Abstract: Provided are crystals relating to human phosphodiesterase 4-D3 (PDE4-D3), methods for forming crystals comprising PDE4-D3 and crystals comprising PDE4-D3 co-crystallized with a ligand molecule, and methods of using crystals comprising PDE4-D3.

Abstract: Compounds are provided for use with kinases that comprise a compound selected from the group consisting of: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.

Abstract: The invention provides methods and apparatus for detecting radiation including x-ray, gamma ray, and particle radiation for nuclear medicine, radiopaphic imaging, material composition analysis, high energy physics, container inspection, mine detection and astronomy. The invention provides detection systems employing one or more detector modules (102) comprising edge-on scintillator detectors (101) with sub-aperture resolution (SAR) capability employed, e.g., in nuclear medicine, such as radiation therapy portal imaging, nuclear remediation, mine detection, container inspection, and high energy physics and astronomy. The invention also provides edge-on imaging probe detectors for use in nuclear medicine, such as radiation therapy portal imaging, or for use in nuclear remediation, mine detection, container inspection, and high energy physics and astronomy.

Abstract: Provided are crystals relating to the carboxyltransferase domain of human Acetyl-Coenzyme A Carboxylase 2 and its various uses.

Abstract: Compounds are provided for use with glucokinase that comprise the formula: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.

Abstract: A crystallization system is provided comprising a trial generation station configured to generate crystallization trials in trial zones of a crystallization plate; an imaging station configured to take images of crystallization trials in the crystallization plate; a transport mechanism configured to transport the crystallization plate to the imaging station after generation of the crystallization trials; and a controller including logic for causing the trial generation station to generate the crystallization trials in the crystallization plate, logic for causing the transport mechanism to transport the crystallization plate to the imaging station and logic for causing the imaging station to take images of the crystallization trials.

Abstract: Provided are crystals relating to histone deacetylase 2 (HDAC-2) and its various uses.

Abstract: Since ultrasonic velocities in anisotropic media can change by a factor of 3 or more depending on the direction of propagation, accounting for these changes is extremely important. Also many anisotropic materials are made up of multiple layers of varying orientation, hence the need to account for refraction at ply boundaries. In the present invention, an algorithm is used to calculate these velocities and travel times and properly account for refraction phenomena. Specifically a multilayer SAFT algorithm has been developed that will calculate the time shift, shift and sum A-scan waveforms in layered anisotropic media at any given depth, ply orientation, and number of plies. The algorithm showed an improvement in signal to noise ratio with synthetic data as was expected. This algorithm can be used as a replacement for homogenizing material properties in layered media and will calculate time shifts with increased accuracy since exact material properties are used.

Abstract: Systems and techniques for reducing distortions in magnetic resonance images. In one aspect, machine-implemented method for reducing image distortion in magnetic resonance imaging (MRI) includes receiving a first MRI image and a second MRI image, estimating displacements of voxels between the first MRI image and the second MRI image by minimizing a cost function expressing a cost of the displacements, reducing distortion in an MRI image using the estimated displacements, and making the MRI image having reduced distortion available. The first MRI image and the second MRI image were acquired using different gradient fields.

Abstract: A method is provided for operating a crystallization system comprising identifying a screen storage plate from among the plurality of screen storage plates stored in a screen storage station, each screen storage plate having a plurality of wells that contain a screen solution and at least a portion of the screen storage plates having a selection of screen solutions that is different from the selection of screen solutions held in other screen storage plates; having a transport mechanism transport the identified screen storage plate to a screen replicator; transporting a plurality of crystallization plates to the screen replicators; and having the screen replicator transfer the screen solutions from the identified screen storage plate to the plurality of crystallization plates.

Abstract: This invention provides a device, or product of manufacture, for use as a teaching device for tying knots, or as an aid in tying knots, e.g., as for use by handicapped or disabled individuals. The invention provides device, or product of manufacture, completely automated for tying knots using the device and/or methods of the invention. The invention also provides methods for making and using these devices of the invention.

Abstract: The Planetary Improvement Motor uses new thermodynamic ideas that redefine heat pumps and engines with an immaculate engine and pump design that can replace nearly all engines and pumps with one basic, simple design. The Planetary Improvement Motor can save the planet if you let it. WOW! YOU MUST BE LIKE A PHYSICIST OR SOMETHING TO COME UP WITH SUCH A GREAT IDEA? Actually, “No, I have never been interested in medicine. I am an artist, this is my art.

Abstract: Poly(ethylene oxide) (PEO) glycodendrimers can serve as multivalent inhibitors of selectin-mediated leukocyte recruitment regulating inflammatory response. Disclosed are compounds and methods relating to functionalized branched glycopolymers. In embodiments, the compounds are capable of modifying cell adhesion events and inflammatory conditions. In a particular embodiment, a multi-arm PEO polymer with sulfated lactose end groups can specifically inhibit interactions involving L-selectin. Also disclosed are methods of synthetic preparation and use.

Abstract: Provided are crystals relating to Aurora/LPL1P-related kinase and its various uses.

Abstract: A trial generation station is provided comprising: a deck configured to receive a crystallization plate from a transport mechanism, the crystallization plate including a plurality of trial zones where crystallization trials are generated; and a head configured to be moved relative to the stage, the head including a plurality of primary fluid dispensers, each fluid dispenser being configured to transfer a portion of a mother liquor from the well region of a trial zone to a sample region associated with the trial zone, and one or more secondary fluid dispensers configured to dispense a molecule solution into the sample regions of the wells, the molecule solution including the molecule to be crystallized by the system and at least one of the secondary fluid dispenser being laterally immobilized relative to one or more of the fluid dispensers.

Abstract: A crystallization system is provided comprising a screen generation station; a screen storage station; including a housing configured to store a plurality of screen storage plates and mechanics for retrieving a selected screen storage plate from among the plurality of screen storage plates for transport to another station a transport mechanism configured to transport a screen storage plate containing the screen solutions generated at the screen generation station to the screen storage station; and a controller.