Abstract: Provided are crystals relating to human mitogen-activated protein kinase kinase2 (MAPKK2), also known as MAPK/ERK Kinase2 (MEK2) and its various uses.
Type:
Grant
Filed:
March 7, 2005
Date of Patent:
May 6, 2008
Assignee:
Takeda San Diego, Inc.
Inventors:
Ciaran N. Cronin, Douglas R. Dougan, Mark W. Knuth, Michelle L. Kraus, Kheng Lim, Clifford D. Mol, Gyorgy Snell, Hua Zou
Abstract: A remote device is capable to receive network address information, such as uniform resource locator (URL) addresses, and other supplemental content that are available along with television signal. A set top box coupled to a television receives the network address information via triggers. The set top box transmits a television program from a first channel to a television, and transmits network address information associated with a second channel to the remote device. After receiving the network address information, the remote device can display the corresponding supplemental content while a viewer is watching the first channel on the television. The supplemental content can include program-related address information and/or non-programming-related content. In another technique, the viewer can subscribe certain channels, such that supplemental content on the subscribed channels is obtained and stored, and can be made available to the remote device via the set top box or via a different communication link.
Abstract: Provided are crystals relating to DPPIV and its various uses.
Type:
Grant
Filed:
September 9, 2003
Date of Patent:
March 18, 2008
Assignee:
Takeda San Diego, Inc.
Inventors:
Kathleen Aertgeerts, Ciaran N. Cronin, David J. Hosfield, Mark W. Knuth, Duncan E. McRee, Sridhar Prasad, Bi Ching Sang, Robert J. Skene, Robert A. Wijnands, Sheng Ye
Abstract: The present invention relates to hepatitis virus core proteins and nucleic acids. In particular, the present invention provides compositions and methods comprising recombinant hepatitis virus core proteins or nucleic acids for use in vaccine formulations.
Abstract: Provided are crystals relating to Cathepsin S and its various uses.
Type:
Grant
Filed:
August 22, 2003
Date of Patent:
January 15, 2008
Assignee:
Takeda San Diego, Inc.
Inventors:
Ellen Chien, Douglas R. Dougan, Mark W. Knuth, Duncan E. McRee, Bi Ching Sang, Robert J. Skene, Ronald V. Swanson, Leslie W. Tari, Robert A. Wijnands
Abstract: The present invention relates to phosphonate, nucleoside phosphonate or nucleoside phosphate compounds, compositions containing them, processes for obtaining them, and their use in treating a variety of medical disorders, in particular viral infections, cancers and the like.
Type:
Application
Filed:
April 18, 2007
Publication date:
January 10, 2008
Applicants:
CHIMERIX, INC., UNIVERSITY OF CALIFORNIA, SAN DIEGO
Inventors:
Karl Hostetler, James Beadle, Jacqueline Ruiz, Merrick Almond, George Painter, Tim Riley, Paula Francom
Abstract: A method of characterizing the biological activity of a candidate compound may include exposing cells to the candidate compound, and then exposing the cells to a repetitive application of electric fields so as to set the transmembrane potential to a level corresponding to a pre-selected voltage dependent state of a target ion channel.
Type:
Grant
Filed:
March 12, 2001
Date of Patent:
December 25, 2007
Assignee:
Vertex Pharmaceuticals (San Diego) LLC
Inventors:
Michael P. Maher, Jesus E. Gonzalez, III
Abstract: This invention provides a class of binding proteins with a range of binding specificities and affinities based upon variation at select amino acid positions within a scaffold. The variable positions may be readily modified to produce a library of binding proteins with different binding specificities and affinities. The library may be screened to identify one or more as binding a ligand of interest. Compositions comprising the binding proteins, as well as methods of using the binding proteins are also provided.
Type:
Application
Filed:
December 31, 2004
Publication date:
November 29, 2007
Applicant:
University of California, San Diego
Inventors:
Partho Ghosh, Stephen McMahon, Jason Miller, Jeffrey Lawton
Abstract: A fluid dispensing system comprising: a fluid container; a dispensing head in fluid communication with the fluid container; a displacement mechanism which delivers fluid from the fluid container to the dispensing head such that an aliquot of liquid is delivered to a distal end of the dispensing head where the aliquot of liquid is retained; and a pressurized gas displacement mechanism which delivers an aliquot of gas to the distal end of the dispensing head which causes the aliquot of liquid retained at the distal end of the dispensing head to separate from the distal end of the dispensing head.
Type:
Grant
Filed:
May 15, 2003
Date of Patent:
November 13, 2007
Assignee:
Takeda San Diego, Inc.
Inventors:
Jeffrey B. Goldberg, William Spencer, Bruce K. Bridges
Abstract: The invention relates to molecules having Formula (100): wherein ————— represents a bond present or absent; Ar is a substituted or unsubstituted benzene or pyridine ring; V is a C or N atom, and W, X, Y and Z together form a 2,4-thiazolidinedione, 2-thioxo-4-thiazolidinedione, isoxazolidinedione, 2,4-imidazolidinedione, [1,2,4]-oxadiazolidine-3,5-dione or 2-thioxo-4-imidazolidinedione residue; or a pharmaceutically acceptable salt thereof.
Type:
Grant
Filed:
March 8, 2002
Date of Patent:
September 4, 2007
Assignees:
Incyte San Diego Inc., Ortho McNeil Pharmaceutical Inc.
Abstract: Techniques for implementing systems and methods for topology management, power control and cross-layer design in directional antenna-based wireless mobile ad hoc networks are described. A multiple access control (MAC) system for a directional antenna and time division multiple access communication (DTMAC) node includes a neighbor discovery computer process designed to identify one or more neighbor nodes. The MAC system also includes a make reservation computer process designed to identify and reserve at least one transmission time slot with at least one of the one or more identified neighbor nodes. Further, the MAC system includes a data transmission computer process designed to transmit data to the at least one of the one or more identified neighbor nodes during the at least one reserved transmission time slot.
Type:
Application
Filed:
February 23, 2007
Publication date:
August 23, 2007
Applicant:
SAN DIEGO RESEARCH CENTER, INC.
Inventors:
Bo Ryu, Zhensheng Zhang, Zhuochuan Huang
Abstract: Interconnection and integration of a WWAN and a WLAN to provide continuous packet data services to mobile users where each mobile access terminal is configured to support both air links with the WWAN and WLAN. The WWAN may be a CDMA2000 system and the WLAN may be an IEEE 802.11 system.
Type:
Grant
Filed:
May 28, 2003
Date of Patent:
August 7, 2007
Assignee:
ZTE San Diego, Inc.
Inventors:
James Jiang, Yonggang Fang, Rajesh Bhalla, Mary Chion
Abstract: Histone deacetylase inhibitors and uses thereof are provided that have the general formula: wherein R1, R2, R3, R4, R5, R6, R7, R8, M and L have the definitions as described herein.