Patents Assigned to Diego
  • Substituted 1,3-dialkyl-2,4-dioxo-6-(arylamino)-1,2,3,4-tetrahydropyrimidine-5-hydroxamic acid inhibitors of MAPK/ERK kinase
    Patent number: 7696218
    Abstract: Compounds of the substituted 1,3-dialkyl-2,4-dioxo-6-(arylamino)-1,2,3,4-tetrahydropyrimidine-5-hydroxamic acids, show below: wherein the variables are as defined herein, and pharmaceutical compositions thereof, are provided for use as inhibitors of with MEK kinase.
    Type: Grant
    Filed: October 22, 2007
    Date of Patent: April 13, 2010
    Assignee: Takeda San Diego, Inc.
    Inventors: Qing Dong, Stephen W. Kaldor
  • ION CHANNEL ASSAY METHODS
    Publication number: 20100081163
    Abstract: A method of characterizing the biological activity of a candidate compound may include exposing cells to the candidate compound, and then exposing the cells to a repetitive application of electric fields so as to set the transmembrane potential to a level corresponding to a pre-selected voltage dependent state of a target ion channel.
    Type: Application
    Filed: September 28, 2009
    Publication date: April 1, 2010
    Applicant: Vertex Pharmaceuticals (San Diego) LLC
    Inventors: Michael P. Maher, Jesus E. Gonzalez, III
  • Dipeptidyl peptidase inhibitors
    Patent number: 7687638
    Abstract: Compounds, pharmaceutical compositions, kits and methods are provided for use with DPP-IV and other S9 proteases that comprise a compound of the formula: wherein the substituents are as defined herein.
    Type: Grant
    Filed: June 3, 2005
    Date of Patent: March 30, 2010
    Assignee: Takeda San Diego, Inc.
    Inventors: Jun Feng, Stephen L. Gwaltney, Michael B. Wallace, Zhlyuan Zhang
  • Histone deacetylase inhibitors
    Patent number: 7642253
    Abstract: Compounds, pharmaceutical compositions, kits and methods useful for inhibiting HDAC, thereby treating a disease state for which HDAC possess activity that contributes to the pathology and/or symptomology of the disease state. The compound is selected from the group consisting of: wherein the variables are as defined herein.
    Type: Grant
    Filed: May 10, 2006
    Date of Patent: January 5, 2010
    Assignee: Takeda San Diego, Inc.
    Inventors: Jerome C. Bressi, Jason W. Brown, Anthony R. Gangloff, Jeffrey A. Stafford, Phong H. Vu
  • Histone deacetylase inhibitors
    Patent number: 7642275
    Abstract: Compounds, pharmaceutical compositions, kits and methods are provided for use with histone deacetylases (HDACs) that comprise a compound of the formulae: wherein the variables are as defined herein.
    Type: Grant
    Filed: December 16, 2005
    Date of Patent: January 5, 2010
    Assignee: Takeda San Diego, Inc.
    Inventors: Jerome C. Bressi, Jason W. Brown, Robert J. Skene, Jeffrey A. Stafford, Phong H. Vu, Anthony R. Gangloff, Andrew J. Jennings, Stephen W. Kaldor
  • Dipeptidyl peptidase inhibitors
    Patent number: 7638638
    Abstract: Pharmaceuticals, kits and methods are provided for use with DPP-IV and other S9 proteases that comprise a compound with the formula: where the labeled substituents are as described herein.
    Type: Grant
    Filed: May 13, 2004
    Date of Patent: December 29, 2009
    Assignee: Takeda San Diego, Inc.
    Inventors: Jun Feng, Stephen L. Gwaltney, Jeffrey A. Stafford, Michael B. Wallace, Xiao-Yi Xiao, Zhiyuan Zhang
  • Edge-on SAR scintillator devices and systems for enhanced SPECT, PET, and compton gamma cameras
    Patent number: 7635848
    Abstract: The invention provides methods and apparatus for detecting radiation including x-ray, gamma ray, and particle radiation for nuclear medicine, radiographic imaging, material composition analysis, high energy physics, container inspection, mine detection and astronomy. The invention provides detection systems employing one or more detector modules (102) comprising edge-on scintillator detectors (101) with sub-aperture resolution (SAR) capability employed, e.g., in nuclear medicine, such as radiation therapy portal imaging, nuclear remediation, mine detection, container inspection, and high energy physics and astronomy. The invention also provides edge-on imaging probe detectors for use in nuclear medicine, such as radiation therapy portal imaging, or for use in nuclear remediation, mine detection, container inspection, and high energy physics and astronomy.
    Type: Grant
    Filed: March 31, 2006
    Date of Patent: December 22, 2009
    Assignee: San Diego State University Research Foundation
    Inventor: Robert Sigurd Nelson
  • Weak hypothesis generation apparatus and method, learning apparatus and method, detection apparatus and method, facial expression learning apparatus and method, facial expression recognition apparatus and method, and robot apparatus
    Patent number: 7624076
    Abstract: A facial expression recognition system that uses a face detection apparatus realizing efficient learning and high-speed detection processing based on ensemble learning when detecting an area representing a detection target and that is robust against shifts of face position included in images and capable of highly accurate expression recognition, and a learning method for the system, are provided. When learning data to be used by the face detection apparatus by Adaboost, processing to select high-performance weak hypotheses from all weak hypotheses, then generate new weak hypotheses from these high-performance weak hypotheses on the basis of statistical characteristics, and select one weak hypothesis having the highest discrimination performance from these weak hypotheses, is repeated to sequentially generate a weak hypothesis, and a final hypothesis is thus acquired.
    Type: Grant
    Filed: March 7, 2008
    Date of Patent: November 24, 2009
    Assignees: Sony Corporation, University of California, San Diego
    Inventors: Javier R. Movellan, Marian S. Bartlett, Gwendolen C. Littlewort, John Hershey, Ian R. Fasel, Eric C. Carlson, Josh Susskind, Kohtaro Sabe, Kenta Kawamoto, Kenichi Hidai
  • Glucokinase Activators
    Publication number: 20090286800
    Abstract: Compounds are provided for use with glucokinase that comprise the formula: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
    Type: Application
    Filed: May 15, 2009
    Publication date: November 19, 2009
    Applicant: TAKEDA SAN DIEGO, INC.
    Inventors: Zacharia Cheruvallath, Stephen L. Gwaltney, Andrew John Jennings, Mark Sabat, Jeffrey A. Stafford, Mingnam Tang, Haxia Wang
  • METALLOPROTEIN INHIBITORS
    Publication number: 20090286987
    Abstract: The present invention relates to metalloprotein inhibitors comprising: a. an organic substituent and at least one zinc binding group (ZBG) covalently attached thereto; or b. a ZBG substituted by a side chain wherein the ZBG is of formula (I): wherein X is O or S and each R1, R2, R3, and R4 is individually hydrogen or an organic radical. The metalloprotein inhibitors are useful for preventing or treating a pathological disease, condition, or symptom that is associated with pathological metalloprotein activity and/or that is alleviated by inhibition of said activity.
    Type: Application
    Filed: July 15, 2009
    Publication date: November 19, 2009
    Applicant: Regents of the University of California, San Diego UCSD Technology Transfer Office
    Inventors: David T. Puerta, Seth M. Cohen, Jana A. Lewis
  • Ion channel assay methods
    Patent number: 7615357
    Abstract: A method of characterizing the biological activity of a candidate compound may include exposing cells to the candidate compound, and then exposing the cells to a repetitive application of electric fields so as to set the transmembrane potential to a level corresponding to a pre-selected voltage dependent state of a target ion channel.
    Type: Grant
    Filed: May 31, 2006
    Date of Patent: November 10, 2009
    Assignee: Vertex Pharmaceuticals (San Diego) LLC
    Inventors: Michael P. Maher, Jesus E. Gonzalez, III
  • Ion channel assay methods
    Patent number: 7615356
    Abstract: A method of characterizing the biological activity of a candidate compound may include exposing cells to the candidate compound, and then exposing the cells to a repetitive application of electric fields so as to set the transmembrane potential to a level corresponding to a pre-selected voltage dependent state of a target ion channel.
    Type: Grant
    Filed: July 14, 2003
    Date of Patent: November 10, 2009
    Assignee: Vertex Pharmaceuticals (San Diego) LLC
    Inventors: Michael P. Maher, Jesus E. Gonzalez, III
  • Ion channel assay methods
    Patent number: 7611850
    Abstract: A method of characterizing the biological activity of a candidate compound may include exposing cells to the candidate compound, and then exposing the cells to a repetitive application of electric fields so as to set the transmembrane potential to a level corresponding to a pre-selected voltage dependent state of a target ion channel.
    Type: Grant
    Filed: May 31, 2006
    Date of Patent: November 3, 2009
    Assignee: Vertex Pharmaceuticals (San Diego) LLC
    Inventors: Michael P. Maher, Jesus E. Gonzalez, III
  • MACROCYCLIC PEPTIDES AND METHODS FOR MAKING AND USING THEM
    Publication number: 20090264345
    Abstract: The invention provides novel macrocyclic peptides and methods for their preparation. The invention also provides pharmaceutical compositions and methods to treat, prevent or ameliorate a cell proliferative disease or conditions. e.g., a cancer. in a subject in need thereof, including but not limited to a colon cancer, such as MSS or MSI colon cancer, and pancreatic cancer. This invention provides for the synthesis and development of novel anticancer agents that are based on the core structure Sansalvamide A (San A).
    Type: Application
    Filed: March 19, 2007
    Publication date: October 22, 2009
    Applicant: San Diego State University Research Foundation
    Inventors: Shelli R. McAlpine, Kathleen McGuire
  • KINASE INHIBITORS
    Publication number: 20090247554
    Abstract: Compounds are provided for use with kinases that comprise (I), (II), (III), (IV): wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
    Type: Application
    Filed: March 27, 2007
    Publication date: October 1, 2009
    Applicant: TAKEDA SAN DIEGO, INC.
    Inventors: Qing Dong, Michael B. Wallace
  • Weak hypothesis generation apparatus and method, learning apparatus and method, detection apparatus and method, facial expression learning apparatus and method, facial expression recognition apparatus and method, and robot apparatus
    Patent number: 7587069
    Abstract: A facial expression recognition system that uses a face detection apparatus realizing efficient learning and high-speed detection processing based on ensemble learning when detecting an area representing a detection target and that is robust against shifts of face position included in images and capable of highly accurate expression recognition, and a learning method for the system, are provided. When learning data to be used by the face detection apparatus by Adaboost, processing to select high-performance weak hypotheses from all weak hypotheses, then generate new weak hypotheses from these high-performance weak hypotheses on the basis of statistical characteristics, and select one weak hypothesis having the highest discrimination performance from these weak hypotheses, is repeated to sequentially generate a weak hypothesis, and a final hypothesis is thus acquired.
    Type: Grant
    Filed: March 7, 2008
    Date of Patent: September 8, 2009
    Assignees: Sony Corporation, San Diego, University of California
    Inventors: Javier R. Movellan, Marian S. Bartlett, Gwendolen C. Littlewort, John Hershey, Ian R. Fasel, Eric C. Carlson, Josh Susskind, Kohtaro Sabe, Kenta Kawamoto, Kenichi Hidai
  • Metalloprotein inhibitors
    Patent number: 7579486
    Abstract: The present invention relates to metalloprotein inhibitors comprising: a. an organic substituent and at least one zinc binding group (ZBG) covalently attached thereto; or b. a ZBG substituted by a side chain wherein the ZBG is of formula (I): wherein X is O or S and each R1, R2, R3, and R4 is individually hydrogen or an organic radical. The metalloprotein inhibitors are useful for preventing or treating a pathological disease, condition, or symptom that is associated with pathological metalloprotein activity and/or that is alleviated by inhibition of said activity.
    Type: Grant
    Filed: October 30, 2006
    Date of Patent: August 25, 2009
    Assignee: Regents of the University of California, San Diego
    Inventors: David T. Puerta, Seth M. Cohen, Jana A. Lewis
  • VISCOUS BUDESONIDE FOR THE TREATMENT OF INFLAMMATORY DISEASES OF THE GASTROINTESTINAL TRACT
    Publication number: 20090191275
    Abstract: Provided herein are methods for preventing or alleviating the symptoms of and inflammation associated with inflammatory diseases and conditions of the gastrointestinal tract, for example, those involving the esophagus. Also provided herein are pharmaceutical compositions useful for the methods of the present invention.
    Type: Application
    Filed: November 12, 2008
    Publication date: July 30, 2009
    Applicant: The Regents of the University of California, San Diego
    Inventors: Ranjan Dohil, John Bastian, Seema Aceves, Elaine Phillips, Malcolm Hill
  • Crystalline composition of farsenyl pyrophosphate synthase (IspA)
    Patent number: 7563610
    Abstract: Provided are crystals relating to Farsenyl Pvrophosphate Synthase (IspA) from E. coli and its various uses.
    Type: Grant
    Filed: August 28, 2003
    Date of Patent: July 21, 2009
    Assignee: Takeda San Diego, Inc.
    Inventors: Alexei Brooun, Douglas R. Dougan, David Hosfield, Yanming Zhang
  • TOPICAL CORTICOSTEROIDS FOR THE TREATMENT OF INFLAMMATORY DISEASES OF THE GASTROINTESTINAL TRACT
    Publication number: 20090181099
    Abstract: Provided herein are methods for preventing or alleviating the symptoms of and inflammation associated with inflammatory diseases and conditions of the gastrointestinal tract, for example, those involving the esophagus. Also provided herein are pharmaceutical compositions useful for the methods of the present invention.
    Type: Application
    Filed: November 12, 2008
    Publication date: July 16, 2009
    Applicant: The Regents of the University of California, San Diego
    Inventors: Ranjan DOHIL, John BASTIAN, Seema ACEVES, Elaine PHILLIPS, Malcolm HILL