Abstract: Provided are crystals relating to human Glucocorticoid Receptor and its various uses.

Abstract: Provided are crystals relating to 11-Beta-Hydroxysteroid Dehydrogenase type 1 and its various uses.

Abstract: Histone deacetylase inhibitors and uses thereof are provided that have the general formula wherein R1, R2, R3 and R4 are each independently selected from the group consisting of hydrogen, a substituted or unsubstituted straight chained C1-12 alkyl, C2-12 aminoalkyl or C2-12 oxaalkyl, and a substituted and unsubstituted 3, 4, 5, 6, 7 or 8 membered ring, with the proviso that R3 and R4 are not both hydrogen; R5 is selected from the group consisting of a carbonyl, a substituted or unsubstituted C1-3 alkyl, a substituted or unsubstituted —C1-3 alkyl-C(O), a substituted or unsubstituted —C(O)—C1-3 alkyl, and a substituted or unsubstituted —C(O)C(O)C1-3 alkyl; M is a substituent capable of complexing with a protein metal ion; and L is a substituent comprising a chain of 3-12 atoms connecting the M substituent to the carbon atom alpha to the L substituent.

Abstract: A probe, kit comprising the probe, and methods for using the probe are provided where the probe comprises: wherein DM is a detectable marker; and L is a straight or branched chain moiety providing between 1 and 20 atom separation between DM and the ring atom to which DM is attached.

Abstract: A transmit-only Bluetooth-compatible apparatus is described comprising: a protocol stack compatible with the Bluetooth protocol standard, the protocol stack including selected portions of the Bluetooth protocol used only for transmitting data; and a transceiver communicatively coupled to the protocol stack and configured to physically transmit the data. Also described is a receive-only Bluetooth-compatible apparatus comprising: a protocol stack compatible with the Bluetooth protocol standard, the protocol stack including selected portions of the Bluetooth protocol used only for receiving data; and a transceiver communicatively coupled to the protocol stack and configured to physically receive the data. Also described is a method comprising: generating a transmit-only Bluetooth protocol stack by removing elements of a standard Bluetooth protocol stack related to receiving data; and configuring the transmit-only Bluetooth protocol stack in a transmit-only wireless device for transmitting data.

Abstract: The present invention relates to certain substituted heterocycles of Formula (I) which are useful in the treatment of diseases related to lipid and carbohydrate metabolism, such as type 2 diabetes, adipocyte differentiation, uncontrolled proliferation, such as lymphoma, Hodgkin's Disease, leukemia, breast cancer, prostate cancer or cancers in general; and inflammation, such as osteoarthritis, rheumatoid arthritis, Crohn's Disease or Inflammatory Bowel Disease

Abstract: The process comprises insertion of an element in tiles by cementing, the element being obtained by sinking organic or inorganic objects into a transparent matrix made using polyester trivalent, acrylic or epoxy resin, and a subsequent hermetic crystallization of the organic or inorganic element in the transparent matrix. The system for fixing the element in the tile can be done using a paper lattice and glass fibre with silicone glue or hot-gluing done on the back of the tile, or by simple cementing between the lateral surface the transparent element and the lateral surface of the recess made in the tile. The fixture can comprise a further stage of decorative and fixture-coating on the visible side of the tile. The invention can be applied on coloured two-faces tiles so that the insert, thanks to the fact that it is transparent, can be visible on both sides.

Abstract: The present invention provides methods of modulating abscisic acid signal transduction in plants. The method comprise introducing into the plant a recombinant expression cassette comprising a promoter operably linked to an ABH1 polynucleotide.

Abstract: The invention relates to certain bicyclic heterocycles havng the structure shown below which are useful in the treatment of diseases related to lipid and carbohydrate metabolism, such as type 2 diabetes, and atherosclerosis.

Abstract: A method and apparatus for tuning a VCO circuit to provide desired modulations is described. In one embodiment, the method of the present invention uses a controlled voltage from a digital-to-analog converter to obtain VCO voltage/frequency characteristics. The VCO voltage/frequency characteristics are used to determine a VCO capacitance value as well as a charge pump current level for each frequency band of interest. For one embodiment, the VCO circuit includes a bank of switchable capacitors used to set the VCO capacitance value. The charge pump includes a number of switch-controlled current meters to set the charge pump current level. The VCO capacitors and charge pump current meters are controlled by an off-chip CPU.

Abstract: Drug candidate screening methods are applied to discover compounds with activity against ion channel targets. The method may include modulating the transmembrane potential of host cells in a plurality of sample wells with a repetitive application of electric fields so as to set the transmembrane potential to a level corresponding to a pre-selected voltage dependent state of a target ion channel.

Abstract: Compositions and methods useful in facilitating or conducting a reaction at effective conditions, such as room temperature (e.g. about 70 degrees F.), utilize a compound including at least two different heteroatoms, and optionally a heterocycle, and a transition metal. The compound is effective in facilitating a variety of reactions including hydrolysis reactions, alcoholysis reactions, aminolysis reactions, carbon dioxide conversion reactions, hydroamination reactions, hydration reactions, and the like.

Abstract: Compounds that may be used to inhibit histone deacetylase having the formula Z-Q-L-M or Z-L-M wherein M is a substituent capable of complexing with a deacetylase catalytic site and/or a metal ion; L is a substituent providing between 0–10 atoms separation between the M substituent and the remainder of the compound; and Z and Q are as defined herein.

Abstract: The invention provides a fertile transgenic monocot, e.g., maize, plant encoding an endosperm specific prolamin box binding factor peptide (PBF) that is expressed so as to increase the methionine and/or lysine content of the seeds of said plant over said content in the seeds of the corresponding plant that lacks said gene, wherein said corresponding plant was used to prepare said transgenic plant, or an ancestor of said transgenic plant.

Abstract: A method is provided for identifying a search model to use in molecular replacement for determining a structure of a target biomolecule, such as a protein, from X-ray diffraction data, the method comprising: employing computer executable logic to perform multiple molecular replacement searches on X-ray diffraction data of the target biomolecule where a group of different biomolecule structures are used as search models for the multiple molecular replacement searches; and employing computer executable logic to compare solutions from the multiple molecular replacement searches, the comparison producing data from which biomolecule structures can be identified as having superior structural identity with the target biomolecule as compared to the other biomolecule structures in the group.

Abstract: The invention relates to certain heterocyclic compounds useful for the treatment of cancer and other diseases, having the Formula (I): wherein: (a) m is an integer 0 or 1; (b) R12 is an alkyl, a substituted alkyl, a cycloalkyl, a substituted cycloalkyl, a heterocyclic, a substituted heterocyclic, a heteroaryl, a substituted heteroaryl, an aryl or a substituted aryl residue; (c) Ar3 is an aryl, a substituted aryl, a heteroaryl or a substituted heteroaryl residue; (d) Ar4 is an aryl, a substituted aryl, a heteroaryl or a substituted heteroaryl residue; (e) R5 is hydrogen, hydroxy, alkyl or substituted alkyl; (f) ----- represents a bond present or absent; and (g) W, X, Y and Z are independently or together —C(O)—, C(S), S, O, or NH; or a pharmaceutically acceptable salt thereof.

Abstract: Histone deacetylase inhibitors and uses thereof are provided that have the general formula wherein R1, R2, R3 and R4 are each independently selected from the group consisting of hydrogen, a substituted or unsubstituted straight chained C1-12 alkyl, C2-12 aminoalkyl or C2-12 oxaalkyl, and a substituted and unsubstituted 3, 4, 5, 6, 7 or 8 membered ring, with the proviso that R3 and R4 are not both hydrogen; R5 is selected from the group consisting of a carbonyl, a substituted or unsubstituted C1-3 alkyl, a substituted or unsubstituted —C1-3 alkyl-C(O), a substituted or unsubstituted —C(O)—C1-3 alkyl, and a substituted or unsubstituted —C(O)C(O)C1-3 alkyl; M is a substituent capable of complexing with a protein metal ion; and L is a substituent comprising a chain of 3–12 atoms connecting the M substituent to the carbon atom alpha to the L substituent.

Abstract: The present invention relates to hepatitis virus core proteins and nucleic acids. In particular, the present invention provides compositions and methods comprising recombinant hepatitis virus core proteins or nucleic acids for use in vaccine formulations.

Abstract: Systems and methods are provided for evaluating a crystallization experiment, where a crystallization experiment of a molecule is to X-rays while housed within a container in which the crystallization experiment is performed; and one or more X-ray diffraction patterns from the X-ray exposure are used to evaluate whether crystalline material is present in the crystallization experiment.

Abstract: A method for emulating a physical connection using a wireless connection includes establishing a communication connection with a peripheral according to a communication protocol using a host controller. The method further includes receiving a wireless signal carrying data having a format specified by the communication protocol, extracting the data from the wireless signal, and communicating the data to the peripheral using the communication connection.