Patents Assigned to DSM
  • Patent number: 12351690
    Abstract: The present invention relates to a composition comprising a specific hyperbranched copolymer (HBC) of the monomers dodecenyl succinic acid anhydride, diisopropanol amine and bis-dimethylaminopropyl amine and the compound 1,3-propandiol and/or N-hydroxyoctanamide. It has been found that said hyperbranched copolymer synergistically enhances the antimicrobial action of a 1,3-propanediol and/or N-hydroxy-octanamide.
    Type: Grant
    Filed: March 31, 2020
    Date of Patent: July 8, 2025
    Assignee: DSM IP ASSETS B.V.
    Inventor: Christine Mendrok-Edinger
  • Patent number: 12343449
    Abstract: The disclosure relates to high-strength polyolefin composite fibers, which fibers have a fiber body comprising a composition consisting of polyolefin; 1-30 mass % of bioceramic particles having particle size D50 of 0.01-10 ?m; at most 0.05 mass % of residual spin solvent; optionally 0-3 mass % of other additives; and wherein the sum of a)-d) is 100 mass %; and which fibers have bioceramic particles exposed at their surface, and show bioactivity. The composite fibers based on a composition of polyolefin with bioceramic particles mixed therein show particles being exposed at the fiber surface by techniques like AFM and XPS, and although apparently only a relatively small amount of bioceramic particles is exposed at the fiber surface, this appears sufficient for effective interaction with their environment and stimulating a positive biological response as demonstrated by in vitro cell studies.
    Type: Grant
    Filed: March 6, 2019
    Date of Patent: July 1, 2025
    Assignee: DSM IP ASSETS B.V.
    Inventors: Aylvin Jorge Angelo Athanasius Dias, Noel L. Davison, Anne Marie Persson, Ynze Mengerink, Paul Mathieu De Bueger
  • Patent number: 12342838
    Abstract: The present invention discloses a LC-PUFA biomass composition which has reduced self-heating propensity and thus requires a lessened packing requirement for shipment. The invention also discloses methods for making such biomass composition.
    Type: Grant
    Filed: August 9, 2019
    Date of Patent: July 1, 2025
    Assignees: DSM IP ASSETS B.V., EVONIK OPERATIONS GMBH
    Inventors: Michael Benjamin Johnson, Shannon Elizabeth Ethier Resop
  • Patent number: 12329180
    Abstract: The present invention discloses a native rapeseed protein isolate comprising 40 to 65% cruciferins and 35 to 60% napins and having a solubility of at least 88% when measured over a pH range from 3 to 10 at a temperature of 23±2° C.; wherein the native rapeseed protein isolate comprises from 5% to 65% on dry matter of 12S rapeseed protein where the presence of 12S is verified by Blue Native PAGE.
    Type: Grant
    Filed: December 20, 2022
    Date of Patent: June 17, 2025
    Assignee: DSM IP ASSETS B.V.
    Inventors: Johannes Hendrikus Maria Willemsen, Johannes Hendrikus Antonius Jeroen Vermunt, Nienke Nina Hylkema, Gerardus Johannes Franciscus Smolders
  • Patent number: 12312556
    Abstract: Disclosed herein are processes for reducing or eliminating emulsion during the process of obtaining a microbial oil comprising one or more polyunsaturated fatty acids (PUFAs) from one or more microbial cells by washing the fermentation broth with at least 1× amount of water. Further disclosed herein is microbial oil comprising one or more PUFAs that is recovered from microbial cells by at least one process described herein.
    Type: Grant
    Filed: March 29, 2019
    Date of Patent: May 27, 2025
    Assignees: DSM IP ASSETS B.V., EVONIK OPERATIONS GMBH
    Inventors: Negash Adugna, Martin Heining, Michael Benjamin Johnson, Neil Francis Leininger, Kirt Lyvell Matthews, Sr., Ginger Marie Shank, Nasrin Tabayehnejad, Vinod Tarwade
  • Patent number: 12295388
    Abstract: The present disclosure relates to methods of feeding animals by providing feed additives that modulate the gut microbiome to improve the health, nutrition, and growth performance. The present disclosure further relates to methods of modulating metabolites present in the gastrointestinal tract of an animal. Such modulation includes, for example, modulating the level said metabolites.
    Type: Grant
    Filed: November 8, 2019
    Date of Patent: May 13, 2025
    Assignee: DSM IP ASSETS B.V.
    Inventors: Estel Canet-Martinez, John Michael Geremia, Ulrich Hoeller, Lisa Ann Laprade, Ghislain Schyns
  • Patent number: 12290083
    Abstract: The present invention is directed to a composition comprising rapeseed protein, a hydrocolloid, and a vegetable oil, and to the use of such composition in food products such as a beverage.
    Type: Grant
    Filed: June 18, 2020
    Date of Patent: May 6, 2025
    Assignee: DSM IP ASSETS B.V.
    Inventors: Ya-Hui Chien, Arjen Sein, Johanna Corline Margriet Vink
  • Patent number: 12285033
    Abstract: A recombinant host capable of producing a steviol glycoside which overexpresses a polypeptide which mediates steviol glycoside transport and which polypeptide comprises the amino acid sequence set forth in SEQ ID NO: 29 or an amino acid sequence having at least about 50% sequence identity thereto. A recombinant host capable of producing a steviol glycoside which has been modified, preferably in its genome, to result in a deficiency in the production of a polypeptide which mediates steviol glycoside transport and which polypeptide comprises the amino acid sequence set forth in SEQ ID NO: 29 or an amino acid sequence having at least about 50% sequence identity thereto.
    Type: Grant
    Filed: January 31, 2024
    Date of Patent: April 29, 2025
    Assignee: DSM IP ASSETS B.V.
    Inventors: Viktor Marius Boer, Priscilla Zwartjens, Eric Van Den Berg
  • Patent number: 12286658
    Abstract: This invention relates to a method of producing one or more human milk oligosaccharides (HMOs), in particular LNT and/or LNnT, in a genetically engineered cell comprising an enhanced oligosaccharide transport capability. The genetically modified cell comprises a series of genetic modification which enable the production of one or more HMO(s), and a series of genetic modification that enhances the transport of lactose and produced HMO(s).
    Type: Grant
    Filed: May 17, 2022
    Date of Patent: April 29, 2025
    Assignee: DSM IP Assets B.V.
    Inventor: Manos Papadakis
  • Publication number: 20250129395
    Abstract: The present disclosure provides a method for increasing production of a polyunsaturated fatty acid, especially eicosapentaenoic acid (EPA), in a microorganism, comprising adjusting the macro-and/or micronutrients during fermentation. The invention includes any culture, biomass, and oil produced by the method.
    Type: Application
    Filed: January 24, 2023
    Publication date: April 24, 2025
    Applicant: DSM IP Assets B.V.
    Inventors: Jose R. GARCIA, Adam BURJA, Xiao Daniel DONG
  • Patent number: 12275755
    Abstract: The present invention is directed to a process for purifying natamycin, to an all-trans polyene amphoteric macrolide, to a composition comprising said polyene amphoteric macrolide and to a process for preparing said polyene amphoteric macrolide.
    Type: Grant
    Filed: February 6, 2023
    Date of Patent: April 15, 2025
    Assignee: DSM IP ASSETS B.V.
    Inventors: Alexander Lucia Leonardus Duchateau, Peter Philip Lankhorst, Willebrordus Bernardus Van Scheppingen
  • Patent number: 12270006
    Abstract: The disclosure relates to a coating composition comprising a polymerizable compound of formula [1], wherein G is a residue of a hydrophobic hydroxy-functional oligomer, n is 1-10, each R1 independently is a residue of a C6-C20 aliphatic, cycloaliphatic, or aromatic hydrocarbon compound, and Z is a moiety having a polymerizable group; Formula [1] a hydrophilic polymer; a photo-initiator; optionally one or more further components, and a solvent. The polymerizable compound of formula [1] is typically present in an amount of 2.0-30 mass % based on total dry mass of the composition. Such coating composition can be made into a well-adhering single-layer hydrophilic coating on a surface of polymer substrates without providing a primer layer or chemically modifying the surface of the substrate. Upon wetting, the coating shows excellent lubricity and durability.
    Type: Grant
    Filed: May 11, 2021
    Date of Patent: April 8, 2025
    Assignee: DSM IP ASSETS B.V.
    Inventor: Johannes Wilhelmus Belt
  • Patent number: 12270065
    Abstract: The present invention is related to the production of bio-based carotenoids, particularly to methods for enhancing the titer and purity of beta-carotene fermentation in a suitable host cell.
    Type: Grant
    Filed: August 3, 2020
    Date of Patent: April 8, 2025
    Assignee: DSM IP ASSETS B.V.
    Inventors: John Royer, Emily Davis Streaker, Warren Nelson Itterly
  • Patent number: 12258311
    Abstract: The present invention relates to a new compound and the dehydrogenation of that compound to produce retinal.
    Type: Grant
    Filed: December 15, 2020
    Date of Patent: March 25, 2025
    Assignee: DSM IP ASSETS B.V.
    Inventors: Werner Bonrath, Marc-André Mueller, Bettina Wuestenberg, Viktor Zimmermann
  • Patent number: 12252614
    Abstract: Disclosed are compositions that may be useful for forming synthetic membranes, methods of forming membranes therefrom, and membranes. In an embodiment, a membrane comprises a free hydrophilic polymer comprising a polyoxazoline, and a polyurethane, the polyurethane comprising a backbone comprising the reaction product of a diisocyanate, a polymeric aliphatic 5 diol, and optionally a chain extender.
    Type: Grant
    Filed: March 29, 2023
    Date of Patent: March 18, 2025
    Assignee: DSM IP ASSETS B.V.
    Inventors: Jennifer Al-Rashid, Jacob Riffey, Chad Sugiyama, John Zupancich
  • Patent number: 12252685
    Abstract: A feed control system and related methods for a heterologous product, such as a human milk oligosaccharide, fermentation system are disclosed. The feed control system comprises a feed controller. The feed controller comprises a processor and an interface. The processor is configured to obtain a biomass content in a fermentation broth. The processor is configured to determine a carbon input parameter based on the biomass content. The processor is configured to control a carbon input to the fermentation broth according to the carbon input parameter.
    Type: Grant
    Filed: November 10, 2022
    Date of Patent: March 18, 2025
    Assignee: DSM IP ASSETS B.V.
    Inventors: Natalia Chrapkova, Peter Becker, Ted Johanson, Mikael Jansen
  • Patent number: 12251391
    Abstract: The present disclosure relates to methods of feeding animals by providing feed additives that modulate the gut microbiome to prevent or treat dysfunctions in a gastrointestinal barrier. The present disclosure further relates to methods of feeding animals by providing feed additives that modulate the gut microbiome to prevent or treat infections.
    Type: Grant
    Filed: November 8, 2019
    Date of Patent: March 18, 2025
    Assignee: DSM IP ASSETS B.V.
    Inventors: Britta Blokker, Stephane Duval, John Michael Geremia, Estefania Perez Calvo, Nathalie Richard, Jerome Schmeisser, Nicole Seifert, Viviane Verlhac
  • Patent number: 12252724
    Abstract: The present invention is related to a novel enzymatic process for production of retinoids via a multi-step process, which process includes the use of heterologous enzymes having activity in a carotene-producing host cell, particularly wherein such process results in high percentage of retinoids, in trans-isoform.
    Type: Grant
    Filed: January 30, 2023
    Date of Patent: March 18, 2025
    Assignee: DSM IP ASSETS B.V.
    Inventors: Nathalie Balch, Paul Blomquist, Reed Doten, Peter Houston, Ethan Lam, Jenna McMahon, Joshua Trueheart, Celine Viarouge
  • Patent number: 12239762
    Abstract: The invention provides composite materials that form a biocompatible and bioresorbable settable ceramic-forming composition, and that possesses high strength when set and other desirable mechanical properties. The composite materials may include additive materials that provide beneficial advantages in the handling and physical properties of the material. When a hydrated precursor, the composite material is capable of being injected through cannulas for placement in treatment sites. The composite material provided desirable handling properties and sets in a clinically relevant time period.
    Type: Grant
    Filed: June 21, 2022
    Date of Patent: March 4, 2025
    Assignee: DSM IP ASSETS B.V.
    Inventors: Andrew Fallis, Steven Leonhardt, Justin Kontra, Rakesh Batish, Timothy Ringeisen
  • Publication number: 20250069708
    Abstract: A computer-based method for determining a sunscreen composition comprising a plurality of UV filter substances, comprises the steps of selecting at least one constraint for at least one characteristic of the composition to be determined (step 30), the at least one constraint comprising a sunscreen performance target; selecting an optimization objective from a plurality of optimization objectives (step 50); and automatically determining the sunscreen composition as a composition of filter substances from a set of filter substances (step 100), the composition meeting the at least one constraint and being optimized with respect to the selected optimization objective. The automatic determination comprises the steps of generating a plurality of candidate compositions, determining a sunscreen performance of the candidate compositions using a performance simulation tool and comparing the determined sunscreen performance of the candidate compositions with the sunscreen performance target.
    Type: Application
    Filed: November 7, 2024
    Publication date: February 27, 2025
    Applicant: DSM IP Assets B.V.
    Inventor: Alexander SCHLIFKE