals and the electrode being in communication with the microprocessor. An integrated cellular module also is included in the system, and the cellular module is connected to the microprocessor and disposed within the housing. The integrated cellular module transmits ECG signals to a remote center.
    Type: Application
    Filed: May 12, 2024
    Publication date: September 5, 2024
    Applicant: ACS DIAGNOSTICS, INC.
    Inventor: Loren A. Manera
  • Methods, apparatus, and systems for ophthalmic testing and measurement
    Patent number: 12076084
    Abstract: Methods, apparatus, and systems for performing an ophthalmic diagnostic test are disclosed. In one aspect, a head-wearable device for administering an ophthalmic test to a subject can comprise a head-wearable frame for mounting the device onto the subject's head, and a light seal configured for coupling to the frame so as to isolate at least one eye of the subject from ambient light when the device is worn by the subject.
    Type: Grant
    Filed: June 2, 2020
    Date of Patent: September 3, 2024
    Assignee: LumiThera Diagnostics, Inc.
    Inventors: Gregory R. Jackson, David E. Beecher, David E. Orr, Frank Jones, Nathan Smith
  • Use of HE4 and other biochemical markers for assessment of endometrial and uterine cancers
    Publication number: 20240288434
    Abstract: The disclosure relates to use of the HE4/HE4a marker(s) to assess endometrial and uterine cancer in a patient. The disclosure also relates to using tumors marks for diagnosis, grading and staging of endometrial and uterine cancers. The disclosure also relates to determining prognosis and treatment effectiveness of a patient who has been diagnosed with endometrial or uterine cancer.
    Type: Application
    Filed: April 8, 2024
    Publication date: August 29, 2024
    Applicant: FUJIREBIO DIAGNOSTICS, INC.
    Inventors: Richard MOORE, Elizabeth SOMERS, W. Jeffrey ALLARD
  • APPARATUS AND METHOD FOR TRANSFERRING A FLUID SAMPLE FROM A FLUID SAMPLE COLLECTION APPARATUS TO A LIQUID SAMPLE ANALYZER
    Publication number: 20240286139
    Abstract: An apparatus and method for transferring a fluid sample from a fluid sample collection apparatus to a liquid sample analyzer. The apparatus includes a barrel having a first end, a second end, a sidewall extending between the first end and the second end, an inner surface defining an internal chamber, and an external surface defining at least a portion of a chromatographic assay chamber in fluid communication with the internal chamber. The first end has an inlet opening with a clot catcher extending across the inlet opening upstream of the passage and the second end has an outlet opening. A chromatographic assay assembly is housed in the chromatographic assay chamber for detecting presence of free hemoglobin in the fluid sample.
    Type: Application
    Filed: August 5, 2022
    Publication date: August 29, 2024
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventors: Janine Cox, Michael Chen, Justin Davis, Justin DeSilva, Mark Vaughan, Joshua Joseph
  • System for increasing the accuracy of non invasive prenatal diagnostics and liquid biopsy by observed loci bias correction at single base resolution
    Patent number: 12073921
    Abstract: Techniques for measuring abundances of sequences includes obtaining first data that indicates a target sequence at a plurality of loci, wherein the target sequence comprises a plurality of bins of loci for which a relative abundance is indicative of a condition of interest. Second data is determined that indicates alignment with the target sequence of reads of DNA fragments in a sample from the subject. Third data is determined that indicates locus dependent observed variations in abundance. A raw count Hj of reads is determined that start at each locus j; and, a copy number of a first bin is determined based on a sum over all loci in the first bin of expected counts for each partition weighted by the locus dependent observed variations. Output data that indicates condition of the subject based at least in part on the copy number of the first bin is presented.
    Type: Grant
    Filed: November 7, 2018
    Date of Patent: August 27, 2024
    Assignee: ECHELON DIAGNOSTICS, INC.
    Inventors: John Burke, Stephen Healy Sanders
  • Fluid transfer adapter
    Patent number: D1043975
    Type: Grant
    Filed: January 13, 2023
    Date of Patent: September 24, 2024
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Janine Cox, Michael Chen, Justin DeSilva, Justin Davis, Mark Vaughan