Patents Assigned to DSM
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Patent number: 12351690Abstract: The present invention relates to a composition comprising a specific hyperbranched copolymer (HBC) of the monomers dodecenyl succinic acid anhydride, diisopropanol amine and bis-dimethylaminopropyl amine and the compound 1,3-propandiol and/or N-hydroxyoctanamide. It has been found that said hyperbranched copolymer synergistically enhances the antimicrobial action of a 1,3-propanediol and/or N-hydroxy-octanamide.Type: GrantFiled: March 31, 2020Date of Patent: July 8, 2025Assignee: DSM IP ASSETS B.V.Inventor: Christine Mendrok-Edinger
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Patent number: 12343449Abstract: The disclosure relates to high-strength polyolefin composite fibers, which fibers have a fiber body comprising a composition consisting of polyolefin; 1-30 mass % of bioceramic particles having particle size D50 of 0.01-10 ?m; at most 0.05 mass % of residual spin solvent; optionally 0-3 mass % of other additives; and wherein the sum of a)-d) is 100 mass %; and which fibers have bioceramic particles exposed at their surface, and show bioactivity. The composite fibers based on a composition of polyolefin with bioceramic particles mixed therein show particles being exposed at the fiber surface by techniques like AFM and XPS, and although apparently only a relatively small amount of bioceramic particles is exposed at the fiber surface, this appears sufficient for effective interaction with their environment and stimulating a positive biological response as demonstrated by in vitro cell studies.Type: GrantFiled: March 6, 2019Date of Patent: July 1, 2025Assignee: DSM IP ASSETS B.V.Inventors: Aylvin Jorge Angelo Athanasius Dias, Noel L. Davison, Anne Marie Persson, Ynze Mengerink, Paul Mathieu De Bueger
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Patent number: 12342838Abstract: The present invention discloses a LC-PUFA biomass composition which has reduced self-heating propensity and thus requires a lessened packing requirement for shipment. The invention also discloses methods for making such biomass composition.Type: GrantFiled: August 9, 2019Date of Patent: July 1, 2025Assignees: DSM IP ASSETS B.V., EVONIK OPERATIONS GMBHInventors: Michael Benjamin Johnson, Shannon Elizabeth Ethier Resop
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Patent number: 12329180Abstract: The present invention discloses a native rapeseed protein isolate comprising 40 to 65% cruciferins and 35 to 60% napins and having a solubility of at least 88% when measured over a pH range from 3 to 10 at a temperature of 23±2° C.; wherein the native rapeseed protein isolate comprises from 5% to 65% on dry matter of 12S rapeseed protein where the presence of 12S is verified by Blue Native PAGE.Type: GrantFiled: December 20, 2022Date of Patent: June 17, 2025Assignee: DSM IP ASSETS B.V.Inventors: Johannes Hendrikus Maria Willemsen, Johannes Hendrikus Antonius Jeroen Vermunt, Nienke Nina Hylkema, Gerardus Johannes Franciscus Smolders
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Patent number: 12312556Abstract: Disclosed herein are processes for reducing or eliminating emulsion during the process of obtaining a microbial oil comprising one or more polyunsaturated fatty acids (PUFAs) from one or more microbial cells by washing the fermentation broth with at least 1× amount of water. Further disclosed herein is microbial oil comprising one or more PUFAs that is recovered from microbial cells by at least one process described herein.Type: GrantFiled: March 29, 2019Date of Patent: May 27, 2025Assignees: DSM IP ASSETS B.V., EVONIK OPERATIONS GMBHInventors: Negash Adugna, Martin Heining, Michael Benjamin Johnson, Neil Francis Leininger, Kirt Lyvell Matthews, Sr., Ginger Marie Shank, Nasrin Tabayehnejad, Vinod Tarwade
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Patent number: 12295388Abstract: The present disclosure relates to methods of feeding animals by providing feed additives that modulate the gut microbiome to improve the health, nutrition, and growth performance. The present disclosure further relates to methods of modulating metabolites present in the gastrointestinal tract of an animal. Such modulation includes, for example, modulating the level said metabolites.Type: GrantFiled: November 8, 2019Date of Patent: May 13, 2025Assignee: DSM IP ASSETS B.V.Inventors: Estel Canet-Martinez, John Michael Geremia, Ulrich Hoeller, Lisa Ann Laprade, Ghislain Schyns
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Patent number: 12290083Abstract: The present invention is directed to a composition comprising rapeseed protein, a hydrocolloid, and a vegetable oil, and to the use of such composition in food products such as a beverage.Type: GrantFiled: June 18, 2020Date of Patent: May 6, 2025Assignee: DSM IP ASSETS B.V.Inventors: Ya-Hui Chien, Arjen Sein, Johanna Corline Margriet Vink
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Patent number: 12285033Abstract: A recombinant host capable of producing a steviol glycoside which overexpresses a polypeptide which mediates steviol glycoside transport and which polypeptide comprises the amino acid sequence set forth in SEQ ID NO: 29 or an amino acid sequence having at least about 50% sequence identity thereto. A recombinant host capable of producing a steviol glycoside which has been modified, preferably in its genome, to result in a deficiency in the production of a polypeptide which mediates steviol glycoside transport and which polypeptide comprises the amino acid sequence set forth in SEQ ID NO: 29 or an amino acid sequence having at least about 50% sequence identity thereto.Type: GrantFiled: January 31, 2024Date of Patent: April 29, 2025Assignee: DSM IP ASSETS B.V.Inventors: Viktor Marius Boer, Priscilla Zwartjens, Eric Van Den Berg
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Patent number: 12286658Abstract: This invention relates to a method of producing one or more human milk oligosaccharides (HMOs), in particular LNT and/or LNnT, in a genetically engineered cell comprising an enhanced oligosaccharide transport capability. The genetically modified cell comprises a series of genetic modification which enable the production of one or more HMO(s), and a series of genetic modification that enhances the transport of lactose and produced HMO(s).Type: GrantFiled: May 17, 2022Date of Patent: April 29, 2025Assignee: DSM IP Assets B.V.Inventor: Manos Papadakis
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Publication number: 20250129395Abstract: The present disclosure provides a method for increasing production of a polyunsaturated fatty acid, especially eicosapentaenoic acid (EPA), in a microorganism, comprising adjusting the macro-and/or micronutrients during fermentation. The invention includes any culture, biomass, and oil produced by the method.Type: ApplicationFiled: January 24, 2023Publication date: April 24, 2025Applicant: DSM IP Assets B.V.Inventors: Jose R. GARCIA, Adam BURJA, Xiao Daniel DONG
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Patent number: 12275755Abstract: The present invention is directed to a process for purifying natamycin, to an all-trans polyene amphoteric macrolide, to a composition comprising said polyene amphoteric macrolide and to a process for preparing said polyene amphoteric macrolide.Type: GrantFiled: February 6, 2023Date of Patent: April 15, 2025Assignee: DSM IP ASSETS B.V.Inventors: Alexander Lucia Leonardus Duchateau, Peter Philip Lankhorst, Willebrordus Bernardus Van Scheppingen
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Patent number: 12270006Abstract: The disclosure relates to a coating composition comprising a polymerizable compound of formula [1], wherein G is a residue of a hydrophobic hydroxy-functional oligomer, n is 1-10, each R1 independently is a residue of a C6-C20 aliphatic, cycloaliphatic, or aromatic hydrocarbon compound, and Z is a moiety having a polymerizable group; Formula [1] a hydrophilic polymer; a photo-initiator; optionally one or more further components, and a solvent. The polymerizable compound of formula [1] is typically present in an amount of 2.0-30 mass % based on total dry mass of the composition. Such coating composition can be made into a well-adhering single-layer hydrophilic coating on a surface of polymer substrates without providing a primer layer or chemically modifying the surface of the substrate. Upon wetting, the coating shows excellent lubricity and durability.Type: GrantFiled: May 11, 2021Date of Patent: April 8, 2025Assignee: DSM IP ASSETS B.V.Inventor: Johannes Wilhelmus Belt
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Patent number: 12270065Abstract: The present invention is related to the production of bio-based carotenoids, particularly to methods for enhancing the titer and purity of beta-carotene fermentation in a suitable host cell.Type: GrantFiled: August 3, 2020Date of Patent: April 8, 2025Assignee: DSM IP ASSETS B.V.Inventors: John Royer, Emily Davis Streaker, Warren Nelson Itterly
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Patent number: 12258311Abstract: The present invention relates to a new compound and the dehydrogenation of that compound to produce retinal.Type: GrantFiled: December 15, 2020Date of Patent: March 25, 2025Assignee: DSM IP ASSETS B.V.Inventors: Werner Bonrath, Marc-André Mueller, Bettina Wuestenberg, Viktor Zimmermann
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Patent number: 12252614Abstract: Disclosed are compositions that may be useful for forming synthetic membranes, methods of forming membranes therefrom, and membranes. In an embodiment, a membrane comprises a free hydrophilic polymer comprising a polyoxazoline, and a polyurethane, the polyurethane comprising a backbone comprising the reaction product of a diisocyanate, a polymeric aliphatic 5 diol, and optionally a chain extender.Type: GrantFiled: March 29, 2023Date of Patent: March 18, 2025Assignee: DSM IP ASSETS B.V.Inventors: Jennifer Al-Rashid, Jacob Riffey, Chad Sugiyama, John Zupancich
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Patent number: 12252685Abstract: A feed control system and related methods for a heterologous product, such as a human milk oligosaccharide, fermentation system are disclosed. The feed control system comprises a feed controller. The feed controller comprises a processor and an interface. The processor is configured to obtain a biomass content in a fermentation broth. The processor is configured to determine a carbon input parameter based on the biomass content. The processor is configured to control a carbon input to the fermentation broth according to the carbon input parameter.Type: GrantFiled: November 10, 2022Date of Patent: March 18, 2025Assignee: DSM IP ASSETS B.V.Inventors: Natalia Chrapkova, Peter Becker, Ted Johanson, Mikael Jansen
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Patent number: 12251391Abstract: The present disclosure relates to methods of feeding animals by providing feed additives that modulate the gut microbiome to prevent or treat dysfunctions in a gastrointestinal barrier. The present disclosure further relates to methods of feeding animals by providing feed additives that modulate the gut microbiome to prevent or treat infections.Type: GrantFiled: November 8, 2019Date of Patent: March 18, 2025Assignee: DSM IP ASSETS B.V.Inventors: Britta Blokker, Stephane Duval, John Michael Geremia, Estefania Perez Calvo, Nathalie Richard, Jerome Schmeisser, Nicole Seifert, Viviane Verlhac
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Patent number: 12252724Abstract: The present invention is related to a novel enzymatic process for production of retinoids via a multi-step process, which process includes the use of heterologous enzymes having activity in a carotene-producing host cell, particularly wherein such process results in high percentage of retinoids, in trans-isoform.Type: GrantFiled: January 30, 2023Date of Patent: March 18, 2025Assignee: DSM IP ASSETS B.V.Inventors: Nathalie Balch, Paul Blomquist, Reed Doten, Peter Houston, Ethan Lam, Jenna McMahon, Joshua Trueheart, Celine Viarouge
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Patent number: 12239762Abstract: The invention provides composite materials that form a biocompatible and bioresorbable settable ceramic-forming composition, and that possesses high strength when set and other desirable mechanical properties. The composite materials may include additive materials that provide beneficial advantages in the handling and physical properties of the material. When a hydrated precursor, the composite material is capable of being injected through cannulas for placement in treatment sites. The composite material provided desirable handling properties and sets in a clinically relevant time period.Type: GrantFiled: June 21, 2022Date of Patent: March 4, 2025Assignee: DSM IP ASSETS B.V.Inventors: Andrew Fallis, Steven Leonhardt, Justin Kontra, Rakesh Batish, Timothy Ringeisen
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Publication number: 20250069708Abstract: A computer-based method for determining a sunscreen composition comprising a plurality of UV filter substances, comprises the steps of selecting at least one constraint for at least one characteristic of the composition to be determined (step 30), the at least one constraint comprising a sunscreen performance target; selecting an optimization objective from a plurality of optimization objectives (step 50); and automatically determining the sunscreen composition as a composition of filter substances from a set of filter substances (step 100), the composition meeting the at least one constraint and being optimized with respect to the selected optimization objective. The automatic determination comprises the steps of generating a plurality of candidate compositions, determining a sunscreen performance of the candidate compositions using a performance simulation tool and comparing the determined sunscreen performance of the candidate compositions with the sunscreen performance target.Type: ApplicationFiled: November 7, 2024Publication date: February 27, 2025Applicant: DSM IP Assets B.V.Inventor: Alexander SCHLIFKE